US20020006899A1
(en)
*
|
1998-10-06 |
2002-01-17 |
Pospisilik Andrew J. |
Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals
|
DE19616486C5
(de)
|
1996-04-25 |
2016-06-30 |
Royalty Pharma Collection Trust |
Verfahren zur Senkung des Blutglukosespiegels in Säugern
|
US6258597B1
(en)
*
|
1997-09-29 |
2001-07-10 |
Point Therapeutics, Inc. |
Stimulation of hematopoietic cells in vitro
|
DE69839279T2
(de)
*
|
1997-11-18 |
2009-05-28 |
Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai |
Neue physiologisch aktive substanz sulphostin, herstellung und verwendung derselben
|
EP1520582A3
(en)
*
|
1998-02-02 |
2009-07-01 |
Trustees Of Tufts College |
Use of dipeptidylpetidase inhibitors to regulate glucose metabolism
|
AU2007202745B2
(en)
*
|
1998-02-02 |
2010-11-18 |
1149336 Ontario, Inc. |
Method of regulating glucose metabolism, and reagents related thereto
|
US6255772B1
(en)
|
1998-02-27 |
2001-07-03 |
Micron Technology, Inc. |
Large-area FED apparatus and method for making same
|
DE19823831A1
(de)
*
|
1998-05-28 |
1999-12-02 |
Probiodrug Ges Fuer Arzneim |
Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
|
DE19828114A1
(de)
|
1998-06-24 |
2000-01-27 |
Probiodrug Ges Fuer Arzneim |
Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
|
DE19828113A1
(de)
*
|
1998-06-24 |
2000-01-05 |
Probiodrug Ges Fuer Arzneim |
Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
|
DE19834591A1
(de)
*
|
1998-07-31 |
2000-02-03 |
Probiodrug Ges Fuer Arzneim |
Verfahren zur Steigerung des Blutglukosespiegels in Säugern
|
US6979697B1
(en)
|
1998-08-21 |
2005-12-27 |
Point Therapeutics, Inc. |
Regulation of substrate activity
|
US20030176357A1
(en)
*
|
1998-10-06 |
2003-09-18 |
Pospisilik Andrew J. |
Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
|
US20050272652A1
(en)
*
|
1999-03-29 |
2005-12-08 |
Gault Victor A |
Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
|
ATE272650T1
(de)
|
1999-03-29 |
2004-08-15 |
Uutech Ltd |
Analoge des magensaft inhibierenden peptides und ihre verwendung für die behandlung von diabetes
|
US6890904B1
(en)
*
|
1999-05-25 |
2005-05-10 |
Point Therapeutics, Inc. |
Anti-tumor agents
|
DE19926233C1
(de)
|
1999-06-10 |
2000-10-19 |
Probiodrug Ges Fuer Arzneim |
Verfahren zur Herstellung von Thiazolidin
|
DE19940130A1
(de)
|
1999-08-24 |
2001-03-01 |
Probiodrug Ges Fuer Arzneim |
Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
|
AU1916401A
(en)
*
|
1999-11-12 |
2001-06-06 |
Guilford Pharmaceuticals Inc. |
Dipeptidyl peptidase iv inhibitors and methods of making and using dipeptidyl peptidase iv inhibitors
|
GB9928330D0
(en)
|
1999-11-30 |
2000-01-26 |
Ferring Bv |
Novel antidiabetic agents
|
CN1413107A
(zh)
*
|
1999-12-23 |
2003-04-23 |
诺瓦提斯公司 |
降血糖剂用于治疗葡萄糖代谢障碍
|
US6380398B2
(en)
|
2000-01-04 |
2002-04-30 |
Novo Nordisk A/S |
Therapeutically active and selective heterocyclic compounds that are inhibitors of the enzyme DPP-IV
|
DE60124861T2
(de)
*
|
2000-01-21 |
2007-05-10 |
Novartis Ag |
Zusammensetzungen bestehend aus dipeptidylpeptidase-iv inhibitoren und antidiabetica
|
JP2003520849A
(ja)
*
|
2000-01-24 |
2003-07-08 |
ノボ ノルディスク アクティーゼルスカブ |
酵素dpp−ivの阻害剤であるn−置換2−シアノピロールおよび−ピロリン
|
WO2001062266A2
(en)
*
|
2000-02-25 |
2001-08-30 |
Novo Nordisk A/S |
Use of dpp-iv inhibitors for the treatment of diabetes
|
US6395767B2
(en)
|
2000-03-10 |
2002-05-28 |
Bristol-Myers Squibb Company |
Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
|
BR0109553A
(pt)
|
2000-03-31 |
2003-06-03 |
Probiodrug Ag |
Método para o melhoramento de sinalização de ilhota em diabetes melito e para sua prevenção
|
AR033390A1
(es)
|
2000-08-22 |
2003-12-17 |
Novartis Ag |
Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
|
US7132104B1
(en)
|
2000-10-27 |
2006-11-07 |
Probiodrug Ag |
Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders
|
EP1891948A1
(en)
|
2000-10-27 |
2008-02-27 |
Probiodrug AG |
Treatment of neurological and neuropsychological disorders
|
IL155157A0
(en)
*
|
2000-10-27 |
2003-10-31 |
Probiodrug Ag |
Pharmaceutical compositions containing an attractin inhibitor
|
ES2253451T3
(es)
*
|
2000-12-14 |
2006-06-01 |
Ortho-Mcneil Pharmaceutical, Inc. |
Productos a base de hormona esteroide y sus procedimientos de fabricacion.
|
WO2002051836A1
(fr)
*
|
2000-12-27 |
2002-07-04 |
Kyowa Hakko Kogyo Co., Ltd. |
Inhibiteur de dipeptidyl peptidase iv
|
DE10100053A1
(de)
*
|
2001-01-02 |
2002-08-22 |
Keyneurotek Ag I G |
Verwendung von Enzyminhibitoren der Dipeptidylpeptidase IV sowie der Aminopeptidase N und pharmazeutischen Zubereitungen daraus zur Prävention und/oder Therapie Ischämie-bedingter akuter und chronischer neurodegenerativer Prozesse und Erkrankungen
|
EA007485B1
(ru)
*
|
2001-02-24 |
2006-10-27 |
Берингер Ингельхайм Фарма Гмбх Унд Ко. Кг |
Производные ксантина, способ их получения, фармацевтическая композиция на их основе и способ ее получения
|
JP2004525929A
(ja)
|
2001-03-27 |
2004-08-26 |
メルク エンド カムパニー インコーポレーテッド |
糖尿病の治療または予防用のジペプチジルペプチダーゼ阻害薬
|
US6890905B2
(en)
|
2001-04-02 |
2005-05-10 |
Prosidion Limited |
Methods for improving islet signaling in diabetes mellitus and for its prevention
|
GB0109146D0
(en)
*
|
2001-04-11 |
2001-05-30 |
Ferring Bv |
Treatment of type 2 diabetes
|
US20030060494A1
(en)
*
|
2001-05-18 |
2003-03-27 |
Nobuyuki Yasuda |
Pharmaceutical use of N-carbamoylazole derivatives
|
FR2826003B1
(fr)
*
|
2001-06-18 |
2003-08-15 |
Servier Lab |
Nouveaux derives cycliques d'alpha-amino-gamma-hydroxy- amides, leur procede de preparation et les compositions pharmaceutiques que les contiennent
|
EP1406872B1
(en)
|
2001-06-20 |
2007-12-19 |
Merck & Co., Inc. |
Dipeptidyl peptidase inhibitors for the treatment of diabetes
|
US7253172B2
(en)
|
2001-06-20 |
2007-08-07 |
Merck & Co., Inc. |
Dipeptidyl peptidase inhibitors for the treatment of diabetes
|
DE10150203A1
(de)
|
2001-10-12 |
2003-04-17 |
Probiodrug Ag |
Peptidylketone als Inhibitoren der DPIV
|
DE60222667T2
(de)
|
2001-06-27 |
2008-07-17 |
Smithkline Beecham Corp. |
Fluorpyrrolidine als dipeptidylpeptidaseinhibitoren
|
US20030130199A1
(en)
|
2001-06-27 |
2003-07-10 |
Von Hoersten Stephan |
Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
|
RU2299066C2
(ru)
*
|
2001-06-27 |
2007-05-20 |
Пробиодруг Аг |
Новые ингибиторы дипептидилпептидазы iv и их применение в качестве противораковых агентов
|
US7368421B2
(en)
|
2001-06-27 |
2008-05-06 |
Probiodrug Ag |
Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
|
UA74912C2
(en)
*
|
2001-07-06 |
2006-02-15 |
Merck & Co Inc |
Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
|
US20040214762A1
(en)
*
|
2001-08-16 |
2004-10-28 |
Hans-Ulrich Demuth |
Use of inhibitors of proline endopeptidase to modulate inositol (1,4,5) triphosphate concentration dependent on intracellular signal cascades
|
US6844316B2
(en)
|
2001-09-06 |
2005-01-18 |
Probiodrug Ag |
Inhibitors of dipeptidyl peptidase I
|
US6861440B2
(en)
|
2001-10-26 |
2005-03-01 |
Hoffmann-La Roche Inc. |
DPP IV inhibitors
|
AU2002360453C1
(en)
|
2001-11-26 |
2009-06-18 |
The Brigham And Women's Hospital, Inc. |
Methods for treating autoimmune disorders, and reagents related thereto
|
RU2327484C2
(ru)
*
|
2001-11-26 |
2008-06-27 |
Асубио Фарма Ко., Лтд |
Фармацевтическая композиция для назального всасывания
|
EP2316470A3
(en)
|
2001-11-26 |
2011-08-24 |
Trustees Of Tufts College |
Peptidomimetic inhibitors of post-proline cleaving enzymes
|
RU2293731C2
(ru)
|
2002-02-13 |
2007-02-20 |
Ф.Хоффманн-Ля Рош Аг |
Производные пиридина и пиримидина, способы их получения (варианты), фармацевтическая композиция и применение
|
MXPA04007743A
(es)
|
2002-02-13 |
2004-10-15 |
Hoffmann La Roche |
Nuevos derivados de piridina y quinolina.
|
EP1338595B1
(en)
|
2002-02-25 |
2006-05-03 |
Eisai Co., Ltd. |
Xanthine derivatives as DPP-IV inhibitors
|
CZ2004973A3
(cs)
|
2002-02-28 |
2004-12-15 |
Prosidion Limited |
Inhibitory DPIV na bázi glutaminylu
|
GB0205693D0
(en)
*
|
2002-03-09 |
2002-04-24 |
Astrazeneca Ab |
Chemical compounds
|
DE10211555A1
(de)
*
|
2002-03-15 |
2003-10-02 |
Imtm Inst Fuer Medizintechnolo |
Verwendung der Inhibitoren von Enzymen mit Aktivitäten der Aminopeptidase N und/oder der Dipeptidylpeptidase IV und pharmazeutischen Zubereitungen daraus zur Therapie und Prävention dermatologischer Erkrankungen mit sebozytärer Hyperproliferation und veränderten Differenzierungszuständen
|
AU2003225916A1
(en)
*
|
2002-03-25 |
2003-10-13 |
Merck & Co., Inc. |
Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
US20030232761A1
(en)
*
|
2002-03-28 |
2003-12-18 |
Hinke Simon A. |
Novel analogues of glucose-dependent insulinotropic polypeptide
|
SI1513519T1
(sl)
*
|
2002-06-03 |
2009-06-30 |
Novartis Ag |
Uporaba substituiranih cianopirolidinov za zdravljenje hiperlipidemije
|
US6710040B1
(en)
|
2002-06-04 |
2004-03-23 |
Pfizer Inc. |
Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors
|
JP4530852B2
(ja)
*
|
2002-07-15 |
2010-08-25 |
メルク・シャープ・エンド・ドーム・コーポレイション |
糖尿病治療のためのピペリジノピリミジンジペプチジルペプチダーゼ阻害剤
|
US7407955B2
(en)
|
2002-08-21 |
2008-08-05 |
Boehringer Ingelheim Pharma Gmbh & Co., Kg |
8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
|
US7495005B2
(en)
*
|
2002-08-22 |
2009-02-24 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Xanthine derivatives, their preparation and their use in pharmaceutical compositions
|
US7569574B2
(en)
|
2002-08-22 |
2009-08-04 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Purine derivatives, the preparation thereof and their use as pharmaceutical compositions
|
US20040058876A1
(en)
*
|
2002-09-18 |
2004-03-25 |
Torsten Hoffmann |
Secondary binding site of dipeptidyl peptidase IV (DP IV)
|
DE60331747D1
(de)
*
|
2002-09-18 |
2010-04-29 |
Prosidion Ltd |
Sekundäre bindungsstelle von dipeptidylpeptidase iv (dp iv)
|
US7262207B2
(en)
|
2002-09-19 |
2007-08-28 |
Abbott Laboratories |
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
|
CA2498423A1
(en)
*
|
2002-09-26 |
2004-04-08 |
Eisai Co., Ltd. |
Combination drug
|
ES2291680T3
(es)
*
|
2002-10-07 |
2008-03-01 |
MERCK & CO., INC. |
Antidiabeticos beta-amino heterociclicos inhibidores de la dipeptidil peptidasa.
|
EP1556362B1
(en)
*
|
2002-10-18 |
2008-03-26 |
Merck & Co., Inc. |
Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
JP4413863B2
(ja)
|
2002-11-07 |
2010-02-10 |
メルク エンド カムパニー インコーポレーテッド |
糖尿病の治療又は予防のためのジペチジルペプチダーゼ阻害剤としてのフェニルアラニン誘導体
|
US7482337B2
(en)
|
2002-11-08 |
2009-01-27 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
|
DE10254304A1
(de)
*
|
2002-11-21 |
2004-06-03 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel
|
US7309714B2
(en)
*
|
2002-12-04 |
2007-12-18 |
Merck & Co., Inc. |
Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
US20060052382A1
(en)
*
|
2002-12-20 |
2006-03-09 |
Duffy Joseph L |
3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
WO2004065380A1
(en)
|
2003-01-14 |
2004-08-05 |
Arena Pharmaceuticals Inc. |
1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
|
EP1589969A4
(en)
|
2003-01-17 |
2008-08-13 |
Merck & Co Inc |
3-AMINO-4-PHENYLBUTANEAN DERIVATEALS DIPEPTIDYLPEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
|
JP2006516573A
(ja)
*
|
2003-01-31 |
2006-07-06 |
メルク エンド カムパニー インコーポレーテッド |
糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての3−アミノ−4−フェニルブタン酸誘導体
|
US7345180B2
(en)
|
2003-01-31 |
2008-03-18 |
Sanwa Kagaku Kenkyusho Co., Ltd. |
Compound inhibiting dipeptidyl peptidase IV
|
CA2518465A1
(en)
|
2003-03-25 |
2004-10-14 |
Takeda San Diego, Inc. |
Dipeptidyl peptidase inhibitors
|
WO2004098591A2
(en)
|
2003-05-05 |
2004-11-18 |
Probiodrug Ag |
Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases
|
DK2206496T3
(da)
|
2003-05-05 |
2014-12-15 |
Probiodrug Ag |
Screening af inhibitorer af pyroglutaminsyredannelse i amyloid beta-peptid
|
AU2004237408C9
(en)
|
2003-05-05 |
2010-04-15 |
Probiodrug Ag |
Medical use of inhibitors of glutaminyl and glutamate cyclases
|
DE602004023932D1
(de)
|
2003-05-14 |
2009-12-17 |
Merck & Co Inc |
3-amino-4-phenylbutansäurederivate als dipeptidylpeptidase-hemmer zur behandlung oder vorbeugung von diabetes
|
WO2004103993A1
(en)
|
2003-05-14 |
2004-12-02 |
Syrrx, Inc. |
Dipeptidyl peptidase inhibitors
|
CN1798556A
(zh)
|
2003-06-06 |
2006-07-05 |
麦克公司 |
作为治疗或者预防糖尿病的二肽基肽酶抑制剂的稠合吲哚
|
WO2004112701A2
(en)
|
2003-06-17 |
2004-12-29 |
Merck & Co., Inc. |
Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
US7566707B2
(en)
*
|
2003-06-18 |
2009-07-28 |
Boehringer Ingelheim International Gmbh |
Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions
|
WO2005000846A1
(en)
|
2003-06-20 |
2005-01-06 |
F.Hoffmann-La Roche Ag |
Hexahydropyridoisoqinolines as dpp-iv inhibitors
|
NZ544221A
(en)
|
2003-06-20 |
2009-05-31 |
Hoffmann La Roche |
Pyrido[2,1-a]-isoquinoline derivatives as DPP-IV inhibitors
|
AR045047A1
(es)
|
2003-07-11 |
2005-10-12 |
Arena Pharm Inc |
Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
|
CA2526957C
(en)
*
|
2003-07-25 |
2011-07-12 |
Conjuchem Inc. |
Long lasting insulin derivatives and methods thereof
|
DE602004018503D1
(de)
|
2003-07-31 |
2009-01-29 |
Merck & Co Inc |
Hexahydrodiazepinone als inhibitoren des dipeptidylpeptidase-iv zur behandlung bzw. prävention von diabetes
|
US7169926B1
(en)
|
2003-08-13 |
2007-01-30 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
DE602004010206T2
(de)
|
2003-08-13 |
2008-10-09 |
Takeda Pharmaceutical Co. Ltd. |
Dipeptidyl Peptidase Inhibitoren.
|
US7678909B1
(en)
|
2003-08-13 |
2010-03-16 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
US7790734B2
(en)
|
2003-09-08 |
2010-09-07 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
NZ546322A
(en)
*
|
2003-10-15 |
2008-11-28 |
Probiodrug Ag |
Use of effectors of glutaminyl and glutamate cyclases
|
AU2004285532A1
(en)
*
|
2003-10-31 |
2005-05-12 |
Alza Corporation |
Administration of levodopa and carbidopa
|
US20100099721A1
(en)
*
|
2003-11-03 |
2010-04-22 |
Probiodrug Ag |
Novel compounds for the treatment of neurological disorders
|
US20050171112A1
(en)
*
|
2003-11-03 |
2005-08-04 |
Probiodrug Ag |
Combinations useful for the treatment of neuronal disorders
|
EP1680120A2
(en)
|
2003-11-03 |
2006-07-19 |
Probiodrug AG |
Combinations useful for the treatment of neuronal disorders
|
AU2004286857A1
(en)
*
|
2003-11-04 |
2005-05-19 |
Merck & Co., Inc. |
Fused phenylalanine derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
|
US7767828B2
(en)
|
2003-11-12 |
2010-08-03 |
Phenomix Corporation |
Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
|
AU2004288831B2
(en)
|
2003-11-12 |
2010-08-26 |
Phenomix Corporation |
Heterocyclic boronic acid compounds
|
US7576121B2
(en)
|
2003-11-12 |
2009-08-18 |
Phenomix Corporation |
Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
|
US7317109B2
(en)
|
2003-11-12 |
2008-01-08 |
Phenomix Corporation |
Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
|
KR20060109911A
(ko)
|
2003-11-17 |
2006-10-23 |
노파르티스 아게 |
디펩티딜 펩티다제 ⅳ 억제제의 용도
|
DE10355304A1
(de)
*
|
2003-11-27 |
2005-06-23 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 8-(Piperazin-1-yl)-und 8-([1,4]Diazepan-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
|
HUE039902T2
(hu)
|
2004-01-20 |
2019-02-28 |
Novartis Ag |
Közvetlenül préselt formula és eljárás
|
US7230002B2
(en)
|
2004-02-03 |
2007-06-12 |
Glenmark Pharmaceuticals Ltd. |
Dipeptidyl peptidase IV inhibitors; processes for their preparation and compositions thereof
|
KR101099206B1
(ko)
|
2004-02-05 |
2011-12-27 |
프로비오드룩 아게 |
신규한 글루타미닐 시클라제 저해제
|
WO2005075421A1
(ja)
|
2004-02-05 |
2005-08-18 |
Kyorin Pharmaceutical Co., Ltd. |
ビシクロエステル誘導体
|
US7501426B2
(en)
*
|
2004-02-18 |
2009-03-10 |
Boehringer Ingelheim International Gmbh |
8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
|
DE102004009039A1
(de)
*
|
2004-02-23 |
2005-09-08 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und Verwendung als Arzneimittel
|
EP1593671A1
(en)
*
|
2004-03-05 |
2005-11-09 |
Graffinity Pharmaceuticals AG |
DPP-IV inhibitors
|
US7732446B1
(en)
|
2004-03-11 |
2010-06-08 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
US7393847B2
(en)
*
|
2004-03-13 |
2008-07-01 |
Boehringer Ingleheim International Gmbh |
Imidazopyridazinediones, their preparation and their use as pharmaceutical compositions
|
UA85871C2
(uk)
|
2004-03-15 |
2009-03-10 |
Такеда Фармасьютікал Компані Лімітед |
Інгібітори дипептидилпептидази
|
US7179809B2
(en)
*
|
2004-04-10 |
2007-02-20 |
Boehringer Ingelheim International Gmbh |
2-Amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions
|
EP1756074A4
(en)
*
|
2004-05-04 |
2010-05-19 |
Merck Sharp & Dohme |
1,2,4-OXADIAZOLE DERIVATIVES AS DIPEPTIDYLPEPTIDASE IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
|
US7439370B2
(en)
|
2004-05-10 |
2008-10-21 |
Boehringer Ingelheim International Gmbh |
Imidazole derivatives, their preparation and their use as intermediates for the preparation of pharmaceutical compositions and pesticides
|
JP2007538079A
(ja)
|
2004-05-18 |
2007-12-27 |
メルク エンド カムパニー インコーポレーテッド |
糖尿病の治療又は予防のためのジペプチジルペプチダーゼ−iv阻害剤としてのシクロヘキシルアラニン誘導体
|
EP1598341A1
(en)
*
|
2004-05-21 |
2005-11-23 |
Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft |
DPP-IV inhibitors
|
EP1753730A1
(en)
|
2004-06-04 |
2007-02-21 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
EP1604989A1
(en)
*
|
2004-06-08 |
2005-12-14 |
Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft |
DPP-IV inhibitors
|
EP1604980A1
(en)
*
|
2004-06-08 |
2005-12-14 |
Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft |
DPP-IV inhibitors
|
DE102004030502A1
(de)
*
|
2004-06-24 |
2006-01-12 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel
|
WO2006019965A2
(en)
|
2004-07-16 |
2006-02-23 |
Takeda San Diego, Inc. |
Dipeptidyl peptidase inhibitors
|
ATE553077T1
(de)
*
|
2004-07-23 |
2012-04-15 |
Nuada Llc |
Peptidaseinhibitoren
|
EP1623983A1
(en)
*
|
2004-08-05 |
2006-02-08 |
Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft |
Heterocyclic compounds useful as DPP-IV inhibitors
|
DE102004043944A1
(de)
*
|
2004-09-11 |
2006-03-30 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 8-(3-Amino-piperidin-1-yl)-7-(but-2-inyl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
|
DE102004044221A1
(de)
*
|
2004-09-14 |
2006-03-16 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 3-Methyl-7-butinyl-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
|
US20060063719A1
(en)
*
|
2004-09-21 |
2006-03-23 |
Point Therapeutics, Inc. |
Methods for treating diabetes
|
AU2005293266B2
(en)
|
2004-10-12 |
2011-09-29 |
Glenmark Pharmaceuticals S.A. |
Novel dipeptidyl peptidase IV inhibitors, pharmaceutical compositions containing them, and process for their preparation
|
DE102004054054A1
(de)
|
2004-11-05 |
2006-05-11 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
|
BRPI0516667A
(pt)
*
|
2004-11-30 |
2008-09-16 |
Hoffmann La Roche |
compostos, processo para a manufatura dos mesmos, composições farmacêuticas que os compreendem, método para o tratamento e/ou profilaxia de enfermidades que estão associadas com dpp-iv e utilização desses compostos
|
US7411093B2
(en)
|
2004-12-20 |
2008-08-12 |
Hoffman-La Roche Inc. |
Aminocycloalkanes as DPP-IV inhibitors
|
CA2590957A1
(en)
*
|
2004-12-20 |
2006-06-29 |
Markus Boehringer |
4-aminopiperidine derivatives
|
WO2006068978A2
(en)
|
2004-12-21 |
2006-06-29 |
Takeda Pharmaceutial Company Limited |
Dipeptidyl peptidase inhibitors
|
DOP2006000008A
(es)
|
2005-01-10 |
2006-08-31 |
Arena Pharm Inc |
Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
|
EP2392595A1
(en)
|
2005-02-11 |
2011-12-07 |
Amylin Pharmaceuticals Inc. |
GIP analog and hybrid polypeptides with selectable properties
|
US8263545B2
(en)
|
2005-02-11 |
2012-09-11 |
Amylin Pharmaceuticals, Inc. |
GIP analog and hybrid polypeptides with selectable properties
|
CN102372705A
(zh)
|
2005-02-18 |
2012-03-14 |
田边三菱制药株式会社 |
脯氨酸衍生物的盐,其溶剂合物,及其生产方法
|
CN101277949A
(zh)
*
|
2005-04-22 |
2008-10-01 |
阿兰托斯制药控股公司 |
二肽基肽酶-ⅳ抑制剂
|
KR101333876B1
(ko)
*
|
2005-04-26 |
2013-11-27 |
미쓰비시 타나베 파마 코퍼레이션 |
당·지질 대사 이상의 예방 및/또는 치료약
|
US7521557B2
(en)
*
|
2005-05-20 |
2009-04-21 |
Bristol-Myers Squibb Company |
Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
|
US7825139B2
(en)
*
|
2005-05-25 |
2010-11-02 |
Forest Laboratories Holdings Limited (BM) |
Compounds and methods for selective inhibition of dipeptidyl peptidase-IV
|
ATE550031T1
(de)
|
2005-06-06 |
2012-04-15 |
Univ Georgetown |
Zusammensetzungen und verfahren für die lipomodellierung
|
DE102005035891A1
(de)
*
|
2005-07-30 |
2007-02-08 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
|
GT200600381A
(es)
|
2005-08-25 |
2007-03-28 |
|
Compuestos organicos
|
WO2007028633A2
(en)
*
|
2005-09-08 |
2007-03-15 |
Uutech Limited |
Treatment of diabetes related obesity
|
EP1937716A2
(en)
*
|
2005-09-08 |
2008-07-02 |
Uutech Limited |
Analogs of gastric inhibitory polypeptide as a treatment for age related decreased pancreatic beta cell function
|
CN101374523B
(zh)
|
2005-09-14 |
2012-04-11 |
武田药品工业株式会社 |
用于治疗糖尿病的二肽基肽酶抑制剂
|
CA2622642C
(en)
|
2005-09-16 |
2013-12-31 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
EP1971614A1
(en)
|
2005-11-14 |
2008-09-24 |
Probiodrug AG |
Cyclopropyl-fused pyrrolidine derivatives as dipeptidyl peptidase iv inhibitors
|
DE102005054994B4
(de)
*
|
2005-11-18 |
2015-02-12 |
Bader Gmbh & Co. Kg |
Verkleidungsanordnung, insbesondere Maschinenverkleidung, mit einer Schiebetür und Führungsanordnung hierfür
|
GB0526291D0
(en)
|
2005-12-23 |
2006-02-01 |
Prosidion Ltd |
Therapeutic method
|
CA2645154C
(en)
*
|
2006-03-08 |
2011-11-29 |
Kyorin Pharmaceutical Co., Ltd. |
Method for producing aminoacetylpyrrolidinecarbonitrile derivative and production intermediate thereof
|
WO2007112347A1
(en)
|
2006-03-28 |
2007-10-04 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
PE20071221A1
(es)
|
2006-04-11 |
2007-12-14 |
Arena Pharm Inc |
Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
|
DE602007010420D1
(de)
|
2006-04-11 |
2010-12-23 |
Arena Pharm Inc |
Verfahren zur verwendung des gpr119-rezeptors zur identifizierung von verbindungen zur erhöhung der knochenmasse bei einer person
|
AU2007235876A1
(en)
|
2006-04-12 |
2007-10-18 |
Probiodrug Ag |
Enzyme inhibitors
|
EP1852108A1
(en)
|
2006-05-04 |
2007-11-07 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
DPP IV inhibitor formulations
|
PE20080251A1
(es)
*
|
2006-05-04 |
2008-04-25 |
Boehringer Ingelheim Int |
Usos de inhibidores de dpp iv
|
NZ573360A
(en)
|
2006-05-04 |
2012-08-31 |
Boehringer Ingelheim Int |
Polymorphic forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine
|
WO2008017670A1
(en)
*
|
2006-08-08 |
2008-02-14 |
Boehringer Ingelheim International Gmbh |
Pyrrolo [3, 2 -d] pyrimidines as dpp-iv inhibitors for the treatment of diabetes mellitus
|
US8497240B2
(en)
|
2006-08-17 |
2013-07-30 |
Amylin Pharmaceuticals, Llc |
DPP-IV resistant GIP hybrid polypeptides with selectable properties
|
HRP20110800T1
(hr)
*
|
2006-09-13 |
2011-12-31 |
Takeda Pharmaceutical Company Limited |
UPORABA 2-6-(3-AMINO-PIPERIDIN-1-IL)-3-METIL-2,4-DIOKSO-3,4-DIHIDRO-2H-PIRIMIDIN-1-ILMETIL-4-FLUORO-BENZONITRILA ZA LIJEČENJE DIJABETESA, RAKA, AUTOIMUNIH POREMEĆAJA I ZARAZE HIV-om
|
US8324383B2
(en)
|
2006-09-13 |
2012-12-04 |
Takeda Pharmaceutical Company Limited |
Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
|
US8278345B2
(en)
|
2006-11-09 |
2012-10-02 |
Probiodrug Ag |
Inhibitors of glutaminyl cyclase
|
US8217025B2
(en)
*
|
2006-11-17 |
2012-07-10 |
Harbor Therapeutics, Inc. |
Drug screening and treatment methods
|
TW200838536A
(en)
|
2006-11-29 |
2008-10-01 |
Takeda Pharmaceutical |
Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
|
US9126987B2
(en)
|
2006-11-30 |
2015-09-08 |
Probiodrug Ag |
Inhibitors of glutaminyl cyclase
|
US8093236B2
(en)
|
2007-03-13 |
2012-01-10 |
Takeda Pharmaceuticals Company Limited |
Weekly administration of dipeptidyl peptidase inhibitors
|
US20070172525A1
(en)
*
|
2007-03-15 |
2007-07-26 |
Ramesh Sesha |
Anti-diabetic combinations
|
US20080064701A1
(en)
*
|
2007-04-24 |
2008-03-13 |
Ramesh Sesha |
Anti-diabetic combinations
|
JPWO2008114857A1
(ja)
|
2007-03-22 |
2010-07-08 |
杏林製薬株式会社 |
アミノアセチルピロリジンカルボニトリル誘導体の製造方法
|
JP5616630B2
(ja)
|
2007-04-03 |
2014-10-29 |
田辺三菱製薬株式会社 |
ジペプチジルペプチダーゼ4阻害化合物と甘味料との併用
|
EP2142514B1
(en)
|
2007-04-18 |
2014-12-24 |
Probiodrug AG |
Thiourea derivatives as glutaminyl cyclase inhibitors
|
WO2008141021A1
(en)
|
2007-05-08 |
2008-11-20 |
Concert Pharmaceuticals, Inc. |
Deuterated derivatives of tetrahydrotriazolopyrazine compounds and their use as dpp-iv inhibitors
|
EP2025674A1
(de)
|
2007-08-15 |
2009-02-18 |
sanofi-aventis |
Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
CL2008002427A1
(es)
*
|
2007-08-16 |
2009-09-11 |
Boehringer Ingelheim Int |
Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2.
|
NZ600126A
(en)
*
|
2007-08-17 |
2013-12-20 |
Boehringer Ingelheim Int |
Purine derivatives for use in the treatment of fap-related diseases
|
US20090076013A1
(en)
*
|
2007-09-17 |
2009-03-19 |
Protia, Llc |
Deuterium-enriched sitagliptin
|
CL2008003653A1
(es)
|
2008-01-17 |
2010-03-05 |
Mitsubishi Tanabe Pharma Corp |
Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
|
US8551524B2
(en)
*
|
2008-03-14 |
2013-10-08 |
Iycus, Llc |
Anti-diabetic combinations
|
PE20140960A1
(es)
|
2008-04-03 |
2014-08-15 |
Boehringer Ingelheim Int |
Formulaciones que comprenden un inhibidor de dpp4
|
EP2108960A1
(en)
|
2008-04-07 |
2009-10-14 |
Arena Pharmaceuticals, Inc. |
Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY
|
PE20100156A1
(es)
*
|
2008-06-03 |
2010-02-23 |
Boehringer Ingelheim Int |
Tratamiento de nafld
|
PL2586782T5
(pl)
|
2008-07-03 |
2018-05-30 |
Ratiopharm Gmbh |
Krystaliczne sole sitagliptyny
|
UY32030A
(es)
|
2008-08-06 |
2010-03-26 |
Boehringer Ingelheim Int |
"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
|
KR20190016601A
(ko)
|
2008-08-06 |
2019-02-18 |
베링거 인겔하임 인터내셔날 게엠베하 |
메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
|
JP5476305B2
(ja)
*
|
2008-08-07 |
2014-04-23 |
杏林製薬株式会社 |
ビシクロ[2.2.2]オクチルアミン誘導体の製造方法
|
WO2010018866A1
(ja)
*
|
2008-08-14 |
2010-02-18 |
杏林製薬株式会社 |
安定化された医薬組成物
|
MY164581A
(en)
*
|
2008-08-15 |
2018-01-15 |
Boehringer Ingelheim Int |
Purin derivatives for use in the treatment of fab-related diseases
|
WO2010029089A2
(en)
|
2008-09-10 |
2010-03-18 |
Boehringer Ingelheim International Gmbh |
Combination therapy for the treatment of diabetes and related conditions
|
US20200155558A1
(en)
|
2018-11-20 |
2020-05-21 |
Boehringer Ingelheim International Gmbh |
Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
|
JO2870B1
(en)
|
2008-11-13 |
2015-03-15 |
ميرك شارب اند دوهم كورب |
Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes
|
EP2364161B1
(en)
|
2008-11-26 |
2020-03-11 |
Satiogen Pharmaceuticals, Inc. |
Compositions containing satiogens and methods of use
|
JP2012509891A
(ja)
*
|
2008-11-26 |
2012-04-26 |
サティオゲン ファーマシューティカルズ,インク. |
肥満症及び糖尿病を治療するための胆汁酸再循環阻害剤
|
CN102256976A
(zh)
|
2008-12-23 |
2011-11-23 |
贝林格尔.英格海姆国际有限公司 |
有机化合物的盐形式
|
US8404727B2
(en)
|
2009-01-07 |
2013-03-26 |
Glenmark Pharmaceuticals S.A. |
Pharmaceutical composition that includes a dipeptidyl peptidase-IV inhibitor
|
AR074990A1
(es)
|
2009-01-07 |
2011-03-02 |
Boehringer Ingelheim Int |
Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
|
ES2797503T3
(es)
|
2009-02-13 |
2020-12-02 |
Boehringer Ingelheim Int |
Composición farmacéutica que comprende un inhibidor de SGLT2, un inhibidor de DPP-IV y opcionalmente un agente antidiabético adicional y sus usos
|
EA201101621A1
(ru)
|
2009-05-15 |
2012-05-30 |
Новартис Аг |
Производные бензоксазолона в качестве ингибиторов альдостеронсинтазы
|
SI2429995T1
(sl)
|
2009-05-15 |
2014-05-30 |
Novartis Ag |
Arilpiridini kot inhibitorji aldosteron sintaze
|
AU2010251967B9
(en)
|
2009-05-28 |
2014-04-03 |
Novartis Ag |
Substituted aminopropionic derivatives as neprilysin inhibitors
|
BRPI1015069A2
(pt)
|
2009-05-28 |
2019-09-24 |
Novartis Ag |
compostos derivados de aminobutíricos substituidos como inibidores de neprilisina, uso dos mesmos, composição farmacêutica, combinação e método para inibição de atividade endopeptidase neutra.
|
AR077642A1
(es)
|
2009-07-09 |
2011-09-14 |
Arena Pharm Inc |
Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
|
KR20120092096A
(ko)
|
2009-09-02 |
2012-08-20 |
머크 샤프 앤드 돔 코포레이션 |
당뇨병의 치료 또는 예방을 위한 디펩티딜 펩티다제-iv 억제제로서의 아미노테트라히드로피란
|
WO2011029920A1
(en)
|
2009-09-11 |
2011-03-17 |
Probiodrug Ag |
Heterocylcic derivatives as inhibitors of glutaminyl cyclase
|
EP2477985B1
(en)
|
2009-09-15 |
2018-11-07 |
BlueLink Pharmaceuticals, Inc. |
Crlx101 for use in the treatment of cancer
|
EP2993169B1
(en)
|
2009-11-17 |
2017-12-20 |
Novartis AG |
Aryl-pyridine derivatives as aldosterone synthase inhibitors
|
JO2967B1
(en)
|
2009-11-20 |
2016-03-15 |
نوفارتس ايه جي |
Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
|
MX2012005987A
(es)
|
2009-11-23 |
2012-06-25 |
Cerulean Pharma Inc |
Polimeros a base de ciclodextrina para administracion terapeutica.
|
AU2010323068B2
(en)
|
2009-11-27 |
2015-09-03 |
Boehringer Ingelheim International Gmbh |
Treatment of genotyped diabetic patients with DPP-IV inhibitors such as linagliptin
|
EP2507234B1
(en)
|
2009-11-30 |
2014-03-12 |
Novartis AG |
Imidazole derivatives as aldosterone synthase inhibitors
|
WO2011090940A1
(en)
|
2010-01-19 |
2011-07-28 |
Cerulean Pharma Inc. |
Cyclodextrin-based polymers for therapeutic delivery
|
US8853212B2
(en)
|
2010-02-22 |
2014-10-07 |
Merck Sharp & Dohme Corp |
Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
|
ES2586231T3
(es)
|
2010-03-03 |
2016-10-13 |
Probiodrug Ag |
Inhibidores de glutaminil ciclasa
|
SG183229A1
(en)
|
2010-03-10 |
2012-09-27 |
Probiodrug Ag |
Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
|
MX2012011631A
(es)
|
2010-04-06 |
2013-01-18 |
Arena Pharm Inc |
Moduladores del receptor gpr119 y el tratamiento de trastornos relacionados con el mismo.
|
JP5945532B2
(ja)
|
2010-04-21 |
2016-07-05 |
プロビオドルグ エージー |
グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
|
JP6034781B2
(ja)
|
2010-05-05 |
2016-11-30 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
併用療法
|
US8980929B2
(en)
|
2010-05-21 |
2015-03-17 |
Merck Sharp & Dohme Corp. |
Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes
|
EP3593802A3
(en)
|
2010-05-26 |
2020-03-25 |
Satiogen Pharmaceuticals, Inc. |
Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
|
WO2011157827A1
(de)
|
2010-06-18 |
2011-12-22 |
Sanofi |
Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
|
US8530413B2
(en)
|
2010-06-21 |
2013-09-10 |
Sanofi |
Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
|
AU2011268940B2
(en)
|
2010-06-24 |
2015-05-21 |
Boehringer Ingelheim International Gmbh |
Diabetes therapy
|
TW201215387A
(en)
|
2010-07-05 |
2012-04-16 |
Sanofi Aventis |
Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
|
TW201215388A
(en)
|
2010-07-05 |
2012-04-16 |
Sanofi Sa |
(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
|
EP2619198A1
(en)
|
2010-09-22 |
2013-07-31 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
WO2012049566A1
(en)
|
2010-10-14 |
2012-04-19 |
Japan Tobacco Inc. |
Combination therapy for use in treating diabetes
|
AR083878A1
(es)
|
2010-11-15 |
2013-03-27 |
Boehringer Ingelheim Int |
Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
|
US8877815B2
(en)
|
2010-11-16 |
2014-11-04 |
Novartis Ag |
Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
|
US8673974B2
(en)
|
2010-11-16 |
2014-03-18 |
Novartis Ag |
Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
|
AR085689A1
(es)
|
2011-03-07 |
2013-10-23 |
Boehringer Ingelheim Int |
Composiciones farmaceuticas de metformina, linagliptina y un inhibidor de sglt-2
|
EP2686313B1
(en)
|
2011-03-16 |
2016-02-03 |
Probiodrug AG |
Benzimidazole derivatives as inhibitors of glutaminyl cyclase
|
US20140018371A1
(en)
|
2011-04-01 |
2014-01-16 |
Arena Pharmaceuticals, Inc. |
Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
|
US20140066369A1
(en)
|
2011-04-19 |
2014-03-06 |
Arena Pharmaceuticals, Inc. |
Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
|
WO2012145603A1
(en)
|
2011-04-22 |
2012-10-26 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
WO2012145604A1
(en)
|
2011-04-22 |
2012-10-26 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
WO2012170702A1
(en)
|
2011-06-08 |
2012-12-13 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
US9051329B2
(en)
|
2011-07-05 |
2015-06-09 |
Merck Sharp & Dohme Corp. |
Tricyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors
|
EP3517539B1
(en)
|
2011-07-15 |
2022-12-14 |
Boehringer Ingelheim International GmbH |
Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes
|
WO2013045413A1
(en)
|
2011-09-27 |
2013-04-04 |
Sanofi |
6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
|
WO2013055910A1
(en)
|
2011-10-12 |
2013-04-18 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
WO2013063512A1
(en)
|
2011-10-28 |
2013-05-02 |
Lumena Pharmaceuticals, Inc |
Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
|
KR102051031B1
(ko)
|
2011-10-28 |
2019-12-02 |
루메나 파마수티컬즈, 인코포레이티드 |
고담혈증 및 담즙 정체성 간 질환 치료용 담즙산 재순환 억제제
|
US9115082B2
(en)
|
2012-01-18 |
2015-08-25 |
Catherine Yang |
Dipeptidyl-peptidase-IV inhibitors for treatment of type 2 diabetes complex with hypertension
|
WO2013122920A1
(en)
|
2012-02-17 |
2013-08-22 |
Merck Sharp & Dohme Corp. |
Dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
|
US9555001B2
(en)
|
2012-03-07 |
2017-01-31 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical composition and uses thereof
|
JP6224084B2
(ja)
|
2012-05-14 |
2017-11-01 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体
|
JP6218811B2
(ja)
|
2012-05-14 |
2017-10-25 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Sirs及び/又は敗血症の治療に用いるdpp−4阻害薬としてのキサンチン誘導体
|
WO2013174767A1
(en)
|
2012-05-24 |
2013-11-28 |
Boehringer Ingelheim International Gmbh |
A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
|
US9315508B2
(en)
|
2012-07-23 |
2016-04-19 |
Merck Sharp & Dohme Corp. |
Treating diabetes with dipeptidyl peptidase-IV inhibitors
|
TWI500613B
(zh)
|
2012-10-17 |
2015-09-21 |
Cadila Healthcare Ltd |
新穎之雜環化合物
|
EP2911655A1
(en)
|
2012-10-24 |
2015-09-02 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Tpl2 kinase inhibitors for preventing or treating diabetes and for promoting -cell survival
|
WO2014074668A1
(en)
|
2012-11-08 |
2014-05-15 |
Arena Pharmaceuticals, Inc. |
Modulators of gpr119 and the treatment of disorders related thereto
|
UY35144A
(es)
|
2012-11-20 |
2014-06-30 |
Novartis Ag |
Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
|
DK2956464T3
(en)
|
2013-02-14 |
2018-07-16 |
Novartis Ag |
Substituted bisphenyl-butane phosphonic acid derivatives as NEP (neutral endopeptidase) inhibitors
|
UY35671A
(es)
|
2013-07-25 |
2015-02-27 |
Novartis Ag |
Bioconjugados de polipéptidos de apelina sintética
|
PE20160878A1
(es)
|
2013-07-25 |
2016-09-08 |
Novartis Ag |
Polipeptidos ciclicos para el tratamiento de la insuficiencia cardiaca
|
US9902751B2
(en)
|
2013-12-30 |
2018-02-27 |
Mylan Laboratories Limited |
Process for the preparation of empagliflozin
|
US9526728B2
(en)
|
2014-02-28 |
2016-12-27 |
Boehringer Ingelheim International Gmbh |
Medical use of a DPP-4 inhibitor
|
GB201415598D0
(en)
|
2014-09-03 |
2014-10-15 |
Univ Birmingham |
Elavated Itercranial Pressure Treatment
|
DE102014018663A1
(de)
|
2014-12-13 |
2015-03-05 |
Heinz Kiefer |
Nachweis von vermehrungsfähigen Zellen zur Überprüfung von Arzneimittel-Wirkstoffangaben bei Zulassungsverfahren
|
CA3002540C
(en)
|
2015-01-06 |
2023-11-07 |
Arena Pharmaceuticals, Inc. |
Use of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid for treating conditions related to the s1p1 receptor
|
JP2018507187A
(ja)
|
2015-01-23 |
2018-03-15 |
ノバルティス アーゲー |
改善された半減期を有する合成アペリン脂肪酸コンジュゲート
|
JP2018507914A
(ja)
|
2015-03-09 |
2018-03-22 |
インテクリン・セラピューティクス・インコーポレイテッド |
非アルコール性脂肪肝疾患および/またはリポジストロフィーの処置のための方法
|
EP3273981B1
(en)
|
2015-03-24 |
2020-04-29 |
INSERM - Institut National de la Santé et de la Recherche Médicale |
Method and pharmaceutical composition for use in the treatment of diabetes
|
JP6838744B2
(ja)
|
2015-06-22 |
2021-03-03 |
アリーナ ファーマシューティカルズ, インコーポレイテッド |
S1P1レセプター関連障害における使用のための(R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸(化合物1)の結晶性L−アルギニン塩
|
RU2706706C1
(ru)
|
2015-12-28 |
2019-11-20 |
Вокхардт Лимитед |
Пероральная осмотическая фармацевтическая композиция вилдаглиптина
|
MX383599B
(es)
*
|
2016-04-29 |
2025-03-14 |
Fundacio Hospital Univ Vall Dhebron Institut De Recerca |
Inhibidores de la dipeptidil peptidasa-4 para su uso en el tratamiento topico ocular de enfermedades neurodegenerativas de la retina, en particular en estadios tempranos de retinopatia diabetica y otras enfermedades retinianas en las que la neurodegeneracion desempe?a un papel esencial
|
EP4233840A3
(en)
|
2016-06-10 |
2023-10-18 |
Boehringer Ingelheim International GmbH |
Combinations of linagliptin and metformin
|
JOP20190086A1
(ar)
|
2016-10-21 |
2019-04-18 |
Novartis Ag |
مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب
|
WO2018162722A1
(en)
|
2017-03-09 |
2018-09-13 |
Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke |
Dpp-4 inhibitors for use in treating bone fractures
|
CN110996951A
(zh)
|
2017-04-03 |
2020-04-10 |
科赫罗斯生物科学股份有限公司 |
治疗进行性核上性麻痹的PPARγ激动剂
|
ES2733477T3
(es)
|
2017-07-04 |
2019-11-29 |
Fis Fabbrica Italiana Sintetici Spa |
Procedimiento eficaz para la preparación de sitagliptina a través de una preparación muy eficaz del intermedio ácido 2,4,5-trifluorofenilacético
|
MX2020001525A
(es)
|
2017-08-24 |
2020-03-20 |
Novo Nordisk As |
Composiciones de peptido similar al glucagon tipo 1 (glp-1) y sus usos.
|
ES2812698T3
(es)
|
2017-09-29 |
2021-03-18 |
Probiodrug Ag |
Inhibidores de glutaminil ciclasa
|
UY38072A
(es)
|
2018-02-07 |
2019-10-01 |
Novartis Ag |
Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
|
ES2770143T3
(es)
|
2018-02-13 |
2020-06-30 |
Fis Fabbrica Italiana Sintetici Spa |
Nuevo procedimiento eficiente para la preparación de sitagliptina
|
US12156866B2
(en)
|
2018-06-06 |
2024-12-03 |
Arena Pharmaceuticals, Inc. |
Methods of treating conditions related to the S1P1 receptor
|
WO2020058358A1
(en)
|
2018-09-18 |
2020-03-26 |
Albert-Ludwigs-Universität Freiburg |
Inhibition of histone methyl transferases to treat cancer
|
UY38485A
(es)
|
2018-11-27 |
2020-06-30 |
Novartis Ag |
Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación
|
JP2022507958A
(ja)
|
2018-11-27 |
2022-01-18 |
ノバルティス アーゲー |
代謝障害の治療用のプロタンパク質転換酵素サブチリシン/ケキシン9型(pcsk9)阻害薬としての環状四量体化合物
|
JP7657151B2
(ja)
|
2018-11-27 |
2025-04-04 |
ノバルティス アーゲー |
代謝性障害の処置のためのプロタンパク質コンバターゼスブチリシン/ケキシン9型(pcsk9)阻害剤としての環状ペプチド
|
EP4335438A1
(en)
|
2019-09-17 |
2024-03-13 |
Novartis AG |
Combination therapy with vildagliptin and metformin
|
EP4106724A1
(en)
|
2020-02-18 |
2022-12-28 |
Novo Nordisk A/S |
Glp-1 compositions and uses thereof
|
JP2023536346A
(ja)
|
2020-08-05 |
2023-08-24 |
エリプシーズ ファーマ リミテッド |
シクロデキストリン含有ポリマートポイソメラーゼ阻害剤コンジュゲートおよびparp阻害剤を用いた癌の処置
|
WO2023084449A1
(en)
|
2021-11-12 |
2023-05-19 |
Novartis Ag |
Diaminocyclopentylpyridine derivatives for the treatment of a disease or disorder
|
AR127698A1
(es)
|
2021-11-23 |
2024-02-21 |
Novartis Ag |
Derivados de naftiridinona para el tratamiento de una enfermedad o un trastorno
|
CN120058836A
(zh)
*
|
2021-12-24 |
2025-05-30 |
西南医科大学 |
一类具有抗糖尿病活性的化合物及其应用
|
WO2024241229A1
(en)
|
2023-05-24 |
2024-11-28 |
Novartis Ag |
Naphthyridinone derivatives for the treatment of a disease or disorder
|