FR2493320B1 - Nouveaux derives de carbostyrile utiles notamment comme cardiotoniques, leurs procedes de preparation et medicaments les contenant - Google Patents

Nouveaux derives de carbostyrile utiles notamment comme cardiotoniques, leurs procedes de preparation et medicaments les contenant

Info

Publication number
FR2493320B1
FR2493320B1 FR8120470A FR8120470A FR2493320B1 FR 2493320 B1 FR2493320 B1 FR 2493320B1 FR 8120470 A FR8120470 A FR 8120470A FR 8120470 A FR8120470 A FR 8120470A FR 2493320 B1 FR2493320 B1 FR 2493320B1
Authority
FR
France
Prior art keywords
cardiotonics
novel
processes
preparation
derivatives useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8120470A
Other languages
English (en)
French (fr)
Other versions
FR2493320A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of FR2493320A1 publication Critical patent/FR2493320A1/fr
Application granted granted Critical
Publication of FR2493320B1 publication Critical patent/FR2493320B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
FR8120470A 1980-10-31 1981-10-30 Nouveaux derives de carbostyrile utiles notamment comme cardiotoniques, leurs procedes de preparation et medicaments les contenant Expired FR2493320B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55154071A JPS5777676A (en) 1980-10-31 1980-10-31 Carbostyril derivative

Publications (2)

Publication Number Publication Date
FR2493320A1 FR2493320A1 (fr) 1982-05-07
FR2493320B1 true FR2493320B1 (fr) 1985-08-23

Family

ID=15576252

Family Applications (2)

Application Number Title Priority Date Filing Date
FR8120470A Expired FR2493320B1 (fr) 1980-10-31 1981-10-30 Nouveaux derives de carbostyrile utiles notamment comme cardiotoniques, leurs procedes de preparation et medicaments les contenant
FR848416085A Expired FR2552760B1 (fr) 1980-10-31 1984-10-19 Procede pour l'obtention de derives de carbostyrile et intermediaires de synthese

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR848416085A Expired FR2552760B1 (fr) 1980-10-31 1984-10-19 Procede pour l'obtention de derives de carbostyrile et intermediaires de synthese

Country Status (24)

Country Link
US (1) US4415572A (US07321065-20080122-C00160.png)
JP (1) JPS5777676A (US07321065-20080122-C00160.png)
KR (1) KR860001944B1 (US07321065-20080122-C00160.png)
AR (2) AR242563A1 (US07321065-20080122-C00160.png)
AT (1) AT381701B (US07321065-20080122-C00160.png)
AU (1) AU524419B2 (US07321065-20080122-C00160.png)
BE (1) BE890942A (US07321065-20080122-C00160.png)
CA (1) CA1209575A (US07321065-20080122-C00160.png)
CH (2) CH650782A5 (US07321065-20080122-C00160.png)
DE (2) DE3153260C2 (US07321065-20080122-C00160.png)
DK (1) DK155665C (US07321065-20080122-C00160.png)
ES (3) ES8306743A1 (US07321065-20080122-C00160.png)
FI (1) FI77450C (US07321065-20080122-C00160.png)
FR (2) FR2493320B1 (US07321065-20080122-C00160.png)
GB (1) GB2086896B (US07321065-20080122-C00160.png)
IT (2) IT1210585B (US07321065-20080122-C00160.png)
MX (1) MX8481A (US07321065-20080122-C00160.png)
NL (2) NL194205C (US07321065-20080122-C00160.png)
NO (1) NO158099C (US07321065-20080122-C00160.png)
PH (1) PH17962A (US07321065-20080122-C00160.png)
PT (1) PT73910B (US07321065-20080122-C00160.png)
SE (2) SE448877B (US07321065-20080122-C00160.png)
SU (1) SU1426452A3 (US07321065-20080122-C00160.png)
ZA (1) ZA817515B (US07321065-20080122-C00160.png)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5883677A (ja) * 1981-11-11 1983-05-19 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
JPS5929667A (ja) * 1982-08-13 1984-02-16 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体および強心剤
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
DK169601B1 (da) * 1983-10-17 1994-12-19 Duphar Int Res Piperazinderivater og farmaceutisk præparat indeholdende et sådant derivat, samt piperazinderivater med mellemproduktanvendelse
JPS60126270A (ja) * 1983-12-14 1985-07-05 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
US4710507A (en) * 1983-12-22 1987-12-01 Pfizer Inc. Quinolone inotropic agents
US4774246A (en) * 1984-01-26 1988-09-27 Abbott Laboratories Quinoline antibacterial compounds
ES8608874A1 (es) * 1984-05-29 1986-09-01 Pfizer Un procedimiento para la preparacion de una 2-(1h)-quinolona
JPS60256133A (ja) * 1984-06-01 1985-12-17 Fuji Photo Film Co Ltd 放射線画像情報記録読取装置
DE3582371D1 (de) * 1984-07-06 1991-05-08 Otsuka Pharma Co Ltd Oxindolverbindungen, diese enthaltende zusammensetzungen sowie verfahren zur herstellung derselben.
US4760064A (en) * 1984-12-18 1988-07-26 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds, compositions containing same and processes for preparing same
JPH07100696B2 (ja) * 1984-12-18 1995-11-01 大塚製薬株式会社 カルボスチリル誘導体
JPS61145162A (ja) * 1984-12-19 1986-07-02 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
DE3571436D1 (en) * 1984-12-21 1989-08-17 Duphar Int Res New pharmaceutical compositions having anti-psychotic properties
ATE81975T1 (de) * 1984-12-21 1992-11-15 Duphar Int Res Arzneimittel mit psychotroper wirkung.
US4845100A (en) * 1985-04-12 1989-07-04 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same
DE3524067A1 (de) * 1985-07-05 1987-01-08 Boehringer Mannheim Gmbh Neue benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
US4666913A (en) * 1985-11-22 1987-05-19 William H. Rorer, Inc. Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses
GB8529362D0 (en) * 1985-11-28 1986-01-02 Pfizer Ltd Quinolone cardiac stimulants
JPH0625123B2 (ja) * 1985-12-12 1994-04-06 大塚製薬株式会社 カルボスチリル誘導体−シクロデキストリン包接化合物
US4689325A (en) * 1985-12-23 1987-08-25 Abbott Laboratories Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives
US4687770A (en) * 1985-12-23 1987-08-18 Abbott Laboratories Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives
US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
DK111387A (da) * 1986-03-05 1987-09-06 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, laegemiddel indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne
GB8630702D0 (en) * 1986-12-23 1987-02-04 Wellcome Found Quinoline compound
US5166160A (en) * 1986-12-23 1992-11-24 Burroughs Wellcome Co. Quinoline compound
JPS63225357A (ja) * 1987-03-12 1988-09-20 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
GB8827189D0 (en) * 1988-11-21 1988-12-29 Fujisawa Pharmaceutical Co 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same
US5658912A (en) * 1991-07-03 1997-08-19 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulating composition
CA2090876A1 (en) * 1991-07-03 1993-01-04 Satoru Nakai Apoptosis regulating composition
WO1993011769A1 (en) * 1991-12-10 1993-06-24 Otsuka Pharmaceutical Co., Ltd Carcinostatic
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
AU666577B2 (en) * 1992-08-19 1996-02-15 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulator
JP2826790B2 (ja) * 1992-12-26 1998-11-18 キッセイ薬品工業株式会社 ３，４−ジヒドロカルボスチリル誘導体
JP3054743B2 (ja) * 1993-03-02 2000-06-19 大塚製薬株式会社 移植組織の拒絶反応抑制剤
JPH0733664A (ja) * 1993-07-26 1995-02-03 Otsuka Pharmaceut Co Ltd 平滑筋細胞増殖抑制剤
GB9326232D0 (en) * 1993-12-23 1994-02-23 Zeneca Ltd Chemical compounds
GB9326373D0 (en) * 1993-12-23 1994-02-23 Zeneca Ltd Chemical compounds
US5504093A (en) * 1994-08-01 1996-04-02 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting nucleoside and nucleobase transport in mammalian cells, and method for inhibition of DNA virus replication
CA2250347C (en) 1996-03-29 2006-02-21 Duphar International Research B.V. Piperazine and piperidine compounds with high affinity for dopamine-d2 and serotonin-5ht1a receptors
GB2312843A (en) * 1996-05-07 1997-11-12 Merck & Co Inc Method of treating rheumatoid arthritis
US5684007A (en) * 1996-09-05 1997-11-04 Otsuka Pharmaceutical Co., Ltd. Methods for inhibiting cardiac fibroblast growth and cardiac fibrosis
BR0013597A (pt) 1999-08-27 2002-07-16 Ligand Pharm Inc Compostos e métodos moduladores de receptor de androgênio
AU6941200A (en) 1999-08-27 2001-03-26 Ligand Pharmaceuticals Incorporated 8-substituted-6-trifluoromethyl-9-pyrido(3,2-g)quinoline compounds as androgen receptor modulators
US6566372B1 (en) * 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
PE20010647A1 (es) 1999-09-14 2001-06-23 Lilly Co Eli Moduladores de receptores de retinoide x (rxr) con perfil farmacologico mejorado
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CA2536349A1 (en) * 2003-08-22 2005-03-03 Ligand Pharmaceuticals Incorporated 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds
US20080171746A1 (en) * 2005-03-14 2008-07-17 Thomas Klein Method for Preventing Cardiovascular Diseases
KR101289995B1 (ko) 2005-09-27 2013-07-26 시오노기 앤드 컴파니, 리미티드 Ｐｇｄ2 수용체 길항제 활성을 갖는 설폰아마이드 유도체
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9580471B2 (en) 2011-03-01 2017-02-28 Synergy Pharmaceuticals, Inc. Process of preparing guanylate cyclase C agonists
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
JP6694385B2 (ja) 2013-08-09 2020-05-13 アーデリクス，インコーポレーテッド リン酸塩輸送阻害のための化合物及び方法
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1278385B (de) * 1965-03-30 1968-09-26 Bayer Ag Aufhellungsmittel
GB1299172A (en) * 1968-10-15 1972-12-06 Lilly Industries Ltd Heterocyclic anti-inflammatory agents
DE2719562C2 (de) * 1976-05-08 1986-05-07 Otsuka Pharmaceutical Co. Ltd., Tokio/Tokyo 3, 4-Dihydrocarbostyrilderivate, Verfahren zu deren Herstellung und Arzneimittel, welche diese enthalten
JPS54130589A (en) * 1978-03-31 1979-10-09 Yoshitomi Pharmaceut Ind Ltd Pyridazine derivative and its preparation
JPS54135785A (en) * 1978-04-12 1979-10-22 Yoshitomi Pharmaceut Ind Ltd Pyridazinone derivative and its preparation
JPS54138585A (en) * 1978-04-18 1979-10-27 Yoshitomi Pharmaceut Ind Ltd Pyridazine derivative and its preparation
JPS54141785A (en) * 1978-04-26 1979-11-05 Yoshitomi Pharmaceut Ind Ltd Preparation of carboxylic acid derivative
JPS6017072B2 (ja) * 1978-09-05 1985-04-30 三菱電機株式会社 赤熱金属検出器
JPS5549319A (en) * 1978-10-06 1980-04-09 Yoshitomi Pharmaceut Ind Ltd Remedy for suppression of blood platelet-agglutination
JPS5553283A (en) * 1978-10-12 1980-04-18 Yoshitomi Pharmaceut Ind Ltd Pyridazinone derivative
JPS5576872A (en) * 1978-12-06 1980-06-10 Yoshitomi Pharmaceut Ind Ltd Imidazolidinone derivative
JPS5583781A (en) * 1978-12-19 1980-06-24 Yoshitomi Pharmaceut Ind Ltd Pyridazinone derivative

Also Published As

Publication number Publication date
SU1426452A3 (ru) 1988-09-23
SE8406209D0 (sv) 1984-12-06
FI813408L (fi) 1982-05-01
FR2552760B1 (fr) 1988-08-05
MX8481A (es) 1994-02-28
AU524419B2 (en) 1982-09-16
BE890942A (fr) 1982-02-15
CH650782A5 (de) 1985-08-15
DE3142982C2 (de) 1985-12-19
FI77450B (fi) 1988-11-30
FI77450C (fi) 1989-03-10
KR860001944B1 (ko) 1986-11-01
DK155665B (da) 1989-05-01
PT73910A (en) 1981-11-01
ZA817515B (en) 1982-10-27
ES507198A0 (es) 1983-06-16
NO158099C (no) 1988-07-13
JPH0143747B2 (US07321065-20080122-C00160.png) 1989-09-22
SE448877B (sv) 1987-03-23
ES520637A0 (es) 1984-04-16
NL194205B (nl) 2001-05-01
DE3153260A1 (US07321065-20080122-C00160.png) 1985-05-15
NL194205C (nl) 2001-09-04
SE8406209L (sv) 1984-12-06
IT1210585B (it) 1989-09-14
IT1226479B (it) 1991-01-16
FR2493320A1 (fr) 1982-05-07
JPS5777676A (en) 1982-05-15
DE3142982A1 (de) 1982-06-24
IT8149588A0 (it) 1981-10-29
PH17962A (en) 1985-02-20
CA1209575A (en) 1986-08-12
KR830007607A (ko) 1983-11-04
ATA460281A (de) 1986-04-15
NL8403096A (nl) 1985-02-01
ES8403886A1 (es) 1984-04-16
GB2086896A (en) 1982-05-19
NL8104923A (nl) 1982-05-17
DK155665C (da) 1989-09-04
ES520638A0 (es) 1984-04-16
DK480381A (da) 1982-05-01
DE3153260C2 (US07321065-20080122-C00160.png) 1989-05-24
NO158099B (no) 1988-04-05
AR242563A1 (es) 1993-04-30
ES8403885A1 (es) 1984-04-16
PT73910B (en) 1983-04-18
FR2552760A1 (fr) 1985-04-05
GB2086896B (en) 1984-10-10
US4415572A (en) 1983-11-15
NO813678L (no) 1982-05-03
ES8306743A1 (es) 1983-06-16
IT8547867A0 (it) 1985-03-26
SE466655B (sv) 1992-03-16
SE8106430L (sv) 1982-05-01
AR242375A1 (es) 1993-03-31
CH656616A5 (de) 1986-07-15
AT381701B (de) 1986-11-25
AU7699681A (en) 1982-05-06

Similar Documents

Publication Publication Date Title
FR2493320B1 (fr) Nouveaux derives de carbostyrile utiles notamment comme cardiotoniques, leurs procedes de preparation et medicaments les contenant
FR2455027B1 (fr) Esters d'acylcarnitines utiles comme medicaments, leurs procedes de preparation et compositions therapeutiques les contenant
FR2329276A1 (fr) Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
FR2569404B1 (fr) Nouveaux derives de 1,2-benzisothiazol-3-ylpiperazine, compositions pharmaceutiques contenant de tels composes et leurs procedes de preparation
IL56557A (en) 6-substituted 2-penem-3-carboxylic acid derivatives,their production and pharmaceutical compositions containing them
FR2345450A1 (fr) Quinoxalinones et quinoxalines, leurs procedes de preparation et composition pharmaceutique les contenant
BE888367A (fr) Compose de platine, procede de preparation et compositions pharmaceutiques en contenant,
IT1195297B (it) Composti xantati antivirali,procedimento per la loro produzione e composizioni farmaceutiche che li contengono
FR2566773B1 (fr) Nouveaux benzamides substitues, procedes de preparation de ces composes et compositions pharmaceutiques les contenant
BE895168A (fr) Nouveaux derives d'aminosulfonyluree utiles notamment comme herbicides, leurs procedes de fabrication et herbicides les contenant
FR2596050B1 (fr) Nouveaux derives benzofuranniques, leurs procedes de preparation et compositions medicamenteuse et cosmetique les contenant
BE881631A (fr) Nouveaux derives de l'oxoimidazoquinoxaline et leurs sels, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2549832B1 (fr) Nouveaux derives de coumarine, leurs procedes de preparation, compositions pharmaceutiques les contenant
FR2512019B1 (fr) Derives de carbostyryle, leurs procedes de preparation et composition therapeutique les contenant
IL62912A0 (en) Penam-3-carboxylic acid derivatives,their manufacture and pharmaceutical compositions containing them
BE888327A (fr) Amines antihypertensives, leur procede de preparation et compositions antihypertensives en contenant,
FR2524890B1 (fr) Nouveaux derives de carbapenem, compositions pharmaceutiques les contenant, composes intermediaires pour leur preparation, et leurs procedes de production
BE883461A (fr) Composition de fonderie contenant certains liants de type fulvene, ces nouveaux liants, et leurs procedes de preparation
BE894765A (fr) Nouveaux derives de l'acide 4-phenyl 4-oxo 2-butenoique, leurs sels, leur preparation, leur application comme medicaments et les compositions les renfermant
FR2556721B1 (fr) Nouveaux derives de o-mercaptopropanamide d'o amino-acides, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
FR2496663B1 (fr) Nouveaux derives de naphtyridine-1,8 utiles notamment comme medicaments antibacteriens
BE888836A (fr) Nouveaux derives de quinoxaline-1,4-dioxyde leurs procedes de preparation et compositions les contenant
BE880043A (fr) Compositions de cephradine et leurs procedes de preparation
DE3162644D1 (en) Novel adenine nucleoside derivatives, their preparation and pharmaceutical compositions containing them
PH17057A (en) Kijanimicin and salts thereof,pharmaceutical compositions containing same and process of preparring same