PL3615545T3 - Pochodne pirolopirymidyny użyteczne jako inhibitory replikacji wirusa grypy - Google Patents

Pochodne pirolopirymidyny użyteczne jako inhibitory replikacji wirusa grypy

Info

Publication number
PL3615545T3
PL3615545T3 PL18723298T PL18723298T PL3615545T3 PL 3615545 T3 PL3615545 T3 PL 3615545T3 PL 18723298 T PL18723298 T PL 18723298T PL 18723298 T PL18723298 T PL 18723298T PL 3615545 T3 PL3615545 T3 PL 3615545T3
Authority
PL
Poland
Prior art keywords
inhibitors
influenza virus
virus replication
derivatives useful
pyrrolopyrimidine derivatives
Prior art date
Application number
PL18723298T
Other languages
English (en)
Inventor
Irina C. Jacobson
Michael David Feese
Sam Sk Lee
Original Assignee
Cocrystal Pharma, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cocrystal Pharma, Inc. filed Critical Cocrystal Pharma, Inc.
Publication of PL3615545T3 publication Critical patent/PL3615545T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL18723298T 2017-04-24 2018-04-24 Pochodne pirolopirymidyny użyteczne jako inhibitory replikacji wirusa grypy PL3615545T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762489167P 2017-04-24 2017-04-24
EP18723298.8A EP3615545B1 (en) 2017-04-24 2018-04-24 Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication
PCT/US2018/028986 WO2018200425A1 (en) 2017-04-24 2018-04-24 Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication

Publications (1)

Publication Number Publication Date
PL3615545T3 true PL3615545T3 (pl) 2022-01-10

Family

ID=62117141

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18723298T PL3615545T3 (pl) 2017-04-24 2018-04-24 Pochodne pirolopirymidyny użyteczne jako inhibitory replikacji wirusa grypy

Country Status (21)

Country Link
US (1) US11014941B2 (pl)
EP (1) EP3615545B1 (pl)
JP (1) JP7165721B2 (pl)
KR (1) KR102598466B1 (pl)
CN (1) CN110637022B (pl)
AU (1) AU2018257778B2 (pl)
CA (1) CA3059449A1 (pl)
DK (1) DK3615545T3 (pl)
EA (1) EA039181B1 (pl)
ES (1) ES2901875T3 (pl)
IL (1) IL269900B (pl)
MX (1) MX393113B (pl)
MY (1) MY199746A (pl)
NZ (1) NZ757442A (pl)
PH (1) PH12019502376B1 (pl)
PL (1) PL3615545T3 (pl)
SG (1) SG11201909478UA (pl)
SM (1) SMT202100684T1 (pl)
TW (1) TWI778052B (pl)
WO (1) WO2018200425A1 (pl)
ZA (1) ZA201906327B (pl)

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* Cited by examiner, † Cited by third party
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PT3866778T (pt) * 2018-10-17 2023-02-28 Cocrystal Pharma Inc Combinações de inibidores da replicação do vírus de la gripe
BR112021009254A2 (pt) * 2018-11-13 2021-08-10 Cocrystal Pharma, Inc. formulações para produtos terapêuticos para influenza
WO2020218316A1 (ja) * 2019-04-26 2020-10-29 日産化学株式会社 アリールスルホン酸エステル化合物の製造方法
CN115698011B (zh) * 2020-07-10 2023-10-20 四川海思科制药有限公司 Pb2抑制剂及其制备方法和用途
WO2022109495A1 (en) * 2020-11-23 2022-05-27 The Regents Of The University Of California Methods and compositions for linking rna stem loops

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Also Published As

Publication number Publication date
KR102598466B1 (ko) 2023-11-03
EA039181B1 (ru) 2021-12-15
US20200123177A1 (en) 2020-04-23
AU2018257778A1 (en) 2019-10-10
EP3615545B1 (en) 2021-09-01
IL269900B (en) 2022-05-01
MY199746A (en) 2023-11-21
CA3059449A1 (en) 2018-11-01
TW201839003A (zh) 2018-11-01
BR112019022307A2 (pt) 2020-05-26
TWI778052B (zh) 2022-09-21
CN110637022B (zh) 2022-09-16
AU2018257778B2 (en) 2022-02-17
MX393113B (es) 2025-03-24
CN110637022A (zh) 2019-12-31
MX2019012759A (es) 2019-12-16
US11014941B2 (en) 2021-05-25
EP3615545A1 (en) 2020-03-04
JP2020517738A (ja) 2020-06-18
PH12019502376B1 (en) 2024-06-05
NZ757442A (en) 2022-10-28
WO2018200425A1 (en) 2018-11-01
ZA201906327B (en) 2025-01-29
DK3615545T3 (da) 2021-11-22
JP7165721B2 (ja) 2022-11-04
SG11201909478UA (en) 2019-11-28
PH12019502376A1 (en) 2020-09-14
ES2901875T3 (es) 2022-03-24
KR20190140971A (ko) 2019-12-20
SMT202100684T1 (it) 2022-01-10
EA201992543A1 (ru) 2020-03-24

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