UY24009A1 - Compuestos ariltio útiles como agentes antivirales y antibacteriales - Google Patents

Compuestos ariltio útiles como agentes antivirales y antibacteriales

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Publication number
UY24009A1
UY24009A1 UY24009A UY24009A UY24009A1 UY 24009 A1 UY24009 A1 UY 24009A1 UY 24009 A UY24009 A UY 24009A UY 24009 A UY24009 A UY 24009A UY 24009 A1 UY24009 A1 UY 24009A1
Authority
UY
Uruguay
Prior art keywords
antiviral
ariltio
compounds
useful
antibacterial agents
Prior art date
Application number
UY24009A
Other languages
English (en)
Inventor
Domagala John
Elslager Edward
Gogliotti Rocco
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of UY24009A1 publication Critical patent/UY24009A1/es

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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Abstract

Los agentes antibacterianos y antivirales ariltio y ditiobisarilamida tienen la siguiente fórmula general (I), donde A es un arilo monocíclico o bicíclico que puede contener hasta 3 heteroátomos seleccionados de O, S, y N, R1 y R2 son grupos sustituyentes, X es (II).
UY24009A 1994-08-05 1995-07-31 Compuestos ariltio útiles como agentes antivirales y antibacteriales UY24009A1 (es)

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US08/286,816 US5463122A (en) 1994-08-05 1994-08-05 Arylthio compounds

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SK81798A3 (en) * 1995-12-15 1998-11-04 Warner Lambert Co Method of making [s-(r*,r*)]-3-methyl-2-(3-oxo-3h- -benzo[d]isothiazol-2-yl)pentanoic acid and [s-(r*,r*)],l-2-{2- -[2-(1-carboxy-2-methylbutylcarbamoyl)phenyldisulfonyl]benzoyl- -amino}-3-methylpentanoic acid
US5932618A (en) * 1996-11-04 1999-08-03 Signal Pharmaceuticals, Inc. Anti-viral agents and methods relating to the use thereof
AU5567501A (en) 2000-05-19 2001-12-03 Alcon Universal Ltd Disulfide derivatives useful for treating allergic diseases
CN1172666C (zh) 2000-05-19 2004-10-27 爱尔康公司 用于治疗过敏性疾病的含有苯甲酰胺二硫化物衍生物的组合物
CN1173697C (zh) 2000-05-19 2004-11-03 爱尔康公司 用于治疗过敏性疾病的苯胺二硫化物衍生物
US20040110802A1 (en) * 2002-08-23 2004-06-10 Atli Thorarensen Antibacterial benzoic acid derivatives
AU2003265382A1 (en) * 2002-08-23 2004-03-11 Pharmacia & Upjohn Company Llc Antibacterial benzoic acid derivatives
CN1300106C (zh) * 2005-09-30 2007-02-14 浙江工业大学 2，2'－二硫代双苯甲酰氯的化学合成方法
GB0806634D0 (en) * 2008-04-11 2008-05-14 Univ Cardiff Chemical compounds

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US3574858A (en) * 1968-07-09 1971-04-13 Fmc Corp Microbiocide for controlling bacteria in water
US3663616A (en) * 1969-10-13 1972-05-16 Sherwin Williams Co Bis(2-carbamylphenyl)disulfides
US3736280A (en) * 1969-10-13 1973-05-29 Sherwin Williams Co Fungicidal compositions and methods of prohibiting the growth thereof
US3786150A (en) * 1971-12-27 1974-01-15 Fmc Corp Fungicidal use of certain benz(d)isothiazoles
GB1532984A (en) * 1975-04-10 1978-11-22 Ici Ltd Method for the control of micro-organisms
DE2967337D1 (en) * 1978-06-16 1985-02-07 Kyowa Hakko Kogyo Kk Antithrombotic pharmaceutical preparation containing 2,2'-dithiobis benzamide derivatives and new 2,2'-dithiobis benzamide derivatives
US4479950A (en) * 1982-11-05 1984-10-30 Usv Pharmaceutical Corporation Aroylaminoacid disulfides
DE3411385A1 (de) * 1984-03-28 1985-10-10 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von o,o'-dithiobenzamiden
US4975367A (en) * 1986-04-04 1990-12-04 Miles Inc. Catalytic test composition intended to produce a range of colors
AU8937491A (en) * 1990-10-22 1992-05-20 Research Corporation Technologies, Inc. Aryl and heteroaryl compounds having anti-retrovirus activity
PT100914A (pt) * 1991-09-30 1993-10-29 Jess G Thoene Uso de compostos capazes de sofrer uma permuta mista com dissulfureto, com uma ligacao dissulfureto, no tratamento de infeccao por hiv

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US5463122A (en) 1995-10-31
MD1687F2 (en) 2001-06-30
GT199500039CA (es) 1997-01-21
MD1687G2 (ro) 2002-03-31
US5668178A (en) 1997-09-16
GT199500039A (es) 1995-08-04
ZA956551B (en) 1996-03-25
MD970135A (en) 1999-03-31
GT199500039AA (es) 1997-01-21
PA7801701A1 (es) 1997-09-30
PE33796A1 (es) 1996-08-31
TJ285B (en) 2000-12-13
BR1100148A (pt) 2000-07-18
GT199500039BA (es) 1997-01-21

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