WO2003027085A3 - 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors - Google Patents
3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors Download PDFInfo
- Publication number
- WO2003027085A3 WO2003027085A3 PCT/US2002/030483 US0230483W WO03027085A3 WO 2003027085 A3 WO2003027085 A3 WO 2003027085A3 US 0230483 W US0230483 W US 0230483W WO 03027085 A3 WO03027085 A3 WO 03027085A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pyridyl
- thiazoles
- isoquinolinyl
- cancer
- lyase inhibitors
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002461360A CA2461360A1 (en) | 2001-09-26 | 2002-09-26 | 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors |
AU2002362603A AU2002362603A1 (en) | 2001-09-26 | 2002-09-26 | 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors |
US10/490,822 US20040267017A1 (en) | 2001-09-26 | 2002-09-26 | 3-pyridyl or 4-isoquinolinyl thiazoles as c17, 20 lyase inhibitors |
EP02799636A EP1432706A2 (en) | 2001-09-26 | 2002-09-26 | 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors |
JP2003530675A JP2005532983A (en) | 2001-09-26 | 2002-09-26 | 3-Pyridyl or 4-isoquinolinyl thiazole as C17,20 lyase inhibitor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32499301P | 2001-09-26 | 2001-09-26 | |
US60/324,993 | 2001-09-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003027085A2 WO2003027085A2 (en) | 2003-04-03 |
WO2003027085A3 true WO2003027085A3 (en) | 2003-12-04 |
Family
ID=23265979
Family Applications (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/030979 WO2003027101A1 (en) | 2001-09-26 | 2002-09-26 | Substituted 3-pyridyl pyrroles and 3-pyridyl pyrazoles as c17,20 lyase inhibitors |
PCT/US2002/030834 WO2003027107A1 (en) | 2001-09-26 | 2002-09-26 | Substituted 3-pyridyl oxazoles as c17,20 lyase inhibitors |
PCT/US2002/030924 WO2003027100A1 (en) | 2001-09-26 | 2002-09-26 | Substituted 3-pyridyl pyrimidines as c17,20 lyase inhibitors |
PCT/US2002/030981 WO2003027105A1 (en) | 2001-09-26 | 2002-09-26 | Substituted 3-pyridyl thiophenes as c17,20 lyase inhibitors |
PCT/US2002/030982 WO2003027095A1 (en) | 2001-09-26 | 2002-09-26 | Substituted 3-pyridyl tetrazoles as steroid c17,20 lyase inhibitors |
PCT/US2002/030983 WO2003027096A1 (en) | 2001-09-26 | 2002-09-26 | Substituted 3-pyridyl imidazoles as c17,20 lyase inhibitors |
PCT/US2002/030483 WO2003027085A2 (en) | 2001-09-26 | 2002-09-26 | 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors |
PCT/US2002/030482 WO2003027094A2 (en) | 2001-09-26 | 2002-09-26 | Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors |
Family Applications Before (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/030979 WO2003027101A1 (en) | 2001-09-26 | 2002-09-26 | Substituted 3-pyridyl pyrroles and 3-pyridyl pyrazoles as c17,20 lyase inhibitors |
PCT/US2002/030834 WO2003027107A1 (en) | 2001-09-26 | 2002-09-26 | Substituted 3-pyridyl oxazoles as c17,20 lyase inhibitors |
PCT/US2002/030924 WO2003027100A1 (en) | 2001-09-26 | 2002-09-26 | Substituted 3-pyridyl pyrimidines as c17,20 lyase inhibitors |
PCT/US2002/030981 WO2003027105A1 (en) | 2001-09-26 | 2002-09-26 | Substituted 3-pyridyl thiophenes as c17,20 lyase inhibitors |
PCT/US2002/030982 WO2003027095A1 (en) | 2001-09-26 | 2002-09-26 | Substituted 3-pyridyl tetrazoles as steroid c17,20 lyase inhibitors |
PCT/US2002/030983 WO2003027096A1 (en) | 2001-09-26 | 2002-09-26 | Substituted 3-pyridyl imidazoles as c17,20 lyase inhibitors |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/030482 WO2003027094A2 (en) | 2001-09-26 | 2002-09-26 | Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors |
Country Status (5)
Country | Link |
---|---|
EP (2) | EP1432706A2 (en) |
JP (2) | JP2005532983A (en) |
AU (2) | AU2002340010A1 (en) |
CA (2) | CA2461363A1 (en) |
WO (8) | WO2003027101A1 (en) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4160295B2 (en) * | 2000-12-08 | 2008-10-01 | 武田薬品工業株式会社 | Substituted thiazole derivatives having a 3-pyridyl group, method for producing the same, and use thereof |
EP1348706B1 (en) * | 2000-12-08 | 2009-08-19 | Takeda Pharmaceutical Company Limited | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof |
US20040147561A1 (en) * | 2002-12-27 | 2004-07-29 | Wenge Zhong | Pyrid-2-one derivatives and methods of use |
JP4847868B2 (en) * | 2003-05-14 | 2011-12-28 | ニューロジェネティック ファーマシューティカルズ、 インコーポレイテッド | Compounds and their use in the regulation of amyloid beta |
ES2222827B1 (en) * | 2003-07-30 | 2006-03-01 | Laboratorios Del Dr. Esteve, S.A. | DERIVATIVES OF 5-INDOLILSULFONAMIDS, ITS PREPARATION AND ITS APPLICATION AS MEDICINES. |
EP1682127B1 (en) * | 2003-11-14 | 2009-07-29 | Vertex Pharmaceuticals Incorporated | Thiazoles and oxazoles useful as modulators of atp-binding cassette transporters |
ATE485824T1 (en) * | 2004-04-13 | 2010-11-15 | Icagen Inc | POLYCYCLIC PYRIMIDINES AS POTASSIUM ION CHANNEL MODULATORS |
JP4602686B2 (en) * | 2004-04-15 | 2010-12-22 | 広栄化学工業株式会社 | Process for producing 2,6-dihalogeno-4-arylpyridines |
EP1799659A1 (en) * | 2004-10-13 | 2007-06-27 | PTC Therapeutics, Inc. | Compounds for nonsense suppression, and methods for their use |
JP5214971B2 (en) | 2004-10-20 | 2013-06-19 | メルク セローノ ソシエテ アノニム | 3-allylaminopiperidine derivatives |
WO2006051723A1 (en) * | 2004-11-09 | 2006-05-18 | Kaneka Corporation | Method for producing 1-halo-3-aryl-2-propanone |
GB0428514D0 (en) * | 2004-12-31 | 2005-02-09 | Prosidion Ltd | Compounds |
KR20070114123A (en) * | 2005-01-19 | 2007-11-29 | 바이올리폭스 에이비 | Indoles useful in the treatment of inflammation |
EP1879575A2 (en) | 2005-05-09 | 2008-01-23 | Achillion Pharmaceuticals, Inc. | Thiazole compounds and methods of use |
BRPI0614188A2 (en) * | 2005-07-29 | 2011-03-15 | 4Sc Ag | heterocyclic nf-kappab inhibitor compounds, their use and pharmaceutical composition |
FR2889526B1 (en) | 2005-08-04 | 2012-02-17 | Aventis Pharma Sa | SUBSTITUTED 7-AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PROCESS FOR PRODUCTION AND USE |
KR20080066938A (en) * | 2005-10-07 | 2008-07-17 | 깃세이 야쿠힌 고교 가부시키가이샤 | Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same |
TWI385169B (en) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | Heterocyclic substituted pyridine derivatives and antifungal agent containing same |
WO2007077961A2 (en) * | 2005-12-28 | 2007-07-12 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds and their use as mineralocorticoid receptor ligands |
JP5068768B2 (en) | 2006-01-18 | 2012-11-07 | エフ.ホフマン−ラ ロシュ アーゲー | Thiazole as an 11 beta-HSD1 inhibitor |
JP4912414B2 (en) * | 2006-01-24 | 2012-04-11 | イーライ リリー アンド カンパニー | Indolesulfonamide-based progesterone receptor modulators |
PL2001849T3 (en) * | 2006-03-29 | 2015-04-30 | Hoffmann La Roche | Pyridine and pyrimidine derivatives as mglur2 antagonists |
US7538107B2 (en) | 2006-08-15 | 2009-05-26 | Wyeth | Oxazinan-2-one derivatives useful as PR modulators |
WO2008021338A2 (en) | 2006-08-15 | 2008-02-21 | Wyeth | Tricyclic oxazolidone derivatives useful as pr modulators |
WO2008021309A1 (en) | 2006-08-15 | 2008-02-21 | Wyeth | Imidazolidin-2-one derivatives useful as pr modulators |
US7649007B2 (en) | 2006-08-15 | 2010-01-19 | Wyeth Llc | Oxazolidine derivatives as PR modulators |
ATE534642T1 (en) * | 2006-09-21 | 2011-12-15 | Eisai R&D Man Co Ltd | PYRIDINE DERIVATIVE SUBSTITUTED BY A HETEROARYL RING AND ANTIFUNGAL AGENT CONTAINING SAME |
WO2008035726A1 (en) | 2006-09-21 | 2008-03-27 | Eisai R & D Management Co., Ltd. | Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same |
EP2076265A4 (en) | 2006-10-02 | 2010-09-22 | Cortendo Invest Ab | Ketoconazole enantiomer in humans |
WO2008070350A2 (en) | 2006-10-27 | 2008-06-12 | The Board Of Regents Of The University Of Texas System | Methods and compositions related to wrapping of dehydrons |
US9187485B2 (en) | 2007-02-02 | 2015-11-17 | Baylor College Of Medicine | Methods and compositions for the treatment of cancer and related hyperproliferative disorders |
CN101801964A (en) | 2007-05-22 | 2010-08-11 | 艾其林医药公司 | Heteroaryl substituted thiazoles and their use as antiviral agents |
HUE036519T2 (en) | 2007-08-13 | 2018-07-30 | Monsanto Technology Llc | Compositions and methods for controlling nematodes |
PT2195312E (en) | 2007-10-09 | 2013-02-20 | Merck Patent Gmbh | Pyridine derivatives useful as glucokinase activators |
US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
AU2009203693B2 (en) * | 2008-01-11 | 2012-06-07 | Novartis Ag | Pyrimidines as kinase inhibitors |
WO2009094224A1 (en) | 2008-01-25 | 2009-07-30 | Millennium Pharmaceuticals, Inc. | Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors |
KR101047242B1 (en) | 2008-02-08 | 2011-07-06 | 가부시키가이샤 시세이도 | Whitening and external skin preparations |
US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
US8822513B2 (en) | 2010-03-01 | 2014-09-02 | Gtx, Inc. | Compounds for treatment of cancer |
TR201903981T4 (en) * | 2008-06-16 | 2019-04-22 | Univ Ohio State Res Found | Compounds for cancer treatment. |
US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
WO2010022121A1 (en) * | 2008-08-20 | 2010-02-25 | Schering Corporation | Substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
KR101406433B1 (en) | 2008-09-22 | 2014-06-13 | 카이맨 케미칼 컴파니 인코포레이티드 | Multiheteroaryl compounds as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
CN102395585A (en) | 2009-01-30 | 2012-03-28 | 米伦纽姆医药公司 | Heteroaryls and their use as pi3k inhibitors |
US9090601B2 (en) | 2009-01-30 | 2015-07-28 | Millennium Pharmaceuticals, Inc. | Thiazole derivatives |
US8796314B2 (en) | 2009-01-30 | 2014-08-05 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
TW201038553A (en) * | 2009-03-19 | 2010-11-01 | Sanofi Aventis | Novel indazole derivatives which inhibit HSP90, compositions containing them and use thereof |
US9216972B2 (en) * | 2009-10-29 | 2015-12-22 | Bristol-Myers Squibb Company | Tricyclic heterocyclic compounds |
WO2011051198A2 (en) * | 2009-10-30 | 2011-05-05 | Bayer Cropscience Ag | Pyridine derivatives as agricultural pesticides |
DE102009058280A1 (en) * | 2009-12-14 | 2011-06-16 | Merck Patent Gmbh | thiazole |
JP5879273B2 (en) | 2010-03-01 | 2016-03-08 | ジーティーエックス・インコーポレイテッド | Compounds for treating cancer |
CN103140490A (en) | 2010-07-15 | 2013-06-05 | 百时美施贵宝公司 | Azaindazole compounds |
CA2807149C (en) | 2010-08-04 | 2017-05-02 | Pellficure Pharmaceuticals, Inc. | Novel treatment of prostate carcinoma |
CA2807971A1 (en) | 2010-08-11 | 2012-02-16 | Millenium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
EP2603216A4 (en) | 2010-08-11 | 2013-12-18 | Millennium Pharm Inc | Heteroaryls and uses thereof |
US9062038B2 (en) | 2010-08-11 | 2015-06-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
UY33671A (en) | 2010-10-13 | 2012-04-30 | Millenium Pharmaceuticals Inc | HETEROARILOS AND ITS USES |
EP2630133A1 (en) * | 2010-10-22 | 2013-08-28 | Bayer Intellectual Property GmbH | Novel heterocyclic compounds as pesticides |
EP2632903A4 (en) * | 2010-10-28 | 2014-11-26 | Viamet Pharmaceuticals Inc | Metalloenzyme inhibitor compounds |
US9266880B2 (en) | 2010-11-12 | 2016-02-23 | Bristol-Myers Squibb Company | Substituted azaindazole compounds |
GB2485404A (en) * | 2010-11-15 | 2012-05-16 | Nat Univ Ireland | Metal-complexed pyridyl-substituted tetrazole compounds and their use in treating cancer |
CN102675286B (en) * | 2011-03-07 | 2015-08-19 | 中国科学院上海药物研究所 | One class indazole compounds and preparation method thereof, purposes and pharmaceutical composition |
MX359399B (en) * | 2011-04-28 | 2018-09-27 | Novartis Ag | 17a-HYDROXYLASE/C17,20-LYASE INHIBITORS. |
US20120302573A1 (en) * | 2011-05-25 | 2012-11-29 | Paul Francis Jackson | Methods of inhibiting pro matrix metalloproteinase activation |
US8969586B2 (en) | 2011-09-27 | 2015-03-03 | Bristol-Myers Squibb Company | Substituted bicyclic heteroaryl compounds |
US9550750B2 (en) | 2012-10-05 | 2017-01-24 | Merck Sharp & Dohme Corp. | Indoline compounds as aldosterone synthase inhibitors |
EP2934144B1 (en) * | 2012-12-20 | 2017-07-19 | Merck Sharp & Dohme Corp. | Indazole compounds as aldosterone synthase inhibitors |
CN109568312A (en) | 2013-03-05 | 2019-04-05 | 田纳西大学研究基金会 | Compound for treating cancer |
CA2902335C (en) | 2013-03-14 | 2021-09-14 | Pellficure Pharmaceuticals, Inc. | Novel therapy for prostate carcinoma |
EP3191087A1 (en) | 2014-09-12 | 2017-07-19 | Pellficure Pharmaceuticals, Inc. | Compositions and methods for treatment of prostate carcinoma |
EP3528799A1 (en) | 2016-10-24 | 2019-08-28 | Pellficure Pharmaceuticals, Inc. | Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione |
JP7193071B2 (en) * | 2017-02-08 | 2022-12-20 | 国立大学法人東海国立大学機構 | Fluorescent materials and UV absorbers |
WO2021126779A1 (en) * | 2019-12-18 | 2021-06-24 | The Regents Of The University Of California | Inhibitors of lin28 and methods of use thereof |
US20210246109A1 (en) * | 2020-02-11 | 2021-08-12 | University Of Kentucky Research Foundation | Potent and selective inhibitors of cytochrome p450 |
WO2023049199A1 (en) * | 2021-09-24 | 2023-03-30 | Zeno Management, Inc. | Azole compounds |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2022085A (en) * | 1978-06-02 | 1979-12-12 | Pfizer | Novel Aminothiazoles |
JPS55133366A (en) * | 1979-04-05 | 1980-10-17 | Otsuka Pharmaceut Factory Inc | Thiazole derivative |
JPH04154773A (en) * | 1990-10-15 | 1992-05-27 | Green Cross Corp:The | Thiazole derivative |
EP0790057A1 (en) * | 1994-11-29 | 1997-08-20 | Hisamitsu Pharmaceutical Co., Inc. | Antibacterial or bactericide comprising 2-aminothiazole derivative and salts thereof |
WO1999058511A1 (en) * | 1998-05-12 | 1999-11-18 | American Home Products Corporation | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia |
WO2001064674A1 (en) * | 2000-03-01 | 2001-09-07 | Janssen Pharmaceutica N.V. | 2,4-disubstituted thiazolyl derivatives |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4536505A (en) * | 1983-05-17 | 1985-08-20 | Ciba-Geigy Corporation | Certain N-(pyridyl) indoles |
DE3940476A1 (en) * | 1989-12-07 | 1991-06-13 | Bayer Ag | PYRIDINYLPYRIMIDINE DERIVATIVES |
DE3940477A1 (en) * | 1989-12-07 | 1991-06-13 | Bayer Ag | HETARYL-SUBSTITUTED PYRIDINYLPYRIMIDINE DERIVATIVES |
DE4117560A1 (en) * | 1991-05-29 | 1992-12-03 | Bayer Ag | USE OF PYRIDINYLPYRIMIDINE DERIVATIVES TO PROTECT TECHNICAL MATERIALS |
TW223004B (en) * | 1991-11-25 | 1994-05-01 | Sumitomo Chemical Co | |
US5395817A (en) * | 1992-01-22 | 1995-03-07 | Imperial Chemical Industries Plc | N-arylindoles and their use as herbicides |
US5599774A (en) * | 1992-01-22 | 1997-02-04 | Imperial Chemical Industries Plc | N-arylindoles and their use as herbicides |
US5444038A (en) * | 1992-03-09 | 1995-08-22 | Zeneca Limited | Arylindazoles and their use as herbicides |
HU217661B (en) * | 1992-03-09 | 2000-03-28 | Zeneca Ltd. | Arylindazol derivatives, process for their preparation and their use as herbicides |
US6046136A (en) * | 1997-06-24 | 2000-04-04 | Zeneca Limited | Herbicidal heterocyclic N-oxides compounds |
US5840721A (en) * | 1997-07-09 | 1998-11-24 | Ontogen Corporation | Imidazole derivatives as MDR modulators |
JP3409029B2 (en) * | 1997-10-03 | 2003-05-19 | メルク フロスト カナダ アンド カンパニー | Arylthiophene derivatives as PDEIV inhibitors |
AU5227999A (en) * | 1998-07-27 | 2000-02-21 | Abbott Laboratories | Substituted oxazolines as antiproliferative agents |
-
2002
- 2002-09-26 EP EP02799636A patent/EP1432706A2/en not_active Withdrawn
- 2002-09-26 WO PCT/US2002/030979 patent/WO2003027101A1/en not_active Application Discontinuation
- 2002-09-26 WO PCT/US2002/030834 patent/WO2003027107A1/en not_active Application Discontinuation
- 2002-09-26 EP EP02778338A patent/EP1432698A2/en not_active Withdrawn
- 2002-09-26 WO PCT/US2002/030924 patent/WO2003027100A1/en not_active Application Discontinuation
- 2002-09-26 WO PCT/US2002/030981 patent/WO2003027105A1/en not_active Application Discontinuation
- 2002-09-26 AU AU2002340010A patent/AU2002340010A1/en not_active Abandoned
- 2002-09-26 CA CA002461363A patent/CA2461363A1/en not_active Abandoned
- 2002-09-26 WO PCT/US2002/030982 patent/WO2003027095A1/en not_active Application Discontinuation
- 2002-09-26 JP JP2003530675A patent/JP2005532983A/en not_active Withdrawn
- 2002-09-26 JP JP2003530682A patent/JP2005528325A/en not_active Withdrawn
- 2002-09-26 CA CA002461360A patent/CA2461360A1/en not_active Abandoned
- 2002-09-26 WO PCT/US2002/030983 patent/WO2003027096A1/en not_active Application Discontinuation
- 2002-09-26 WO PCT/US2002/030483 patent/WO2003027085A2/en not_active Application Discontinuation
- 2002-09-26 AU AU2002362603A patent/AU2002362603A1/en not_active Abandoned
- 2002-09-26 WO PCT/US2002/030482 patent/WO2003027094A2/en not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2022085A (en) * | 1978-06-02 | 1979-12-12 | Pfizer | Novel Aminothiazoles |
JPS55133366A (en) * | 1979-04-05 | 1980-10-17 | Otsuka Pharmaceut Factory Inc | Thiazole derivative |
JPH04154773A (en) * | 1990-10-15 | 1992-05-27 | Green Cross Corp:The | Thiazole derivative |
EP0790057A1 (en) * | 1994-11-29 | 1997-08-20 | Hisamitsu Pharmaceutical Co., Inc. | Antibacterial or bactericide comprising 2-aminothiazole derivative and salts thereof |
WO1999058511A1 (en) * | 1998-05-12 | 1999-11-18 | American Home Products Corporation | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia |
WO2001064674A1 (en) * | 2000-03-01 | 2001-09-07 | Janssen Pharmaceutica N.V. | 2,4-disubstituted thiazolyl derivatives |
Non-Patent Citations (3)
Title |
---|
DN GRIGORYEV, BJ LONG, IP NANE,VCO NJAR, Y LIU AND AMH BRODIE: "Effects of new 17alpha-hydroxylase/C17,20-lyase inhibitors on LNCaP prostate cancer cell growth in vitro and in vivo", BRITISH JOURNAL OF CANCER, vol. 81, no. 4, 1999, pages 622 - 630, XP009001303 * |
PATENT ABSTRACTS OF JAPAN * |
YAN ZHUANG AND ROLF W. HARTMANN: "Synthesis and Evaluation of Azole-substituted 2-Aryl-6-methoxy-3,4-dihydronaphthalenes and -naphthalenes as Inhibitors of 17 alpha-Hydroxylase-C17,20-Lyase (P450 17)", ARCH. PHARM. PHARM. MED. CHEM., vol. 332, 1999, pages 25 - 30, XP002222972 * |
Also Published As
Publication number | Publication date |
---|---|
WO2003027094A3 (en) | 2003-10-23 |
WO2003027107A1 (en) | 2003-04-03 |
WO2003027096A1 (en) | 2003-04-03 |
WO2003027100A1 (en) | 2003-04-03 |
WO2003027105A1 (en) | 2003-04-03 |
WO2003027085A2 (en) | 2003-04-03 |
AU2002362603A1 (en) | 2003-04-07 |
JP2005528325A (en) | 2005-09-22 |
AU2002340010A1 (en) | 2003-04-07 |
EP1432706A2 (en) | 2004-06-30 |
JP2005532983A (en) | 2005-11-04 |
WO2003027094A2 (en) | 2003-04-03 |
WO2003027095A1 (en) | 2003-04-03 |
EP1432698A2 (en) | 2004-06-30 |
CA2461363A1 (en) | 2003-04-03 |
WO2003027101A1 (en) | 2003-04-03 |
CA2461360A1 (en) | 2003-04-03 |
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