GEP20156325B - Inhibitors of influenza viruses replication - Google Patents

Inhibitors of influenza viruses replication

Info

Publication number
GEP20156325B
GEP20156325B GEAP201012538A GEAP2010012538A GEP20156325B GE P20156325 B GEP20156325 B GE P20156325B GE AP201012538 A GEAP201012538 A GE AP201012538A GE AP2010012538 A GEAP2010012538 A GE AP2010012538A GE P20156325 B GEP20156325 B GE P20156325B
Authority
GE
Georgia
Prior art keywords
influenza viruses
inhibitors
viruses replication
replication
patient
Prior art date
Application number
GEAP201012538A
Other languages
English (en)
Inventor
Paul Charifson
Michael P Clark
Upul K Bandarage
Randy S Bethiel
John J Court
Hongbo Deng
Ioana Drutu
John P Duffy
Luc Farmer
Huai Gao
Wenxin Gu
Dylan H Jacobs
Joseph M Kennedy
Mark W Ledeboer
Brian Ledford
Francois Maltais
Emanuele Perola
Tiansheng Wang
M Woods Wannamaker
Randal Byrn
Yi Zhou
Chao Lin
Min Jiang
Steven Jones
Ursula A Germann
Francesco G Salituro
Ann Dak-Yee Kwong
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42537408&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GEP20156325(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of GEP20156325B publication Critical patent/GEP20156325B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GEAP201012538A 2009-06-17 2010-06-17 Inhibitors of influenza viruses replication GEP20156325B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18771309P 2009-06-17 2009-06-17
US28778109P 2009-12-18 2009-12-18
PCT/US2010/038988 WO2010148197A1 (en) 2009-06-17 2010-06-17 Inhibitors of influenza viruses replication

Publications (1)

Publication Number Publication Date
GEP20156325B true GEP20156325B (en) 2015-07-10

Family

ID=42537408

Family Applications (3)

Application Number Title Priority Date Filing Date
GEAP201012538A GEP20156325B (en) 2009-06-17 2010-06-17 Inhibitors of influenza viruses replication
GEAP201013376A GEP20227397B (en) 2009-06-17 2010-06-17 Inhibitors of influenza viruses replication
GEAP201013375A GEP20207129B (en) 2009-06-17 2010-06-17 Inhibitors of influenza viruses replication

Family Applications After (2)

Application Number Title Priority Date Filing Date
GEAP201013376A GEP20227397B (en) 2009-06-17 2010-06-17 Inhibitors of influenza viruses replication
GEAP201013375A GEP20207129B (en) 2009-06-17 2010-06-17 Inhibitors of influenza viruses replication

Country Status (37)

Country Link
US (7) US20120171245A1 (cg-RX-API-DMAC7.html)
EP (3) EP3427738B1 (cg-RX-API-DMAC7.html)
JP (6) JP5721706B2 (cg-RX-API-DMAC7.html)
KR (3) KR101702609B1 (cg-RX-API-DMAC7.html)
CN (5) CN104922128B (cg-RX-API-DMAC7.html)
AP (1) AP3631A (cg-RX-API-DMAC7.html)
AR (1) AR077130A1 (cg-RX-API-DMAC7.html)
AU (1) AU2010262905B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI1011993A2 (cg-RX-API-DMAC7.html)
CA (1) CA2764177C (cg-RX-API-DMAC7.html)
CL (1) CL2011003192A1 (cg-RX-API-DMAC7.html)
CO (1) CO6491048A2 (cg-RX-API-DMAC7.html)
CY (2) CY1118246T1 (cg-RX-API-DMAC7.html)
DK (2) DK3141252T3 (cg-RX-API-DMAC7.html)
EA (3) EA037529B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP12011610A (cg-RX-API-DMAC7.html)
ES (2) ES2692396T3 (cg-RX-API-DMAC7.html)
GE (3) GEP20156325B (cg-RX-API-DMAC7.html)
HR (2) HRP20161577T1 (cg-RX-API-DMAC7.html)
HU (1) HUE031048T2 (cg-RX-API-DMAC7.html)
IL (2) IL216980B (cg-RX-API-DMAC7.html)
LT (2) LT3141252T (cg-RX-API-DMAC7.html)
ME (1) ME02558B (cg-RX-API-DMAC7.html)
MX (3) MX375432B (cg-RX-API-DMAC7.html)
NZ (2) NZ597059A (cg-RX-API-DMAC7.html)
PE (2) PE20120508A1 (cg-RX-API-DMAC7.html)
PH (1) PH12015501678B1 (cg-RX-API-DMAC7.html)
PL (2) PL2442809T3 (cg-RX-API-DMAC7.html)
PT (2) PT3141252T (cg-RX-API-DMAC7.html)
RS (2) RS57869B1 (cg-RX-API-DMAC7.html)
SG (3) SG10201405826RA (cg-RX-API-DMAC7.html)
SI (2) SI3141252T1 (cg-RX-API-DMAC7.html)
TR (1) TR201815272T4 (cg-RX-API-DMAC7.html)
TW (4) TWI574963B (cg-RX-API-DMAC7.html)
UY (1) UY32717A (cg-RX-API-DMAC7.html)
WO (1) WO2010148197A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA201109127B (cg-RX-API-DMAC7.html)

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