HK1059453A1 - Modified vaccinia ankara virus variant - Google Patents
Modified vaccinia ankara virus variantInfo
- Publication number
- HK1059453A1 HK1059453A1 HK04102348.1A HK04102348A HK1059453A1 HK 1059453 A1 HK1059453 A1 HK 1059453A1 HK 04102348 A HK04102348 A HK 04102348A HK 1059453 A1 HK1059453 A1 HK 1059453A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- virus
- modified vaccinia
- vaccinia ankara
- patients
- ankara virus
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/275—Poxviridae, e.g. avipoxvirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/275—Poxviridae, e.g. avipoxvirus
- A61K39/285—Vaccinia virus or variola virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pulmonology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200001764 | 2000-11-23 | ||
PCT/EP2001/013628 WO2002042480A2 (en) | 2000-11-23 | 2001-11-22 | Modified vaccinia ankara virus variant |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1059453A1 true HK1059453A1 (en) | 2004-07-02 |
Family
ID=8159864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK04102348.1A HK1059453A1 (en) | 2000-11-23 | 2004-03-31 | Modified vaccinia ankara virus variant |
Country Status (30)
Country | Link |
---|---|
US (11) | US6761893B2 (de) |
EP (4) | EP2204452A1 (de) |
JP (1) | JP4421188B2 (de) |
KR (3) | KR100910297B1 (de) |
CN (2) | CN101676389A (de) |
AT (1) | ATE314483T2 (de) |
AU (2) | AU2002231639B2 (de) |
BE (1) | BE2013C065I2 (de) |
BR (1) | BRPI0115533B8 (de) |
CA (1) | CA2421151C (de) |
CY (2) | CY1105594T1 (de) |
CZ (1) | CZ295808B6 (de) |
DE (2) | DE20122302U1 (de) |
DK (1) | DK1335987T4 (de) |
EE (1) | EE05680B1 (de) |
ES (1) | ES2256323T5 (de) |
FR (1) | FR13C0070I2 (de) |
HK (1) | HK1059453A1 (de) |
HU (2) | HU230198B1 (de) |
IL (2) | IL154712A0 (de) |
LU (1) | LU92311I2 (de) |
MX (1) | MXPA03002513A (de) |
NO (1) | NO337867B1 (de) |
NZ (1) | NZ524661A (de) |
PL (1) | PL212047B1 (de) |
PT (1) | PT1335987E (de) |
RU (1) | RU2290438C2 (de) |
SI (1) | SI1335987T2 (de) |
UA (1) | UA76731C2 (de) |
WO (1) | WO2002042480A2 (de) |
Families Citing this family (154)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7628980B2 (en) | 2000-11-23 | 2009-12-08 | Bavarian Nordic A/S | Modified vaccinia virus ankara for the vaccination of neonates |
US7445924B2 (en) | 2000-11-23 | 2008-11-04 | Bavarian Nordic A/S | Modified Vaccinia Ankara virus variant and cultivation method |
US7097842B2 (en) | 2000-11-23 | 2006-08-29 | Bavarian Nordic A/S | Modified vaccinia virus ankara for the vaccination of neonates |
WO2002042480A2 (en) | 2000-11-23 | 2002-05-30 | Bavarian Nordic A/S | Modified vaccinia ankara virus variant |
UA82466C2 (uk) * | 2001-07-18 | 2008-04-25 | Бавариан Нордика А/С | Спосіб посилення ампліфікації хордопоксвірусу |
WO2003048184A2 (en) * | 2001-12-04 | 2003-06-12 | Bavarian Nordic A/S | Flavivirus ns1 subunit vaccine |
NZ547776A (en) | 2002-04-19 | 2009-08-28 | Bavarian Nordic As | Modified vaccinia virus ankara for protecting an animal against an antigen or self-protein |
NZ536500A (en) * | 2002-05-16 | 2008-01-31 | Bavarian Nordic As | Expression of genes in modified vaccinia virus ankara by using the cowpox ATI promoter |
US7501127B2 (en) | 2002-05-16 | 2009-03-10 | Bavarian Nordic A/S | Intergenic regions as novel sites for insertion of HIV DNA sequences in the genome of Modified Vaccinia virus Ankara |
DK1407033T3 (da) * | 2002-05-16 | 2006-05-22 | Bavarian Nordic As | Intergeniske områder som insertionssteder i genomet af Modified Vaccinia Virus Ankara (MVA) |
PT1434858E (pt) | 2002-09-05 | 2008-07-28 | Bavarian Nordic As | Método de amplificação de um poxvírus em condições sem soro |
EP1536015B1 (de) * | 2003-11-24 | 2007-10-31 | Bavarian Nordic A/S | Promotoren zur Expression in modifiziertem Vaccinia Virus Ankara |
DE602005026005D1 (de) * | 2004-06-14 | 2011-03-03 | Ishihara Sangyo Kaisha | Gefriergetrocknete zusammensetzung aus einer inaktivierten virushülle mit membranfusionsaktivität |
CN1295339C (zh) * | 2005-01-11 | 2007-01-17 | 武汉大学 | 减毒痘苗病毒天坛株载体及制备方法和应用 |
NZ556409A (en) * | 2005-02-23 | 2010-09-30 | Bavarian Nordic As | Use of a modified poxvirus for the rapid induction of immunity against a poxvirus or other infectious agents |
WO2006113927A2 (en) * | 2005-04-20 | 2006-10-26 | University Of Washington | Immunogenic vaccinia peptides and methods of using same |
KR100717279B1 (ko) * | 2005-08-08 | 2007-05-15 | 삼성전자주식회사 | 마스크롬 소자 및 그 형성 방법 |
US7913477B2 (en) * | 2006-01-27 | 2011-03-29 | William Anthony Harper | Insert registration in packets |
EP1826264A1 (de) * | 2006-02-24 | 2007-08-29 | Deutsches Primatenzentrum GmbH | Primatmodell für Orthopoxvirus-Infektionen |
EP1835031A1 (de) | 2006-03-14 | 2007-09-19 | Paul-Ehrlich-Institut Bundesamt für Sera und Impfstoffe | Verwendung eines rekombinanten modifizierten Vaccinia Ankara Virus (MVA) zur Behandlung der Typ-I Hypersensitivität in einem lebenden Tier einschließlich des Menschen |
US20100129403A1 (en) | 2006-06-20 | 2010-05-27 | Transgene S.A. | Recombinant viral vaccine |
ES2671230T3 (es) * | 2006-06-20 | 2018-06-05 | Transgene Sa | Procedimiento para producir poxvirus y composiciones de poxvirus |
EP2064351A1 (de) * | 2006-09-08 | 2009-06-03 | Bavarian Nordic A/S | Phänotypische und genotypische unterschiede von mva-stämmen |
US7807146B2 (en) | 2006-10-06 | 2010-10-05 | Bn Immunotherapeutics, Inc. | Methods for treating cancer with a recombinant MVA expressing HER-2 |
US8268327B2 (en) | 2007-04-27 | 2012-09-18 | Bavarian Nordic A/S | Immediate protection against pathogens via MVA |
AU2008250596C1 (en) | 2007-05-14 | 2010-11-25 | Bavarian Nordic A/S | Purification of Vaccinia virus- and recombinant Vaccinia virus-based vaccines |
US8003364B2 (en) | 2007-05-14 | 2011-08-23 | Bavarian Nordic A/S | Purification of vaccinia viruses using hydrophobic interaction chromatography |
DK2207564T3 (en) * | 2007-10-18 | 2017-01-16 | Bavarian Nordic As | USE OF VAT FOR TREATMENT OF PROSTATACANCES |
KR100970449B1 (ko) * | 2007-12-21 | 2010-07-16 | (주)이지아이 | 안전성을 갖는 어린이 놀이터용 고무 바닥재 및 설치방법 |
US20110052627A1 (en) * | 2008-06-20 | 2011-03-03 | Paul Chaplin | Recombinant modified vaccinia virus measles vaccine |
KR20110116016A (ko) | 2009-01-20 | 2011-10-24 | 트랜스진 에스.에이. | 치료적 반응의 예측을 위한 바이오마커로서의 가용성 icam―1 |
US8613936B2 (en) | 2009-03-13 | 2013-12-24 | Bavarian Nordic A/S | Replication deficient recombinant viruses expressing antigens regulated by transcriptional control elements comprising multiple elements |
US8394385B2 (en) | 2009-03-13 | 2013-03-12 | Bavarian Nordic A/S | Optimized early-late promoter combined with repeated vaccination favors cytotoxic T cell response against recombinant antigen in MVA vaccines |
US20120028279A1 (en) | 2009-03-24 | 2012-02-02 | Bruce Acres | Biomarker for monitoring patients |
PT2419728E (pt) | 2009-04-17 | 2014-03-12 | Transgene Sa | Marcadores biológicos para monitorizar doentes |
JP5650212B2 (ja) | 2009-07-10 | 2015-01-07 | トランジェーヌ、ソシエテ、アノニムTransgene S.A. | 患者を選択するためのバイオマーカーおよび関連方法 |
KR20120093941A (ko) | 2009-10-08 | 2012-08-23 | 버베리안 노딕 에이/에스 | 인간에서 hiv에 대한 광범위한 t-세포 반응의 생성 |
EP2501405A4 (de) * | 2009-11-20 | 2013-12-04 | Inviragen Inc | Zusammensetzung, verfahren und verwendungen für poxvirenelemente in impfstoffkonstrukten |
AU2011209175B2 (en) | 2010-01-28 | 2016-02-04 | Bavarian Nordic A/S | Vaccinia virus mutants containing the major genomic deletions of MVA |
WO2011119920A2 (en) | 2010-03-25 | 2011-09-29 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
CA2802430C (en) | 2010-07-20 | 2021-07-20 | Bavarian Nordic A/S | Method for harvesting poxvirus |
WO2012018856A2 (en) * | 2010-08-02 | 2012-02-09 | Virxsys Corporation | Hiv vaccine therapy with concomitant antiviral monotherapy |
WO2012048817A2 (en) | 2010-10-15 | 2012-04-19 | Bavarian Nordic A/S | Recombinant modified vaccinia virus ankara influenza vaccine |
DK2691530T3 (en) | 2011-06-10 | 2018-05-22 | Univ Oregon Health & Science | CMV GLYCOPROTEIN AND RECOMBINANT VECTORS |
PL2739293T3 (pl) * | 2011-08-05 | 2020-11-16 | Sillajen Biotherapeutics, Inc. | Sposoby i kompozycje wytwarzania wirusa krowianki |
AU2012216792A1 (en) | 2011-09-12 | 2013-03-28 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing HIV-1 proteins by broadly neutralizing antibodies |
US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
EP2788021B1 (de) | 2011-12-09 | 2017-01-18 | Bavarian Nordic A/S | Pockenvirus-vektor zur expression von bakteriellen antigen, welche mit tetanus toxin fragment c verbunden sind |
EP2620446A1 (de) | 2012-01-27 | 2013-07-31 | Laboratorios Del Dr. Esteve, S.A. | Immunogene zur HIV-Impfung |
US10111946B2 (en) | 2012-06-22 | 2018-10-30 | Bavarian Nordic A/S | Poxviral vectors for low antibody response after a first priming immunization |
ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
WO2014009433A1 (en) | 2012-07-10 | 2014-01-16 | Transgene Sa | Mycobacterium resuscitation promoting factor for use as adjuvant |
BR112015000530A2 (pt) | 2012-07-10 | 2018-08-28 | Transgene Sa | vacina de antígeno micobacteriano. |
CN104540520B (zh) | 2012-08-01 | 2018-10-23 | 巴法里安诺迪克有限公司 | 重组改良型安卡拉痘苗病毒(mva)呼吸道合胞病毒(rsv)疫苗 |
EP2892549A1 (de) | 2012-09-04 | 2015-07-15 | Bavarian Nordic A/S | Verfahren und zusammensetzungen zur verbesserung von impfstoffimmunreaktionen |
WO2014043535A1 (en) | 2012-09-14 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions for the treatment of cancer |
US20150283220A1 (en) | 2012-10-19 | 2015-10-08 | Bavarian Nordic, Inc. | Methods and compositions for the treatment of cancer |
IN2015DN03326A (de) | 2012-10-28 | 2015-10-09 | Bavarian Nordic As | |
SG10201707340XA (en) * | 2013-03-15 | 2017-10-30 | Bavarian Nordic As | Single high dose of mva induces a protective immune response in neonates and infants |
EP2848937A1 (de) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Verfahren zur Identifizierung neuartiger HIV-1-Immunogene |
EP2873423B1 (de) | 2013-10-07 | 2017-05-31 | International Aids Vaccine Initiative | Lösliche hiv-1-hüllglykoproteintrimere |
EP3060232B1 (de) | 2013-10-23 | 2018-07-04 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Hla-a24-agonistische epitope von muc1-c-oncoprotein sowie zusammensetzungen und verfahren zur verwendung |
WO2015077717A1 (en) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status |
AU2014356546A1 (en) | 2013-11-28 | 2016-06-02 | Bavarian Nordic A/S | Compositions and methods vectors for inducing an enhanced immune response using poxvirus vectors |
US11725237B2 (en) | 2013-12-05 | 2023-08-15 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
EP3082853A2 (de) | 2013-12-20 | 2016-10-26 | The Broad Institute, Inc. | Kombinationstherapie mit neoantigen-impfstoff |
WO2015104380A1 (en) | 2014-01-09 | 2015-07-16 | Transgene Sa | Fusion of heterooligomeric mycobacterial antigens |
JP2017515841A (ja) | 2014-05-13 | 2017-06-15 | バヴァリアン・ノルディック・アクティーゼルスカブ | 腫瘍抗原を発現するポックスウイルス及びtim−3に対するモノクローナル抗体を用いた癌治療のための併用療法 |
EP3154576A1 (de) | 2014-06-13 | 2017-04-19 | GlaxoSmithKline Biologicals S.A. | Immunogene kombinationen |
SG11201701745TA (en) | 2014-09-03 | 2017-04-27 | Bavarian Nordic As | Methods and compositions for enhancing immune responses |
UA125013C2 (uk) | 2014-09-03 | 2021-12-29 | Баваріан Нордік А/С | Вакцинна комбінація та спосіб індукування імунної відповіді проти філовірусу у суб'єкта |
PT3197489T (pt) | 2014-09-26 | 2021-04-30 | Beth Israel Deaconess Medical Ct Inc | Métodos e composições para induzir a imunidade protetora contra a infeção pelo vírus da imunodeficiência humana |
KR101645642B1 (ko) | 2014-10-16 | 2016-08-11 | 대한민국 | Kvac103 유래의 재조합 백시니아 바이러스 |
KR101623498B1 (ko) | 2014-10-16 | 2016-05-24 | 대한민국 | 약독화 백시니아 바이러스주 kvac103 |
HUE040440T2 (hu) | 2014-11-04 | 2019-03-28 | Janssen Vaccines & Prevention Bv | Terápiás HPV16-oltóanyagok |
EP3234193B1 (de) | 2014-12-19 | 2020-07-15 | Massachusetts Institute of Technology | Molekulare biomarker für krebsimmuntherapie |
US10993997B2 (en) | 2014-12-19 | 2021-05-04 | The Broad Institute, Inc. | Methods for profiling the t cell repertoire |
EP3261669B1 (de) | 2015-02-25 | 2022-08-03 | Memorial Sloan Kettering Cancer Center | Verwendung von inaktiviertem nichtreplizierendem modified-vaccinia-ankara-virus (mva) als monoimmunotherapie oder in kombination mit immun-checkpoint-blockierungsmitteln für solide tumoren |
EP3069730A3 (de) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Lösliche hiv-1-hüllglykoproteintrimere |
EP3072901A1 (de) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Lösliche hiv-1-hüllglykoproteintrimere |
CN116173193A (zh) | 2015-04-17 | 2023-05-30 | 纪念斯隆凯特琳癌症中心 | Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用 |
EP3297660A2 (de) | 2015-05-20 | 2018-03-28 | The Broad Institute Inc. | Gemeinsam genutzte neoantigene |
TW202241500A (zh) | 2015-06-09 | 2022-11-01 | 美商博德研究所有限公司 | 用於贅瘤疫苗之調配物及其製備方法 |
AU2016278806A1 (en) * | 2015-06-15 | 2017-12-14 | Bavarian Nordic A/S | Recombinant modified vaccinia virus Ankara (MVA) foot and mouth disease virus (FMDV) vaccine |
US9925258B2 (en) | 2015-10-02 | 2018-03-27 | International Aids Vaccine Initiative | Replication-competent VSV-HIV Env vaccines |
FR3042121A1 (fr) | 2015-10-08 | 2017-04-14 | Jean-Marc Limacher | Composition anti-tumorale |
CN106591361A (zh) * | 2015-10-20 | 2017-04-26 | 钱文斌 | 一种重组痘溶瘤病毒及其构建方法和应用 |
HUE045993T2 (hu) | 2015-12-15 | 2020-01-28 | Janssen Vaccines & Prevention Bv | Emberi immunhiány vírus antigének, vektorok, készítmények és alkalmazásukra szolgáló eljárások |
EP3407910B1 (de) | 2016-01-29 | 2022-04-13 | Bavarian Nordic A/S | Rekombinantes modifiziertes vaccinia virus ankara (mva) vakzin gegen pferdeenzephalitis virus |
BR112018016948A2 (pt) | 2016-02-25 | 2019-01-08 | Memorial Sloan Kettering Cancer Center | mva recombinante ou mva¿e3l que expressa flt3l humano e uso do mesmo como agente imunoterapêutico contra tumores sólidos |
CA3015650A1 (en) | 2016-02-25 | 2017-08-31 | Memorial Sloan Kettering Cancer Center | Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human flt3l or gm-csf for cancer immunotherapy |
CA3020426A1 (en) | 2016-04-13 | 2017-10-19 | Synthetic Genomics, Inc. | Recombinant arterivirus replicon systems and uses thereof |
US20190346442A1 (en) | 2016-04-18 | 2019-11-14 | The Broad Institute, Inc. | Improved hla epitope prediction |
BR112018072372A2 (pt) | 2016-05-02 | 2019-02-19 | Janssen Vaccines & Prevention B.V. | combinações de vacina terapêutica contra o hpv |
US10273268B2 (en) | 2016-06-16 | 2019-04-30 | Janssen Vaccines & Prevention B.V. | HIV vaccine formulation |
US10925956B2 (en) | 2016-07-15 | 2021-02-23 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against a marburg virus infection |
EP3506937A1 (de) | 2016-09-02 | 2019-07-10 | Janssen Vaccines & Prevention B.V. | Verfahren zur induzierung einer immunreaktion gegen hiv-infektionen bei patienten während einer antiretroviralen therapie |
SG10202001956UA (en) | 2016-09-15 | 2020-04-29 | Janssen Vaccines & Prevention Bv | Trimer stabilizing hiv envelope protein mutations |
AU2017336269B2 (en) | 2016-09-28 | 2022-06-16 | Bavarian Nordic A/S | Compositions and methods for enhancing the stability of transgenes in poxviruses |
AU2017347725B2 (en) | 2016-10-17 | 2024-01-04 | Janssen Pharmaceuticals, Inc. | Recombinant virus replicon systems and uses thereof |
EP3535284B1 (de) | 2016-11-07 | 2021-04-21 | The United States of America as represented by The Secretary Department of Health and Human Services | Entwicklung von agonistenepitopen des humanen papillomavirus |
AU2017372731B2 (en) | 2016-12-05 | 2024-05-23 | Janssen Pharmaceuticals, Inc. | Compositions and methods for enhancing gene expression |
US11549149B2 (en) | 2017-01-24 | 2023-01-10 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
WO2018185732A1 (en) | 2017-04-06 | 2018-10-11 | Janssen Vaccines & Prevention B.V. | Mva-bn and ad26.zebov or ad26.filo prime-boost regimen |
CN111107872A (zh) | 2017-05-12 | 2020-05-05 | 纪念斯隆-凯特林癌症中心 | 有用于癌症免疫疗法的牛痘病毒突变体 |
CN110603058A (zh) | 2017-05-15 | 2019-12-20 | 扬森疫苗与预防公司 | 含有病毒的稳定组合物 |
KR102658198B1 (ko) | 2017-05-15 | 2024-04-16 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정한 바이러스 함유 조성물 |
JP7272965B2 (ja) | 2017-06-15 | 2023-05-12 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | Hiv抗原をコードするポックスウイルスベクターおよびその使用方法 |
CA3069052A1 (en) | 2017-07-19 | 2019-01-24 | Janssen Vaccines & Prevention B.V. | Trimer stabilizing hiv envelope protein mutations |
WO2019018724A1 (en) | 2017-07-21 | 2019-01-24 | Janssen Vaccines & Prevention B.V. | METHODS FOR SAFE INDUCTION OF MULTICLADED CROSS-IMMUNITY AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN HUMAN BEINGS |
EP3691675A1 (de) | 2017-08-24 | 2020-08-12 | Bavarian Nordic A/S | Kombinationstherapie zur behandlung von krebs mit intravenöser verabreichung eines rekombinanten mva und eines antikörpers |
WO2019055888A1 (en) | 2017-09-18 | 2019-03-21 | Janssen Vaccines & Prevention B.V. | METHODS OF INDUCING AN IMMUNE RESPONSE AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN SUBJECTS UNDER ANTIRETROVIRAL TREATMENT |
MX2020006471A (es) | 2017-12-19 | 2020-09-22 | Janssen Sciences Ireland Unlimited Co | Metodos y composiciones para inducir una respuesta inmune contra el virus de hepatitis b (hbv). |
EA202091517A1 (ru) | 2017-12-19 | 2020-11-03 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Способы и устройство для доставки вакцин против вируса гепатита b (hbv) |
EA202091513A1 (ru) | 2017-12-19 | 2020-09-09 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Вакцины против вируса гепатита b (hbv) и их применение |
US11020476B2 (en) | 2017-12-19 | 2021-06-01 | Janssen Sciences Ireland Unlimited Company | Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV) |
BR112020012361A2 (pt) | 2017-12-20 | 2020-11-24 | Glaxosmithkline Biologicals S.A. | constructos de antígeno do vírus epstein-barr |
US11083786B2 (en) | 2018-01-19 | 2021-08-10 | Janssen Pharmaceuticals, Inc. | Induce and enhance immune responses using recombinant replicon systems |
US20220001001A1 (en) * | 2018-07-13 | 2022-01-06 | University Of Georgia Research Foundation | Broadly reactive immunogens of dengue virus, compositions, and methods of use thereof |
CA3111273C (en) | 2018-09-06 | 2024-03-26 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
WO2020072700A1 (en) | 2018-10-02 | 2020-04-09 | Dana-Farber Cancer Institute, Inc. | Hla single allele lines |
JP7555334B2 (ja) | 2018-10-05 | 2024-09-24 | バヴァリアン・ノルディック・アクティーゼルスカブ | 組み換えmva、及び免疫チェックポイントアンタゴニストまたは免疫チェックポイントアゴニストの静脈内投与によって、がんを治療する併用療法 |
US20220009980A1 (en) | 2018-11-14 | 2022-01-13 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | Tp5, a peptide inhibitor of aberrant and hyperactive cdk5/p25 as treatment for cancer |
JP2022507744A (ja) | 2018-11-20 | 2022-01-18 | バヴァリアン・ノルディック・アクティーゼルスカブ | 4-1bbl(cd137l)及び/またはcd40lをコードする組み換えmvaの腫瘍内及び/または静脈内投与によって、がんを治療する療法 |
US20220062394A1 (en) | 2018-12-17 | 2022-03-03 | The Broad Institute, Inc. | Methods for identifying neoantigens |
CN113573729A (zh) | 2019-01-10 | 2021-10-29 | 詹森生物科技公司 | 前列腺新抗原及其用途 |
TW202110476A (zh) | 2019-05-22 | 2021-03-16 | 荷蘭商傑森疫苗防護公司 | 於接受抗反轉錄病毒治療之個體中誘發抗人類免疫缺乏病毒感染之免疫反應的方法 |
CN113966228A (zh) | 2019-06-11 | 2022-01-21 | 葛兰素史密斯克莱生物公司 | 黏膜疫苗配制剂 |
WO2021094984A1 (en) | 2019-11-14 | 2021-05-20 | Aelix Therapeutics, S.L. | Dosage regimens for vaccines |
IL293051A (en) | 2019-11-18 | 2022-07-01 | Janssen Biotech Inc | calr and jak2 mutant-based vaccines and their uses |
BR112022009798A2 (pt) | 2019-11-20 | 2022-10-18 | Bavarian Nordic As | Vírus mva recombinante para administração intratumoral e/ou intravenosa para tratamento de câncer |
US20230059344A1 (en) | 2019-11-20 | 2023-02-23 | Bavarian Nordic A/S | Medical Uses of 4-1BBL Adjuvanted Recombinant Modified Vaccinia Virus Ankara (MVA) |
WO2021150713A2 (en) | 2020-01-21 | 2021-07-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human immunogenic epitopes of h, k, and e human endogenous retroviruses (hervs) |
EP4093432A1 (de) | 2020-01-21 | 2022-11-30 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Humane immunogene epitope von hämo- und hhla2-humanen endogenen retroviren (hervs) |
CN115243717A (zh) | 2020-03-12 | 2022-10-25 | 巴法里安诺迪克有限公司 | 改善痘病毒稳定性的组合物 |
JP2023528984A (ja) | 2020-06-10 | 2023-07-06 | バヴァリアン・ノルディック・アクティーゼルスカブ | コロナウイルス病に対する組換え修飾ワクシニアウイルスアンカラ(mva)ワクチン |
WO2021260065A1 (en) | 2020-06-24 | 2021-12-30 | Consejo Superior De Investigaciones Científicas (Csic) | Mva-based vaccine against covid-19 expressing sars-cov-2 antigens |
EP3928789A1 (de) | 2020-06-24 | 2021-12-29 | Consejo Superior de Investigaciones Científicas (CSIC) | Mva-basierter impfstoff gegen covid-19 exprimierende sars-cov-2-antigene |
BR112022027038A2 (pt) | 2020-07-08 | 2023-01-24 | Janssen Sciences Ireland Unlimited Co | Vacinas de replicon de rna contra hbv |
US20220118081A1 (en) | 2020-10-20 | 2022-04-21 | Janssen Vaccines & Prevention B.V. | HIV vaccine regimens |
WO2022269003A1 (en) | 2021-06-23 | 2022-12-29 | Consejo Superior De Investigaciones Cientificas | MVA-BASED VACCINE EXPRESSING A PREFUSION-STABILIZED SARS-CoV-2 S PROTEIN |
EP4108257A1 (de) | 2021-06-23 | 2022-12-28 | Consejo Superior De Investigaciones Científicas | Impfstoff auf mva-basis gegen covid-19, der ein präfusionsstabilisiertes sars-cov-2-s-protein exprimiert |
EP4396333A1 (de) | 2021-09-03 | 2024-07-10 | Bavarian Nordic A/S | Verwendung von mikro-rna zur herunterregulierung der expression eines zytotoxischen transgens durch modifiziertes vaccinia-virus ankara (mva) |
WO2023118508A1 (en) | 2021-12-23 | 2023-06-29 | Bavarian Nordic A/S | Recombinant mva viruses for intraperitoneal administration for treating cancer |
CA3240596A1 (en) | 2021-12-23 | 2023-06-29 | Cigdem ATAY LANGBEIN | Therapy for modulating immune response with recombinant mva encoding il-12 |
WO2023198815A1 (en) | 2022-04-14 | 2023-10-19 | Janssen Vaccines & Prevention B.V. | Sequential administration of adenoviruses |
WO2024003238A1 (en) | 2022-06-29 | 2024-01-04 | Bavarian Nordic A/S | Epstein-barr-virus vaccine |
WO2024003239A1 (en) | 2022-06-29 | 2024-01-04 | Bavarian Nordic A/S | RECOMBINANT MODIFIED saRNA (VRP) AND VACCINIA VIRUS ANKARA (MVA) PRIME-BOOST REGIMEN |
WO2024003346A1 (en) | 2022-06-30 | 2024-01-04 | Bavarian Nordic A/S | Mammalian cell line for the production of modified vaccinia virus ankara (mva) |
WO2024015892A1 (en) | 2022-07-13 | 2024-01-18 | The Broad Institute, Inc. | Hla-ii immunopeptidome methods and systems for antigen discovery |
EP4316514A1 (de) | 2022-08-03 | 2024-02-07 | Consejo Superior de Investigaciones Científicas (CSIC) | Vektoren auf mva-basis und ihre verwendung als impfstoff gegen sars-cov-2 |
WO2024188803A1 (en) | 2023-03-10 | 2024-09-19 | Bavarian Nordic A/S | Production of poxviruses from quail cell cultures |
WO2024188801A1 (en) | 2023-03-10 | 2024-09-19 | Bavarian Nordic A/S | Use of quail cell lines for poxvirus production |
WO2024188802A1 (en) | 2023-03-10 | 2024-09-19 | Bavarian Nordic A/S | Methods of isolating poxviruses from avian cell cultures |
Family Cites Families (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4072565A (en) * | 1974-11-04 | 1978-02-07 | The Dow Chemical Company | Production of viruses in tissue culture without use of serum |
US3914408A (en) * | 1973-10-12 | 1975-10-21 | Univ Nebraska | Vaccine for neonatal calf diarrhea |
DE2714665A1 (de) * | 1977-04-01 | 1978-10-05 | Mayr Anton | Praeparat zur behandlung von herpes zoster und anderen herpes-infektionen, sowie verfahren zu seiner herstellung |
US5338683A (en) | 1981-12-24 | 1994-08-16 | Health Research Incorporated | Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins |
US5155020A (en) * | 1989-03-08 | 1992-10-13 | Health Research Inc. | Recombinant poxvirus host range selection system |
GB8322414D0 (en) * | 1983-08-19 | 1983-09-21 | Szelke M | Renin inhibitors |
AU613583B2 (en) | 1986-08-22 | 1991-08-08 | Transgene S.A. | Proteins and the method for preparing them, DNA sequences, antibodies and their application, poxviruses, transformed or infected cells, pharmaceutical compositions which are useful in the prevention of schistosomiasis and application by way of an agent possessing glutathione s-transferase activity |
FR2603040B1 (fr) | 1986-08-22 | 1990-01-26 | Transgene Sa | Proteine, sequence d'adn, poxvirus, cellules et leur procede de culture, ainsi que les compositions pharmaceutiques les contenant, utiles dans la prevention de la schistosomose |
DE3743298A1 (de) | 1987-12-19 | 1989-06-29 | Wilkinson Sword Gmbh | Rasierapparat und verfahren zur herstellung einer flaeche geringen reibungswiderstands an einem rasierapparat |
CA1341245C (en) | 1988-01-12 | 2001-06-05 | F. Hoffmann-La Roche Ag | Recombinant vaccinia virus mva |
US6248333B1 (en) * | 1990-04-04 | 2001-06-19 | Health Research Inc. | Isolated nucleic acid sequence of equine herpesvirus type 1 glycoprotein D (EHV-1 gD) |
CA2091443A1 (en) | 1990-09-25 | 1992-03-26 | Luciano Ramos | Medium for culture of mammalian cells |
AU672359B2 (en) * | 1991-03-07 | 1996-10-03 | Virogenetics Corporation | Genetically engineered vaccine strain |
US5843456A (en) * | 1991-03-07 | 1998-12-01 | Virogenetics Corporation | Alvac poxvirus-rabies compositions and combination compositions and uses |
US5403582A (en) | 1993-01-21 | 1995-04-04 | Nippon Zeon Co., Ltd. | Vaccine comprising fowlpox virus recombinants expressing the envelope glycoprotein of an avian reticuloendotheliosis retrovirus |
US5405772A (en) | 1993-06-18 | 1995-04-11 | Amgen Inc. | Medium for long-term proliferation and development of cells |
US6015686A (en) * | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
US5490794A (en) * | 1993-11-05 | 1996-02-13 | Sumitomo Wiring Systems, Ltd. | Branch joint box |
US6190655B1 (en) | 1993-12-03 | 2001-02-20 | Immunex Corporation | Methods of using Flt-3 ligand for exogenous gene transfer |
DE4405841C1 (de) † | 1994-02-23 | 1995-01-05 | Mayr Anton Prof Dr Med Vet Dr | Multipotente Paramunitätsinducer auf der Basis von Kombinationen von Pockenviruskomponenten, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
AU694519B2 (en) * | 1994-04-29 | 1998-07-23 | Immuno Aktiengesellschaft | Recombinant poxviruses with foreign polynucleotides in essential regions |
CN1180843C (zh) * | 1994-07-27 | 2004-12-22 | 昆士兰医学研究所 | 多表位疫苗 |
US5676950A (en) * | 1994-10-28 | 1997-10-14 | University Of Florida | Enterically administered recombinant poxvirus vaccines |
US5756341A (en) | 1994-11-10 | 1998-05-26 | Immuno Ag | Method for controlling the infectivity of viruses |
US5753489A (en) | 1994-11-10 | 1998-05-19 | Immuno Ag | Method for producing viruses and vaccines in serum-free culture |
US5566011A (en) * | 1994-12-08 | 1996-10-15 | Luncent Technologies Inc. | Antiflector black matrix having successively a chromium oxide layer, a molybdenum layer and a second chromium oxide layer |
UA68327C2 (en) † | 1995-07-04 | 2004-08-16 | Gsf Forschungszentrum Fur Unwe | A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals |
ATE429505T1 (de) | 1996-02-21 | 2009-05-15 | Genetic Immunity Kft | Verfahren und zusammensetzungen zur genetisch schützenden und therapeutischen immunisierung |
AU3813597A (en) | 1996-07-26 | 1998-02-20 | University Of Manitoba | Serum-free medium for growth of anchorage-dependant mammalian cells |
MY150893A (en) * | 1996-09-24 | 2014-03-14 | Bavarian Nordic As | Recombinant mva virus expressing dengue virus antigens, and the use thereof in vaccines |
WO1998017283A1 (en) | 1996-10-25 | 1998-04-30 | The Wistar Institute Of Anatomy & Biology | Method of vaccinating infants against infections |
US6204250B1 (en) * | 1996-11-22 | 2001-03-20 | The Mount Sinai Medical Center Of The City Of New York | Immunization of infants |
GB0023203D0 (en) | 2000-09-21 | 2000-11-01 | Isis Innovation | Vaccination method |
GB9711957D0 (en) * | 1997-06-09 | 1997-08-06 | Isis Innovation | Methods and reagents for vaccination |
US20030138454A1 (en) * | 1997-06-09 | 2003-07-24 | Oxxon Pharmaccines, Ltd. | Vaccination method |
DE19729279A1 (de) † | 1997-07-09 | 1999-01-14 | Peter Hildebrandt | Urologisches Implantat, insbesondere Gefäßwandstütze für den Urinaltrakt |
AU3910097A (en) * | 1997-08-05 | 1999-03-01 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Live recombinant vaccine comprising inefficiently or non-replicating vir us |
US6667176B1 (en) * | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
EP1137769B1 (de) | 1998-11-10 | 2008-09-03 | University Of Rochester | Methoden zu herstellung von genbanken |
GB2370571B (en) | 1998-11-18 | 2003-05-07 | Oxford Biomedica Ltd | A modified 5t4 antigen |
CA2351622A1 (en) | 1998-11-18 | 2000-05-25 | Oxford Biomedica (Uk) Limited | Polypeptide |
US6173813B1 (en) | 1998-12-23 | 2001-01-16 | Otis Elevator Company | Electronic control for an elevator braking system |
US6497883B1 (en) | 1999-06-10 | 2002-12-24 | Merial | Porcine circovirus recombinant poxvirus vaccine |
US20020106798A1 (en) * | 2000-03-02 | 2002-08-08 | Robinson Harriet L. | DNA expression vectors and methods of use |
PL205922B1 (pl) | 2000-03-14 | 2010-06-30 | Bavarian Nordic As | Zmodyfikowany wirus Ankara (MVA), zakażona nim komórka gospodarza, jego zastosowania, kompozycja farmaceutyczna i sposoby otrzymywania wirusa oraz sekwencji kwasu nukleinowego, peptydu i/lub polipeptydu |
KR100341030B1 (ko) | 2000-03-16 | 2002-06-20 | 유태욱 | 캡션 데이터와 음성 데이터의 재생방법 및 이를 이용한 디스플레이장치 |
PL360096A1 (en) | 2000-05-24 | 2004-09-06 | Merial | Porcine reproductive and respiratory syndrome virus (prrsv) recombinant avipoxvirus vaccine |
WO2002004002A2 (de) * | 2000-07-11 | 2002-01-17 | Bayer Aktiengesellschaft | Verwendung von stämmen des parapoxvirus ovis zur herstellung von antiviralen arzneimitteln und arzneimitteln gegen krebs |
US6733993B2 (en) * | 2000-09-15 | 2004-05-11 | Merck & Co., Inc. | Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-gag, pol, nef and modifications |
US7628980B2 (en) * | 2000-11-23 | 2009-12-08 | Bavarian Nordic A/S | Modified vaccinia virus ankara for the vaccination of neonates |
US7097842B2 (en) * | 2000-11-23 | 2006-08-29 | Bavarian Nordic A/S | Modified vaccinia virus ankara for the vaccination of neonates |
WO2002042480A2 (en) | 2000-11-23 | 2002-05-30 | Bavarian Nordic A/S | Modified vaccinia ankara virus variant |
US7445924B2 (en) * | 2000-11-23 | 2008-11-04 | Bavarian Nordic A/S | Modified Vaccinia Ankara virus variant and cultivation method |
UA82466C2 (uk) * | 2001-07-18 | 2008-04-25 | Бавариан Нордика А/С | Спосіб посилення ампліфікації хордопоксвірусу |
WO2003048184A2 (en) * | 2001-12-04 | 2003-06-12 | Bavarian Nordic A/S | Flavivirus ns1 subunit vaccine |
CA2467099C (en) | 2001-12-20 | 2013-01-29 | Bavarian Nordic A/S | Method for the recovery and purification of poxviruses from infected cells |
AU2003219057A1 (en) | 2002-03-15 | 2003-09-29 | Baxter Healthcare S.A. | Recombinant drug-sensitive vaccinia virus as smallpox vaccine |
NZ547776A (en) | 2002-04-19 | 2009-08-28 | Bavarian Nordic As | Modified vaccinia virus ankara for protecting an animal against an antigen or self-protein |
NZ536500A (en) * | 2002-05-16 | 2008-01-31 | Bavarian Nordic As | Expression of genes in modified vaccinia virus ankara by using the cowpox ATI promoter |
DK1407033T3 (da) * | 2002-05-16 | 2006-05-22 | Bavarian Nordic As | Intergeniske områder som insertionssteder i genomet af Modified Vaccinia Virus Ankara (MVA) |
PT1434858E (pt) * | 2002-09-05 | 2008-07-28 | Bavarian Nordic As | Método de amplificação de um poxvírus em condições sem soro |
EA012723B1 (ru) * | 2002-11-25 | 2009-12-30 | Бавариан Нордик А/С | Рекомбинантный поксвирус, содержащий по меньшей мере два промотора ati вируса коровьей оспы, и его применение |
US6976752B2 (en) * | 2003-10-28 | 2005-12-20 | Lexmark International, Inc. | Ink jet printer with resistance compensation circuit |
EP1536015B1 (de) * | 2003-11-24 | 2007-10-31 | Bavarian Nordic A/S | Promotoren zur Expression in modifiziertem Vaccinia Virus Ankara |
EP1586330A1 (de) * | 2004-04-16 | 2005-10-19 | Georg-August-Universität Göttingen | Impfstoffe gegen Melanoma |
WO2006044716A2 (en) * | 2004-10-15 | 2006-04-27 | Washington University In St.Louis | CELL PERMEABLE NANOCONJUGATES OF SHELL-CROSSLINKED KNEDEL (SCK) AND PEPTIDE NUCLEIC ACIDS ('PNAs') WITH UNIQUELY EXPRESSED OR OVER-EXPRESSED mRNA TARGETING SEQUENCES FOR EARLY DIAGNOSIS AND THERAPY OF CANCER |
EP1835031A1 (de) | 2006-03-14 | 2007-09-19 | Paul-Ehrlich-Institut Bundesamt für Sera und Impfstoffe | Verwendung eines rekombinanten modifizierten Vaccinia Ankara Virus (MVA) zur Behandlung der Typ-I Hypersensitivität in einem lebenden Tier einschließlich des Menschen |
US7807146B2 (en) * | 2006-10-06 | 2010-10-05 | Bn Immunotherapeutics, Inc. | Methods for treating cancer with a recombinant MVA expressing HER-2 |
EP1925318A1 (de) | 2006-11-20 | 2008-05-28 | Paul-Ehrlich-Institut | Rekombinanter modifizierter Vaccinia Virus Ankara (MVA)-basierter Impfstoff gegen Vogelgrippe |
US8268327B2 (en) * | 2007-04-27 | 2012-09-18 | Bavarian Nordic A/S | Immediate protection against pathogens via MVA |
DK2207564T3 (en) * | 2007-10-18 | 2017-01-16 | Bavarian Nordic As | USE OF VAT FOR TREATMENT OF PROSTATACANCES |
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