FI90353C - Plasmidi humaani mangaanisuperoksididismutaasin ilmentämiseksi bakteereissa sekä menetelmä entsymaattisesti aktiivisen humaani mangaanisuperoksididismutaasin tuottamiseksi ja talteenottamiseksi - Google Patents

Plasmidi humaani mangaanisuperoksididismutaasin ilmentämiseksi bakteereissa sekä menetelmä entsymaattisesti aktiivisen humaani mangaanisuperoksididismutaasin tuottamiseksi ja talteenottamiseksi Download PDF

Info

Publication number
FI90353C
FI90353C FI864756A FI864756A FI90353C FI 90353 C FI90353 C FI 90353C FI 864756 A FI864756 A FI 864756A FI 864756 A FI864756 A FI 864756A FI 90353 C FI90353 C FI 90353C
Authority
FI
Finland
Prior art keywords
superoxide dismutase
manganese superoxide
analog
plasmid
human manganese
Prior art date
Application number
FI864756A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI90353B (fi
FI864756A (fi
FI864756A0 (fi
Inventor
Jacob R Hartman
Yaffa Beck
Original Assignee
Bio Technology General Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Technology General Corp filed Critical Bio Technology General Corp
Publication of FI864756A0 publication Critical patent/FI864756A0/fi
Publication of FI864756A publication Critical patent/FI864756A/fi
Application granted granted Critical
Publication of FI90353B publication Critical patent/FI90353B/fi
Publication of FI90353C publication Critical patent/FI90353C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI864756A 1985-11-22 1986-11-21 Plasmidi humaani mangaanisuperoksididismutaasin ilmentämiseksi bakteereissa sekä menetelmä entsymaattisesti aktiivisen humaani mangaanisuperoksididismutaasin tuottamiseksi ja talteenottamiseksi FI90353C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80109085A 1985-11-22 1985-11-22
US80109085 1985-11-22
US90705186A 1986-09-12 1986-09-12
US90705186 1986-09-12

Publications (4)

Publication Number Publication Date
FI864756A0 FI864756A0 (fi) 1986-11-21
FI864756A FI864756A (fi) 1987-05-23
FI90353B FI90353B (fi) 1993-10-15
FI90353C true FI90353C (fi) 1994-01-25

Family

ID=27122291

Family Applications (1)

Application Number Title Priority Date Filing Date
FI864756A FI90353C (fi) 1985-11-22 1986-11-21 Plasmidi humaani mangaanisuperoksididismutaasin ilmentämiseksi bakteereissa sekä menetelmä entsymaattisesti aktiivisen humaani mangaanisuperoksididismutaasin tuottamiseksi ja talteenottamiseksi

Country Status (21)

Country Link
JP (2) JP2609449B2 (fr)
AT (1) AT400443B (fr)
AU (1) AU607897B2 (fr)
BE (1) BE905796A (fr)
CA (1) CA1341362C (fr)
CH (1) CH676990A5 (fr)
DE (1) DE3639725C2 (fr)
DK (1) DK534686A (fr)
ES (1) ES2003518A6 (fr)
FI (1) FI90353C (fr)
FR (1) FR2590591B1 (fr)
GB (1) GB2183658B (fr)
GR (1) GR862713B (fr)
HK (1) HK75195A (fr)
IE (1) IE59498B1 (fr)
IL (2) IL80702A0 (fr)
IT (1) IT1205418B (fr)
LU (1) LU86676A1 (fr)
NL (1) NL8602960A (fr)
PT (1) PT83792B (fr)
SE (1) SE8604884L (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610520B1 (en) * 1985-11-22 2003-08-26 Bio-Technology General Corp. Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby
JPS62215532A (ja) * 1986-03-18 1987-09-22 Ube Ind Ltd 抗炎症剤
JPH0643341B2 (ja) * 1986-03-27 1994-06-08 宇部興産株式会社 臓器機能改善剤
JPH0643340B2 (ja) * 1986-09-03 1994-06-08 宇部興産株式会社 虚血性心疾患治療薬
JPS6377822A (ja) * 1986-09-18 1988-04-08 Ube Ind Ltd 臓器機能改善剤
US6326003B1 (en) 1986-10-14 2001-12-04 Chiron Corporation Manganese superoxide dismutase cloning and expression in microorganisms
ES2083357T3 (es) * 1987-03-14 1996-04-16 Boehringer Ingelheim Int Manganeso-superoxido-dismutasa humana (hmn-sod).
US5260204A (en) * 1987-03-14 1993-11-09 Boehringer Ingelheim International Gmbh Human manganese superoxide dismutase (hMn-SOD)
DE3854678T2 (de) * 1987-03-27 1996-06-13 Bio Technology General Corp Menschliches Mangansuperoxiddismutase und Behandlungsverfahren.
JPH01233228A (ja) * 1988-03-11 1989-09-19 Toyo Jozo Co Ltd 悪性腫瘍細胞転移防止剤
US5772996A (en) * 1990-08-03 1998-06-30 Public Health Laboratory Service Board Pharmaceutical compositions containing superoxide dismutase from Bacillus Stearothermophilus and Bacillus Caldotenax
DE4038563A1 (de) * 1990-12-04 1992-06-11 Gruenenthal Gmbh Verwendung von superoxiddismutasen zur prophylaxe und/oder behandlung von organversagen bei risikopatienten mit polytrauma
ATE209928T1 (de) * 1992-09-09 2001-12-15 Bio Technology General Corp Verwendung von mangan-superoxiddismutase (mn-sod) zur herstellung von arzneimitteln zur behandlung von erkrankungen in niedriger dosierung
DE4239877C1 (de) * 1992-11-27 1994-03-17 Boehringer Ingelheim Int Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56102787A (en) * 1980-01-18 1981-08-17 Mamoru Sugiura Preparation of human placenta superoxide dismutase
BG49718A3 (en) * 1983-07-15 1992-01-15 Bio Technology General Corp Method for preparing of polypeptid with superoxiddismutasne activitty
EP0656418B1 (fr) * 1983-10-03 2002-12-04 Chiron Corporation Clonage de la dismutase du peroxyde et expression dans des microorganismes

Also Published As

Publication number Publication date
JP2967557B2 (ja) 1999-10-25
HK75195A (en) 1995-05-26
AT400443B (de) 1995-12-27
JPS62289187A (ja) 1987-12-16
FI90353B (fi) 1993-10-15
IL106449A (en) 1997-02-18
FI864756A (fi) 1987-05-23
GB2183658B (en) 1990-04-25
IT8667865A0 (it) 1986-11-21
AU607897B2 (en) 1991-03-21
BE905796A (fr) 1987-03-16
DK534686D0 (da) 1986-11-07
GB8627294D0 (en) 1986-12-17
PT83792A (en) 1986-12-01
SE8604884L (sv) 1987-05-23
JP2609449B2 (ja) 1997-05-14
FR2590591A1 (fr) 1987-05-29
DE3639725A1 (de) 1987-07-23
CA1341362C (fr) 2002-05-28
FI864756A0 (fi) 1986-11-21
IL106449A0 (en) 1993-11-15
PT83792B (pt) 1989-01-17
IT1205418B (it) 1989-03-15
IE862851L (en) 1987-05-22
ATA308986A (de) 1995-05-15
DK534686A (da) 1987-05-23
FR2590591B1 (fr) 1989-12-01
IL80702A0 (en) 1987-02-27
IE59498B1 (en) 1994-03-09
GB2183658A (en) 1987-06-10
ES2003518A6 (es) 1988-11-01
NL8602960A (nl) 1987-06-16
GR862713B (en) 1987-03-24
DE3639725C2 (de) 1998-02-19
SE8604884D0 (sv) 1986-11-14
CH676990A5 (fr) 1991-03-28
AU6497586A (en) 1987-05-28
LU86676A1 (fr) 1987-05-04
JPH08289792A (ja) 1996-11-05

Similar Documents

Publication Publication Date Title
FI90353C (fi) Plasmidi humaani mangaanisuperoksididismutaasin ilmentämiseksi bakteereissa sekä menetelmä entsymaattisesti aktiivisen humaani mangaanisuperoksididismutaasin tuottamiseksi ja talteenottamiseksi
EP0284105B1 (fr) Manganèse superoxyde dismutase humaine et méthodes de traitement
Beck et al. Efficient production of active human manganese superoxide dismutase in Escherichia coli
US4742004A (en) Method for producing enzymatically active eucaryotic sod in bacteria
EP0483113B1 (fr) Méthode de production d'un analogue de Cu/Zn SOD humain enzymatiquement actif
US5246847A (en) Polypeptide analogs of human manganese superoxide dismutase and compositions and complexes thereof
EP0362259B1 (fr) Procede de production de cystatine c ou modifications de la cystatine et sequence d'adn destinee a etre utilisee lors de la realisation dudit procede
US6361772B1 (en) Human manganese superoxide dismutase DNA, its expression and method of recovering human manganese superoxide dismutase
EP0594311B1 (fr) Procédé de preparation et usages d'une protéine inhibitrice de metastases.
DE3880511T2 (de) Thermostabile menschliche cu/zn-superoxid-dismutase-muteine.
US5270195A (en) Plasmids for expression and method of producing a human manganese superoxide dimutase analog
US5527691A (en) Expression vectors containing lambdapl promoter and T1 T2 rRNA termination sequence, plasmids containing the vectors, hosts containing the plasmids and related methods
EP1859810A1 (fr) Arginine/lysine-oxidoreductase modifiée par peg
WO1991013158A1 (fr) Production de proteines dans la levure
EP0548095A1 (fr) Compositions pharmaceutiques contenant une dismutase de suroxyde de bacillus stearothermophilus et bacillus caldotenax
TWI331531B (en) Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation
JPH02219570A (ja) ヒト５―リポキシゲナーゼの製造方法

Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed

Owner name: BIO-TECHNOLOGY GENERAL CORP.