BR112022027038A2 - Vacinas de replicon de rna contra hbv - Google Patents
Vacinas de replicon de rna contra hbvInfo
- Publication number
- BR112022027038A2 BR112022027038A2 BR112022027038A BR112022027038A BR112022027038A2 BR 112022027038 A2 BR112022027038 A2 BR 112022027038A2 BR 112022027038 A BR112022027038 A BR 112022027038A BR 112022027038 A BR112022027038 A BR 112022027038A BR 112022027038 A2 BR112022027038 A2 BR 112022027038A2
- Authority
- BR
- Brazil
- Prior art keywords
- hbv
- antigens
- vaccines against
- rna replicon
- against hbv
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
VACINAS DE REPLICON DE RNA CONTRA HBV. A presente invenção refere-se a moléculas de ácido nucleico que codificam os antígenos de superfície de vírus da hepatite B (HBV), antígenos de núcleo de HBV, e antígenos de HBV polimerase e combinações relacionadas. Também descritos são vetores, tal como, plasmídeos de DNA ou vetores virais, e replicons de RNA, expressando os antígenos de HBV, e composições farmacêuticas contendo os vetores de expressão. Métodos de indução de uma resposta imune contra HBV ou tratamento de uma doença induzida por HBV, particularmente em indivíduos com infecção crônica por HBV, usando as composições farmacêuticas da invenção também são descritos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063049400P | 2020-07-08 | 2020-07-08 | |
US202163144051P | 2021-02-01 | 2021-02-01 | |
PCT/EP2021/068879 WO2022008613A1 (en) | 2020-07-08 | 2021-07-07 | Rna replicon vaccines against hbv |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022027038A2 true BR112022027038A2 (pt) | 2023-01-24 |
Family
ID=77104021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022027038A BR112022027038A2 (pt) | 2020-07-08 | 2021-07-07 | Vacinas de replicon de rna contra hbv |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220016237A1 (pt) |
EP (1) | EP4178613A1 (pt) |
JP (1) | JP2023533528A (pt) |
KR (1) | KR20230050328A (pt) |
CN (1) | CN116367854A (pt) |
AU (1) | AU2021303478A1 (pt) |
BR (1) | BR112022027038A2 (pt) |
CA (1) | CA3188801A1 (pt) |
IL (1) | IL299571A (pt) |
TW (1) | TW202216190A (pt) |
WO (1) | WO2022008613A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2991639A1 (en) | 2015-08-07 | 2017-02-16 | Arrowhead Pharmaceuticals, Inc. | Rnai therapy for hepatitis b virus infection |
JOP20170161A1 (ar) | 2016-08-04 | 2019-01-30 | Arrowhead Pharmaceuticals Inc | عوامل RNAi للعدوى بفيروس التهاب الكبد ب |
EA202091513A1 (ru) | 2017-12-19 | 2020-09-09 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Вакцины против вируса гепатита b (hbv) и их применение |
WO2022133230A1 (en) * | 2020-12-18 | 2022-06-23 | Janssen Pharmaceuticals, Inc. | Combination therapy for treating hepatitis b virus infection |
WO2024124232A1 (en) * | 2022-12-09 | 2024-06-13 | Advanced Rna Vaccine (Arv) Technologies, Inc. | Nucleic acid based cancer vaccine and methods thereof |
WO2024133160A1 (en) * | 2022-12-19 | 2024-06-27 | Glaxosmithkline Biologicals Sa | Hepatitis b compositions |
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-
2021
- 2021-07-07 TW TW110124915A patent/TW202216190A/zh unknown
- 2021-07-07 KR KR1020237004630A patent/KR20230050328A/ko unknown
- 2021-07-07 WO PCT/EP2021/068879 patent/WO2022008613A1/en active Application Filing
- 2021-07-07 CN CN202180055052.7A patent/CN116367854A/zh active Pending
- 2021-07-07 JP JP2023501042A patent/JP2023533528A/ja active Pending
- 2021-07-07 CA CA3188801A patent/CA3188801A1/en active Pending
- 2021-07-07 IL IL299571A patent/IL299571A/en unknown
- 2021-07-07 EP EP21746660.6A patent/EP4178613A1/en active Pending
- 2021-07-07 AU AU2021303478A patent/AU2021303478A1/en active Pending
- 2021-07-07 BR BR112022027038A patent/BR112022027038A2/pt unknown
- 2021-07-08 US US17/370,337 patent/US20220016237A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN116367854A (zh) | 2023-06-30 |
US20220016237A1 (en) | 2022-01-20 |
JP2023533528A (ja) | 2023-08-03 |
EP4178613A1 (en) | 2023-05-17 |
CA3188801A1 (en) | 2022-01-13 |
AU2021303478A1 (en) | 2023-02-16 |
IL299571A (en) | 2023-02-01 |
WO2022008613A1 (en) | 2022-01-13 |
KR20230050328A (ko) | 2023-04-14 |
TW202216190A (zh) | 2022-05-01 |
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