BE881278A - Derives 6-alkyles d'acide 1,2-dihydro-2-oxonicotinique et composition pharmaceutique les contenant - Google Patents

Derives 6-alkyles d'acide 1,2-dihydro-2-oxonicotinique et composition pharmaceutique les contenant

Info

Publication number
BE881278A
BE881278A BE0/199060A BE199060A BE881278A BE 881278 A BE881278 A BE 881278A BE 0/199060 A BE0/199060 A BE 0/199060A BE 199060 A BE199060 A BE 199060A BE 881278 A BE881278 A BE 881278A
Authority
BE
Belgium
Prior art keywords
dihydro
pharmaceutical composition
composition containing
alkyl derivatives
oxonicotinic acid
Prior art date
Application number
BE0/199060A
Other languages
English (en)
Inventor
G Youngdale
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of BE881278A publication Critical patent/BE881278A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/185—Saturated compounds containing keto groups bound to acyclic carbon atoms containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
BE0/199060A 1979-01-22 1980-01-22 Derives 6-alkyles d'acide 1,2-dihydro-2-oxonicotinique et composition pharmaceutique les contenant BE881278A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/005,454 US4220648A (en) 1979-01-22 1979-01-22 Antidiabetic 1,2-dihydro-2-oxo-6-neopentyl-nicotinic acids

Publications (1)

Publication Number Publication Date
BE881278A true BE881278A (fr) 1980-07-22

Family

ID=21715959

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/199060A BE881278A (fr) 1979-01-22 1980-01-22 Derives 6-alkyles d'acide 1,2-dihydro-2-oxonicotinique et composition pharmaceutique les contenant

Country Status (8)

Country Link
US (1) US4220648A (fr)
JP (1) JPS55100363A (fr)
BE (1) BE881278A (fr)
DE (1) DE2952652A1 (fr)
FR (1) FR2446819B1 (fr)
GB (1) GB2040287B (fr)
IT (1) IT8047619A0 (fr)
NL (1) NL7909349A (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314063A (en) * 1979-07-13 1982-02-02 Hoffmann-La Roche Inc. 1-Ethyl-1,4,5,6-tetrahydro-6-(2-naphthyl)-4-oxo-nicotinic acid and lower alkyl esters thereof
US4288440A (en) * 1980-08-29 1981-09-08 The Upjohn Company Pyridinones
US4645766A (en) * 1981-10-19 1987-02-24 The Upjohn Company 1,2-dihydro-2-oxo-3-hydroxymethyl pyridines, compositions and use
ZA848428B (en) * 1983-11-03 1985-06-26 Merrell Pharma Inc Novel alkoxyimino ether derivatives of 5-acyl-2(1h)-pyridiones
US5212314A (en) * 1983-11-03 1993-05-18 Merrell Dow Pharmaceuticals Inc. Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
US4849522A (en) * 1983-11-03 1989-07-18 Merrell Dow Pharmaceuticals Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
US6099859A (en) * 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
US9060941B2 (en) * 2002-09-20 2015-06-23 Actavis, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7959946B2 (en) 2002-09-20 2011-06-14 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7785627B2 (en) * 2002-09-20 2010-08-31 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
EP1882472B1 (fr) * 2005-05-17 2018-08-22 Morinaga Milk Industry Co., Ltd. Médicaments, aliment ou boisson destinés à l'amélioration des fonctions pancréatiques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873523A (en) * 1972-12-15 1975-03-25 Parke Davis & Co Derivatives of ampicillin
US4038065A (en) * 1974-10-11 1977-07-26 Rohm And Haas Company 1-alkylpyrid-2-one
DE2637477A1 (de) * 1976-08-20 1978-02-23 Hoechst Ag Dihydro-oxo-nicotinsaeuren und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
NL7909349A (nl) 1980-07-24
GB2040287A (en) 1980-08-28
GB2040287B (en) 1982-12-08
DE2952652A1 (de) 1980-07-24
US4220648A (en) 1980-09-02
FR2446819B1 (fr) 1986-02-28
FR2446819A1 (fr) 1980-08-14
IT8047619A0 (it) 1980-01-16
JPS55100363A (en) 1980-07-31

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: THE UPJOHN CY

Effective date: 19860131