IE791069L - Thiazole derivatives - Google Patents

Thiazole derivatives

Info

Publication number
IE791069L
IE791069L IE791069A IE106979A IE791069L IE 791069 L IE791069 L IE 791069L IE 791069 A IE791069 A IE 791069A IE 106979 A IE106979 A IE 106979A IE 791069 L IE791069 L IE 791069L
Authority
IE
Ireland
Prior art keywords
thiazole
phenethylamino
phenyl
thenylamino
thiazole derivatives
Prior art date
Application number
IE791069A
Other versions
IE48426B1 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IE791069L publication Critical patent/IE791069L/en
Publication of IE48426B1 publication Critical patent/IE48426B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B15/00—Nails; Staples
    • F16B15/0023—Nail plates
    • F16B2015/0076—Nail plates with provisions for additional fastening means, e.g. hooks, holes for separate screws or nails, adhesive

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A series of 2-aryl aminothiazoles and the pharmaceutically acceptable acid addition salts thereof having anti- antiflammatory and immune regulant activity are disclosed. Preferred compounds include 2- phenethylamino-4-phenyl-thiazole, 2- phenethylamino-4,5-diphenyl- thiazole, 5-methyl-2-phenethylamino- 4-phenyl-thiazole, 2-thenylamino-4- phenyl-thiazole and 2-thenylamino-4- (p-fluorophenyl)thiazole. [GB2022085A]
IE1069/79A 1978-06-02 1979-08-08 Novel aminothiazoles IE48426B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91183078A 1978-06-02 1978-06-02

Publications (2)

Publication Number Publication Date
IE791069L true IE791069L (en) 1979-12-02
IE48426B1 IE48426B1 (en) 1985-01-23

Family

ID=25430923

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1069/79A IE48426B1 (en) 1978-06-02 1979-08-08 Novel aminothiazoles

Country Status (36)

Country Link
JP (1) JPS5936988B2 (en)
AR (1) AR226285A1 (en)
AT (1) AT373248B (en)
AU (1) AU511242B2 (en)
BE (1) BE876732A (en)
CA (1) CA1117949A (en)
CH (1) CH639653A5 (en)
CS (1) CS216927B2 (en)
DD (1) DD144055A5 (en)
DE (1) DE2922523C2 (en)
DK (1) DK150068C (en)
EG (1) EG14354A (en)
ES (1) ES481220A1 (en)
FI (1) FI68820C (en)
FR (1) FR2427333A1 (en)
GB (1) GB2022085B (en)
GR (1) GR73142B (en)
HK (1) HK66487A (en)
HU (1) HU180045B (en)
IE (1) IE48426B1 (en)
IL (1) IL57450A (en)
IT (1) IT1121238B (en)
KE (1) KE3459A (en)
LU (1) LU81349A1 (en)
MY (1) MY8500318A (en)
NL (1) NL178421C (en)
NO (1) NO150760C (en)
NZ (1) NZ190623A (en)
PH (1) PH17020A (en)
PL (1) PL117515B1 (en)
PT (1) PT69718A (en)
SE (1) SE438333B (en)
SG (1) SG56184G (en)
SU (1) SU843746A3 (en)
YU (1) YU40997B (en)
ZA (1) ZA792729B (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982001481A1 (en) * 1980-10-24 1982-05-13 Ronald P Hansen Dust mitigation system
JPS57136579A (en) * 1981-01-21 1982-08-23 Mitsui Toatsu Chem Inc Thiazolylurea derivative, its preparation, and pharmaceutical composition containing the same
EP0068033B1 (en) * 1981-01-08 1985-07-10 Mitsui Toatsu Kagaku Kabushiki Kaisha N-(4-phenyl-2-thiazolyl)carbamate derivatives, process for their preparation, and medicinal composition containing same
JPS57116067A (en) * 1981-01-12 1982-07-19 Sankyo Kagaku Kk Novel 8-quinolinesulfonyl derivative, its synthesis and use
WO1982002383A1 (en) * 1981-01-13 1982-07-22 Sakano Isao Novel thiazole compounds,process for their preparation,and medicinal composition containing same
WO1982002386A1 (en) * 1981-01-13 1982-07-22 Sakano Isao Aminothiazole derivatives,process for their preparation,and medicinal composition containing same
JPS57154175A (en) * 1981-03-16 1982-09-22 Mitsui Toatsu Chem Inc 2-thiazoleamine derivative, its preparation, and drug composition comprising it
DE3227329A1 (en) * 1982-07-22 1984-01-26 Basf Ag, 6700 Ludwigshafen METHOD FOR PRODUCING 2-N, N-DISUBSTITUTED AMINOTHIAZOLES
WO1986003203A1 (en) * 1984-11-22 1986-06-05 Yoshitomi Pharmaceutical Industries, Ltd. Thienylthiazole derivatives
FR2581063B1 (en) * 1985-04-30 1987-07-17 Chauvin Blache Lab AMINO-2 THIAZOLES N-SUBSTITUTED, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THERAPEUTICS
JPS63152368A (en) * 1986-06-03 1988-06-24 Sumitomo Pharmaceut Co Ltd Novel aminoazole derivatives and their acid addition salts
JPH075579B2 (en) * 1986-09-01 1995-01-25 吉富製薬株式会社 Aminothiazole compound
JPH0753666B2 (en) * 1987-09-14 1995-06-07 久光製薬株式会社 Anti-inflammatory agent consisting of substituted diphenylthiazole derivative
DE69031624T2 (en) * 1989-08-10 1998-05-14 Auspharm Int Ltd METHOD FOR PRODUCING AN ELECTROSUSPENSION OF MICROPARTICLES
DE69132293D1 (en) * 1991-03-07 2000-08-10 Hisamitsu Pharmaceutical Co DIPHENYLTHIAZOLE DERIVATIVES WITH ANTI-INFLAMMATORY ACTIVITY
FR2692893B1 (en) * 1992-06-24 1994-09-02 Sanofi Elf Branched alkylamino thiazole derivatives, processes for their preparation and pharmaceutical compositions containing them.
CA2195847A1 (en) * 1994-07-27 1996-02-08 John J. Talley Substituted thiazoles for the treatment of inflammation
FR2754258B1 (en) 1996-10-08 1998-12-31 Sanofi Sa AMINOTHIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AU2001237401B2 (en) * 2000-03-01 2006-11-09 Janssen Pharmaceutica N.V. 2,4-disubstituted thiazolyl derivatives
EP1423113A4 (en) * 2001-08-13 2007-04-18 Phenex Pharmaceuticals Ag Nr1h4 nuclear receptor binding compounds
WO2003027105A1 (en) * 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation Substituted 3-pyridyl thiophenes as c17,20 lyase inhibitors
AU2003202495B2 (en) 2002-01-11 2006-07-20 Sankyo Company, Limited Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these
EP1555264A1 (en) * 2004-01-15 2005-07-20 Sireen AG Five-membered heterocyclic compounds as inhibitors of SRC family protein kinase.
KR20110136901A (en) 2004-02-24 2011-12-21 상꾜 가부시키가이샤 Amino alcohol compounds
BRPI0608910A2 (en) 2005-05-09 2010-02-17 Achillion Pharmaceuticals Inc use of a compound of the formula or a pharmaceutically acceptable salt or hydrate thereof, compound or salt or hydrate thereof, pharmaceutical composition and packaged pharmaceutical composition
WO2007084391A2 (en) 2006-01-18 2007-07-26 Amgen Inc. Thiazole compounds as protein kinase b ( pkb) inhibitors
US7897619B2 (en) 2007-07-17 2011-03-01 Amgen Inc. Heterocyclic modulators of PKB
CA2693473A1 (en) 2007-07-17 2009-01-22 Amgen Inc. Thiadiazole modulators of pkb
US20120316182A1 (en) 2011-06-10 2012-12-13 Calcimedica, Inc. Compounds that modulate intracellular calcium
US20130143927A1 (en) * 2011-06-10 2013-06-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2013059677A1 (en) 2011-10-19 2013-04-25 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN110590785B (en) * 2019-09-23 2021-02-02 武汉大学 A kind of aminothiazole compound and its preparation method and application of anti-enterovirus type 71

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458526A (en) * 1966-09-26 1969-07-29 Upjohn Co Certain 2-amino-4,5-bis(p-methoxyphenyl)thiazoles

Also Published As

Publication number Publication date
ZA792729B (en) 1981-03-25
IE48426B1 (en) 1985-01-23
FI68820B (en) 1985-07-31
JPS54160369A (en) 1979-12-19
DK177679A (en) 1979-12-03
FI791754A7 (en) 1979-11-26
IT1121238B (en) 1986-03-26
FR2427333B1 (en) 1983-05-20
FI68820C (en) 1985-11-11
IL57450A (en) 1982-11-30
JPS5936988B2 (en) 1984-09-06
IL57450A0 (en) 1979-09-30
DE2922523A1 (en) 1979-12-06
CA1117949A (en) 1982-02-09
LU81349A1 (en) 1979-12-07
HU180045B (en) 1983-01-28
SG56184G (en) 1985-03-08
ES481220A1 (en) 1980-09-01
DD144055A5 (en) 1980-09-24
PL216030A1 (en) 1980-03-10
GB2022085A (en) 1979-12-12
NL7904337A (en) 1979-12-04
AR226285A1 (en) 1982-06-30
SE7904798L (en) 1979-12-03
GR73142B (en) 1984-02-09
DK150068B (en) 1986-12-01
ATA401679A (en) 1983-05-15
DK150068C (en) 1987-06-29
NO150760B (en) 1984-09-03
GB2022085B (en) 1983-01-12
NO791831L (en) 1979-12-04
AU511242B2 (en) 1980-08-07
NZ190623A (en) 1984-07-06
EG14354A (en) 1984-06-30
IT7923228A0 (en) 1979-06-01
NO150760C (en) 1984-12-12
YU128879A (en) 1982-10-31
YU40997B (en) 1986-10-31
MY8500318A (en) 1985-12-31
CS216927B2 (en) 1982-12-31
NL178421C (en) 1986-03-17
AU4763479A (en) 1979-12-06
AT373248B (en) 1983-12-27
PL117515B1 (en) 1981-08-31
PT69718A (en) 1979-07-01
PH17020A (en) 1984-05-11
FR2427333A1 (en) 1979-12-28
NL178421B (en) 1985-10-16
KE3459A (en) 1984-10-12
SE438333B (en) 1985-04-15
DE2922523C2 (en) 1982-10-21
CH639653A5 (en) 1983-11-30
HK66487A (en) 1987-09-25
SU843746A3 (en) 1981-06-30
BE876732A (en) 1979-12-03

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