FR2609991A1 - Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments - Google Patents

Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments Download PDF

Info

Publication number
FR2609991A1
FR2609991A1 FR8713949A FR8713949A FR2609991A1 FR 2609991 A1 FR2609991 A1 FR 2609991A1 FR 8713949 A FR8713949 A FR 8713949A FR 8713949 A FR8713949 A FR 8713949A FR 2609991 A1 FR2609991 A1 FR 2609991A1
Authority
FR
France
Prior art keywords
peptide
residue
group
amino
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8713949A
Other languages
English (en)
French (fr)
Other versions
FR2609991B1 (OSRAM
Inventor
Rainer Albert
Wilfried Bauer
Francois Cardinaux
Monika Mergler
Janos Pless
Walter Prikoszovich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2609991A1 publication Critical patent/FR2609991A1/fr
Application granted granted Critical
Publication of FR2609991B1 publication Critical patent/FR2609991B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
FR8713949A 1986-10-13 1987-10-07 Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments Granted FR2609991A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE3634797 1986-10-13
DE3634825 1986-10-13
DE3634826 1986-10-13
DE3712626 1987-04-14
CH315387 1987-08-17

Publications (2)

Publication Number Publication Date
FR2609991A1 true FR2609991A1 (fr) 1988-07-29
FR2609991B1 FR2609991B1 (OSRAM) 1995-03-10

Family

ID=27509117

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8713949A Granted FR2609991A1 (fr) 1986-10-13 1987-10-07 Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments

Country Status (23)

Country Link
US (1) US5656721A (OSRAM)
JP (2) JPH0645639B2 (OSRAM)
KR (1) KR960016861B1 (OSRAM)
AU (2) AU617986B2 (OSRAM)
BE (1) BE1003752A4 (OSRAM)
CA (1) CA1340985C (OSRAM)
CH (2) CH680512A5 (OSRAM)
DE (1) DE3790635T1 (OSRAM)
DK (1) DK174337B1 (OSRAM)
ES (1) ES2007418A6 (OSRAM)
FI (1) FI874495A7 (OSRAM)
FR (1) FR2609991A1 (OSRAM)
GB (2) GB2199829B (OSRAM)
GR (1) GR871567B (OSRAM)
HU (3) HU906340D0 (OSRAM)
IE (1) IE912442A1 (OSRAM)
LU (1) LU87014A1 (OSRAM)
NL (1) NL194729C (OSRAM)
NZ (1) NZ222133A (OSRAM)
PL (1) PL157156B1 (OSRAM)
PT (1) PT85904B (OSRAM)
SE (2) SE8703938L (OSRAM)
WO (1) WO1988002756A2 (OSRAM)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU906340D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Synthesis in solid phase for producing peptonic alcohols
DE3822557C2 (de) * 1987-07-10 1998-07-02 Ciba Geigy Ag Arzneimittel, enthaltend Somatostatine
WO1989007109A1 (en) * 1988-02-01 1989-08-10 The Upjohn Company Renin inhibiting peptides with polar end groups
DK163689A (da) * 1988-04-08 1989-10-30 Sandoz Ag Peptidderivater
DE3910667A1 (de) * 1988-04-11 1989-10-19 Sandoz Ag Peptidderivate
GB8813339D0 (en) * 1988-06-06 1988-07-13 Sandoz Ltd Improvements in/relating to organic compounds
BE1003762A3 (fr) * 1988-11-11 1992-06-09 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives.
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
US5776894A (en) * 1988-12-05 1998-07-07 Novartis Ag Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
US5753627A (en) * 1988-12-05 1998-05-19 Novartis Ag Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis
IT1229514B (it) * 1989-01-30 1991-09-03 Farmhispania S A A Montme Glicoconiugati anfifilici sintetici per impiego neurologico.
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
DE4206858A1 (de) * 1992-03-05 1993-09-09 Behringwerke Ag Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
IT1260156B (it) * 1992-08-03 1996-03-28 Fidia Spa Derivati dell'acido neuraminico
TW263437B (OSRAM) * 1992-09-24 1995-11-21 Takeda Pharm Industry Co Ltd
US5710244A (en) * 1992-12-31 1998-01-20 Labroo; Virender M. Derivatized calcitonins
US5508387A (en) * 1993-08-04 1996-04-16 Glycomed Incorporated Selectin binding glycopeptides
DE69435105D1 (de) * 1993-08-09 2008-08-07 Sod Conseils Rech Applic Derivate therapeutischer Peptide
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
JP3896430B2 (ja) * 1996-07-15 2007-03-22 アークレイ株式会社 糖化アミノ化合物の製造方法
IL119029A0 (en) 1996-08-07 1996-11-14 Yeda Res & Dev Long-acting drugs and pharamaceutical compositions comprising them
EP0981364B1 (en) 1997-05-13 2006-03-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Method and compositions for treating hyperlipidemia
EP0981363B1 (en) 1997-05-13 2003-07-30 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Somatostatin agonists for decreasing body weight
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
AU766653B2 (en) * 1998-02-13 2003-10-23 Amylin Pharmaceuticals, Inc. Novel mixed amylin activity compounds
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
US20050037490A1 (en) * 1999-10-29 2005-02-17 Lawrence Rosenberg Medium for preparing dedifferentiated cells
DE60231801D1 (de) * 2001-04-23 2009-05-14 Mallinckrodt Inc Tc und re markierte radioaktive glycosylierte octreotid-derivate
CN1514843A (zh) 2001-06-08 2004-07-21 �о���Ӧ�ÿ�ѧЭ��ɷ����޹�˾ 生长激素释放抑制因子-多巴胺嵌合类似物
EP1480998B1 (en) * 2002-02-27 2006-11-22 Ferring BV Intermediates and methods for making heptapeptide oxytocin analogues
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2007025286A2 (en) * 2005-08-26 2007-03-01 The Board Of Trustees Of The Leland Stanford Junior University Therapy procedure for drug delivery for trigeminal pain
PL1787658T3 (pl) 2005-11-10 2012-08-31 Italfarmaco Spa Formulacje o przedłużonym uwalnianiu analogów somatostatyny będących inhibitorami hormonu wzrostu
WO2008011168A2 (en) * 2006-07-21 2008-01-24 Amgen Inc. Glycosylated peptide antagonists of the bradykinin b1 receptor
CA2677045C (en) 2007-01-31 2016-10-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
KR101623985B1 (ko) 2007-03-28 2016-05-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
CA2700587A1 (en) 2007-09-25 2009-04-02 Glycom A/S Glycoproteins and glycosylated cells and a method for the preparation of the same
CA2713394C (en) * 2007-11-09 2016-01-19 Charles Yates Anti-inflammatory quinic acid derivatives for oral administration
EP2719392B1 (en) 2008-06-12 2019-07-24 Ipsen Bioinnovation Limited Fusion proteins for use in the treatment of acromegaly
CN107446053A (zh) 2008-06-12 2017-12-08 益普生生物创新有限公司 癌症的抑制
WO2010089757A2 (en) * 2008-11-07 2010-08-12 Usv Limited An improved process for synthesis of cyclic octapeptide
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
KR102104762B1 (ko) 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
SG10201601327RA (en) 2011-09-04 2016-03-30 Glytech Inc Glycosylated polypeptide and drug composition containing said polypeptide
AU2012302636B2 (en) 2011-09-04 2016-09-15 Glytech, Inc. Glycosylated polypeptide and drug composition containing said polypeptide
CN108929375A (zh) 2011-10-18 2018-12-04 爱勒让治疗公司 拟肽大环化合物
EP2819688A4 (en) 2012-02-15 2015-10-28 Aileron Therapeutics Inc PEPTIDOMIMETIC MACROCYCLES CROSS-LINKED WITH TRIAZOLE AND THIOETHER
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
KR20150082307A (ko) 2012-11-01 2015-07-15 에일러론 테라퓨틱스 인코포레이티드 이치환 아미노산 및 이의 제조 및 사용 방법
AU2014280847B2 (en) 2013-06-13 2019-07-04 Antisense Therapeutics Ltd Combination therapy
CN106999541A (zh) 2014-09-24 2017-08-01 艾瑞朗医疗公司 拟肽大环化合物及其用途
WO2016112205A1 (en) 2015-01-07 2016-07-14 Trigemina, Inc. Magnesium-containing oxytocin formulations and methods of use
MX2017011834A (es) 2015-03-20 2018-04-11 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
EP4541348A3 (en) 2016-04-12 2025-06-04 Tonix Pharma Limited Magnesium-containing oxytocin formulations and methods of use
EP3713545A1 (en) 2017-11-22 2020-09-30 Dauntless 1, Inc. Therapeutic compound formulations
WO2019104214A1 (en) 2017-11-22 2019-05-31 Dauntless 2, Inc. Membrane emulsification device for microsphere creation
WO2020005842A1 (en) 2018-06-25 2020-01-02 Dauntless 2, Inc. Membrane emulsification device with impeller for microsphere creation
WO2020212477A1 (en) 2019-04-16 2020-10-22 Bachem Holding Ag Manufacture of disulfide bonded peptides
EP4232464A4 (en) * 2020-10-22 2025-02-12 The Trustees of Indiana University MOLECULAR DESIGNS OF GLUCOSE-RESPONSIVE AND GLUCOSE-CLAVABLE INSULIN ANALOGUES
WO2025229200A1 (en) 2024-05-03 2025-11-06 Bachem Holding Ag Manufacture of disulfide bonded peptides

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254023A (en) * 1979-10-16 1981-03-03 Pennwalt Corporation Synthesis of peptide alcohols by the solid phase method
US4280953A (en) * 1979-11-08 1981-07-28 The Salk Institute For Biological Studies Glycosylated analogs of somatostatin
ATE2512T1 (de) * 1979-11-27 1983-03-15 Sandoz Ag Polypeptide, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen, die diese polypeptide enthalten, und ihre verwendung.
FR2522967B1 (fr) * 1982-03-15 1986-03-07 Anvar Conjugues d'haptenes et de muramyl-peptides, doues d'activite immunogene et compositions les contenant
US4444683A (en) * 1982-11-17 1984-04-24 University Of Utah Glycosylated insulin derivatives
US4483792A (en) * 1982-11-17 1984-11-20 Kim Wan S Glycosylated insulin derivatives
FR2546163B1 (fr) * 1983-05-16 1987-10-09 Centre Nat Rech Scient Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application
FR2548673B1 (fr) * 1983-07-05 1985-10-04 Essilor Int Polymeres supports de produits actifs relargables et leur procede de preparation
LU85269A1 (fr) * 1984-03-26 1985-10-14 Techland S A Composes nouveaux de somatostatine,procede pour leur synthese,preparation a usage veterinaire contenant lesdits composes et procede pour le traitement d'animaux
US4564998A (en) * 1984-10-19 1986-01-21 Westinghouse Electric Corp. Coil winding methods and apparatus
DE3439610A1 (de) * 1984-10-30 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Immunogene, verfahren zu deren herstellung sowie damit gewonnene antikoerper gegen glykosiliertes haemoglobin
FI860708A7 (fi) * 1985-02-20 1986-08-21 Ciba Geigy Ag Acylerade hexosderivat och foerfarande foer deras framstaellning.
JPS61264260A (ja) * 1985-05-17 1986-11-22 Rikagaku Kenkyusho アルデヒド化多孔性高分子材料によるタンパク質の除去方法
CA1337041C (en) * 1985-10-09 1995-09-19 Brett Alan Evans Granular detergent compositions having improved solubility
SE8506094D0 (sv) * 1985-12-20 1985-12-20 Astra Laekemedel Ab New antibacterial agents and intermediates therefor
JPS63165411A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製法
JPS63165410A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製造方法
HU906340D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Synthesis in solid phase for producing peptonic alcohols
US4859736A (en) * 1987-03-30 1989-08-22 Ciba-Geigy Corporation Synthetic polystyrene resin and its use in solid phase peptide synthesis
CH679045A5 (OSRAM) * 1987-06-29 1991-12-13 Sandoz Ag

Also Published As

Publication number Publication date
DK174337B1 (da) 2002-12-16
NZ222133A (en) 1993-02-25
FI874495L (fi) 1988-04-14
FI874495A0 (fi) 1987-10-12
GB8723737D0 (en) 1987-11-11
NL8702345A (nl) 1988-05-02
AU7956487A (en) 1988-04-14
PL268173A1 (en) 1988-09-01
NL194729B (nl) 2002-09-02
GB2199829B (en) 1991-04-17
DK532787D0 (da) 1987-10-12
SE9301172L (OSRAM) 1900-01-01
GB2199831A (en) 1988-07-20
JPH0645639B2 (ja) 1994-06-15
IE912442L (en) 1988-04-13
JPH0314599A (ja) 1991-01-23
DK532787A (da) 1988-04-14
AU8015091A (en) 1991-10-31
KR880005153A (ko) 1988-06-28
DE3790635T1 (OSRAM) 1988-10-06
AU617986B2 (en) 1991-12-12
PL157156B1 (pl) 1992-05-29
FI874495A7 (fi) 1988-04-14
SE8703938L (sv) 1988-04-14
JPS63101399A (ja) 1988-05-06
CA1340985C (en) 2000-05-09
HU906341D0 (en) 1991-04-29
JP2744910B2 (ja) 1998-04-28
HU906340D0 (en) 1991-04-29
PT85904A (en) 1987-11-01
WO1988002756A3 (en) 1988-07-14
BE1003752A4 (fr) 1992-06-09
CH680512A5 (OSRAM) 1992-09-15
PT85904B (pt) 1990-08-31
IE912442A1 (en) 1992-02-12
GB8800537D0 (en) 1988-02-10
GB2199831B (en) 1991-04-17
GB2199829A (en) 1988-07-20
HUT46710A (en) 1988-11-28
NL194729C (nl) 2003-01-07
AU634664B2 (en) 1993-02-25
KR960016861B1 (ko) 1996-12-23
GR871567B (en) 1988-02-16
US5656721A (en) 1997-08-12
ES2007418A6 (es) 1989-06-16
SE518630C2 (sv) 2002-11-05
FR2609991B1 (OSRAM) 1995-03-10
SE8703938D0 (sv) 1987-10-12
CH682632A5 (de) 1993-10-29
SE9301172D0 (sv) 1993-04-07
WO1988002756A2 (en) 1988-04-21
HU206890B (en) 1993-01-28
LU87014A1 (fr) 1988-05-03

Similar Documents

Publication Publication Date Title
BE1003752A4 (fr) Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments.
BE1004357A4 (fr) Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments.
AU702993B2 (en) Cyclic prodrugs of peptides and peptide nucleic acids having improved metabolic stability and cell membrane permeability
JP2882679B2 (ja) 線状ソマトスタチン類似体
Gacel et al. Evidence of the preferential involvement of. mu.-receptors in analgesia using enkephalins highly selective for peripheral. mu. or. delta. receptors
CA1175810A (en) Synthetic peptides having pituitary growth hormone releasing activity
CA1126261A (en) Polypeptides and processes for the synthesis thereof
NL8801640A (nl) Polypeptiden en werkwijzen voor het bereiden en toepassen van deze polypeptiden.
EP0333071A2 (en) Polypeptides, methods for their preparation, pharmaceutical compositions comprising them and use
US4280953A (en) Glycosylated analogs of somatostatin
KR100360975B1 (ko) 위장운동자극활성을가지는폴리펩티드
US3801561A (en) Derivatives of salmon thyrocalcitonin
FR2619566A1 (fr) Procede de preparation d'un peptide-alcool
DE3790635B4 (de) Verfahren zur Herstellung eines Peptidalkohols und Ausgangsverbindungen dafür
PL157648B1 (en) The method of peptide derivative manufacture
JP7437578B2 (ja) 新規オピオイドペプチド、その糖鎖付加体及びそれらを含む医薬組成物
GB2233652A (en) Synthesis of peptide alcohols
GB2224280A (en) Modified somatostatin
FR2682680A1 (fr) Derives peptidiques d'antagonistes de la lr-rh, leur preparation et leur utilisation comme medicaments.
Malkinson Lipoamino acid-and glycolipid-based peptide delivery system for somatostatin analogue TT-232 with anti-tumour activity
GB2227488A (en) Modified somatostatin
JPH08500324A (ja) 治療活性を有するペプチド化合物

Legal Events

Date Code Title Description
TP Transmission of property