GB2022085A - Novel Aminothiazoles - Google Patents

Novel Aminothiazoles

Info

Publication number
GB2022085A
GB2022085A GB7917872A GB7917872A GB2022085A GB 2022085 A GB2022085 A GB 2022085A GB 7917872 A GB7917872 A GB 7917872A GB 7917872 A GB7917872 A GB 7917872A GB 2022085 A GB2022085 A GB 2022085A
Authority
GB
United Kingdom
Prior art keywords
thiazole
phenethylamino
phenyl
aminothiazoles
thenylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7917872A
Other versions
GB2022085B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of GB2022085A publication Critical patent/GB2022085A/en
Application granted granted Critical
Publication of GB2022085B publication Critical patent/GB2022085B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B15/00—Nails; Staples
    • F16B15/0023—Nail plates
    • F16B2015/0076—Nail plates with provisions for additional fastening means, e.g. hooks, holes for separate screws or nails, adhesive

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A series of 2-aryl aminothiazoles and the pharmaceutically acceptable acid addition salts thereof having anti- antiflammatory and immune regulant activity are disclosed. Preferred compounds include 2- phenethylamino-4-phenyl-thiazole, 2- phenethylamino-4,5-diphenyl- thiazole, 5-methyl-2-phenethylamino- 4-phenyl-thiazole, 2-thenylamino-4- phenyl-thiazole and 2-thenylamino-4- (p-fluorophenyl)thiazole.
GB7917872A 1978-06-02 1979-05-23 Aminothiazoles Expired GB2022085B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91183078A 1978-06-02 1978-06-02

Publications (2)

Publication Number Publication Date
GB2022085A true GB2022085A (en) 1979-12-12
GB2022085B GB2022085B (en) 1983-01-12

Family

ID=25430923

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7917872A Expired GB2022085B (en) 1978-06-02 1979-05-23 Aminothiazoles

Country Status (36)

Country Link
JP (1) JPS5936988B2 (en)
AR (1) AR226285A1 (en)
AT (1) AT373248B (en)
AU (1) AU511242B2 (en)
BE (1) BE876732A (en)
CA (1) CA1117949A (en)
CH (1) CH639653A5 (en)
CS (1) CS216927B2 (en)
DD (1) DD144055A5 (en)
DE (1) DE2922523C2 (en)
DK (1) DK150068C (en)
EG (1) EG14354A (en)
ES (1) ES481220A1 (en)
FI (1) FI68820C (en)
FR (1) FR2427333A1 (en)
GB (1) GB2022085B (en)
GR (1) GR73142B (en)
HK (1) HK66487A (en)
HU (1) HU180045B (en)
IE (1) IE48426B1 (en)
IL (1) IL57450A (en)
IT (1) IT1121238B (en)
KE (1) KE3459A (en)
LU (1) LU81349A1 (en)
MY (1) MY8500318A (en)
NL (1) NL178421C (en)
NO (1) NO150760C (en)
NZ (1) NZ190623A (en)
PH (1) PH17020A (en)
PL (1) PL117515B1 (en)
PT (1) PT69718A (en)
SE (1) SE438333B (en)
SG (1) SG56184G (en)
SU (1) SU843746A3 (en)
YU (1) YU40997B (en)
ZA (1) ZA792729B (en)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0183191A1 (en) * 1984-11-22 1986-06-04 Yoshitomi Pharmaceutical Industries, Ltd. Thienylthiazole compounds
FR2581063A1 (en) * 1985-04-30 1986-10-31 Chauvin Blache Lab N-SUBSTITUTED AMINO-2 THIAZOLES, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC USE THEREOF
EP0576350A1 (en) * 1992-06-24 1993-12-29 Sanofi Branched alkylamino thiozole derivatives, process for their preparation and pharmaceutical compositions containing them
WO1996003392A1 (en) * 1994-07-27 1996-02-08 G.D. Searle & Co. Substituted thiazoles for the treatment of inflammation
WO2001064674A1 (en) * 2000-03-01 2001-09-07 Janssen Pharmaceutica N.V. 2,4-disubstituted thiazolyl derivatives
US6344470B1 (en) 1996-10-08 2002-02-05 Sanofi-Synthelabo Aminothiazole derivatives, method of preparation and pharmaceutical compositions containing same
WO2003027085A2 (en) * 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors
EP1423113A1 (en) * 2001-08-13 2004-06-02 LION Bioscience AG Nr1h4 nuclear receptor binding compounds
EP1555264A1 (en) * 2004-01-15 2005-07-20 Sireen AG Five-membered heterocyclic compounds as inhibitors of SRC family protein kinase.
WO2006122011A2 (en) * 2005-05-09 2006-11-16 Achillion Pharmaceuticals, Inc. Thiazole compounds and methods of use
US7514566B2 (en) 2006-01-18 2009-04-07 Amgen, Inc. Thiazole compounds and methods of use
US7897619B2 (en) 2007-07-17 2011-03-01 Amgen Inc. Heterocyclic modulators of PKB
US7910617B2 (en) 2004-02-24 2011-03-22 Sankyo Company, Limited Method for suppressing the number of peripheral blood lymphocytes using an amino alcohol compound
US7919504B2 (en) 2007-07-17 2011-04-05 Amgen Inc. Thiadiazole modulators of PKB
US8067396B2 (en) 2002-01-11 2011-11-29 Sankyo Company, Limited Amino alcohol compounds or phosphonic acid derivatives thereof

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0063575A4 (en) * 1980-10-24 1983-02-14 Ronald Peter Hansen Dust mitigation system.
JPS57136579A (en) * 1981-01-21 1982-08-23 Mitsui Toatsu Chem Inc Thiazolylurea derivative, its preparation, and pharmaceutical composition containing the same
WO1982002384A1 (en) * 1981-01-08 1982-07-22 Sakano Isao Their preparation,and medicinal composition containing same
JPS57116067A (en) * 1981-01-12 1982-07-19 Sankyo Kagaku Kk Novel 8-quinolinesulfonyl derivative, its synthesis and use
EP0069154B1 (en) * 1981-01-13 1986-10-15 Mitsui Toatsu Kagaku Kabushiki Kaisha Novel thiazole compounds, process for their preparation, and medicinal composition containing same
WO1982002386A1 (en) * 1981-01-13 1982-07-22 Sakano Isao Aminothiazole derivatives,process for their preparation,and medicinal composition containing same
JPS57154175A (en) * 1981-03-16 1982-09-22 Mitsui Toatsu Chem Inc 2-thiazoleamine derivative, its preparation, and drug composition comprising it
DE3227329A1 (en) * 1982-07-22 1984-01-26 Basf Ag, 6700 Ludwigshafen METHOD FOR PRODUCING 2-N, N-DISUBSTITUTED AMINOTHIAZOLES
JPS63152368A (en) * 1986-06-03 1988-06-24 Sumitomo Pharmaceut Co Ltd Novel aminoazole derivative and acid addition salt thereof
JPH075579B2 (en) * 1986-09-01 1995-01-25 吉富製薬株式会社 Aminothiazole compound
JPH0753666B2 (en) * 1987-09-14 1995-06-07 久光製薬株式会社 Anti-inflammatory agent consisting of substituted diphenylthiazole derivative
EP0486543B1 (en) * 1989-08-10 1997-10-22 Commonwealth Scientific And Industrial Research Organisation Method for producing an electrosuspension of micronised particles
DE69132293D1 (en) * 1991-03-07 2000-08-10 Hisamitsu Pharmaceutical Co DIPHENYLTHIAZOLE DERIVATIVES WITH ANTI-INFLAMMATORY ACTIVITY
US20130143927A1 (en) * 2011-06-10 2013-06-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
US20120316182A1 (en) 2011-06-10 2012-12-13 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2013059677A1 (en) 2011-10-19 2013-04-25 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN110590785B (en) * 2019-09-23 2021-02-02 武汉大学 Aminothiazole compound, preparation method thereof and application of aminothiazole compound in resisting enterovirus 71

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458526A (en) * 1966-09-26 1969-07-29 Upjohn Co Certain 2-amino-4,5-bis(p-methoxyphenyl)thiazoles

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4720493A (en) * 1984-11-22 1988-01-19 Yoshitomi Pharmaceutical Industries, Ltd. Thienylthiazole compounds
EP0183191A1 (en) * 1984-11-22 1986-06-04 Yoshitomi Pharmaceutical Industries, Ltd. Thienylthiazole compounds
FR2581063A1 (en) * 1985-04-30 1986-10-31 Chauvin Blache Lab N-SUBSTITUTED AMINO-2 THIAZOLES, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC USE THEREOF
EP0202157A1 (en) * 1985-04-30 1986-11-20 Laboratoires Chauvin S.A. N-substituted 2-amino-thiazoles, process for their preparation and their therapeutical use
US4785008A (en) * 1985-04-30 1988-11-15 Laboratoires Chauvin-Blache N-substituted 2-amino-thiazoles, process for their preparation and their therapeutic application
EP0576350A1 (en) * 1992-06-24 1993-12-29 Sanofi Branched alkylamino thiozole derivatives, process for their preparation and pharmaceutical compositions containing them
US5464847A (en) * 1992-06-24 1995-11-07 Elf Sanofi Branched alkylamino derivatives of thiazole, processes for preparing them and pharmaceutical compositions containing them
WO1996003392A1 (en) * 1994-07-27 1996-02-08 G.D. Searle & Co. Substituted thiazoles for the treatment of inflammation
US6344470B1 (en) 1996-10-08 2002-02-05 Sanofi-Synthelabo Aminothiazole derivatives, method of preparation and pharmaceutical compositions containing same
US7893280B2 (en) 2000-03-01 2011-02-22 Janssen Pharmaceutica Nv 2,4-disubstituted thiazolyl derivatives
US7105550B2 (en) 2000-03-01 2006-09-12 Christopher Love 2,4-disubstituted thiazolyl derivatives
WO2001064674A1 (en) * 2000-03-01 2001-09-07 Janssen Pharmaceutica N.V. 2,4-disubstituted thiazolyl derivatives
EP1423113A4 (en) * 2001-08-13 2007-04-18 Phenex Pharmaceuticals Ag Nr1h4 nuclear receptor binding compounds
EP1423113A1 (en) * 2001-08-13 2004-06-02 LION Bioscience AG Nr1h4 nuclear receptor binding compounds
WO2003027085A3 (en) * 2001-09-26 2003-12-04 Bayer Pharmaceuticals Corp 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors
WO2003027085A2 (en) * 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors
US8101650B2 (en) 2002-01-11 2012-01-24 Daiichi Sankyo Company, Limited Method for treating a immunology-related disease
US8067396B2 (en) 2002-01-11 2011-11-29 Sankyo Company, Limited Amino alcohol compounds or phosphonic acid derivatives thereof
WO2005068458A2 (en) * 2004-01-15 2005-07-28 Sirenade Pharmaceuticals Ag Five-membered heterocyclic compounds as inhibitors of src family protein kinase
WO2005068458A3 (en) * 2004-01-15 2005-11-24 Sirenade Pharmaceuticals Ag Five-membered heterocyclic compounds as inhibitors of src family protein kinase
EP1555264A1 (en) * 2004-01-15 2005-07-20 Sireen AG Five-membered heterocyclic compounds as inhibitors of SRC family protein kinase.
US7910617B2 (en) 2004-02-24 2011-03-22 Sankyo Company, Limited Method for suppressing the number of peripheral blood lymphocytes using an amino alcohol compound
WO2006122011A3 (en) * 2005-05-09 2007-05-03 Achillion Pharmaceuticals Inc Thiazole compounds and methods of use
WO2006122011A2 (en) * 2005-05-09 2006-11-16 Achillion Pharmaceuticals, Inc. Thiazole compounds and methods of use
US8088806B2 (en) 2005-05-09 2012-01-03 Achillion Pharmaceuticals, Inc. Thiazole compounds and methods of use
US7514566B2 (en) 2006-01-18 2009-04-07 Amgen, Inc. Thiazole compounds and methods of use
US8084479B2 (en) 2006-01-18 2011-12-27 Amgen Inc. Thiazole compounds and methods of use
US7897619B2 (en) 2007-07-17 2011-03-01 Amgen Inc. Heterocyclic modulators of PKB
US7919504B2 (en) 2007-07-17 2011-04-05 Amgen Inc. Thiadiazole modulators of PKB

Also Published As

Publication number Publication date
NO791831L (en) 1979-12-04
DE2922523C2 (en) 1982-10-21
FI68820B (en) 1985-07-31
YU128879A (en) 1982-10-31
IT7923228A0 (en) 1979-06-01
HK66487A (en) 1987-09-25
AR226285A1 (en) 1982-06-30
NO150760C (en) 1984-12-12
NZ190623A (en) 1984-07-06
DE2922523A1 (en) 1979-12-06
SE438333B (en) 1985-04-15
FR2427333B1 (en) 1983-05-20
CH639653A5 (en) 1983-11-30
SG56184G (en) 1985-03-08
PH17020A (en) 1984-05-11
NL178421B (en) 1985-10-16
DK177679A (en) 1979-12-03
YU40997B (en) 1986-10-31
FI791754A (en) 1979-11-26
AU511242B2 (en) 1980-08-07
EG14354A (en) 1984-06-30
IL57450A (en) 1982-11-30
NL178421C (en) 1986-03-17
BE876732A (en) 1979-12-03
NL7904337A (en) 1979-12-04
IE48426B1 (en) 1985-01-23
SE7904798L (en) 1979-12-03
FR2427333A1 (en) 1979-12-28
FI68820C (en) 1985-11-11
IE791069L (en) 1979-12-02
HU180045B (en) 1983-01-28
JPS5936988B2 (en) 1984-09-06
PL117515B1 (en) 1981-08-31
PT69718A (en) 1979-07-01
ZA792729B (en) 1981-03-25
CS216927B2 (en) 1982-12-31
DK150068B (en) 1986-12-01
GR73142B (en) 1984-02-09
SU843746A3 (en) 1981-06-30
GB2022085B (en) 1983-01-12
AT373248B (en) 1983-12-27
LU81349A1 (en) 1979-12-07
NO150760B (en) 1984-09-03
ATA401679A (en) 1983-05-15
PL216030A1 (en) 1980-03-10
ES481220A1 (en) 1980-09-01
KE3459A (en) 1984-10-12
DK150068C (en) 1987-06-29
CA1117949A (en) 1982-02-09
DD144055A5 (en) 1980-09-24
IL57450A0 (en) 1979-09-30
AU4763479A (en) 1979-12-06
MY8500318A (en) 1985-12-31
JPS54160369A (en) 1979-12-19
IT1121238B (en) 1986-03-26

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930523