FI970417A0 - Aryylitioyhdisteet bakteerien ja virusten vastaisina aineina - Google Patents

Aryylitioyhdisteet bakteerien ja virusten vastaisina aineina

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Publication number
FI970417A0
FI970417A0 FI970417A FI970417A FI970417A0 FI 970417 A0 FI970417 A0 FI 970417A0 FI 970417 A FI970417 A FI 970417A FI 970417 A FI970417 A FI 970417A FI 970417 A0 FI970417 A0 FI 970417A0
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FI
Finland
Prior art keywords
antibacterial
antiviral agents
arylthio compounds
image
arylthio
Prior art date
Application number
FI970417A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI970417A (fi
Inventor
John Michael Domagala
Edward Faith Elslager
Rocco Dean Gogliotti
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/286,816 external-priority patent/US5463122A/en
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of FI970417A publication Critical patent/FI970417A/fi
Publication of FI970417A0 publication Critical patent/FI970417A0/fi

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
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    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
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    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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FI970417A 1994-08-05 1997-01-31 Aryylitioyhdisteet bakteerien ja virusten vastaisina aineina FI970417A0 (fi)

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Application Number Priority Date Filing Date Title
US08/286,816 US5463122A (en) 1994-08-05 1994-08-05 Arylthio compounds
US08/446,917 US5734081A (en) 1994-08-05 1995-06-01 Arylthio compounds
PCT/US1995/008802 WO1996004242A1 (en) 1994-08-05 1995-07-11 Arylthio compounds as antibacterial and antiviral agents

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Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2736914B1 (fr) * 1995-07-21 1997-08-22 Adir Nouveaux derives d'acide aminophenylphosphonique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR20000064403A (ko) * 1995-12-15 2000-11-06 로즈 암스트롱, 크리스틴 에이. 트러트웨인 9(s-(r,r))-3-메틸-2-(3-옥소-3h-벤조d)이소티아졸-2-일)펜탄산및(s-rr)),l-2-(2-(2-(1-카르복시-2-메틸부틸카르바모일)페닐디술포닐)벤조일아미노)-3-메틸펜탄산의제조방법
ZA974703B (en) * 1996-05-30 1997-12-30 Bayer Ag Substituted sulfonylamino(thio)carbonyl compounds.
WO1998040056A2 (en) * 1997-03-13 1998-09-17 Smithkline Beecham Plc Pyrrolidine and thiazole derivatives with metallo-beta-lactamase inhibitory properties
DE19735120A1 (de) * 1997-08-13 1999-02-18 Peter Hans Prof D Hofschneider Verwendung von Thiolverbindungen zur Inaktivierung von Viren
FR2779430B1 (fr) * 1998-05-25 2001-07-13 Pasteur Institut Dithio-bis-nitrobenzenes substitues et leurs applications
DE69932820D1 (de) * 1998-06-19 2006-09-28 Us Health Thiolester und ihre anwendungen
US6706729B1 (en) 1998-06-19 2004-03-16 The United States Of America As Represented By The Department Of Health And Human Services Thiolesters and uses thereof
UA74781C2 (en) * 1999-04-02 2006-02-15 Abbott Lab Antiinflammatory and immumosuppressive compounds inhibiting cell adhesion
AU5567501A (en) 2000-05-19 2001-12-03 Alcon Universal Ltd Disulfide derivatives useful for treating allergic diseases
PT1289945E (pt) 2000-05-19 2004-10-29 Alcon Inc Derivados dissulfureto de anilina para o tratamento de doencas alergicas
EP1284722B1 (en) 2000-05-19 2005-08-24 Alcon Inc. Compositions containing a benzamide disulfide derivative for treating allergic diseases
EP1357948A4 (en) * 2000-12-21 2006-12-06 Polymer Group Inc METHOD FOR CONTROLLING NOISOM DECOMPOSITION INGREDIENTS FROM HUMAN EXPERIENCE IN PERSONAL HYGIENE PRODUCTS
EP1383499B1 (en) * 2001-01-10 2013-03-06 The GRASSETTI Family Trust Method of immunomodulation using thione-forming disulfides
US6710068B2 (en) 2001-04-11 2004-03-23 Idenix Pharmaceuticals, Inc. Phenylindoles for the treatment of HIV
US20040018983A1 (en) * 2001-12-21 2004-01-29 Achillion Pharmaceuticals, Inc. Antifungal compositions
US7101676B2 (en) * 2002-01-11 2006-09-05 Douglas Buechter Methods for identifying compounds which inhibit binding of nucleocapsid 7 protein to HIV-1 RNA
WO2004014364A1 (en) * 2002-08-07 2004-02-19 Idenix (Cayman) Limited Substituted phenylindoles for the treatment of hiv
JP4926403B2 (ja) * 2002-12-10 2012-05-09 ヴァイロケム ファーマ インコーポレイテッド フラビウイルス感染の処置もしくは予防のための化合物および方法
EP1581488B1 (en) 2002-12-19 2009-09-16 Vertex Pharmaceuticals Incorporated Inhibitors of tace
WO2004096147A2 (en) * 2003-04-28 2004-11-11 Idenix (Cayman) Limited Oxo-pyrimidine compounds
JP4771468B2 (ja) 2003-12-26 2011-09-14 正敏 萩原 Ｓｒ蛋白質のリン酸化制御方法、および、ｓｒ蛋白質の活性制御剤を有効成分とする抗ウイルス剤
RS50981B (sr) 2004-09-17 2010-10-31 Idenix Pharmaceuticals Inc. Fosfoindoli kao hiv inhibitori
US20060185098A1 (en) * 2004-12-03 2006-08-24 Sylvain Kravtchenko Composition for bleaching and simultaneously dyeing keratin fibers, comprising 7-(6'-methylphenylazo)-1-acetamido-3,6-disulfo-8-hydroxynaphthalene
US7960428B2 (en) 2006-09-29 2011-06-14 Idenix Pharmaceuticals, Inc. Enantiomerically pure phosphoindoles as HIV inhibitors
EP1911451A1 (en) * 2006-10-10 2008-04-16 INSERM (Institut National de la Santé et de la Recherche Medicale) Protein-kinase CK2 inhibitors and their therapeutic applications
CA2668859A1 (en) 2006-11-07 2008-05-15 Proteologics Ltd. Pyrimidine derivatives as posh and posh-ap inhibitors
WO2008112938A2 (en) * 2007-03-13 2008-09-18 New England Medical Center Hospitals, Inc. Composition and method for the treatment of diseases affected by a peptide receptor
AU2011258009B2 (en) 2010-05-28 2016-04-21 The Board Of Regents Of The University Of Texas System Oligo-benzamide compounds and their use
US8835493B2 (en) 2011-11-23 2014-09-16 Board Of Regents, The University Of Texas System Oligo-benzamide compounds for use in treating cancers
WO2013078277A1 (en) 2011-11-23 2013-05-30 The Board Of Regents Of The University Of Texas System Oligo-benzamide compounds and their use in treating cancers
JP6957459B2 (ja) * 2015-10-19 2021-11-02 カルディオキシル ファーマシューティカルズ，インク． ニトロキシルドナーとしてのｎ−ヒドロキシルスルホンアミド誘導体
JP6814312B1 (ja) * 2020-02-05 2021-01-13 株式会社タイショーテクノス 抗ウイルス剤及び物品に抗ウイルス性を付与する方法
CN111647034B (zh) * 2020-05-13 2021-05-28 山东大学 2-巯基苯甲酰胺硫酯类化合物及其制备方法和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE724034C (de) * 1938-11-04 1942-08-17 Algemeene Kunstvezel Mij N V Verfahren zum Erzeugen farbiger Glasfasern
US3012039A (en) * 1958-03-14 1961-12-05 Ici Ltd 2-p-chlorobenzyl-1, 2-benzisothiazolone
US3517022A (en) * 1967-10-03 1970-06-23 Rohm & Haas Certain 2-carbamoyl-1,2-benzisothiazolones
US3574858A (en) * 1968-07-09 1971-04-13 Fmc Corp Microbiocide for controlling bacteria in water
US3736280A (en) * 1969-10-13 1973-05-29 Sherwin Williams Co Fungicidal compositions and methods of prohibiting the growth thereof
US3663616A (en) * 1969-10-13 1972-05-16 Sherwin Williams Co Bis(2-carbamylphenyl)disulfides
GB1306493A (en) * 1970-04-27 1973-02-14 Sherwin Williams Co Aromatic sulphenamides the preparation thereof and cyclization thereof
US3661974A (en) * 1970-04-27 1972-05-09 Sherwin Williams Co 2-carbalkoxy-phenyl sulfenamides
US3761489A (en) * 1971-12-20 1973-09-25 Sherwin Williams Co Substituted n-alkyl benzisothiazolinones
US3786150A (en) * 1971-12-27 1974-01-15 Fmc Corp Fungicidal use of certain benz(d)isothiazoles
US3965107A (en) * 1974-07-08 1976-06-22 Rohm And Haas Company Isothiazolopyridinones
GB1532984A (en) * 1975-04-10 1978-11-22 Ici Ltd Method for the control of micro-organisms
DE2602643C2 (de) * 1976-01-24 1984-12-20 Bayer Ag, 5090 Leverkusen 1,2-Benzisothiazolinone-3, Verfahren zu ihrer Herstellung sowie Arzneimittel
GB1560726A (en) * 1976-04-28 1980-02-06 Beecham Group Ltd Isothiazolo-pyridines
DE2967337D1 (en) * 1978-06-16 1985-02-07 Kyowa Hakko Kogyo Kk Antithrombotic pharmaceutical preparation containing 2,2'-dithiobis benzamide derivatives and new 2,2'-dithiobis benzamide derivatives
US4479950A (en) * 1982-11-05 1984-10-30 Usv Pharmaceutical Corporation Aroylaminoacid disulfides
DE3411385A1 (de) * 1984-03-28 1985-10-10 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von o,o'-dithiobenzamiden
US4975367A (en) * 1986-04-04 1990-12-04 Miles Inc. Catalytic test composition intended to produce a range of colors
JPH0477476A (ja) * 1990-07-19 1992-03-11 Sankyo Co Ltd 抗潰瘍剤
WO1992006683A1 (en) * 1990-10-22 1992-04-30 Research Corporation Technologies, Inc. Aryl and heteroaryl compounds having anti-retrovirus activity
PT100914A (pt) * 1991-09-30 1993-10-29 Jess G Thoene Uso de compostos capazes de sofrer uma permuta mista com dissulfureto, com uma ligacao dissulfureto, no tratamento de infeccao por hiv

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NZ300073A (en) 1999-07-29
RO119193B1 (ro) 2004-05-28
DE69534502D1 (de) 2006-02-16
MY113732A (en) 2002-05-31
TW313565B (hr) 1997-08-21
EP0775110B1 (en) 2005-10-05
NO970495D0 (no) 1997-02-04
UA52588C2 (uk) 2003-01-15
CA2193845A1 (en) 1996-02-15
BG63301B1 (bg) 2001-09-28
MX9700249A (es) 1997-05-31
EP0775110A1 (en) 1997-05-28
SK15497A3 (en) 1998-01-14
HUT77653A (hu) 1998-07-28
US5734081A (en) 1998-03-31
KR20040004371A (ko) 2004-01-13
RU2156236C2 (ru) 2000-09-20
NO308656B1 (no) 2000-10-09
AU3008795A (en) 1996-03-04
CZ26297A3 (cs) 1998-06-17
IS1806B (is) 2002-03-08
US5668291A (en) 1997-09-16
HRP950429A2 (en) 1997-04-30
BG101189A (en) 1998-03-31
FI970417A (fi) 1997-01-31
PL181425B1 (pl) 2001-07-31
WO1996004242A1 (en) 1996-02-15
US5929114A (en) 1999-07-27
PL318540A1 (en) 1997-06-23
SV1995000048A (es) 1997-05-27
JPH10504292A (ja) 1998-04-28
OA10467A (en) 2002-04-05
ATE305923T1 (de) 2005-10-15
NO970495L (no) 1997-04-02
AU710806B2 (en) 1999-09-30
IS4425A (is) 1997-02-03

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