WO1990005183A1
(en)
*
|
1988-10-31 |
1990-05-17 |
Immunex Corporation |
Interleukin-4 receptors
|
EP0490975A1
(en)
*
|
1989-09-07 |
1992-06-24 |
Schering Corporation |
Interleukin-4 receptors
|
DK0417563T3
(da)
|
1989-09-12 |
2000-11-06 |
Hoffmann La Roche |
TNF-bindende proteiner
|
AU635377B2
(en)
*
|
1989-11-21 |
1993-03-18 |
University Of Melbourne, The |
Anti-inflammatory compositions and methods
|
US7253264B1
(en)
|
1990-06-28 |
2007-08-07 |
Sanofi-Arentideutschland GmbH |
Immunoglobulin fusion proteins, their production and use
|
US20030064480A1
(en)
*
|
1990-06-28 |
2003-04-03 |
Leander Lauffer |
Fusion proteins with immunoglobulin portions, the preparation and use thereof
|
US5453491A
(en)
*
|
1990-09-11 |
1995-09-26 |
Kiyoshi Takatsu |
Murine interleukin-5 receptor
|
US5770197A
(en)
*
|
1991-06-27 |
1998-06-23 |
Bristol-Myers Squibb Company |
Methods for regulating the immune response using B7 binding molecules and IL4-binding molecules
|
JP3122139B2
(ja)
*
|
1991-10-15 |
2001-01-09 |
マラーキー,ミッシェル,エフ. |
後期段階炎症反応の治療用組成物
|
EP0615546A1
(en)
*
|
1991-11-27 |
1994-09-21 |
Schering Corporation |
Region of cytoplasmic domain of the human interleukin-4 receptor, as antagonists of il-4
|
DE4322330A1
(de)
*
|
1992-08-31 |
1994-03-03 |
Behringwerke Ag |
Verwendung des IL-4-Rezeptors zur Therapie, Prophylaxe und Diagnose von allergischen, viralen, parasitären und bakteriellen Erkrankungen sowie von Pilzinfektionen
|
US5714146A
(en)
*
|
1992-08-26 |
1998-02-03 |
Board Of Regents Of The University Of Washington |
IL-4 bone therapy
|
DE4228839A1
(de)
*
|
1992-08-29 |
1994-03-03 |
Behringwerke Ag |
Verfahren zum Nachweis und zur Bestimmung von Mediatoren
|
EP0604693A1
(en)
*
|
1992-12-29 |
1994-07-06 |
Schering-Plough |
Monoclonal antibodies against the human interleukin-4 receptor and hybridomas producing the same
|
JPH08508035A
(ja)
*
|
1993-03-19 |
1996-08-27 |
イミュネックス・コーポレーション |
可溶性レセプターと複合化したリガンドを含む医薬組成物
|
US5470952A
(en)
*
|
1993-10-20 |
1995-11-28 |
Regeneron Pharmaceuticals, Inc. |
CNTF and IL-6 antagonists
|
US5591825A
(en)
*
|
1994-07-05 |
1997-01-07 |
Tularik, Inc. |
Interleukin 4 signal transducers
|
US7091181B2
(en)
|
1994-12-12 |
2006-08-15 |
Omeros Corporation |
Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
|
US20020028798A1
(en)
*
|
1995-12-12 |
2002-03-07 |
Omeros Medical Systems |
Irrigation solution and method for inhibition of pain and inflammation
|
US5795966A
(en)
|
1995-02-22 |
1998-08-18 |
Immunex Corp |
Antagonists of interleukin-15
|
DK0835305T3
(da)
|
1995-06-29 |
2006-02-13 |
Immunex Corp |
Cytokin som inducerer apoptose
|
US7074397B1
(en)
|
1996-01-08 |
2006-07-11 |
Genentech, Inc. |
Method for enhancing proliferation or differentiation of a cell using ob protein
|
US6541604B1
(en)
*
|
1996-01-08 |
2003-04-01 |
Genentech, Inc. |
Leptin receptor having a WSX motif
|
US20050019325A1
(en)
*
|
1996-01-08 |
2005-01-27 |
Carter Paul J. |
WSX receptor agonist antibodies
|
US7078494B1
(en)
*
|
1996-03-01 |
2006-07-18 |
Genetics Institute, Llc |
Antibodies to human IL-13bc and methods of their use in inhibiting IL-13 binding
|
US5710023A
(en)
*
|
1996-03-01 |
1998-01-20 |
Genetics Institute, Inc. |
IL-13 cytokine receptor chain
|
US20060205660A1
(en)
*
|
1996-06-20 |
2006-09-14 |
Sauvage Frederic D |
OB protein-immunoglobulin chimeras
|
US6605271B2
(en)
*
|
1996-08-23 |
2003-08-12 |
Human Genome Sciences, Inc. |
T1 receptor-like ligand II and uses thereof
|
US6586210B1
(en)
*
|
1996-08-23 |
2003-07-01 |
Human Genome Sciences, Inc. |
Polynucleotides encoding T1 receptor like ligand II
|
DE69738841D1
(de)
|
1996-12-23 |
2008-08-28 |
Immunex Corp |
Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilie
|
US6384203B1
(en)
|
1999-05-12 |
2002-05-07 |
Immunex Corporation |
Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR)
|
AU1126099A
(en)
*
|
1997-10-29 |
1999-05-17 |
Genentech Inc. |
Polypeptides and nucleic acids encoding the same
|
US6703488B1
(en)
*
|
1998-01-15 |
2004-03-09 |
Center For Molecular Medicine And Immunology |
Antibody/receptor targeting moiety for enhanced delivery of armed ligand
|
US6630140B1
(en)
*
|
1998-03-10 |
2003-10-07 |
The Children's Hospital Of Philadelphia |
Compositions and methods for treatment of asthma
|
ATE332373T1
(de)
|
1998-08-21 |
2006-07-15 |
Immunex Corp |
Menschlisches il-1 epsilon dna und polypeptide
|
EP1939297A1
(en)
|
1998-09-24 |
2008-07-02 |
Pharmacia & Upjohn Company LLC |
Alzheimer's disease secretase
|
US6472179B2
(en)
|
1998-09-25 |
2002-10-29 |
Regeneron Pharmaceuticals, Inc. |
Receptor based antagonists and methods of making and using
|
US7067144B2
(en)
*
|
1998-10-20 |
2006-06-27 |
Omeros Corporation |
Compositions and methods for systemic inhibition of cartilage degradation
|
PT1141286E
(pt)
|
1998-12-14 |
2007-01-31 |
Genetics Inst Llc |
Cadeia de receptores de citocina
|
US7553487B2
(en)
*
|
1998-12-14 |
2009-06-30 |
Genetics Institute, Llc |
Method and compositions for treating asthma
|
US20010021380A1
(en)
*
|
1999-04-19 |
2001-09-13 |
Pluenneke John D. |
Soluble tumor necrosis factor receptor treatment of medical disorders
|
US20040220103A1
(en)
*
|
1999-04-19 |
2004-11-04 |
Immunex Corporation |
Soluble tumor necrosis factor receptor treatment of medical disorders
|
GB9912350D0
(en)
*
|
1999-05-26 |
1999-07-28 |
European Molecular Biology Lab Embl |
Modified cytokine
|
US6693172B1
(en)
|
1999-05-27 |
2004-02-17 |
Pharmacia And Upjohn Company |
Double mutant alpha-7 nicotinic acetylcholine receptor
|
US6455290B1
(en)
|
1999-07-09 |
2002-09-24 |
Pharmacia Italia S.P.A. |
Tankyrase homolog protein (THP), nucleic acids, and methods related to the same
|
AU2000263446A1
(en)
*
|
1999-07-13 |
2001-01-30 |
Genaissance Pharmaceuticals, Inc. |
Drug target isogenes: polymorphisms in the interleukin 4 receptor alpha gene
|
CA2388599A1
(en)
|
1999-10-22 |
2001-05-03 |
Pharmacia & Upjohn Company |
Drosophila g protein coupled receptors, nucleic acids, and methods related to the same
|
JP2003516164A
(ja)
*
|
1999-12-10 |
2003-05-13 |
ヒューマン ジノーム サイエンシーズ, インコーポレイテッド |
T1レセプター様リガンドiiおよびこれの使用
|
WO2001045730A2
(en)
|
1999-12-20 |
2001-06-28 |
Immunex Corporation |
Tweak receptor
|
US6846486B1
(en)
|
2000-02-24 |
2005-01-25 |
Advanced Biotherapy Concepts, Inc. |
Method of treating allergy by administering an anti-histamine antibody
|
US6498026B2
(en)
|
2000-02-25 |
2002-12-24 |
Hercules Incorporated |
Variant galactose oxidase, nucleic acid encoding same, and methods of using same
|
US20010053764A1
(en)
*
|
2000-05-12 |
2001-12-20 |
Sims John E. |
Interleukin-1 inhibitors in the treatment of diseases
|
EP1158058A1
(en)
*
|
2000-05-19 |
2001-11-28 |
Centre National De La Recherche Scientifique |
Compositions and methods suitable for nucleic acid analyses
|
AU2001274894A1
(en)
|
2000-05-22 |
2001-12-03 |
Pharmacia And Upjohn Company |
Novel matrix metalloproteinases
|
AU2001272925A1
(en)
|
2000-05-26 |
2001-12-11 |
Immunex Corporation |
Use of interleukin-4 antagonists and compositions thereof
|
US7259244B2
(en)
|
2000-06-16 |
2007-08-21 |
Nerviano Medical Sciences S.R.L. |
Human homologue of the DBF4/ASK1 protein, nucleic acids, and methods related to the same
|
US6686449B2
(en)
|
2000-06-30 |
2004-02-03 |
Pharmacia & Upjohn Company |
Mutant presenilin 1 polypeptides
|
AU2001271839A1
(en)
|
2000-07-05 |
2002-01-14 |
Pharmacia And Upjohn Company |
Human ion channels
|
AU2001273413A1
(en)
*
|
2000-07-12 |
2002-01-21 |
Immunex Corporation |
Method for treating cancer using an interleukin- 4 antagonist
|
US6652854B2
(en)
*
|
2000-08-08 |
2003-11-25 |
Immunex Corporation |
Methods for treating autoimmune and chronic inflammatory conditions using antagonists of CD30 or CD30L
|
ES2281458T3
(es)
*
|
2000-12-21 |
2007-10-01 |
Nektar Therapeutics |
Composiciones de polvo estables en almacenamiento del receptor de interleucina 4.
|
EP3467117B1
(en)
*
|
2001-09-20 |
2020-07-15 |
Immunex Corporation |
Selection of cells expressing heteromeric polypeptides
|
PL373594A1
(en)
|
2001-10-04 |
2005-09-05 |
Immunex Corporation |
Ul16 binding protein 4
|
US20050112616A1
(en)
*
|
2001-12-10 |
2005-05-26 |
William Lee |
Functionalized materials and libraries thereof
|
AU2003220529B2
(en)
|
2002-03-27 |
2006-09-07 |
Immunex Corporation |
Methods for increasing polypeptide production
|
DK1408106T3
(da)
*
|
2002-10-11 |
2007-06-11 |
Sentoclone Ab |
Cancer immunterapi
|
AU2003285874A1
(en)
|
2002-10-16 |
2004-05-04 |
Amgen Inc. |
HUMAN ANTI-IFN-Gamma NEUTRALIZING ANTIBODIES AS SELECTIVE IFN-Gamma PATHWAY INHIBITORS
|
CN100549163C
(zh)
|
2002-12-16 |
2009-10-14 |
技术研究及发展基金有限公司 |
制备无饲养细胞、无异源的人胚胎干细胞的方法以及使用该方法制备的干细胞培养物
|
CA2512808A1
(en)
*
|
2003-01-18 |
2004-08-12 |
Marc Elliot Rothenberg |
Regulation of allergen induced gene
|
EP1444989A1
(en)
*
|
2003-02-07 |
2004-08-11 |
Giorgio Dr. Stassi |
Sensitizing cells for apoptosis by selectively blocking cytokines
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
JP2007500132A
(ja)
|
2003-07-25 |
2007-01-11 |
アムジェン インコーポレイテッド |
Ldcamのアンタゴニストおよびアゴニスト、並びにその使用法
|
CA2543982C
(en)
|
2003-11-07 |
2013-01-08 |
Immunex Corporation |
Antibodies that bind interleukin-4 receptor
|
AU2004290070A1
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
Neonatal Fc receptor (FcRn)-binding polypeptide variants, dimeric Fc binding proteins and methods related thereto
|
PT2805728T
(pt)
*
|
2003-12-23 |
2020-04-08 |
Genentech Inc |
Novos anticorpos anti-il13 e o uso dos mesmos
|
CA2554596A1
(en)
|
2004-02-27 |
2005-09-15 |
Regeneron Pharmaceuticals, Inc. |
Il-4/il-13 specific polypetides and therapeutic uses thereof
|
ATE465172T1
(de)
|
2004-03-05 |
2010-05-15 |
Univ Illinois |
Peptidträger für die verabreichung von arzneimitteln
|
US7319015B2
(en)
|
2004-03-16 |
2008-01-15 |
The Regents Of The University Of Michigan |
Methods and compositions for using alveolar macrophage phospholipase A2
|
US7582442B2
(en)
|
2004-03-16 |
2009-09-01 |
The Regents Of The University Of Michigan |
Methods and compositions for using aleveolar macrophage phospholipase A2
|
WO2005094879A2
(en)
*
|
2004-03-23 |
2005-10-13 |
Amgen, Inc. |
Monoclonal antibodies specific for human ox40l (cd 134l)
|
WO2005116069A2
(en)
|
2004-04-14 |
2005-12-08 |
Monell Chemical Senses Center |
Taste receptors of the t1r family from domestic dog
|
EA013071B1
(ru)
|
2004-04-23 |
2010-02-26 |
ФАРМАЦИЯ ЭНД АПДЖОН КОМПАНИ ЭлЭлСи |
Способ получения вируса репродуктивно-респираторного синдрома свиней (pprsv) и способ получения pprsv вакцины
|
US20090098142A1
(en)
*
|
2004-06-09 |
2009-04-16 |
Kasaian Marion T |
Methods and compositions for treating and monitoring treatment of IL-13-associated disorders
|
US7501121B2
(en)
*
|
2004-06-17 |
2009-03-10 |
Wyeth |
IL-13 binding agents
|
AR049390A1
(es)
*
|
2004-06-09 |
2006-07-26 |
Wyeth Corp |
Anticuerpos contra la interleuquina-13 humana y usos de los mismos
|
EP1838736B1
(en)
|
2005-01-05 |
2013-03-06 |
Biogen Idec MA Inc. |
Cripto binding molecules
|
EP1909831A4
(en)
*
|
2005-06-14 |
2013-02-20 |
Amgen Inc |
PREPARATIONS OF SPONTANEOUS TAMPING PROTEINS
|
US20070009479A1
(en)
*
|
2005-06-17 |
2007-01-11 |
Aerovance, Inc. |
Methods for treating dermatitis using mutant human IL-4 compositions
|
KR20070009269A
(ko)
|
2005-07-15 |
2007-01-18 |
한국생명공학연구원 |
재조합단백질 생산용 단백질융합인자 라이브러리 및이로부터 획득된 단백질융합인자
|
CA2627446A1
(en)
*
|
2005-11-21 |
2007-05-31 |
Laboratoires Serono S.A. |
Compositions and methods of producing hybrid antigen binding molecules and uses thereof
|
AU2006328945B2
(en)
*
|
2005-12-21 |
2011-06-30 |
Sentoclone International Ab |
Method for treating malignant melanoma
|
WO2007071410A1
(en)
*
|
2005-12-21 |
2007-06-28 |
Sentoclone Ab |
Method for treating urinary bladder cancer
|
WO2007071389A1
(en)
*
|
2005-12-21 |
2007-06-28 |
Sentoclone Ab |
Method for treating disseminated cancer
|
EP1966369B1
(en)
*
|
2005-12-21 |
2010-10-06 |
Sentoclone AB |
Method for expansion of tumour-reactive t-lymphocytes for immunotherapy of patients with cancer
|
US8129334B2
(en)
|
2006-03-31 |
2012-03-06 |
The Regents Of The University Of California |
Methods and compositions for treating neurodegenerative disorders and Alzheimer'S disease and improving normal memory
|
RU2009101783A
(ru)
|
2006-06-21 |
2010-07-27 |
Апогеникс Гмбх (De) |
Дифференциальная экспрессия цитокинов il-4 и/или il-10 в злокачественной опухоли человека
|
EP2049147A2
(en)
*
|
2006-07-06 |
2009-04-22 |
Apogenix GmbH |
Human il-4 muteins in combination with chemotherapeutics or pro-apoptotic agents in cancer therapy
|
EP2074139B1
(en)
|
2006-09-08 |
2013-10-23 |
Amgen, Inc |
Il-1 family variants
|
WO2008033517A2
(en)
|
2006-09-13 |
2008-03-20 |
Abbott Laboratories |
Cell culture improvements
|
EP2500416A1
(en)
|
2006-09-13 |
2012-09-19 |
Abbott Laboratories |
Cell culture improvements
|
US7833527B2
(en)
|
2006-10-02 |
2010-11-16 |
Amgen Inc. |
Methods of treating psoriasis using IL-17 Receptor A antibodies
|
PL2769992T3
(pl)
|
2006-10-02 |
2021-08-02 |
Regeneron Pharmaceuticals, Inc. |
Przeciwciała ludzkie o wysokim powinowactwie względem ludzkiego receptora IL-4
|
US7608693B2
(en)
|
2006-10-02 |
2009-10-27 |
Regeneron Pharmaceuticals, Inc. |
High affinity human antibodies to human IL-4 receptor
|
US20080260820A1
(en)
*
|
2007-04-19 |
2008-10-23 |
Gilles Borrelly |
Oral dosage formulations of protease-resistant polypeptides
|
WO2008131376A2
(en)
*
|
2007-04-23 |
2008-10-30 |
Wyeth |
Methods and compositions for treating and monitoring treatment of il-13-associated disorders
|
CA2696761C
(en)
|
2007-08-21 |
2017-02-14 |
Amgen Inc. |
Human c-fms antigen binding proteins
|
TW200918553A
(en)
|
2007-09-18 |
2009-05-01 |
Amgen Inc |
Human GM-CSF antigen binding proteins
|
EP2245064B1
(en)
*
|
2007-12-21 |
2014-07-23 |
Medimmune Limited |
BINDING MEMBERS FOR INTERLEUKIN-4 RECEPTOR ALPHA (IL-4Ralpha)
|
US8092804B2
(en)
*
|
2007-12-21 |
2012-01-10 |
Medimmune Limited |
Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
|
GB0803076D0
(en)
|
2008-02-20 |
2008-03-26 |
Univ Ghent |
Mucosal Membrane Receptor and uses thereof
|
SG190572A1
(en)
|
2008-04-29 |
2013-06-28 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
EP2113262B1
(en)
*
|
2008-04-29 |
2013-11-06 |
Proxy Biomedical Limited |
A Tissue Repair Implant
|
AR072001A1
(es)
|
2008-06-03 |
2010-07-28 |
Abbott Lab |
Inmunoglobulina con dominio variable dual y usos de la misma
|
KR20110016959A
(ko)
|
2008-06-03 |
2011-02-18 |
아보트 러보러터리즈 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
JP2011526916A
(ja)
|
2008-06-30 |
2011-10-20 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
全身性紅斑性狼瘡を同定および処置するための診断標的および治療標的としてのリソソームホスホリパーゼa2(lpla2)活性
|
RU2011104348A
(ru)
|
2008-07-08 |
2012-08-20 |
Эбботт Лэборетриз (Us) |
Иммуноглобулины с двойным вариабельным доменом против простагландина е2 и их применение
|
US20100015161A1
(en)
*
|
2008-07-18 |
2010-01-21 |
Sentoclone Ab |
Composition Comprising In Vitro Expanded T-Lymphocytes and Vessel Formation Inhibitors Suitable in the Treatment of Cancer
|
US8815794B2
(en)
|
2008-08-28 |
2014-08-26 |
The Research Foundation For The State University Of New York |
Treatment of amyloidoses using myelin basic protein and fragments thereof
|
JP5524977B2
(ja)
|
2008-12-04 |
2014-06-18 |
コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー |
高分泌性蛋白質のスクリーニングおよび組換え蛋白質の生産のための融合パートナーとしてのその用途
|
JO3382B1
(ar)
|
2008-12-23 |
2019-03-13 |
Amgen Inc |
أجسام مضادة ترتبط مع مستقبل cgrp بشري
|
US20120076754A1
(en)
|
2009-05-20 |
2012-03-29 |
Ziad Mallat |
Use of IL-17 Polypeptides for Use in the Prevention or Treatment of Atherosclerosis
|
TW201117824A
(en)
|
2009-10-12 |
2011-06-01 |
Amgen Inc |
Use of IL-17 receptor a antigen binding proteins
|
JO3244B1
(ar)
|
2009-10-26 |
2018-03-08 |
Amgen Inc |
بروتينات ربط مستضادات il – 23 البشرية
|
US20120311728A1
(en)
|
2009-11-06 |
2012-12-06 |
Ziad Mallat |
Methods and pharmaceutical composition for the treatment of atherosclerosis
|
MX2012005527A
(es)
|
2009-11-13 |
2012-08-08 |
Grifols Therapeutics Inc |
Preparaciones que contienen el factor de von willebrand (fvw) procedimientos, kits y aplicaciones relacionados con las mismas.
|
UA109888C2
(uk)
|
2009-12-07 |
2015-10-26 |
|
ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
|
WO2011089152A1
(en)
|
2010-01-20 |
2011-07-28 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical composition for the preservation of vascular endothelial cell barrier integrity
|
WO2011127418A1
(en)
|
2010-04-09 |
2011-10-13 |
Amgen Inc. |
Btnl9 proteins, nucleic acids, and antibodies and uses thereof
|
JP2013523184A
(ja)
|
2010-04-15 |
2013-06-17 |
アムジエン・インコーポレーテツド |
ヒトFGF受容体およびβ−KLOTHO結合性タンパク質
|
EA201291482A1
(ru)
|
2010-07-09 |
2013-10-30 |
Байоджен Айдек Хемофилия Инк. |
Химерные факторы коагуляции
|
AR082461A1
(es)
|
2010-08-03 |
2012-12-12 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
SG187198A1
(en)
|
2010-08-05 |
2013-03-28 |
Amgen Inc |
Dipeptides to enhance yield and viability from cell cultures
|
KR20130139884A
(ko)
|
2010-08-26 |
2013-12-23 |
애브비 인코포레이티드 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
WO2012042289A1
(en)
|
2010-09-28 |
2012-04-05 |
Inserm ( Institut National De La Sante Et De La Recherche Medicale) |
Methods and pharmaceutical compositions for the treatment of bone density related diseases
|
CA2828405A1
(en)
|
2011-02-28 |
2012-09-07 |
Istituto Di Ricovero E Cura A Carattere Scientifico Materno-Infantile Bu Rlo Garofolo - Ospedale Di Alta Specializzazione E Di Rilievo Nazionale |
Apoptosis-inducing molecules and uses therefor
|
CA2830254C
(en)
|
2011-03-16 |
2019-09-10 |
Amgen Inc. |
Fc variants
|
WO2012145682A1
(en)
|
2011-04-21 |
2012-10-26 |
Amgen Inc. |
A method for culturing mammalian cells to improve recombinant protein production
|
US20140086895A1
(en)
|
2011-05-10 |
2014-03-27 |
Universite De Rouen |
Methods and pharmaceutical compositions for the treatment of autoimmune diseases
|
US9574002B2
(en)
|
2011-06-06 |
2017-02-21 |
Amgen Inc. |
Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor
|
EP2535714A1
(en)
*
|
2011-06-16 |
2012-12-19 |
Istituto Nazionale Di Genetica Molecolare-INGM |
Biomarkers for autoimmune liver diseases and uses thereof
|
LT2837680T
(lt)
|
2011-07-01 |
2020-07-10 |
Amgen Inc. |
Žinduolių ląstelių kultūra
|
WO2013009971A1
(en)
|
2011-07-12 |
2013-01-17 |
E. I. Du Pont De Nemours And Company |
Detection and screening method and materials useful in performance thereof
|
WO2013012733A1
(en)
|
2011-07-15 |
2013-01-24 |
Biogen Idec Ma Inc. |
Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
|
WO2013016220A1
(en)
|
2011-07-22 |
2013-01-31 |
Amgen Inc. |
Il-17 receptor a is required for il-17c biology
|
BR112014004591A2
(pt)
|
2011-09-02 |
2017-03-28 |
Amgen Inc |
produto farmacêutico de análise da exposição à luz de um produto farmacêutico
|
ES2806146T3
(es)
|
2011-09-22 |
2021-02-16 |
Amgen Inc |
Proteínas de unión al antígeno CD27L
|
WO2013050441A1
(en)
|
2011-10-05 |
2013-04-11 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical composition for inhibiting or preventing platelet aggregation
|
EP2596802A1
(en)
|
2011-11-23 |
2013-05-29 |
PLS-Design GmbH |
Pharmaceutical composition for treatment of allergic reactions
|
ES2638649T3
(es)
|
2011-11-28 |
2017-10-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Composición farmacéutica para su uso en el tratamiento de disfunciones asociadas al envejecimiento
|
CN104220460A
(zh)
|
2011-12-08 |
2014-12-17 |
安姆根有限公司 |
激动人lcat抗原结合蛋白和它们在疗法中的用途
|
AR089231A1
(es)
|
2011-12-15 |
2014-08-06 |
Amgen Inc |
Metodo de floculacion
|
CA2861610A1
(en)
|
2011-12-30 |
2013-07-04 |
Abbvie Inc. |
Dual specific binding proteins directed against il-13 and/or il-17
|
WO2013106577A2
(en)
|
2012-01-10 |
2013-07-18 |
Biogen Idec Ma Inc. |
Enhancement of transport of therapeutic molecules across the blood brain barrier
|
RU2650800C2
(ru)
|
2012-04-27 |
2018-04-17 |
Ново Нордиск А/С |
Белки, связывающие антиген - лиганд cd30 человека
|
AR091069A1
(es)
|
2012-05-18 |
2014-12-30 |
Amgen Inc |
Proteinas de union a antigeno dirigidas contra el receptor st2
|
WO2013182650A1
(en)
|
2012-06-06 |
2013-12-12 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Method and pharmaceutical composition for use in the treatment of cancer
|
EP2674168A1
(en)
|
2012-06-14 |
2013-12-18 |
PLS-Design GmbH |
Modulation of effector T cell responses by local depletion of complement component C3
|
US20150166630A1
(en)
|
2012-07-19 |
2015-06-18 |
Amgen Inc. |
Btnl3 proteins, nucleic acids, and antibodies and uses thereof
|
PT3470432T
(pt)
|
2012-08-21 |
2021-12-14 |
Regeneron Pharma |
Métodos para tratamento ou prevenção da asma por meio de administração de um antagonista de il-4r
|
US9309318B2
(en)
|
2012-10-17 |
2016-04-12 |
Amgen, Inc. |
Compositions relating to anti-IL-21 receptor antibodies
|
KR20210111353A
(ko)
|
2012-11-01 |
2021-09-10 |
애브비 인코포레이티드 |
항-vegf/dll4 이원 가변 도메인 면역글로불린 및 이의 용도
|
UY35148A
(es)
|
2012-11-21 |
2014-05-30 |
Amgen Inc |
Immunoglobulinas heterodiméricas
|
TW201425336A
(zh)
|
2012-12-07 |
2014-07-01 |
Amgen Inc |
Bcma抗原結合蛋白質
|
AU2013354937B2
(en)
|
2012-12-07 |
2019-09-19 |
North Carolina State University |
Beta-hexosyl-transferases and uses thereof
|
US20140199728A1
(en)
|
2013-01-14 |
2014-07-17 |
Amgen Inc. |
Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
|
US10023608B1
(en)
|
2013-03-13 |
2018-07-17 |
Amgen Inc. |
Protein purification methods to remove impurities
|
WO2014159441A1
(en)
|
2013-03-14 |
2014-10-02 |
Amgen Inc. |
Removal of leaked affinity purification ligand
|
US9580486B2
(en)
|
2013-03-14 |
2017-02-28 |
Amgen Inc. |
Interleukin-2 muteins for the expansion of T-regulatory cells
|
TWI771890B
(zh)
|
2013-03-14 |
2022-07-21 |
美商安美基公司 |
用於增加重組蛋白質之甘露糖含量之方法
|
AU2014244444A1
(en)
|
2013-03-14 |
2015-09-24 |
Amgen Inc. |
CHRDL-1 antigen binding proteins and methods of treatment
|
WO2014144553A1
(en)
|
2013-03-15 |
2014-09-18 |
Amgen Inc. |
Secreted frizzle-related protein 5 (sfrp5) binding proteins and methods of treatment
|
AU2014236867A1
(en)
|
2013-03-15 |
2015-09-24 |
Amgen Inc. |
Methods and compositions relating to anti-CCR7 antigen binding proteins
|
TWI788044B
(zh)
|
2013-03-15 |
2022-12-21 |
美商百歐維拉提夫治療公司 |
因子ix多肽調配物
|
WO2014144817A2
(en)
|
2013-03-15 |
2014-09-18 |
Amgen Inc. |
Inhibitory polypeptides specific to wnt inhibitors
|
JP2016522793A
(ja)
|
2013-03-15 |
2016-08-04 |
アッヴィ・インコーポレイテッド |
IL−1βおよび/またはIL−17に対して指向された二重特異的結合タンパク質
|
AU2014228924B2
(en)
|
2013-03-15 |
2019-04-18 |
Amgen Inc. |
Human PAC1 antibodies
|
CN110511279B
(zh)
|
2013-05-30 |
2024-03-29 |
基尼克萨制药有限公司 |
制瘤素m受体抗原结合蛋白
|
US9481901B2
(en)
|
2013-05-30 |
2016-11-01 |
Amgen Inc. |
Methods for increasing mannose content of recombinant proteins
|
TWI755763B
(zh)
|
2013-06-04 |
2022-02-21 |
美商再生元醫藥公司 |
藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
|
US10059771B2
(en)
|
2013-06-21 |
2018-08-28 |
Sanofi Biotechnology |
Methods for treating nasal polyposis by administering an IL-4R antagonist
|
TWI682781B
(zh)
|
2013-07-11 |
2020-01-21 |
美商再生元醫藥公司 |
藉由投與il-4r抑制劑治療嗜酸性食道炎的方法
|
TW201605896A
(zh)
|
2013-08-30 |
2016-02-16 |
安美基股份有限公司 |
Gitr抗原結合蛋白
|
JP6668241B2
(ja)
|
2013-09-05 |
2020-03-18 |
アムジエン・インコーポレーテツド |
予測可能で、一貫性のある、且つ再現可能な糖型特性を示すFc含有分子
|
RU2016107435A
(ru)
|
2013-09-13 |
2017-10-18 |
Дженентек, Инк. |
Композиции и способы обнаружения и количественного определения белка клеток-хозяев в клеточных линиях и рекомбинантные полипептидные продукты
|
SG11201601823TA
(en)
|
2013-09-13 |
2016-04-28 |
Genentech Inc |
Methods and compositions comprising purified recombinant polypeptides
|
WO2015048272A1
(en)
|
2013-09-25 |
2015-04-02 |
Amgen Inc. |
V-c-fc-v-c antibody
|
US11130980B2
(en)
|
2013-10-31 |
2021-09-28 |
Amgen Inc. |
Use of monensin to regulate glycosylation of recombinant proteins
|
WO2015086727A2
(en)
|
2013-12-11 |
2015-06-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
New prognostic method for patients suffering of a cancer
|
DE202014010499U1
(de)
|
2013-12-17 |
2015-10-20 |
Kymab Limited |
Targeting von humaner PCSK9 zur Cholesterinbehandlung
|
US8986691B1
(en)
|
2014-07-15 |
2015-03-24 |
Kymab Limited |
Method of treating atopic dermatitis or asthma using antibody to IL4RA
|
US8980273B1
(en)
|
2014-07-15 |
2015-03-17 |
Kymab Limited |
Method of treating atopic dermatitis or asthma using antibody to IL4RA
|
CN112481337A
(zh)
|
2014-01-13 |
2021-03-12 |
美国安进公司 |
调控鸟氨酸代谢以操控重组蛋白的高甘露糖糖型含量
|
EA202190244A3
(ru)
|
2014-01-29 |
2021-08-31 |
Эмджен Инк. |
Сверхэкспрессия регуляторов пути n-гликозилирования для модуляции гликозилирования рекомбинантных белков
|
US10106829B2
(en)
|
2014-01-29 |
2018-10-23 |
Amgen Inc. |
Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
|
RU2019119857A
(ru)
|
2014-02-20 |
2019-07-12 |
Аллерган, Инк. |
Антитела к компоненту комплемента c5
|
KR102368450B1
(ko)
|
2014-02-21 |
2022-02-28 |
사노피 바이오테크놀로지 |
Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법
|
WO2015130826A1
(en)
|
2014-02-27 |
2015-09-03 |
Allergan, Inc. |
COMPLEMENT FACTOR Bb ANTIBODIES
|
MX2016011132A
(es)
|
2014-02-28 |
2016-12-08 |
Regeneron Pharma |
Métodos para tratar una infección cutánea mediante la administración de un antagonista de il-4r.
|
NO2785538T3
(el)
|
2014-05-07 |
2018-08-04 |
|
|
WO2015175861A1
(en)
|
2014-05-16 |
2015-11-19 |
Amgen Inc. |
Assay for detecting th1 and th2 cell populations
|
ES2709994T3
(es)
|
2014-06-04 |
2019-04-22 |
Amgen Inc |
Métodos de recolección en cultivos de células de mamífero
|
WO2016023916A1
(en)
|
2014-08-12 |
2016-02-18 |
Kymab Limited |
Treatment of disease using ligand binding to targets of interest
|
MX2017003247A
(es)
|
2014-09-15 |
2017-11-30 |
Amgen Inc |
Proteina de union a antigenos, bi-especificos del receptor anti-cgrp/receptor pac1 y usos de las mismas.
|
WO2016071701A1
(en)
|
2014-11-07 |
2016-05-12 |
Kymab Limited |
Treatment of disease using ligand binding to targets of interest
|
EP3218412A1
(en)
|
2014-11-14 |
2017-09-20 |
Sanofi Biotechnology |
Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist
|
MX2017006463A
(es)
|
2014-11-19 |
2018-04-20 |
Amgen Inc |
Cuantificacion de porcion de glicano en glicoproteinas recombinantes.
|
CA2969225C
(en)
|
2014-12-01 |
2023-08-22 |
Amgen Inc. |
Process for manipulating the level of glycan content of a glycoprotein
|
WO2016094881A2
(en)
|
2014-12-11 |
2016-06-16 |
Abbvie Inc. |
Lrp-8 binding proteins
|
AU2016215155A1
(en)
|
2015-02-04 |
2017-08-17 |
F. Hoffmann-La Roche Ag |
Tau antisense oligomers and uses thereof
|
EP3254104B1
(en)
|
2015-02-04 |
2021-08-25 |
Bristol-Myers Squibb Company |
Methods of selecting therapeutic molecules
|
US10426818B2
(en)
|
2015-03-24 |
2019-10-01 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Method and pharmaceutical composition for use in the treatment of diabetes
|
CA3232537A1
(en)
|
2015-04-02 |
2016-10-06 |
Intervet International B.V. |
Antibodies to canine interleukin-4 receptor alpha
|
CA2980189A1
(en)
|
2015-04-24 |
2016-10-27 |
Genentech, Inc. |
Multispecific antigen-binding proteins
|
JOP20200116A1
(ar)
|
2015-04-24 |
2017-06-16 |
Amgen Inc |
طرق لعلاج أو الوقاية من الصداع النصفي
|
TW201710286A
(zh)
|
2015-06-15 |
2017-03-16 |
艾伯維有限公司 |
抗vegf、pdgf及/或其受體之結合蛋白
|
AU2016323440B2
(en)
|
2015-09-15 |
2023-07-13 |
Amgen Inc. |
Tetravalent bispecific and tetraspecific antigen binding proteins and uses thereof
|
CN108138147B
(zh)
|
2015-09-22 |
2022-11-01 |
豪夫迈·罗氏有限公司 |
含Fc蛋白的表达
|
BR112018007356A2
(pt)
|
2015-11-02 |
2018-10-23 |
Genentech Inc |
métodos de produção de formas fucosiladas e não fucosiladas de uma proteína
|
EP3390447A1
(en)
|
2015-12-15 |
2018-10-24 |
Amgen Inc. |
Pacap antibodies and uses thereof
|
PE20181327A1
(es)
|
2015-12-23 |
2018-08-20 |
Amgen Inc |
Metodo para tratar o mejorar trastornos metabolicos con proteinas de union para el receptor peptidico inhibidor gastrico (gipr) en combinacion con agonistas de glp-1
|
JP7422480B2
(ja)
|
2016-05-04 |
2024-01-26 |
アムジエン・インコーポレーテツド |
制御性t細胞の増殖のためのインターロイキン-2変異タンパク質
|
CN109563125B
(zh)
|
2016-07-22 |
2022-08-09 |
美国安进公司 |
含有Fc的蛋白的纯化方法
|
MA46098A
(fr)
|
2016-09-01 |
2019-07-10 |
Regeneron Pharma |
Méthodes de prévention ou de traitement de l'allergie par administration d'un antagoniste d'il-4 r
|
US10485844B2
(en)
|
2016-09-22 |
2019-11-26 |
Regeneron Pharmaceuticals, Inc. |
Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor
|
US20180110856A1
(en)
|
2016-10-21 |
2018-04-26 |
Amgen Inc. |
Pharmaceutical Formulations and Methods of Making the Same
|
AU2017356317A1
(en)
|
2016-11-14 |
2019-05-30 |
Amgen Inc. |
Bispecific or biparatopic antigen binding proteins and uses thereof
|
TW202332696A
(zh)
|
2016-12-01 |
2023-08-16 |
美商再生元醫藥公司 |
治療發炎症狀的方法
|
AU2018206279B2
(en)
|
2017-01-06 |
2020-09-03 |
Abl Bio Inc. |
Anti-alpha-syn antibody and use thereof
|
JOP20190177A1
(ar)
|
2017-01-17 |
2019-07-16 |
Amgen Inc |
طريقة لعلاج أو تحسين اضطرابات أيضية باستخدام مساعدات مستقبل glp-1 مقترنة بمناهضات لمستقبل ببتيد مثبط معوي (gipr)
|
CA3056011A1
(en)
|
2017-03-14 |
2018-09-20 |
Amgen Inc. |
Control of total afucosylated glycoforms of antibodies produced in cell culture
|
US11970526B2
(en)
|
2017-04-21 |
2024-04-30 |
Elanco Us Inc. |
IL4/IL13 receptor molecule for veterinary use
|
JOP20190259A1
(ar)
|
2017-05-31 |
2019-10-31 |
Amgen Inc |
بروتينات ربط مولد ضد مضادة لـ jagged1
|
CR20190532A
(es)
|
2017-06-20 |
2020-01-10 |
Amgen Inc |
Método para tratar o mejorar trastornos metabólicos con proteínas de unión para el receptor peptídico inhibidor gástrico (gipr) en combinación con agonistas de glp-1
|
US20210228738A1
(en)
|
2017-07-17 |
2021-07-29 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins
|
WO2019020480A1
(en)
|
2017-07-24 |
2019-01-31 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
ANTIBODIES AND PEPTIDES FOR TREATING HCMV RELATED DISEASES
|
US11053309B2
(en)
|
2017-08-04 |
2021-07-06 |
Regeneron Pharmaceuticals, Inc. |
Methods for treating active eosinophilic esophagitis
|
EP3661562A1
(en)
|
2017-08-04 |
2020-06-10 |
Amgen Inc. |
Method of conjugation of cys-mabs
|
CN111526920A
(zh)
|
2017-10-30 |
2020-08-11 |
赛诺菲生物技术公司 |
通过施用il-4r拮抗剂来治疗或预防哮喘的方法
|
JP7339262B2
(ja)
|
2018-01-12 |
2023-09-05 |
アムジェン インコーポレイテッド |
Pac1抗体及びその使用
|
SG11202009216YA
(en)
|
2018-03-26 |
2020-10-29 |
Amgen Inc |
Total afucosylated glycoforms of antibodies produced in cell culture
|
MX2020012064A
(es)
|
2018-05-13 |
2021-04-13 |
Regeneron Pharma |
Metodos para tratar la dermatitis atopica administrando un inhibidor de il-4r.
|
WO2019225787A1
(ko)
|
2018-05-24 |
2019-11-28 |
에이비엘바이오 주식회사 |
항-b7-h3 항체 및 그 용도
|
JP2022502454A
(ja)
|
2018-10-04 |
2022-01-11 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
認知機能を回復又は改善するための方法
|
WO2020074005A1
(en)
*
|
2018-10-12 |
2020-04-16 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric genes
|
BR112021011063A2
(pt)
|
2018-12-10 |
2021-08-31 |
Amgen Inc. |
Transposase piggybac mutada
|
CA3132587A1
(en)
|
2019-03-21 |
2020-09-24 |
Regeneron Pharmaceuticals, Inc. |
Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy
|
MX2021014534A
(es)
|
2019-05-30 |
2022-02-11 |
Amgen Inc |
Modificación por ingeniería genética de la región bisagra para impulsar la dimerización de anticuerpos.
|
US20220363770A1
(en)
|
2019-06-28 |
2022-11-17 |
Amgen Inc. |
Anti-cgrp receptor/anti-pac1 receptor bispecific antigen binding proteins
|
CN114173819A
(zh)
|
2019-08-05 |
2022-03-11 |
瑞泽恩制药公司 |
通过施用il-4r拮抗剂治疗过敏和增强过敏原特异性免疫疗法的方法
|
AU2020328038A1
(en)
|
2019-08-13 |
2022-03-31 |
Amgen Inc. |
Interleukin-2 muteins for the expansion of T-regulatory cells
|
KR20220069982A
(ko)
|
2019-09-26 |
2022-05-27 |
암젠 인크 |
항체 조성물의 생산 방법
|
EP4054590A1
(en)
|
2019-11-04 |
2022-09-14 |
Amgen Inc. |
Methods for treating leukemia
|
CA3160482A1
(en)
|
2019-11-08 |
2021-05-14 |
Amgen Inc. |
Engineering charge pair mutations for pairing of hetero-igg molecules
|
CA3160438A1
(en)
|
2019-11-19 |
2021-05-27 |
Amgen Inc. |
Novel multispecific antibody format
|
KR20220114595A
(ko)
|
2019-12-17 |
2022-08-17 |
암젠 인크 |
치료에서의 사용을 위한 이중 인터류킨-2/tnf 수용체 효현제
|
CA3164129A1
(en)
|
2019-12-20 |
2021-06-24 |
Amgen Inc. |
Mesothelin-targeted cd40 agonistic multispecific antibody constructs for the treatment of solid tumors
|
WO2021247892A1
(en)
|
2020-06-04 |
2021-12-09 |
Amgen Inc. |
Assessment of cleaning procedures of a biotherapeutic manufacturing process
|
WO2022040466A1
(en)
|
2020-08-20 |
2022-02-24 |
Amgen Inc. |
Antigen binding proteins with non-canonical disulfide in fab region
|
US20230374162A1
(en)
|
2020-10-07 |
2023-11-23 |
Amgen Inc. |
Rational selection of building blocks for the assembly of multispecific antibodies
|
JP2023548767A
(ja)
|
2020-10-15 |
2023-11-21 |
アムジエン・インコーポレーテツド |
抗体製造方法における相対不対グリカン
|
TW202233660A
(zh)
|
2020-10-30 |
2022-09-01 |
美商安進公司 |
過表現胰島素樣生長因子受體突變體以調節igf補充
|
AU2021379598A1
(en)
|
2020-11-10 |
2023-06-08 |
Amgen Inc. |
Novel linkers of multispecific antigen binding domains
|
EP4326761A1
(en)
|
2021-04-20 |
2024-02-28 |
Amgen Inc. |
Balanced charge distribution in electrostatic steering of chain pairing in multi-specific and monovalent igg molecule assembly
|
EP4330281A1
(en)
|
2021-04-29 |
2024-03-06 |
Amgen Inc. |
Methods for reducing low molecular weight species of recombinantly-produced proteins
|
AR126089A1
(es)
|
2021-06-07 |
2023-09-13 |
Amgen Inc |
Uso de fucosidasa para controlar el nivel de afucosilación de proteínas glucosiladas
|
WO2022261299A1
(en)
|
2021-06-10 |
2022-12-15 |
Amgen Inc. |
Engineered nrg-1 variants with improved selectivity toward erbb4 but not against erbb3
|
TW202328442A
(zh)
|
2021-09-10 |
2023-07-16 |
美商安進公司 |
平臺宿主對igf—培養基之適應
|
WO2023059607A1
(en)
|
2021-10-05 |
2023-04-13 |
Amgen Inc. |
Fc-gamma receptor ii binding and glycan content
|
WO2023129974A1
(en)
|
2021-12-29 |
2023-07-06 |
Bristol-Myers Squibb Company |
Generation of landing pad cell lines
|
WO2023172965A1
(en)
|
2022-03-09 |
2023-09-14 |
Amgen Inc. |
Optimized transfection protocol
|
WO2023175022A1
(en)
|
2022-03-16 |
2023-09-21 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
New method to treat infectious diseases
|
WO2023215725A1
(en)
|
2022-05-02 |
2023-11-09 |
Fred Hutchinson Cancer Center |
Compositions and methods for cellular immunotherapy
|
US20240024472A1
(en)
|
2022-05-02 |
2024-01-25 |
Regeneron Pharmaceuticals, Inc. |
Anti-Interleukin-4 Receptor (IL-4R) Antibody Formulations
|
WO2023215750A2
(en)
|
2022-05-02 |
2023-11-09 |
Regeneron Pharmaceuticals, Inc. |
Methods for reducing lipase activity
|