EA201500871A1 - Ингибиторы репликации вирусов гриппа - Google Patents
Ингибиторы репликации вирусов гриппаInfo
- Publication number
- EA201500871A1 EA201500871A1 EA201500871A EA201500871A EA201500871A1 EA 201500871 A1 EA201500871 A1 EA 201500871A1 EA 201500871 A EA201500871 A EA 201500871A EA 201500871 A EA201500871 A EA 201500871A EA 201500871 A1 EA201500871 A1 EA 201500871A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- patient
- structural formula
- biological sample
- pharmaceutically acceptable
- acceptable salt
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Способы ингибирования репликации вируса гриппа в биологическом образце или у пациента, уменьшения количества вирусов гриппа в биологическом образце или у пациента и лечения гриппа у пациента, которые включают введение в указанный биологический образец или пациенту эффективного количества соединения, представленного структурной формулой (I)или его фармацевтически приемлемой соли, где обозначения, указанные в структурной формуле (IA), представлены в описании выше. Соединение, представленное структурной формулой (IA), или его фармацевтически приемлемая соль, где обозначения, указанные в структурной формуле (IA), описаны выше. Фармацевтическая композиция, содержащая эффективное количество такого соединения или его фармацевтически приемлемой соли и фармацевтически приемлемый носитель, наполнитель или разбавитель.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18771309P | 2009-06-17 | 2009-06-17 | |
US28778109P | 2009-12-18 | 2009-12-18 |
Publications (3)
Publication Number | Publication Date |
---|---|
EA201500871A1 true EA201500871A1 (ru) | 2016-11-30 |
EA201500871A8 EA201500871A8 (ru) | 2019-02-28 |
EA037529B1 EA037529B1 (ru) | 2021-04-08 |
Family
ID=42537408
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201500266A EA030188B1 (ru) | 2009-06-17 | 2010-06-17 | Ингибиторы репликации вирусов гриппа |
EA201500871A EA037529B1 (ru) | 2009-06-17 | 2010-06-17 | Способ получения соединения для ингибирования репликации вирусов гриппа |
EA201270032A EA025276B1 (ru) | 2009-06-17 | 2010-06-17 | (2S,3S)-3-((2-(5-ФТОР-1Н-ПИРРОЛО[2,3-b]ПИРИДИН-3-ИЛ)-5-ФТОРПИРИМИДИН-4-ИЛ)АМИНО)БИЦИКЛО[2,2,2]ОКТАН-2-КАРБОНОВАЯ КИСЛОТА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ВКЛЮЧАЮЩАЯ ЕЁ, И СПОСОБЫ ПРИМЕНЕНИЯ УКАЗАННОГО СОЕДИНЕНИЯ |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201500266A EA030188B1 (ru) | 2009-06-17 | 2010-06-17 | Ингибиторы репликации вирусов гриппа |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201270032A EA025276B1 (ru) | 2009-06-17 | 2010-06-17 | (2S,3S)-3-((2-(5-ФТОР-1Н-ПИРРОЛО[2,3-b]ПИРИДИН-3-ИЛ)-5-ФТОРПИРИМИДИН-4-ИЛ)АМИНО)БИЦИКЛО[2,2,2]ОКТАН-2-КАРБОНОВАЯ КИСЛОТА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ВКЛЮЧАЮЩАЯ ЕЁ, И СПОСОБЫ ПРИМЕНЕНИЯ УКАЗАННОГО СОЕДИНЕНИЯ |
Country Status (38)
Country | Link |
---|---|
US (7) | US20120171245A1 (ru) |
EP (3) | EP3427738B1 (ru) |
JP (6) | JP5721706B2 (ru) |
KR (3) | KR101702609B1 (ru) |
CN (5) | CN102458408B (ru) |
AP (1) | AP3631A (ru) |
AR (1) | AR077130A1 (ru) |
AU (1) | AU2010262905B2 (ru) |
BR (1) | BRPI1011993A2 (ru) |
CA (1) | CA2764177C (ru) |
CL (1) | CL2011003192A1 (ru) |
CO (1) | CO6491048A2 (ru) |
CY (2) | CY1118246T1 (ru) |
DK (2) | DK3141252T3 (ru) |
EA (3) | EA030188B1 (ru) |
EC (1) | ECSP12011610A (ru) |
ES (2) | ES2604667T3 (ru) |
GE (3) | GEP20156325B (ru) |
HK (4) | HK1215675A1 (ru) |
HR (2) | HRP20161577T1 (ru) |
HU (1) | HUE031048T2 (ru) |
IL (2) | IL216980B (ru) |
LT (2) | LT3141252T (ru) |
ME (1) | ME02558B (ru) |
MX (2) | MX348066B (ru) |
NZ (2) | NZ619259A (ru) |
PE (2) | PE20160127A1 (ru) |
PH (1) | PH12015501678A1 (ru) |
PL (2) | PL3141252T3 (ru) |
PT (2) | PT2442809T (ru) |
RS (2) | RS57869B1 (ru) |
SG (3) | SG10201405826RA (ru) |
SI (2) | SI3141252T1 (ru) |
TR (1) | TR201815272T4 (ru) |
TW (4) | TWI666209B (ru) |
UY (1) | UY32717A (ru) |
WO (1) | WO2010148197A1 (ru) |
ZA (2) | ZA201109127B (ru) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2435769C2 (ru) * | 2005-05-20 | 2011-12-10 | Вертекс Фармасьютикалз Инкорпорейтед | Пирролопиридины, полезные в качестве ингибиторов протеинкиназы |
GEP20156325B (en) * | 2009-06-17 | 2015-07-10 | Vertex Pharma | Inhibitors of influenza viruses replication |
WO2012083117A1 (en) * | 2010-12-16 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
CA2822062A1 (en) * | 2010-12-16 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
RU2013132717A (ru) * | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
HUE028439T2 (en) | 2011-07-04 | 2016-12-28 | Rottapharm Biotech Srl | Ring amine derivatives as EP4 receptor antagonists |
BR112014000115A2 (pt) * | 2011-07-05 | 2016-10-04 | Vertex Pharma | processos e intermediários para a produção de azaindóis, e suas formas sólidas |
UA118010C2 (uk) * | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
US10323012B2 (en) * | 2012-06-05 | 2019-06-18 | Hong Kong Baptist University | Miliusanes as antiviral agents |
WO2013184985A1 (en) * | 2012-06-08 | 2013-12-12 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
WO2014081906A2 (en) * | 2012-11-21 | 2014-05-30 | Ptc Therapeutics, Inc. | Substituted reverse pyrimidine bmi-1 inhibitors |
EP3039015B1 (en) | 2013-08-30 | 2019-10-30 | PTC Therapeutics, Inc. | Substituted pyrimidine bmi-1 inhibitors |
US9296727B2 (en) | 2013-10-07 | 2016-03-29 | Vertex Pharmaceuticals Incorporated | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines |
JP6618901B2 (ja) * | 2013-11-13 | 2019-12-11 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルスの複製の阻害剤を調製する方法 |
PL3068776T3 (pl) * | 2013-11-13 | 2019-10-31 | Vertex Pharma | Inhibitory replikacji wirusów grypy |
SG10201804024VA (en) * | 2013-11-13 | 2018-07-30 | Vertex Pharma | Formulations of azaindole compounds |
US10584115B2 (en) | 2013-11-21 | 2020-03-10 | Ptc Therapeutics, Inc. | Substituted pyridine and pyrazine BMI-1 inhibitors |
LT3126352T (lt) | 2014-04-04 | 2019-01-10 | Syros Pharmaceuticals, Inc. | Nuo ciklino priklausomos kinazės 7 (cdk7) inhibitoriai |
BR112017002370B1 (pt) * | 2014-08-08 | 2022-11-22 | Janssen Sciences Ireland Uc | Compostos indóis, composição farmacêutica que os compreende e seu uso na inibição da replicação do vírus da gripe |
SI3191489T1 (sl) * | 2014-09-08 | 2021-02-26 | Janssen Sciences Ireland Unlimited Company | Pirolopirimidini za uporabo pri okužbi z virusom gripe |
MA40772A (fr) | 2014-10-02 | 2017-08-08 | Vertex Pharma | Variants du virus de la grippe a |
MA40773A (fr) | 2014-10-02 | 2017-08-08 | Vertex Pharma | Variants du virus influenza a |
US10150731B2 (en) * | 2015-01-16 | 2018-12-11 | Bayer Cropscience Aktiengesellschaft | Method for preparing 4-cyanopiperidine hydrochloride |
EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
WO2016191079A1 (en) * | 2015-05-26 | 2016-12-01 | Boropharm, Inc. | Improved process for preparing boryl 7-azaindole compounds |
HUE055200T2 (hu) * | 2015-11-27 | 2021-11-29 | Janssen Sciences Ireland Unlimited Co | Heterociklusos indolok influenzavírus fertõzésben való alkalmazásra |
KR20180088466A (ko) | 2015-12-09 | 2018-08-03 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 인플루엔자 바이러스 복제 저해제, 활용 방법 및 그 용도 |
MA43583A (fr) * | 2016-01-07 | 2021-05-19 | Janssen Sciences Ireland Unlimited Co | Dérivés d'acide pentanoïque substitués par pyrrolo-[2,3-b]pyrimidne-pyridines pour traiter des infections par le virus de la grippe |
DK3405466T3 (da) | 2016-01-20 | 2021-02-01 | Janssen Sciences Ireland Unlimited Co | Arylsubstituerede pyrimidiner til anvendelse ved influenzavirusinfektion |
WO2017133667A1 (en) * | 2016-02-05 | 2017-08-10 | Savira Pharmaceuticals Gmbh | Pyrimidine and pyridine derivatives and use in treatment, amelioration or prevention of influenza thereof |
WO2017198122A1 (zh) * | 2016-05-19 | 2017-11-23 | 四川大学 | 抗流感小分子化合物及其制备方法和用途 |
WO2018033082A1 (en) | 2016-08-16 | 2018-02-22 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication, application methods and uses thereof |
CN109641868B (zh) | 2016-08-30 | 2021-12-03 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其使用方法和用途 |
CN110627784B (zh) * | 2016-09-05 | 2021-09-21 | 广东众生睿创生物科技有限公司 | 抗流感病毒嘧啶衍生物 |
JP7071383B2 (ja) * | 2016-11-08 | 2022-05-18 | キャンサー・リサーチ・テクノロジー・リミテッド | cdc7阻害剤としてのピリミジノン誘導体 |
US10987354B2 (en) | 2016-12-15 | 2021-04-27 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication and uses thereof |
JP7299837B2 (ja) * | 2016-12-23 | 2023-06-28 | アクイナ ファーマシューティカルズ, インコーポレイテッド | 化合物、組成物、および使用方法 |
WO2018127096A1 (en) | 2017-01-05 | 2018-07-12 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication and uses thereof |
WO2018157830A1 (en) | 2017-03-02 | 2018-09-07 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication and uses thereof |
CA3059362A1 (en) | 2017-04-12 | 2018-10-18 | Vertex Pharmaceuticals Incorporated | Combination therapies for treating influenza virus infection |
PL3615545T3 (pl) * | 2017-04-24 | 2022-01-10 | Cocrystal Pharma, Inc. | Pochodne pirolopirymidyny użyteczne jako inhibitory replikacji wirusa grypy |
CN108727369B (zh) * | 2017-04-25 | 2023-06-09 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其用途 |
CN111094233B (zh) | 2017-08-09 | 2024-03-15 | 戴纳立制药公司 | 化合物、组合物及方法 |
CN109745309B (zh) * | 2017-11-03 | 2022-01-28 | 香港浸会大学 | 作为抗病毒剂的密瘤杀 |
CN110117285B (zh) * | 2018-02-07 | 2023-02-03 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其用途 |
KR102484804B1 (ko) * | 2018-03-05 | 2023-01-04 | 광둥 레이노벤트 바이오테크 컴퍼니 리미티드 | 이미다졸계 화합물의 결정 형태, 염 형태 및 그의 제조 방법 |
EP3774794A1 (en) | 2018-04-06 | 2021-02-17 | Janssen Pharmaceuticals, Inc. | Isothermal reactive crystallisation process for the preparation of a crystalline form of pimodivir hydrochloride hemihydrate |
CN110590768B (zh) * | 2018-06-13 | 2021-02-26 | 银杏树药业(苏州)有限公司 | 杂环化合物、其组合物及其作为抗流感病毒药物的应用 |
US20210121462A1 (en) * | 2018-07-27 | 2021-04-29 | Cocrystal Pharma, Inc. | Pyrrolo[2,3-b]pyridin derivatives as inhibitors of influenza virus replication |
WO2020168011A1 (en) | 2019-02-13 | 2020-08-20 | Denali Therapeutics Inc. | Compounds, compositions and methods |
WO2020181247A1 (en) * | 2019-03-06 | 2020-09-10 | Denali Therapeutics Inc. | Compounds, compositions and methods |
WO2020212399A1 (en) | 2019-04-15 | 2020-10-22 | Janssen Pharmaceutica Nv | Method for preparing an alkyl trans-3-aminobicyclo[2.2.2]octane-2-carboxylic acid ester compound |
US20200397784A1 (en) | 2019-06-20 | 2020-12-24 | Janssen Pharmaceuticals, Inc. | Formulations of azaindole compounds |
JP7450017B2 (ja) * | 2019-07-22 | 2024-03-14 | 広東衆生睿創生物科技有限公司 | ピリミジン誘導体の優位な塩形およびその結晶形 |
CN114555595B (zh) * | 2019-08-30 | 2023-12-26 | Tsd生命科学有限公司 | 咪唑并吡啶衍生物及将其作为有效成分的药学组合物 |
WO2021047437A1 (zh) * | 2019-09-10 | 2021-03-18 | 广东众生睿创生物科技有限公司 | 一种用于治疗病毒性感冒的药物组合物及其制剂 |
RU2726119C1 (ru) * | 2019-11-22 | 2020-07-09 | Общество С Ограниченной Ответственностью "Валента - Интеллект" | Новые производные полиолов, их применение, фармацевтическая композиция на их основе |
EP4180434A1 (en) | 2020-07-10 | 2023-05-17 | Sichuan Haisco Pharmaceutical Co., Ltd. | Pb2 inhibitor, and preparation method therefor and use thereof |
CN112979647B (zh) * | 2021-03-12 | 2022-05-20 | 浙江大学 | 含氮杂氨基酸的氮杂吲哚衍生物及制备和应用 |
Family Cites Families (174)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4349552A (en) | 1978-10-30 | 1982-09-14 | Fujisawa Pharmaceutical Company, Ltd. | 5-Fluorouracil derivatives, and their pharmaceutical compositions |
PT85662B (pt) | 1986-09-10 | 1990-06-29 | Sandoz Sa | Processo para a preparacao de derivados de aza-indol e de indolizina e de composicoes farmaceuticas que os contem |
MX19185A (es) | 1989-01-20 | 1993-12-01 | Pfizer | Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas. |
US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
FR2687402B1 (fr) | 1992-02-14 | 1995-06-30 | Lipha | Nouveaux azaindoles, procedes de preparation et medicaments les contenant. |
DE4304455A1 (de) | 1993-02-15 | 1994-08-18 | Bayer Ag | Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate |
US5716981A (en) | 1993-07-19 | 1998-02-10 | Angiogenesis Technologies, Inc. | Anti-angiogenic compositions and methods of use |
IL129871A (en) | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
JPH10510510A (ja) | 1994-06-09 | 1998-10-13 | スミスクライン・ビーチャム・コーポレイション | エンドセリン受容体拮抗物質 |
US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
US5821243A (en) | 1996-07-22 | 1998-10-13 | Viropharma Incorporated | Compounds compositions and methods for treating influenza |
US6187713B1 (en) | 1996-10-31 | 2001-02-13 | Corning Incorporated | Method of making activated carbon bodies having improved adsorption properties |
GB9721437D0 (en) | 1997-10-10 | 1997-12-10 | Glaxo Group Ltd | Heteroaromatic compounds and their use in medicine |
WO2000040581A1 (en) | 1999-01-07 | 2000-07-13 | American Home Products Corporation | 3,4-dihydro-2h-benzo[1,4]oxazine derivatives |
KR20010086163A (ko) | 1999-01-07 | 2001-09-08 | 이곤 이 버그 | 우울증 치료용 아릴피페라지닐-사이클로헥실 인돌 유도체 |
US6313126B1 (en) | 1999-01-07 | 2001-11-06 | American Home Products Corp | Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression |
US6265403B1 (en) | 1999-01-20 | 2001-07-24 | Merck & Co., Inc. | Angiogenesis inhibitors |
AR028475A1 (es) | 1999-04-22 | 2003-05-14 | Wyeth Corp | Derivados de azaindol y uso de los mismos para la manufactura de un medicamento para el tratamiento de la depresion. |
US20030153560A1 (en) | 1999-04-23 | 2003-08-14 | Salituro Francesco G. | Inhibitors of c-Jun N-terminal kinases (JNK) |
EP1196167B1 (en) | 1999-07-02 | 2006-04-19 | Stuart A. Lipton | Use of p38 MAPK inhibitors in the treatment of ophthalmic conditions |
GB9919843D0 (en) | 1999-08-20 | 1999-10-27 | Smithkline Beecham Plc | Novel compounds |
DE19948417A1 (de) | 1999-10-07 | 2001-04-19 | Morphochem Ag | Imidazol-Derivate und ihre Verwendung als Arzneimittel |
US20020065270A1 (en) | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
AU2457201A (en) | 1999-12-28 | 2001-07-09 | Bristol-Myers Squibb Company | Cytokine, especially tnf-alpha, inhibitors |
HUP0301117A3 (en) | 2000-02-17 | 2004-01-28 | Amgen Inc Thousand Oaks | Imidazole derivatives kinase inhibitors, their use, process for their preparation and pharmaceutical compositions containing them |
US7041277B2 (en) | 2000-03-10 | 2006-05-09 | Cadbury Adams Usa Llc | Chewing gum and confectionery compositions with encapsulated stain removing agent compositions, and methods of making and using the same |
CA2308994A1 (en) | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
JP4911864B2 (ja) | 2000-08-14 | 2012-04-04 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 置換ピラゾール |
CN1642973A (zh) | 2000-09-06 | 2005-07-20 | 奥索-麦克尼尔药品公司 | 治疗变态反应的方法 |
DK1315492T3 (da) | 2000-09-06 | 2008-10-13 | Ortho Mcneil Pharm Inc | Anvendelse af substituerede pyrazoler til behandling af allergier |
AR031130A1 (es) | 2000-09-20 | 2003-09-10 | Abbott Lab | N-acilsulfonamidas promotoras de la apoptosis |
JP2004509897A (ja) | 2000-09-22 | 2004-04-02 | イーライ・リリー・アンド・カンパニー | シクロヘキシルアミン誘導体の立体選択的製造方法 |
HUP0400684A2 (hu) | 2000-12-22 | 2004-07-28 | Wyeth | 5-Hidroxitriptamin-6-ligandumként használható heterociklilindazol- és -azaindazol-származékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények |
WO2002070662A2 (en) | 2001-03-02 | 2002-09-12 | Gpc Biotech Ag | Three hybrid assay system |
ATE281459T1 (de) | 2001-03-14 | 2004-11-15 | Wyeth Corp | Azaheterocyclylmethyl derivative des 2,3-dihydro- 1,4-dioxino(2,3-f)quinolins als antidepressiva |
US7081454B2 (en) | 2001-03-28 | 2006-07-25 | Bristol-Myers Squibb Co. | Tyrosine kinase inhibitors |
AU2002258971A1 (en) | 2001-04-24 | 2002-11-05 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan |
US6656950B2 (en) | 2001-04-25 | 2003-12-02 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine |
ATE334989T1 (de) | 2001-04-26 | 2006-08-15 | Wyeth Corp | Antidepressive azaheterocyclylmethyl-derivate von 2,3-dihydro-1,4-dioxino 2,3-föchinoxalin |
ATE279415T1 (de) | 2001-04-26 | 2004-10-15 | Wyeth Corp | Antidepressiv wirksame azaheterocyclymethyl- derivative von oxaheterocycyl-anellierten (1,4)- benzodioxanen |
US6573283B2 (en) | 2001-04-26 | 2003-06-03 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalene |
WO2002088129A1 (en) | 2001-04-26 | 2002-11-07 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline |
US6593350B2 (en) | 2001-04-26 | 2003-07-15 | Wyeth | Antidepressant indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole |
BR0209407A (pt) | 2001-04-30 | 2004-07-06 | Wyeth Corp | Antidepressivos de azaheterociclilmetila derivados de 7,8-dihidro-1,6,9-trioxa-3-aza-ciclopenta[a[]naftaleno , método de tratamento usando tais compostos e processo para prepará-los |
US6555560B2 (en) | 2001-04-30 | 2003-04-29 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene |
GB0111186D0 (en) | 2001-05-08 | 2001-06-27 | Smithkline Beecham Plc | Novel compounds |
CN1247590C (zh) | 2001-05-17 | 2006-03-29 | 惠氏公司 | 2,3-二氢-1,4-二氧芑并[2,3-f]喹啉衍生物的合成方法 |
MXPA03011652A (es) | 2001-06-15 | 2004-05-31 | Vertex Pharma | 5-(2-aminopirimidin-4-il) benzioxazoles como inhibidores de proteinas cinasa. |
GB0115109D0 (en) * | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
AR035083A1 (es) | 2001-07-25 | 2004-04-14 | Wyeth Corp | Derivados azaheterociclilmetilicos de 7,8-dihidro-6h-5-oxa-1-aza-fenantreno, composiciones farmaceuticas, el uso de dichos derivados para la preparacion de un medicamento antidepresivo e intermediarios |
BR0211900A (pt) | 2001-08-14 | 2004-08-24 | Toyama Chemical Co Ltd | Método para inibição do desenvolvimento de vìrus e/ou virucida, análogos de nucleotìdeo de pirazina e de nucleosìdeo de pirazina, precursor do inibidor da polimerase de rna, inibidor da polimerase de rna, método para tratar pacientes infectados por vìrus, e, usos de um análogo de nucleotìdeo de pirazina ou um sal deste e de um análogo de nucleosìdeo de pirazina ou um sal deste |
US20040236110A1 (en) | 2001-09-26 | 2004-11-25 | Ladouceur Gaetan H | Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors |
WO2003031439A1 (en) | 2001-10-05 | 2003-04-17 | Wyeth | Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole |
US7361671B2 (en) | 2001-11-15 | 2008-04-22 | The Institute For Pharmaceutical Discovery, Inc. | Substituted heteroarylalkanoic acids |
TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
BR0308787A (pt) | 2002-04-26 | 2005-01-11 | Pfizer Prod Inc | Inibidores de metaloproteinase de n-substituìdos-heteroarilóxi-aril-espiro-pirimidina- 2,4,6-triona |
EP1506189A1 (en) | 2002-04-26 | 2005-02-16 | Vertex Pharmaceuticals Incorporated | Pyrrole derivatives as inhibitors of erk2 and uses thereof |
KR20050004214A (ko) | 2002-05-31 | 2005-01-12 | 에자이 가부시키가이샤 | 피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물 |
UA78999C2 (en) | 2002-06-04 | 2007-05-10 | Wyeth Corp | 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6 |
ES2273043T3 (es) | 2002-08-02 | 2007-05-01 | Vertex Pharmaceuticals Incorporated | Composiciones de pirazol utiles como inhibidores de gsk-3. |
AU2002368154A1 (en) | 2002-08-08 | 2004-02-25 | Ribapharm Inc. | Improved synthesis for hydroxyalkylated heterocyclic bases |
SE0202463D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
US7262200B2 (en) | 2002-10-25 | 2007-08-28 | Vertex Pharmaceuticals Incorporated | Indazolinone compositions useful as kinase inhibitors |
DE50307267D1 (de) | 2003-02-26 | 2007-06-21 | Boehringer Ingelheim Pharma | Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
WO2004078756A2 (en) | 2003-03-06 | 2004-09-16 | Eisai Co., Ltd. | Jnk inhibitors |
EP1608628A2 (en) | 2003-03-17 | 2005-12-28 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
WO2004106298A1 (en) | 2003-05-30 | 2004-12-09 | Janssen Pharmaceutica N.V. | Indole derivatives with an improved antipsychotic activity |
WO2005000813A1 (en) | 2003-05-30 | 2005-01-06 | Imclone Systems Incorporated | Heteroarylamino-phenylketone derivatives and their use as kinase inhibitors |
EP1781659B1 (en) | 2003-07-16 | 2008-11-05 | Janssen Pharmaceutica N.V. | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors |
AR045595A1 (es) | 2003-09-04 | 2005-11-02 | Vertex Pharma | Composiciones utiles como inhibidores de proteinas quinasas |
WO2005044181A2 (en) | 2003-09-09 | 2005-05-19 | Temple University-Of The Commonwealth System Of Higher Education | Protection of tissues and cells from cytotoxic effects of ionizing radiation by abl inhibitors |
WO2005033072A2 (en) | 2003-09-30 | 2005-04-14 | Scios Inc. | Heterocyclic amides and sulfonamides |
CN1897950A (zh) | 2003-10-14 | 2007-01-17 | 惠氏公司 | 稠合芳基和杂芳基衍生物及其使用方法 |
PL1696920T3 (pl) | 2003-12-19 | 2015-03-31 | Plexxikon Inc | Związki i sposoby opracowywania modulatorów Ret |
US20070066641A1 (en) | 2003-12-19 | 2007-03-22 | Prabha Ibrahim | Compounds and methods for development of RET modulators |
GB0405055D0 (en) | 2004-03-05 | 2004-04-07 | Eisai London Res Lab Ltd | JNK inhibitors |
MXPA06011327A (es) | 2004-03-30 | 2006-12-15 | Vertex Pharma | Azaindoles utiles como inhibidores de jak y otras proteinas cinasas. |
CN101014597A (zh) | 2004-04-02 | 2007-08-08 | 沃泰克斯药物股份有限公司 | 可用作rock和其他蛋白激酶抑制剂的吖吲哚 |
ITMI20040874A1 (it) | 2004-04-30 | 2004-07-30 | Ist Naz Stud Cura Dei Tumori | Derivati indolici ed azaindolici con azione antitumorale |
KR100476851B1 (ko) | 2004-05-18 | 2005-03-17 | (주)성신엔지니어링 | 중력식 섬유여과기 |
WO2006009755A2 (en) | 2004-06-17 | 2006-01-26 | Plexxikon, Inc. | Azaindoles modulating c-kit activity and uses therefor |
DE102004029784A1 (de) | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
US7173031B2 (en) | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
US20060122213A1 (en) | 2004-06-30 | 2006-06-08 | Francoise Pierard | Azaindoles useful as inhibitors of protein kinases |
MX2007001127A (es) | 2004-07-27 | 2007-07-11 | Sgx Pharmaceuticals Inc | Moduladores de pirrolo-piridina cinasa. |
GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
EP2439207A1 (en) | 2004-10-04 | 2012-04-11 | Millennium Pharmaceuticals, Inc. | Lactam Compounds Useful as Protein Kinase Inhibitors |
WO2006038001A1 (en) | 2004-10-06 | 2006-04-13 | Celltech R & D Limited | Aminopyrimidine derivatives as jnk inhibitors |
WO2006050076A1 (en) | 2004-10-29 | 2006-05-11 | Janssen Pharmaceutica, N.V. | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders |
AU2005304784B2 (en) | 2004-11-04 | 2011-03-24 | Vertex Pharmaceuticals Incorporated | Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases |
JP2008520738A (ja) | 2004-11-22 | 2008-06-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼの阻害剤として有用なピロロピラジンおよびピラゾロピラジン |
PL2486942T3 (pl) | 2004-11-24 | 2019-05-31 | Meda Pharmaceuticals Inc | Kompozycje zawierające azelastynę oraz sposoby ich stosowania |
JP4954086B2 (ja) | 2004-12-08 | 2012-06-13 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 1h−ピロロ[2,3−b]ピリジン |
MX2007007330A (es) | 2004-12-16 | 2007-10-04 | Vertex Pharma | Piridonas de utilidad como inhibidores de quinasas . |
US20060161001A1 (en) | 2004-12-20 | 2006-07-20 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
WO2006096270A1 (en) | 2005-02-03 | 2006-09-14 | Vertex Pharmaceuticals Incorporated | Pyrrolopyrimidines useful as inhibitors of protein kinase |
MX2007014327A (es) | 2005-05-16 | 2008-02-11 | Irm Llc | Derivados de pirrolopiridina como inhibidores de cinasa de proteina. |
RU2435769C2 (ru) | 2005-05-20 | 2011-12-10 | Вертекс Фармасьютикалз Инкорпорейтед | Пирролопиридины, полезные в качестве ингибиторов протеинкиназы |
DK1893612T3 (da) | 2005-06-22 | 2011-11-21 | Plexxikon Inc | Pyrrol [2,3-B]pyridin-derivater som proteinkinasehæmmere |
EP1749523A1 (en) | 2005-07-29 | 2007-02-07 | Neuropharma, S.A. | GSK-3 inhibitors |
GB0516156D0 (en) | 2005-08-05 | 2005-09-14 | Eisai London Res Lab Ltd | JNK inhibitors |
RU2008117151A (ru) | 2005-09-30 | 2009-11-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Деазапурины, пригодные в качестве ингибиторов янус-киназ |
US20130096302A1 (en) | 2005-11-22 | 2013-04-18 | Hayley Binch | Pyrrolopyrazines and pyrazolopyrazines useful as inhibitors of protein kinases |
CN101374839A (zh) * | 2006-01-17 | 2009-02-25 | 沃泰克斯药物股份有限公司 | 适用作詹纳斯激酶抑制剂的吖吲哚类 |
EP2559694A3 (en) | 2006-01-17 | 2013-04-03 | Vertex Pharmaceuticals, Inc. | Azaindoles useful as inhibitors of Janus kinases |
EP2004645A2 (en) | 2006-02-14 | 2008-12-24 | Vertex Pharmaceuticals, Inc. | Pyrrolo(3,2-c) pyridines useful as inhibitors of protein kinases |
NZ570530A (en) | 2006-02-14 | 2011-09-30 | Vertex Pharma | Pharmaceutical compositions comprising 6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4)diazepine derivatives |
DE102006012617A1 (de) | 2006-03-20 | 2007-09-27 | Merck Patent Gmbh | 4-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate |
EP2001884A1 (en) | 2006-04-05 | 2008-12-17 | Vertex Pharmaceuticals, Inc. | Deazapurines useful as inhibitors of janus kinases |
KR20090021155A (ko) * | 2006-04-26 | 2009-02-27 | 에프. 호프만-라 로슈 아게 | Pi3k 억제제로서의 피리미딘 유도체 |
WO2007129195A2 (en) | 2006-05-04 | 2007-11-15 | Pfizer Products Inc. | 4-pyrimidine-5-amino-pyrazole compounds |
US20090017444A1 (en) | 2006-06-09 | 2009-01-15 | Wisconsin Alumni Research Foundation | Screening method for modulators of viral transcription or replication |
WO2008005457A2 (en) | 2006-06-30 | 2008-01-10 | Sunesis Pharmaceuticals | Pyridinonyl pdk1 inhibitors |
TW200808325A (en) | 2006-07-06 | 2008-02-16 | Astrazeneca Ab | Novel compounds |
LT2050749T (lt) | 2006-08-08 | 2018-01-10 | Chugai Seiyaku Kabushiki Kaisha | Pirimidino darinys, kaip pi3k inhibitorius, ir jo panaudojimas |
EP2057140B1 (en) * | 2006-08-24 | 2012-08-08 | AstraZeneca AB | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
MX2009006345A (es) | 2006-12-14 | 2009-06-23 | Vertex Pharma | Compuestos utiles como inhibidores de proteina cinasa. |
MX2009006700A (es) | 2006-12-21 | 2009-06-30 | Vertex Pharma | Derivados de 5-ciano-4-(pirolo)[2,3b]piridina-3-il)-pirimidinas utiles como inhibidores de proteina-cinasas. |
TW200840581A (en) | 2007-02-28 | 2008-10-16 | Astrazeneca Ab | Novel pyrimidine derivatives |
EP2134709A1 (en) | 2007-03-09 | 2009-12-23 | Vertex Pharmaceuticals, Inc. | Aminopyridines useful as inhibitors of protein kinases |
WO2008112651A2 (en) | 2007-03-09 | 2008-09-18 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as inhibitors of protein kinases |
CA2679884A1 (en) | 2007-03-09 | 2008-09-18 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as inhibitors of protein kinases |
BRPI0809088A2 (pt) | 2007-03-22 | 2014-09-09 | Hoffmann La Roche | Pirimidodiazepinas substituídas úteis como inibidoras de plk1 |
RU2339637C1 (ru) | 2007-04-05 | 2008-11-27 | Андрей Александрович Иващенко | Блокаторы гистаминного рецептора для фармацевтических композиций, обладающих противоаллергическим и аутоиммунным действием |
RU2334747C1 (ru) | 2007-04-05 | 2008-09-27 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
MX2010001677A (es) | 2007-08-15 | 2010-03-11 | Vertex Pharma | Derivados de 4-(9-(3,3-difluorociclopentil)-5,7,7-trimetil-6-oxo-6 ,7,8,9-tetrahidro-5h-pirimido[4,5-b][1,4]diazepin-2-ilamino)-3-me toxibenzamida como inhibidores de las proteinas cinasas humanas plk1 a plk4 para el tratamiento de enfermedades proli |
JP5410432B2 (ja) | 2007-09-28 | 2014-02-05 | サイクラセル リミテッド | プロテインキナーゼ阻害剤としてのピリミジン誘導体 |
SG185289A1 (en) | 2007-10-09 | 2012-11-29 | European Molecular Biology Lab Embl | Soluble fragments of influenza virus pb2 protein capable of binding rna-cap |
ES2389992T3 (es) | 2007-11-02 | 2012-11-05 | Vertex Pharmaceuticals Incorporated | Derivados de [1H-pirazolo[3,4-b]piridin-4-il]-fenilo o -piridin-2-ilo como proteína cinasa c-theta |
EP2463282B1 (en) | 2007-11-05 | 2013-08-07 | Novartis AG | 4-Benzylamino-1-carboxyacyl-piperidine derivatives as CETP inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosis |
EP2247592B1 (en) | 2008-02-25 | 2011-08-31 | F. Hoffmann-La Roche AG | Pyrrolopyrazine kinase inhibitors |
EP2262498A2 (en) | 2008-03-10 | 2010-12-22 | Vertex Pharmceuticals Incorporated | Pyrimidines and pyridines useful as inhibitors of protein kinases |
EP2297200A1 (en) | 2008-04-09 | 2011-03-23 | Technion Research & Development Foundation Ltd. | Anti influenza antibodies and uses thereof |
MX2011000021A (es) | 2008-06-23 | 2011-02-24 | Vertex Pharma | Inhibidores de proteina cinasas. |
MX2011000026A (es) | 2008-06-23 | 2011-02-24 | Vertex Pharma | Inhibidores de proteina cinasas. |
JP5631310B2 (ja) | 2008-07-23 | 2014-11-26 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | 三環式ピラゾロピリジンキナーゼ阻害剤 |
MX2011000834A (es) | 2008-07-23 | 2011-04-05 | Vertex Pharma | Inhibidores de pirazolopiridin cinasa. |
ES2402087T3 (es) | 2008-07-23 | 2013-04-26 | Vertex Pharmaceuticals Incorporated | Inhibidores de la pirazolopiridina quinasa |
US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
WO2010129668A1 (en) | 2009-05-06 | 2010-11-11 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridines |
WO2010143207A1 (en) | 2009-06-11 | 2010-12-16 | Rubicon Research Private Limited | Taste-masked oral formulations of influenza antivirals |
GEP20156325B (en) * | 2009-06-17 | 2015-07-10 | Vertex Pharma | Inhibitors of influenza viruses replication |
WO2011000566A2 (en) | 2009-06-30 | 2011-01-06 | Savira Pharmaceuticals Gmbh | Compounds and pharmaceutical compositions for the treatment of negative-sense ssrna virus infections |
CN102471339A (zh) | 2009-07-15 | 2012-05-23 | 雅培制药有限公司 | 激酶的吡咯并吡啶抑制剂 |
US8563530B2 (en) | 2010-03-31 | 2013-10-22 | Gilead Pharmassel LLC | Purine nucleoside phosphoramidate |
WO2011127290A2 (en) | 2010-04-07 | 2011-10-13 | Vertex Pharmaceuticals Incorporated | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
NZ603446A (en) | 2010-04-14 | 2014-05-30 | Array Biopharma Inc | 5, 7-substituted-imidazo [1, 2-c] pyrimidines as inhibitors of jak kinases |
EP2563125A4 (en) | 2010-04-27 | 2013-10-02 | Merck Sharp & Dohme | AZAINDOLE AS JANUSKINASE HEMMER |
WO2012083117A1 (en) | 2010-12-16 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
CA2822062A1 (en) | 2010-12-16 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
RU2013132717A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
BR112014000115A2 (pt) | 2011-07-05 | 2016-10-04 | Vertex Pharma | processos e intermediários para a produção de azaindóis, e suas formas sólidas |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
EP2776036A1 (en) | 2011-11-07 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Methods for treating inflammatory diseases and pharmaceutical combinations useful therefor |
WO2013184985A1 (en) | 2012-06-08 | 2013-12-12 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
WO2014201332A1 (en) | 2013-06-14 | 2014-12-18 | Vertex Pharmaceuticals Incorporated | Pharmaceutical combinations useful for treating rheumatoid arthritis |
EP3036225A1 (en) | 2013-08-22 | 2016-06-29 | Vertex Pharmaceuticals Incorporated | Isotopically enriched azaindoles |
EA037949B1 (ru) | 2013-09-12 | 2021-06-10 | Янссен Байофарма, Инк. | Азапиридоновые соединения и их применение |
US9296727B2 (en) | 2013-10-07 | 2016-03-29 | Vertex Pharmaceuticals Incorporated | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines |
JP6618901B2 (ja) | 2013-11-13 | 2019-12-11 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルスの複製の阻害剤を調製する方法 |
SG10201804024VA (en) | 2013-11-13 | 2018-07-30 | Vertex Pharma | Formulations of azaindole compounds |
PL3068776T3 (pl) | 2013-11-13 | 2019-10-31 | Vertex Pharma | Inhibitory replikacji wirusów grypy |
BR112017002370B1 (pt) | 2014-08-08 | 2022-11-22 | Janssen Sciences Ireland Uc | Compostos indóis, composição farmacêutica que os compreende e seu uso na inibição da replicação do vírus da gripe |
SI3191489T1 (sl) | 2014-09-08 | 2021-02-26 | Janssen Sciences Ireland Unlimited Company | Pirolopirimidini za uporabo pri okužbi z virusom gripe |
MA40773A (fr) | 2014-10-02 | 2017-08-08 | Vertex Pharma | Variants du virus influenza a |
MA40772A (fr) | 2014-10-02 | 2017-08-08 | Vertex Pharma | Variants du virus de la grippe a |
EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
HUE055200T2 (hu) | 2015-11-27 | 2021-11-29 | Janssen Sciences Ireland Unlimited Co | Heterociklusos indolok influenzavírus fertõzésben való alkalmazásra |
MA43583A (fr) | 2016-01-07 | 2021-05-19 | Janssen Sciences Ireland Unlimited Co | Dérivés d'acide pentanoïque substitués par pyrrolo-[2,3-b]pyrimidne-pyridines pour traiter des infections par le virus de la grippe |
DK3405466T3 (da) | 2016-01-20 | 2021-02-01 | Janssen Sciences Ireland Unlimited Co | Arylsubstituerede pyrimidiner til anvendelse ved influenzavirusinfektion |
WO2017223231A1 (en) | 2016-06-21 | 2017-12-28 | Alios Biopharma, Inc. | (s)-8-(benzhydryl )-6-isopropyl-3,5-dioxo- 5, 6,7,8,-tetrahydro-3h-pyrazino-[1,2-b]pyridazin-yl-isobutyrate antiviral agent for use in treating influenza |
CA3059362A1 (en) | 2017-04-12 | 2018-10-18 | Vertex Pharmaceuticals Incorporated | Combination therapies for treating influenza virus infection |
-
2010
- 2010-06-17 GE GEAP201012538A patent/GEP20156325B/en unknown
- 2010-06-17 CN CN201080036505.3A patent/CN102458408B/zh active Active
- 2010-06-17 TW TW107126935A patent/TWI666209B/zh active
- 2010-06-17 GE GEAP201013375A patent/GEP20207129B/en unknown
- 2010-06-17 NZ NZ619259A patent/NZ619259A/en not_active IP Right Cessation
- 2010-06-17 EP EP18177481.1A patent/EP3427738B1/en active Active
- 2010-06-17 EP EP10726760.1A patent/EP2442809B1/en active Active
- 2010-06-17 AR ARP100102150A patent/AR077130A1/es not_active Application Discontinuation
- 2010-06-17 JP JP2012516299A patent/JP5721706B2/ja not_active Expired - Fee Related
- 2010-06-17 MX MX2015000091A patent/MX348066B/es unknown
- 2010-06-17 ES ES10726760.1T patent/ES2604667T3/es active Active
- 2010-06-17 SG SG10201405826RA patent/SG10201405826RA/en unknown
- 2010-06-17 EA EA201500266A patent/EA030188B1/ru unknown
- 2010-06-17 PE PE2015002683A patent/PE20160127A1/es unknown
- 2010-06-17 PE PE2011002120A patent/PE20120508A1/es active IP Right Grant
- 2010-06-17 SI SI201031779T patent/SI3141252T1/sl unknown
- 2010-06-17 SI SI201031307A patent/SI2442809T1/sl unknown
- 2010-06-17 CN CN201410195237.XA patent/CN104151312B/zh active Active
- 2010-06-17 RS RS20181199A patent/RS57869B1/sr unknown
- 2010-06-17 CN CN201910673938.2A patent/CN110540538A/zh active Pending
- 2010-06-17 SG SG10201405827PA patent/SG10201405827PA/en unknown
- 2010-06-17 EA EA201500871A patent/EA037529B1/ru not_active IP Right Cessation
- 2010-06-17 KR KR1020127001354A patent/KR101702609B1/ko active IP Right Grant
- 2010-06-17 HU HUE10726760A patent/HUE031048T2/en unknown
- 2010-06-17 CN CN201510221329.5A patent/CN104940202B/zh active Active
- 2010-06-17 TW TW104103498A patent/TWI574963B/zh not_active IP Right Cessation
- 2010-06-17 KR KR1020177002581A patent/KR101903354B1/ko active IP Right Grant
- 2010-06-17 TW TW099119816A patent/TWI483941B/zh not_active IP Right Cessation
- 2010-06-17 GE GEAP201013376A patent/GEP20227397B/en unknown
- 2010-06-17 UY UY0001032717A patent/UY32717A/es active IP Right Grant
- 2010-06-17 SG SG2011090651A patent/SG176722A1/en unknown
- 2010-06-17 TW TW105139121A patent/TWI639596B/zh not_active IP Right Cessation
- 2010-06-17 PL PL16181549T patent/PL3141252T3/pl unknown
- 2010-06-17 EP EP16181549.3A patent/EP3141252B8/en active Active
- 2010-06-17 PT PT107267601T patent/PT2442809T/pt unknown
- 2010-06-17 ES ES16181549.3T patent/ES2692396T3/es active Active
- 2010-06-17 LT LTEP16181549.3T patent/LT3141252T/lt unknown
- 2010-06-17 WO PCT/US2010/038988 patent/WO2010148197A1/en active Application Filing
- 2010-06-17 NZ NZ597059A patent/NZ597059A/en not_active IP Right Cessation
- 2010-06-17 EA EA201270032A patent/EA025276B1/ru unknown
- 2010-06-17 PL PL10726760T patent/PL2442809T3/pl unknown
- 2010-06-17 KR KR1020187027093A patent/KR102050712B1/ko active IP Right Grant
- 2010-06-17 PT PT16181549T patent/PT3141252T/pt unknown
- 2010-06-17 LT LTEP10726760.1T patent/LT2442809T/lt unknown
- 2010-06-17 CN CN201510221305.XA patent/CN104922128B/zh active Active
- 2010-06-17 AU AU2010262905A patent/AU2010262905B2/en not_active Ceased
- 2010-06-17 MX MX2011013475A patent/MX2011013475A/es active IP Right Grant
- 2010-06-17 AP AP2012006067A patent/AP3631A/xx active
- 2010-06-17 TR TR2018/15272T patent/TR201815272T4/tr unknown
- 2010-06-17 CA CA2764177A patent/CA2764177C/en not_active Expired - Fee Related
- 2010-06-17 ME MEP-2016-272A patent/ME02558B/me unknown
- 2010-06-17 RS RS20161032A patent/RS55341B1/sr unknown
- 2010-06-17 DK DK16181549.3T patent/DK3141252T3/en active
- 2010-06-17 DK DK10726760.1T patent/DK2442809T3/en active
- 2010-06-17 BR BRPI1011993-0A patent/BRPI1011993A2/pt active Search and Examination
-
2011
- 2011-12-12 ZA ZA2011/09127A patent/ZA201109127B/en unknown
- 2011-12-14 IL IL216980A patent/IL216980B/en active IP Right Grant
- 2011-12-15 US US13/327,206 patent/US20120171245A1/en not_active Abandoned
- 2011-12-16 CL CL2011003192A patent/CL2011003192A1/es unknown
-
2012
- 2012-01-17 EC EC2012011610A patent/ECSP12011610A/es unknown
- 2012-01-17 CO CO12006237A patent/CO6491048A2/es active IP Right Grant
- 2012-10-12 HK HK16103636.6A patent/HK1215675A1/zh not_active IP Right Cessation
- 2012-10-12 HK HK15104769.4A patent/HK1204322A1/xx not_active IP Right Cessation
- 2012-10-12 HK HK12110126.2A patent/HK1169326A1/xx not_active IP Right Cessation
- 2012-10-12 HK HK16103417.1A patent/HK1215530A1/zh unknown
-
2013
- 2013-12-06 US US14/098,867 patent/US8829007B2/en active Active
-
2014
- 2014-06-16 US US14/305,393 patent/US9345708B2/en active Active
- 2014-11-13 JP JP2014230557A patent/JP2015034177A/ja not_active Withdrawn
- 2014-11-13 JP JP2014230556A patent/JP6030619B2/ja not_active Expired - Fee Related
-
2015
- 2015-02-04 ZA ZA2015/00820A patent/ZA201500820B/en unknown
- 2015-07-29 PH PH12015501678A patent/PH12015501678A1/en unknown
- 2015-11-02 US US14/929,634 patent/US9518056B2/en active Active
-
2016
- 2016-09-06 JP JP2016173354A patent/JP6348939B2/ja not_active Expired - Fee Related
- 2016-10-21 US US15/299,757 patent/US9808459B2/en active Active
- 2016-11-21 CY CY20161101196T patent/CY1118246T1/el unknown
- 2016-11-28 HR HRP20161577TT patent/HRP20161577T1/hr unknown
-
2017
- 2017-09-28 US US15/718,186 patent/US10039762B2/en active Active
- 2017-10-17 JP JP2017200914A patent/JP6620135B2/ja not_active Expired - Fee Related
-
2018
- 2018-06-25 US US16/016,917 patent/US10874673B2/en active Active
- 2018-10-19 HR HRP20181715TT patent/HRP20181715T1/hr unknown
- 2018-10-31 CY CY181101086T patent/CY1120778T1/el unknown
- 2018-11-01 IL IL262734A patent/IL262734B/en active IP Right Grant
-
2019
- 2019-10-01 JP JP2019181224A patent/JP2020011990A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201500871A1 (ru) | Ингибиторы репликации вирусов гриппа | |
EA201692506A3 (ru) | Ингибиторы репликации вирусов гриппа | |
EA201290089A1 (ru) | Химические соединения | |
BR112013020042A2 (pt) | inibidores de vírus da hepatite c | |
UY32062A (es) | Inhibidores de beta-secretasa | |
MX2012000959A (es) | Inhibidores de los virus flaviviridae. | |
NZ703064A (en) | Inhibitors of hepatitis c virus | |
EA201491548A1 (ru) | 2'-замещенные карбануклеозидные аналоги для противовирусного лечения | |
EA201390190A1 (ru) | Ингибиторы вируса гепатита с | |
MX2013006846A (es) | Inhibidores de la replicacion de los virus de la influenza. | |
CR20130043A (es) | Compuestos terapéuticos | |
EA201001508A1 (ru) | Мостиковые гетероциклические соединения в качестве ингибиторов интегразы вич | |
MX2012008221A (es) | Inhibidores de virus flaviviridae. | |
MX2012008211A (es) | Inhibidores de virus flaviviridae. | |
EA201270560A1 (ru) | Спиропиперидиновые соединения и их фармацевтическое применение для лечения диабета | |
EA201190224A1 (ru) | Ингибиторы гепатита c, содержащие конденсированные кольца | |
EA201590358A1 (ru) | Ингибиторы репликации вируса иммунодефицита человека | |
EA201490654A1 (ru) | Новые ингибиторы вирусной репликации | |
EA201201677A1 (ru) | Производные гетероарилимидазолона в качестве ингибиторов jak | |
EA201290416A1 (ru) | Новые спиропиперидиновые соединения | |
MX2012002925A (es) | Inhibidores de virus flaviviridae. | |
EA201200472A1 (ru) | Сульфонамиды в качестве ингибиторов белков семейства bcl-2, предназначенные для лечения рака | |
BR112013028679A2 (pt) | inibidores do vírus da hepatite c | |
EA201992543A1 (ru) | Производные пиролопиримидина, пригодные в качестве ингибиторов репликации вируса гриппа | |
EA201200868A1 (ru) | Ингибиторы диацилглицеролацилтрансферазы |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |