FR2427333A1 - Nouveaux aminothiazoles et composition pharmaceutique les contenant - Google Patents
Nouveaux aminothiazoles et composition pharmaceutique les contenantInfo
- Publication number
- FR2427333A1 FR2427333A1 FR7914164A FR7914164A FR2427333A1 FR 2427333 A1 FR2427333 A1 FR 2427333A1 FR 7914164 A FR7914164 A FR 7914164A FR 7914164 A FR7914164 A FR 7914164A FR 2427333 A1 FR2427333 A1 FR 2427333A1
- Authority
- FR
- France
- Prior art keywords
- new
- aminothiazoles
- pharmaceutical composition
- phenylthiazole
- phenethylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- UXZPFPLPTODLCU-UHFFFAOYSA-N 4,5-diphenyl-n-(2-phenylethyl)-1,3-thiazol-2-amine Chemical compound N=1C(C=2C=CC=CC=2)=C(C=2C=CC=CC=2)SC=1NCCC1=CC=CC=C1 UXZPFPLPTODLCU-UHFFFAOYSA-N 0.000 abstract 1
- JUGUBOQRAJASOS-UHFFFAOYSA-N 4-(4-fluorophenyl)-n-(thiophen-2-ylmethyl)-1,3-thiazol-2-amine Chemical compound C1=CC(F)=CC=C1C1=CSC(NCC=2SC=CC=2)=N1 JUGUBOQRAJASOS-UHFFFAOYSA-N 0.000 abstract 1
- MFBJXMMGIRSWAP-UHFFFAOYSA-N 4-phenyl-n-(thiophen-2-ylmethyl)-1,3-thiazol-2-amine Chemical compound C=1C=CSC=1CNC(SC=1)=NC=1C1=CC=CC=C1 MFBJXMMGIRSWAP-UHFFFAOYSA-N 0.000 abstract 1
- NTUXEUGLSZFNPX-UHFFFAOYSA-N 5-methyl-4-phenyl-n-(2-phenylethyl)-1,3-thiazol-2-amine Chemical compound N=1C(C=2C=CC=CC=2)=C(C)SC=1NCCC1=CC=CC=C1 NTUXEUGLSZFNPX-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- WEEYMMXMBFJUAI-UHFFFAOYSA-N fanetizole Chemical compound N=1C(C=2C=CC=CC=2)=CSC=1NCCC1=CC=CC=C1 WEEYMMXMBFJUAI-UHFFFAOYSA-N 0.000 abstract 1
- 230000004957 immunoregulator effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
- F16B15/00—Nails; Staples
- F16B15/0023—Nail plates
- F16B2015/0076—Nail plates with provisions for additional fastening means, e.g. hooks, holes for separate screws or nails, adhesive
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'invention a trait au domaine de la chimie pharmaceutique. Elle concerne une nouvelle série de 2-arylaminothiazoles et leurs sels d'addition d'acides acceptables du point de vue pharmaceutique. Des composés appréciés dans cette série comprennent le 2-phénéthylamino-4-phénylthiazole, le 2-phénéthylamino-4,5-diphénylthiazole, le 5-méthyl-2-phénéthylamino-4-phénylthiazole, le 2-thénylamino-4-phénylthiazole et le 2-thénylamino-4-(p-fluorophényl)-thiazole. Les nouveaux composes de l'invention sont doués d'activité anti-inflammatoire et d'activité immunorégulatrice.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91183078A | 1978-06-02 | 1978-06-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2427333A1 true FR2427333A1 (fr) | 1979-12-28 |
| FR2427333B1 FR2427333B1 (fr) | 1983-05-20 |
Family
ID=25430923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7914164A Granted FR2427333A1 (fr) | 1978-06-02 | 1979-06-01 | Nouveaux aminothiazoles et composition pharmaceutique les contenant |
Country Status (36)
| Country | Link |
|---|---|
| JP (1) | JPS5936988B2 (fr) |
| AR (1) | AR226285A1 (fr) |
| AT (1) | AT373248B (fr) |
| AU (1) | AU511242B2 (fr) |
| BE (1) | BE876732A (fr) |
| CA (1) | CA1117949A (fr) |
| CH (1) | CH639653A5 (fr) |
| CS (1) | CS216927B2 (fr) |
| DD (1) | DD144055A5 (fr) |
| DE (1) | DE2922523C2 (fr) |
| DK (1) | DK150068C (fr) |
| EG (1) | EG14354A (fr) |
| ES (1) | ES481220A1 (fr) |
| FI (1) | FI68820C (fr) |
| FR (1) | FR2427333A1 (fr) |
| GB (1) | GB2022085B (fr) |
| GR (1) | GR73142B (fr) |
| HK (1) | HK66487A (fr) |
| HU (1) | HU180045B (fr) |
| IE (1) | IE48426B1 (fr) |
| IL (1) | IL57450A (fr) |
| IT (1) | IT1121238B (fr) |
| KE (1) | KE3459A (fr) |
| LU (1) | LU81349A1 (fr) |
| MY (1) | MY8500318A (fr) |
| NL (1) | NL178421C (fr) |
| NO (1) | NO150760C (fr) |
| NZ (1) | NZ190623A (fr) |
| PH (1) | PH17020A (fr) |
| PL (1) | PL117515B1 (fr) |
| PT (1) | PT69718A (fr) |
| SE (1) | SE438333B (fr) |
| SG (1) | SG56184G (fr) |
| SU (1) | SU843746A3 (fr) |
| YU (1) | YU40997B (fr) |
| ZA (1) | ZA792729B (fr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1982001481A1 (fr) * | 1980-10-24 | 1982-05-13 | Ronald P Hansen | Systeme de reduction de la poussiere |
| EP0068033B1 (fr) * | 1981-01-08 | 1985-07-10 | Mitsui Toatsu Kagaku Kabushiki Kaisha | Derives de n-(4-phenyl-2-thiazolyl)carbamate, procede de preparation et composition medicinale les contenant |
| JPS57136579A (en) * | 1981-01-21 | 1982-08-23 | Mitsui Toatsu Chem Inc | Thiazolylurea derivative, its preparation, and pharmaceutical composition containing the same |
| JPS57116067A (en) * | 1981-01-12 | 1982-07-19 | Sankyo Kagaku Kk | Novel 8-quinolinesulfonyl derivative, its synthesis and use |
| WO1982002386A1 (fr) * | 1981-01-13 | 1982-07-22 | Sakano Isao | Derives d'aminothiazoles, procede de preparation et composition medicinale les contenant |
| EP0069154B1 (fr) * | 1981-01-13 | 1986-10-15 | Mitsui Toatsu Kagaku Kabushiki Kaisha | Nouveaux composes de thiazole, procede de preparation, et composition medicinale en contenant |
| JPS57154175A (en) * | 1981-03-16 | 1982-09-22 | Mitsui Toatsu Chem Inc | 2-thiazoleamine derivative, its preparation, and drug composition comprising it |
| DE3227329A1 (de) * | 1982-07-22 | 1984-01-26 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von 2-n,n-disubstituierten aminothiazolen |
| WO1986003203A1 (fr) * | 1984-11-22 | 1986-06-05 | Yoshitomi Pharmaceutical Industries, Ltd. | Derives de thienylthiazole |
| FR2581063B1 (fr) * | 1985-04-30 | 1987-07-17 | Chauvin Blache Lab | Amino-2 thiazoles n-substitues, leur procede de preparation et leur application en therapeutique |
| JPS63152368A (ja) * | 1986-06-03 | 1988-06-24 | Sumitomo Pharmaceut Co Ltd | 新規なアミノアゾ−ル誘導体およびその酸付加塩 |
| JPH075579B2 (ja) * | 1986-09-01 | 1995-01-25 | 吉富製薬株式会社 | アミノチアゾ−ル化合物 |
| JPH0753666B2 (ja) * | 1987-09-14 | 1995-06-07 | 久光製薬株式会社 | 置換ジフェニルチアゾール誘導体からなる抗炎症剤 |
| DE69031624T2 (de) * | 1989-08-10 | 1998-05-14 | Commw Scient Ind Res Org | Verfahren zur herstellung von einer elektrosuspension von mikropartikeln |
| WO1992015570A1 (fr) * | 1991-03-07 | 1992-09-17 | Hisamitsu Pharmaceutical Co., Inc. | Nouveau derive de diphenylthiazole |
| FR2692893B1 (fr) * | 1992-06-24 | 1994-09-02 | Sanofi Elf | Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
| JPH10504542A (ja) * | 1994-07-27 | 1998-05-06 | ジー．ディー．サール アンド カンパニー | 炎症処置用の置換チアゾール化合物 |
| FR2754258B1 (fr) | 1996-10-08 | 1998-12-31 | Sanofi Sa | Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
| WO2001064674A1 (fr) | 2000-03-01 | 2001-09-07 | Janssen Pharmaceutica N.V. | Derives de thiazolyle 2,4-disubstitue |
| WO2003015777A1 (fr) * | 2001-08-13 | 2003-02-27 | Lion Bioscience Ag | Composes de liaison au recepteur nucleaire nr1h4 |
| AU2002362603A1 (en) * | 2001-09-26 | 2003-04-07 | Bayer Corporation | 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors |
| WO2003059880A1 (fr) | 2002-01-11 | 2003-07-24 | Sankyo Company, Limited | Derive d'amino-alcool ou derive d'acide phosphonique et composition medicamenteuse les contenant |
| EP1555264A1 (fr) * | 2004-01-15 | 2005-07-20 | Sireen AG | Hétérocycles à cinq chaínons comme inhibiteurs de la famille des SRC proteines kinases |
| CN1921847B (zh) | 2004-02-24 | 2010-06-16 | 三共株式会社 | 氨基醇化合物 |
| SG159561A1 (en) * | 2005-05-09 | 2010-03-30 | Achillion Pharmaceuticals Inc | Thiazole compounds and methods of use |
| US7514566B2 (en) | 2006-01-18 | 2009-04-07 | Amgen, Inc. | Thiazole compounds and methods of use |
| AU2008276512A1 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of PKB |
| JP2010533715A (ja) | 2007-07-17 | 2010-10-28 | アムジエン・インコーポレーテツド | 複素環系ｐｋｂ調節剤 |
| US20130143927A1 (en) * | 2011-06-10 | 2013-06-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| WO2012170931A2 (fr) | 2011-06-10 | 2012-12-13 | Calcimedica, Inc. | Composés qui modulent le calcium intracellulaire |
| US9856240B2 (en) | 2011-10-19 | 2018-01-02 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| CN110590785B (zh) * | 2019-09-23 | 2021-02-02 | 武汉大学 | 一种氨基噻唑类化合物及其制备方法与抗肠道病毒71型的应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3458526A (en) * | 1966-09-26 | 1969-07-29 | Upjohn Co | Certain 2-amino-4,5-bis(p-methoxyphenyl)thiazoles |
-
1979
- 1979-04-30 DK DK177679A patent/DK150068C/da not_active IP Right Cessation
- 1979-05-23 GB GB7917872A patent/GB2022085B/en not_active Expired
- 1979-05-29 CH CH501679A patent/CH639653A5/fr not_active IP Right Cessation
- 1979-05-30 EG EG333/79A patent/EG14354A/xx active
- 1979-05-30 CS CS793728A patent/CS216927B2/cs unknown
- 1979-05-31 YU YU1288/79A patent/YU40997B/xx unknown
- 1979-05-31 AU AU47634/79A patent/AU511242B2/en not_active Ceased
- 1979-05-31 HU HU79PI679A patent/HU180045B/hu not_active IP Right Cessation
- 1979-05-31 LU LU81349A patent/LU81349A1/fr unknown
- 1979-05-31 PH PH22588A patent/PH17020A/en unknown
- 1979-05-31 IL IL57450A patent/IL57450A/xx unknown
- 1979-05-31 SU SU792773929A patent/SU843746A3/ru active
- 1979-05-31 CA CA000328805A patent/CA1117949A/fr not_active Expired
- 1979-05-31 SE SE7904798A patent/SE438333B/sv not_active IP Right Cessation
- 1979-06-01 ES ES481220A patent/ES481220A1/es not_active Expired
- 1979-06-01 NO NO791831A patent/NO150760C/no unknown
- 1979-06-01 AR AR276782A patent/AR226285A1/es active
- 1979-06-01 FR FR7914164A patent/FR2427333A1/fr active Granted
- 1979-06-01 IT IT23228/79A patent/IT1121238B/it active
- 1979-06-01 NZ NZ190623A patent/NZ190623A/en unknown
- 1979-06-01 FI FI791754A patent/FI68820C/fi not_active IP Right Cessation
- 1979-06-01 GR GR59240A patent/GR73142B/el unknown
- 1979-06-01 PL PL1979216030A patent/PL117515B1/pl unknown
- 1979-06-01 NL NLAANVRAGE7904337,A patent/NL178421C/xx not_active IP Right Cessation
- 1979-06-01 AT AT0401679A patent/AT373248B/de not_active IP Right Cessation
- 1979-06-01 DE DE2922523A patent/DE2922523C2/de not_active Expired
- 1979-06-01 DD DD79213371A patent/DD144055A5/de not_active IP Right Cessation
- 1979-06-01 JP JP54068781A patent/JPS5936988B2/ja not_active Expired
- 1979-06-01 ZA ZA792729A patent/ZA792729B/xx unknown
- 1979-06-01 BE BE0/195534A patent/BE876732A/fr not_active IP Right Cessation
- 1979-06-01 PT PT69718A patent/PT69718A/pt unknown
- 1979-08-08 IE IE1069/79A patent/IE48426B1/en unknown
-
1984
- 1984-08-13 SG SG561/84A patent/SG56184G/en unknown
- 1984-09-24 KE KE3459A patent/KE3459A/xx unknown
-
1985
- 1985-12-30 MY MY318/85A patent/MY8500318A/xx unknown
-
1987
- 1987-09-17 HK HK664/87A patent/HK66487A/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |