FR2446819A1 - Derives 6-alkyles d'acide 1,2-dihydro-2-oxonicotinique et composition pharmaceutique les contenant - Google Patents

Derives 6-alkyles d'acide 1,2-dihydro-2-oxonicotinique et composition pharmaceutique les contenant

Info

Publication number
FR2446819A1
FR2446819A1 FR8001220A FR8001220A FR2446819A1 FR 2446819 A1 FR2446819 A1 FR 2446819A1 FR 8001220 A FR8001220 A FR 8001220A FR 8001220 A FR8001220 A FR 8001220A FR 2446819 A1 FR2446819 A1 FR 2446819A1
Authority
FR
France
Prior art keywords
dihydro
alkyl derivatives
pharmaceutical composition
composition containing
oxonicotinic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8001220A
Other languages
English (en)
Other versions
FR2446819B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FR2446819A1 publication Critical patent/FR2446819A1/fr
Application granted granted Critical
Publication of FR2446819B1 publication Critical patent/FR2446819B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/185—Saturated compounds containing keto groups bound to acyclic carbon atoms containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention a trait au domaine de la chimie pharmaceutique. Elle concerne certains nouveaux dérivés 6-alkyliques d'acide 1,2-dihydro-2-oxonicotinique de formule :
FR8001220A 1979-01-22 1980-01-21 Derives 6-alkyles d'acide 1,2-dihydro-2-oxonicotinique et composition pharmaceutique les contenant Expired FR2446819B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/005,454 US4220648A (en) 1979-01-22 1979-01-22 Antidiabetic 1,2-dihydro-2-oxo-6-neopentyl-nicotinic acids

Publications (2)

Publication Number Publication Date
FR2446819A1 true FR2446819A1 (fr) 1980-08-14
FR2446819B1 FR2446819B1 (fr) 1986-02-28

Family

ID=21715959

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8001220A Expired FR2446819B1 (fr) 1979-01-22 1980-01-21 Derives 6-alkyles d'acide 1,2-dihydro-2-oxonicotinique et composition pharmaceutique les contenant

Country Status (8)

Country Link
US (1) US4220648A (fr)
JP (1) JPS55100363A (fr)
BE (1) BE881278A (fr)
DE (1) DE2952652A1 (fr)
FR (1) FR2446819B1 (fr)
GB (1) GB2040287B (fr)
IT (1) IT8047619A0 (fr)
NL (1) NL7909349A (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2489330A1 (fr) * 1980-08-29 1982-03-05 Upjohn Co 6-alkyl-1, 2-dihydro-2-oxo-pyridines a substituant tetrazolyle ou carboxaldehyde en position 3 et composition pharmaceutique les contenant
FR2514762A1 (fr) * 1981-10-19 1983-04-22 Upjohn Co Nouveaux composes a la pyridine et composition pharmaceutique les contenant

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314063A (en) * 1979-07-13 1982-02-02 Hoffmann-La Roche Inc. 1-Ethyl-1,4,5,6-tetrahydro-6-(2-naphthyl)-4-oxo-nicotinic acid and lower alkyl esters thereof
US5212314A (en) * 1983-11-03 1993-05-18 Merrell Dow Pharmaceuticals Inc. Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
US4849522A (en) * 1983-11-03 1989-07-18 Merrell Dow Pharmaceuticals Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
ZA848428B (en) * 1983-11-03 1985-06-26 Merrell Pharma Inc Novel alkoxyimino ether derivatives of 5-acyl-2(1h)-pyridiones
US6099859A (en) * 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
US7959946B2 (en) 2002-09-20 2011-06-14 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US9060941B2 (en) * 2002-09-20 2015-06-23 Actavis, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7785627B2 (en) * 2002-09-20 2010-08-31 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
EP1882472B1 (fr) * 2005-05-17 2018-08-22 Morinaga Milk Industry Co., Ltd. Médicaments, aliment ou boisson destinés à l'amélioration des fonctions pancréatiques

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873523A (en) * 1972-12-15 1975-03-25 Parke Davis & Co Derivatives of ampicillin
US4038065A (en) * 1974-10-11 1977-07-26 Rohm And Haas Company 1-alkylpyrid-2-one
DE2637477A1 (de) * 1976-08-20 1978-02-23 Hoechst Ag Dihydro-oxo-nicotinsaeuren und verfahren zu ihrer herstellung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873523A (en) * 1972-12-15 1975-03-25 Parke Davis & Co Derivatives of ampicillin
US4038065A (en) * 1974-10-11 1977-07-26 Rohm And Haas Company 1-alkylpyrid-2-one
DE2637477A1 (de) * 1976-08-20 1978-02-23 Hoechst Ag Dihydro-oxo-nicotinsaeuren und verfahren zu ihrer herstellung

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CA1953 *
EXBK/47 *
EXBK/50 *
EXBK/51 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2489330A1 (fr) * 1980-08-29 1982-03-05 Upjohn Co 6-alkyl-1, 2-dihydro-2-oxo-pyridines a substituant tetrazolyle ou carboxaldehyde en position 3 et composition pharmaceutique les contenant
FR2514762A1 (fr) * 1981-10-19 1983-04-22 Upjohn Co Nouveaux composes a la pyridine et composition pharmaceutique les contenant

Also Published As

Publication number Publication date
IT8047619A0 (it) 1980-01-16
BE881278A (fr) 1980-07-22
FR2446819B1 (fr) 1986-02-28
GB2040287B (en) 1982-12-08
DE2952652A1 (de) 1980-07-24
JPS55100363A (en) 1980-07-31
NL7909349A (nl) 1980-07-24
GB2040287A (en) 1980-08-28
US4220648A (en) 1980-09-02

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