SE7904798L - NEW AMINOTIAZOLES - Google Patents

NEW AMINOTIAZOLES

Info

Publication number
SE7904798L
SE7904798L SE7904798A SE7904798A SE7904798L SE 7904798 L SE7904798 L SE 7904798L SE 7904798 A SE7904798 A SE 7904798A SE 7904798 A SE7904798 A SE 7904798A SE 7904798 L SE7904798 L SE 7904798L
Authority
SE
Sweden
Prior art keywords
thiazole
phenethylamino
phenyl
aminotiazoles
new
Prior art date
Application number
SE7904798A
Other languages
Swedish (sv)
Other versions
SE438333B (en
Inventor
J G Lombardino
J S Bindra
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SE7904798L publication Critical patent/SE7904798L/en
Publication of SE438333B publication Critical patent/SE438333B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B15/00—Nails; Staples
    • F16B15/0023—Nail plates
    • F16B2015/0076—Nail plates with provisions for additional fastening means, e.g. hooks, holes for separate screws or nails, adhesive

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A series of 2-aryl aminothiazoles and the pharmaceutically acceptable acid addition salts thereof having anti- antiflammatory and immune regulant activity are disclosed. Preferred compounds include 2- phenethylamino-4-phenyl-thiazole, 2- phenethylamino-4,5-diphenyl- thiazole, 5-methyl-2-phenethylamino- 4-phenyl-thiazole, 2-thenylamino-4- phenyl-thiazole and 2-thenylamino-4- (p-fluorophenyl)thiazole.
SE7904798A 1978-06-02 1979-05-31 NEW AMINOTIAZOLS SE438333B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91183078A 1978-06-02 1978-06-02

Publications (2)

Publication Number Publication Date
SE7904798L true SE7904798L (en) 1979-12-03
SE438333B SE438333B (en) 1985-04-15

Family

ID=25430923

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7904798A SE438333B (en) 1978-06-02 1979-05-31 NEW AMINOTIAZOLS

Country Status (36)

Country Link
JP (1) JPS5936988B2 (en)
AR (1) AR226285A1 (en)
AT (1) AT373248B (en)
AU (1) AU511242B2 (en)
BE (1) BE876732A (en)
CA (1) CA1117949A (en)
CH (1) CH639653A5 (en)
CS (1) CS216927B2 (en)
DD (1) DD144055A5 (en)
DE (1) DE2922523C2 (en)
DK (1) DK150068C (en)
EG (1) EG14354A (en)
ES (1) ES481220A1 (en)
FI (1) FI68820C (en)
FR (1) FR2427333A1 (en)
GB (1) GB2022085B (en)
GR (1) GR73142B (en)
HK (1) HK66487A (en)
HU (1) HU180045B (en)
IE (1) IE48426B1 (en)
IL (1) IL57450A (en)
IT (1) IT1121238B (en)
KE (1) KE3459A (en)
LU (1) LU81349A1 (en)
MY (1) MY8500318A (en)
NL (1) NL178421C (en)
NO (1) NO150760C (en)
NZ (1) NZ190623A (en)
PH (1) PH17020A (en)
PL (1) PL117515B1 (en)
PT (1) PT69718A (en)
SE (1) SE438333B (en)
SG (1) SG56184G (en)
SU (1) SU843746A3 (en)
YU (1) YU40997B (en)
ZA (1) ZA792729B (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0063575A4 (en) * 1980-10-24 1983-02-14 Ronald Peter Hansen Dust mitigation system.
WO1982002384A1 (en) * 1981-01-08 1982-07-22 Sakano Isao Their preparation,and medicinal composition containing same
JPS57136579A (en) * 1981-01-21 1982-08-23 Mitsui Toatsu Chem Inc Thiazolylurea derivative, its preparation, and pharmaceutical composition containing the same
JPS57116067A (en) * 1981-01-12 1982-07-19 Sankyo Kagaku Kk Novel 8-quinolinesulfonyl derivative, its synthesis and use
DE3273781D1 (en) * 1981-01-13 1986-11-20 Mitsui Toatsu Chemicals Novel thiazole compounds, process for their preparation, and medicinal composition containing same
WO1982002386A1 (en) * 1981-01-13 1982-07-22 Sakano Isao Aminothiazole derivatives,process for their preparation,and medicinal composition containing same
JPS57154175A (en) * 1981-03-16 1982-09-22 Mitsui Toatsu Chem Inc 2-thiazoleamine derivative, its preparation, and drug composition comprising it
DE3227329A1 (en) * 1982-07-22 1984-01-26 Basf Ag, 6700 Ludwigshafen METHOD FOR PRODUCING 2-N, N-DISUBSTITUTED AMINOTHIAZOLES
WO1986003203A1 (en) * 1984-11-22 1986-06-05 Yoshitomi Pharmaceutical Industries, Ltd. Thienylthiazole derivatives
FR2581063B1 (en) * 1985-04-30 1987-07-17 Chauvin Blache Lab AMINO-2 THIAZOLES N-SUBSTITUTED, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THERAPEUTICS
JPS63152368A (en) * 1986-06-03 1988-06-24 Sumitomo Pharmaceut Co Ltd Novel aminoazole derivative and acid addition salt thereof
JPH075579B2 (en) * 1986-09-01 1995-01-25 吉富製薬株式会社 Aminothiazole compound
JPH0753666B2 (en) * 1987-09-14 1995-06-07 久光製薬株式会社 Anti-inflammatory agent consisting of substituted diphenylthiazole derivative
DE69031624T2 (en) * 1989-08-10 1998-05-14 Commw Scient Ind Res Org METHOD FOR PRODUCING AN ELECTROSUSPENSION OF MICROPARTICLES
DE69132293D1 (en) * 1991-03-07 2000-08-10 Hisamitsu Pharmaceutical Co DIPHENYLTHIAZOLE DERIVATIVES WITH ANTI-INFLAMMATORY ACTIVITY
FR2692893B1 (en) * 1992-06-24 1994-09-02 Sanofi Elf Branched alkylamino thiazole derivatives, processes for their preparation and pharmaceutical compositions containing them.
WO1996003392A1 (en) * 1994-07-27 1996-02-08 G.D. Searle & Co. Substituted thiazoles for the treatment of inflammation
FR2754258B1 (en) 1996-10-08 1998-12-31 Sanofi Sa AMINOTHIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO2001064674A1 (en) 2000-03-01 2001-09-07 Janssen Pharmaceutica N.V. 2,4-disubstituted thiazolyl derivatives
EP1423113A4 (en) * 2001-08-13 2007-04-18 Phenex Pharmaceuticals Ag Nr1h4 nuclear receptor binding compounds
WO2003027095A1 (en) * 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation Substituted 3-pyridyl tetrazoles as steroid c17,20 lyase inhibitors
BR0306811A (en) 2002-01-11 2004-10-26 Sankyo Co Compound, pharmacologically acceptable ester thereof, pharmaceutical composition and methods for the prevention or treatment of autoimmune diseases, rheumatoid arthritis and rejection caused by the transplantation of various organs in a mammal
EP1555264A1 (en) * 2004-01-15 2005-07-20 Sireen AG Five-membered heterocyclic compounds as inhibitors of SRC family protein kinase.
AU2005215320B2 (en) 2004-02-24 2008-04-17 Sankyo Company, Limited Amino alcohol compound
AU2006244203B2 (en) * 2005-05-09 2012-05-03 Achillion Pharmaceuticals, Inc. Thiazole compounds and methods of use
CA2636077C (en) 2006-01-18 2012-01-03 Amgen Inc. Thiazole compounds as protein kinase b (pkb) inhibitors
CA2692713A1 (en) 2007-07-17 2009-01-22 Amgen Inc. Heterocyclic modulators of pkb
CA2693473A1 (en) 2007-07-17 2009-01-22 Amgen Inc. Thiadiazole modulators of pkb
WO2012170951A2 (en) * 2011-06-10 2012-12-13 Calcimedica, Inc. Compounds that modulate intracellular calcium
US20120316182A1 (en) 2011-06-10 2012-12-13 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2013059677A1 (en) 2011-10-19 2013-04-25 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN110590785B (en) * 2019-09-23 2021-02-02 武汉大学 Aminothiazole compound, preparation method thereof and application of aminothiazole compound in resisting enterovirus 71

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458526A (en) * 1966-09-26 1969-07-29 Upjohn Co Certain 2-amino-4,5-bis(p-methoxyphenyl)thiazoles

Also Published As

Publication number Publication date
CA1117949A (en) 1982-02-09
IE791069L (en) 1979-12-02
HK66487A (en) 1987-09-25
FR2427333B1 (en) 1983-05-20
NO791831L (en) 1979-12-04
IL57450A (en) 1982-11-30
DK150068C (en) 1987-06-29
AU4763479A (en) 1979-12-06
DD144055A5 (en) 1980-09-24
NL178421C (en) 1986-03-17
NO150760C (en) 1984-12-12
JPS54160369A (en) 1979-12-19
BE876732A (en) 1979-12-03
GB2022085B (en) 1983-01-12
IE48426B1 (en) 1985-01-23
PH17020A (en) 1984-05-11
DK150068B (en) 1986-12-01
GB2022085A (en) 1979-12-12
LU81349A1 (en) 1979-12-07
IT7923228A0 (en) 1979-06-01
JPS5936988B2 (en) 1984-09-06
HU180045B (en) 1983-01-28
DE2922523A1 (en) 1979-12-06
SG56184G (en) 1985-03-08
AU511242B2 (en) 1980-08-07
IL57450A0 (en) 1979-09-30
SU843746A3 (en) 1981-06-30
SE438333B (en) 1985-04-15
NO150760B (en) 1984-09-03
ZA792729B (en) 1981-03-25
YU128879A (en) 1982-10-31
MY8500318A (en) 1985-12-31
GR73142B (en) 1984-02-09
FR2427333A1 (en) 1979-12-28
AT373248B (en) 1983-12-27
FI68820C (en) 1985-11-11
IT1121238B (en) 1986-03-26
AR226285A1 (en) 1982-06-30
FI68820B (en) 1985-07-31
DE2922523C2 (en) 1982-10-21
FI791754A (en) 1979-11-26
ATA401679A (en) 1983-05-15
YU40997B (en) 1986-10-31
PL117515B1 (en) 1981-08-31
PT69718A (en) 1979-07-01
NL7904337A (en) 1979-12-04
PL216030A1 (en) 1980-03-10
KE3459A (en) 1984-10-12
CH639653A5 (en) 1983-11-30
DK177679A (en) 1979-12-03
EG14354A (en) 1984-06-30
NL178421B (en) 1985-10-16
ES481220A1 (en) 1980-09-01
CS216927B2 (en) 1982-12-31
NZ190623A (en) 1984-07-06

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