FR2446819B1 - Derives 6-alkyles d'acide 1,2-dihydro-2-oxonicotinique et composition pharmaceutique les contenant - Google Patents
Derives 6-alkyles d'acide 1,2-dihydro-2-oxonicotinique et composition pharmaceutique les contenantInfo
- Publication number
- FR2446819B1 FR2446819B1 FR8001220A FR8001220A FR2446819B1 FR 2446819 B1 FR2446819 B1 FR 2446819B1 FR 8001220 A FR8001220 A FR 8001220A FR 8001220 A FR8001220 A FR 8001220A FR 2446819 B1 FR2446819 B1 FR 2446819B1
- Authority
- FR
- France
- Prior art keywords
- dihydro
- pharmaceutical composition
- composition containing
- alkyl derivatives
- oxonicotinic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/185—Saturated compounds containing keto groups bound to acyclic carbon atoms containing —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/005,454 US4220648A (en) | 1979-01-22 | 1979-01-22 | Antidiabetic 1,2-dihydro-2-oxo-6-neopentyl-nicotinic acids |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2446819A1 FR2446819A1 (fr) | 1980-08-14 |
FR2446819B1 true FR2446819B1 (fr) | 1986-02-28 |
Family
ID=21715959
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8001220A Expired FR2446819B1 (fr) | 1979-01-22 | 1980-01-21 | Derives 6-alkyles d'acide 1,2-dihydro-2-oxonicotinique et composition pharmaceutique les contenant |
Country Status (8)
Country | Link |
---|---|
US (1) | US4220648A (fr) |
JP (1) | JPS55100363A (fr) |
BE (1) | BE881278A (fr) |
DE (1) | DE2952652A1 (fr) |
FR (1) | FR2446819B1 (fr) |
GB (1) | GB2040287B (fr) |
IT (1) | IT8047619A0 (fr) |
NL (1) | NL7909349A (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4314063A (en) * | 1979-07-13 | 1982-02-02 | Hoffmann-La Roche Inc. | 1-Ethyl-1,4,5,6-tetrahydro-6-(2-naphthyl)-4-oxo-nicotinic acid and lower alkyl esters thereof |
US4288440A (en) * | 1980-08-29 | 1981-09-08 | The Upjohn Company | Pyridinones |
US4645766A (en) * | 1981-10-19 | 1987-02-24 | The Upjohn Company | 1,2-dihydro-2-oxo-3-hydroxymethyl pyridines, compositions and use |
US5212314A (en) * | 1983-11-03 | 1993-05-18 | Merrell Dow Pharmaceuticals Inc. | Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones |
US4849522A (en) * | 1983-11-03 | 1989-07-18 | Merrell Dow Pharmaceuticals | Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones |
ZA848428B (en) * | 1983-11-03 | 1985-06-26 | Merrell Pharma Inc | Novel alkoxyimino ether derivatives of 5-acyl-2(1h)-pyridiones |
US6099859A (en) | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
US9060941B2 (en) * | 2002-09-20 | 2015-06-23 | Actavis, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
US7785627B2 (en) * | 2002-09-20 | 2010-08-31 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
US7959946B2 (en) | 2002-09-20 | 2011-06-14 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
JP4065018B2 (ja) * | 2005-05-17 | 2008-03-19 | 森永乳業株式会社 | 膵臓機能改善のための医薬又は飲食品 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3873523A (en) * | 1972-12-15 | 1975-03-25 | Parke Davis & Co | Derivatives of ampicillin |
US4038065A (en) * | 1974-10-11 | 1977-07-26 | Rohm And Haas Company | 1-alkylpyrid-2-one |
DE2637477A1 (de) * | 1976-08-20 | 1978-02-23 | Hoechst Ag | Dihydro-oxo-nicotinsaeuren und verfahren zu ihrer herstellung |
-
1979
- 1979-01-22 US US06/005,454 patent/US4220648A/en not_active Expired - Lifetime
- 1979-12-28 NL NL7909349A patent/NL7909349A/nl not_active Application Discontinuation
- 1979-12-28 DE DE19792952652 patent/DE2952652A1/de not_active Withdrawn
-
1980
- 1980-01-16 IT IT8047619A patent/IT8047619A0/it unknown
- 1980-01-16 GB GB8001443A patent/GB2040287B/en not_active Expired
- 1980-01-21 FR FR8001220A patent/FR2446819B1/fr not_active Expired
- 1980-01-22 JP JP625380A patent/JPS55100363A/ja active Pending
- 1980-01-22 BE BE0/199060A patent/BE881278A/fr not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE2952652A1 (de) | 1980-07-24 |
JPS55100363A (en) | 1980-07-31 |
GB2040287B (en) | 1982-12-08 |
US4220648A (en) | 1980-09-02 |
FR2446819A1 (fr) | 1980-08-14 |
NL7909349A (nl) | 1980-07-24 |
GB2040287A (en) | 1980-08-28 |
BE881278A (fr) | 1980-07-22 |
IT8047619A0 (it) | 1980-01-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |