ES2083357T3 - Manganeso-superoxido-dismutasa humana (hmn-sod). - Google Patents

Manganeso-superoxido-dismutasa humana (hmn-sod).

Info

Publication number
ES2083357T3
ES2083357T3 ES88103754T ES88103754T ES2083357T3 ES 2083357 T3 ES2083357 T3 ES 2083357T3 ES 88103754 T ES88103754 T ES 88103754T ES 88103754 T ES88103754 T ES 88103754T ES 2083357 T3 ES2083357 T3 ES 2083357T3
Authority
ES
Spain
Prior art keywords
hmn
sod
dismutase
superoxide
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88103754T
Other languages
English (en)
Inventor
Konrad Dr Heckl
Walter Dr Spevak
Elinborg Dr Ostermann
Andreas Dr Zophel
Edeltraud Dr Krystek
Ingrid Dr Maurer-Fogy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19873708306 external-priority patent/DE3708306A1/de
Priority claimed from DE19873717695 external-priority patent/DE3717695A1/de
Priority claimed from DE19873722884 external-priority patent/DE3722884A1/de
Priority claimed from DE19873744038 external-priority patent/DE3744038A1/de
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Application granted granted Critical
Publication of ES2083357T3 publication Critical patent/ES2083357T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/07—Fusion polypeptide containing a localisation/targetting motif containing a mitochondrial localisation signal

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)

Abstract

EL OBJETO DE LA PRESENTE INVENCIONES UN PROCEDIMIENTO DE INGENIERIA GENETICA PARA LA OBTENCION DE MANGANESO-SUPEROXIDO-DISMUTASA HUMANA (HMN-SOD), LAS SECUENCIAS DE ADN QUE CODIFICAN ESTA ENZIMA, LOS VECTORES QUE CONTIENEN ESTAS SECUENCIAS DE ADN Y LAS CELULAS HUESPED QUE PUEDEN EXPRESARLAS ASI COMO LA ENZIMA PROPIAMENTE DICHA. SE DESCRIBEN ADEMAS PROPUESTA PARA LA UTILIZACION DE ESTA ENZIMA.
ES88103754T 1987-03-14 1988-03-10 Manganeso-superoxido-dismutasa humana (hmn-sod). Expired - Lifetime ES2083357T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19873708306 DE3708306A1 (de) 1987-03-14 1987-03-14 Humane mangan-superoxiddismutase (hmn-sod)
DE19873717695 DE3717695A1 (de) 1987-05-26 1987-05-26 Humane mangan-superoxiddismutase (hmn-sod)
DE19873722884 DE3722884A1 (de) 1987-07-10 1987-07-10 Humane mangan-superoxiddismutase (hmn-sod)
DE19873744038 DE3744038A1 (de) 1987-12-24 1987-12-24 Humane mangan-superoxiddismutase (hmn-sod)

Publications (1)

Publication Number Publication Date
ES2083357T3 true ES2083357T3 (es) 1996-04-16

Family

ID=27433860

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88103754T Expired - Lifetime ES2083357T3 (es) 1987-03-14 1988-03-10 Manganeso-superoxido-dismutasa humana (hmn-sod).

Country Status (18)

Country Link
US (3) US5240847A (es)
EP (2) EP0676472A1 (es)
JP (1) JP2860100B2 (es)
KR (1) KR880011339A (es)
AT (1) ATE132902T1 (es)
AU (1) AU618526B2 (es)
CA (1) CA1341387C (es)
DE (1) DE3854872D1 (es)
DK (1) DK133388A (es)
ES (1) ES2083357T3 (es)
FI (1) FI881185A (es)
GR (1) GR3019091T3 (es)
HU (1) HU212920B (es)
IE (2) IE960190L (es)
IL (1) IL85701A0 (es)
MX (1) MX9203619A (es)
NO (1) NO176884C (es)
PT (1) PT86955B (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714362A (en) * 1983-04-29 1998-02-03 Yeda Research And Development Co. Ltd. Human superoxide dismutase cDNA
US6610520B1 (en) * 1985-11-22 2003-08-26 Bio-Technology General Corp. Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby
US6326003B1 (en) 1986-10-14 2001-12-04 Chiron Corporation Manganese superoxide dismutase cloning and expression in microorganisms
EP0676472A1 (de) * 1987-03-14 1995-10-11 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Humane Mangan-Superoxiddismutase (hMn-SOD)
EP0284105B1 (en) * 1987-03-27 1995-11-15 Bio-Technology General Corporation Human manganese superoxide dismutase and methods of treatment
JP2500543B2 (ja) * 1991-05-24 1996-05-29 住友化学工業株式会社 キメラｐ４５０産生菌株
DK0587055T3 (da) * 1992-09-09 2002-04-02 Bio Technology General Corp Anvendelse af mangan-superoxiddismutase (Mn-SOD) til fremstilling af lægemidler til behandling af sygdomme i lav dosering
US5843641A (en) * 1993-02-26 1998-12-01 Massachusetts Institute Of Technology Methods for the daignosis, of familial amyotrophic lateral sclerosis
IL109112A0 (en) * 1993-03-24 1994-06-24 Boehringer Ingelheim Pharma Pharmaceutical compositions containing human manganese superoxide dismutase
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
US5994339A (en) * 1993-10-15 1999-11-30 University Of Alabama At Birmingham Research Foundation Oxidant scavengers
US6887856B1 (en) * 1993-10-15 2005-05-03 University Of Pittsburgh Protection from ionizing irradiation or chemotherapeutic drug damage by in vivo gene therapy
US6127356A (en) * 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US5506133A (en) * 1994-04-11 1996-04-09 Human Genome Sciences, Inc. Superoxide dismutase-4
JP2517894B2 (ja) * 1994-08-12 1996-07-24 住友化学工業株式会社 フェレドキシン及びフェレドキシン還元酵素を同時に発現させるキメラｐ４５０産生菌株
WO1996009053A1 (en) * 1994-09-20 1996-03-28 Duke University Oxidoreductase activity of manganic porphyrins
US6359194B1 (en) 1995-02-10 2002-03-19 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease
US5834248A (en) * 1995-02-10 1998-11-10 Millennium Pharmaceuticals Inc. Compositions and methods using rchd534, a gene uregulated by shear stress
US6099823A (en) * 1996-02-16 2000-08-08 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease
AU725192B2 (en) 1996-02-16 2000-10-05 Brigham And Women's Hospital Compositions and methods for the treatment and diagnosis of cardiovascular disease
WO1999006059A2 (en) * 1997-07-30 1999-02-11 Board Of Regents, The University Of Texas System Methods and compositions relating to no-mediated cytotoxicity
US6171856B1 (en) 1997-07-30 2001-01-09 Board Of Regents, The University Of Texas System Methods and compositions relating to no-mediated cytotoxicity
AU737650B2 (en) 1997-11-03 2001-08-23 Duke University Substituted porphyrins
US6737506B1 (en) * 1998-02-25 2004-05-18 Paul Anziano Manganese superoxide dismutase exon 3-deleted isoforms and nucleic acid molecules encoding the isoforms
CA2321934C (en) * 1998-02-25 2012-02-21 Paul Q. Anziano Manganese superoxide dismutase exon 3-deleted isoforms and nucleic acid molecules encoding the isoforms
DE69928655T2 (de) 1998-04-24 2006-08-24 Duke University Substituierte porphyrine
US6190658B1 (en) 1998-05-08 2001-02-20 Webb-Waring Institute For Biomedical Research Genetically modified manganese superoxide dismutase for treating oxidative damage
US6221848B1 (en) 1998-05-11 2001-04-24 University Of Pittsburgh Protection of the esophagus from chemotherapeutic or irradiation damage by gene therapy
GB9824282D0 (en) * 1998-11-05 1998-12-30 Microbiological Research Agenc Delivery of superoxide dismutase to neuronal cells
ATE552260T1 (de) 1999-01-25 2012-04-15 Nat Jewish Health Substituierte porphyrine und deren therapeutische verwendung
US6265172B1 (en) * 1999-02-08 2001-07-24 University Of Kentucky Diagnostic test and therapy for manganese superoxide dismutate (mNsod) associated diseases
FR2806911B1 (fr) * 2000-03-28 2003-01-10 Univ Rene Descartes Utilisation de mimetiques de la sod dans le traitement d'insuffisances hepatocellulaires
CN1322825A (zh) * 2000-05-09 2001-11-21 上海博德基因开发有限公司 一种新的多肽——超氧化物歧化酶11和编码这种多肽的多核苷酸
AU2002248366B2 (en) 2001-01-19 2006-10-26 Aeolus Sciences, Inc. Cancer therapy
AU2002312194B8 (en) 2001-06-01 2008-05-15 Aeolus Sciences, Inc. Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
AU2002345699A1 (en) * 2001-06-13 2002-12-23 Webb-Waring Institute For Biomedical Research A diagnostic and prognostic method for evaluating ocular inflammation and oxidative stress and the treatment of the same
CA2488500A1 (en) 2002-06-07 2003-12-18 Duke University Substituted porphyrins
EP1687410A4 (en) * 2003-10-07 2008-04-09 Isis Pharmaceuticals Inc ANTISENSE OLIGONUCLEOTIDES OPTIMIZED TO TARGET THE KIDNEY
US20050191653A1 (en) * 2003-11-03 2005-09-01 Freier Susan M. Modulation of SGLT2 expression
US7232808B2 (en) * 2004-08-02 2007-06-19 University Of Iowa Research Foundation Methods of inhibiting manganese-containing superoxide dismutase 2 (MnSOD)
US9546312B2 (en) * 2007-08-31 2017-01-17 Hayes & Associates Endotherm systems and methods utilizing carbohydrate in non-oxidizing environment
RU2506083C2 (ru) 2008-05-23 2014-02-10 Нэшнл Джуиш Хелт Способ лечения поражений, ассоциированных с воздействием алкилирующих веществ

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029819A (en) * 1973-04-16 1977-06-14 Etablissement Public Det: Agence Nationale De Valorisation De La Recherche Anver Superoxide dismutase and its application as an oxidation inhibitor
BE813485A (fr) * 1973-04-16 1974-10-09 Superoxyde dismutases et leur application comme inhibiteurs d'oxydation
FR2240277B2 (es) * 1973-08-10 1976-12-17 Anvar
FR2225443B1 (es) * 1973-04-16 1976-11-12 Anvar
JPS5816685A (ja) * 1981-07-22 1983-01-31 Takeda Chem Ind Ltd 固定化酵素，その製造法および製剤
US5196335A (en) * 1983-04-29 1993-03-23 Yeda Research And Development Co., Ltd. Human superoxide dismutase cDNA
US5066591A (en) * 1983-10-03 1991-11-19 Chiron Corporation Polypeptides of human copper/zinc superoxide dimutase
EP0656418B1 (en) * 1983-10-03 2002-12-04 Chiron Corporation Superoxide dismutase and expression in microorganisms
US4751180A (en) * 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
DK402785D0 (da) * 1985-09-03 1985-09-03 Syn Tek Ab Fremgangsmaade til fremstilling af et enzym
US5270195A (en) * 1985-11-22 1993-12-14 Bio-Technology General Corp. Plasmids for expression and method of producing a human manganese superoxide dimutase analog
IE59498B1 (en) * 1985-11-22 1994-03-09 Bio Technology General Corp Human manganese superoxide dismutase analog, plasmid for its expression and method of recovering it in enzymatically active form
US5246847A (en) * 1985-11-22 1993-09-21 Bio-Technology General Corp. Polypeptide analogs of human manganese superoxide dismutase and compositions and complexes thereof
EP0676472A1 (de) * 1987-03-14 1995-10-11 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Humane Mangan-Superoxiddismutase (hMn-SOD)
US5260204A (en) * 1987-03-14 1993-11-09 Boehringer Ingelheim International Gmbh Human manganese superoxide dismutase (hMn-SOD)
EP0284105B1 (en) * 1987-03-27 1995-11-15 Bio-Technology General Corporation Human manganese superoxide dismutase and methods of treatment
US5223538A (en) * 1987-03-31 1993-06-29 Duke University Superoxide dismutase mimic
NZ225760A (en) * 1987-08-14 1991-02-26 Bio Technology General Corp Expression plasmids containing the deo promoter and bacterial hosts containing these plasmids
JPH0283398A (ja) * 1988-09-21 1990-03-23 Ube Ind Ltd 合成ペプチド、それを用いたヒトＭｎ−スーパーオキシドジスムターゼの測定キットおよび測定法
EP0462836A3 (en) * 1990-06-20 1992-08-26 Mitsui Toatsu Chemicals, Inc. Recombinant vector plasmid capable of expressing human manganese superoxide dismutase, and process of producing this enzyme

Also Published As

Publication number Publication date
CA1341387C (en) 2002-09-03
NO176884B (no) 1995-03-06
IL85701A0 (en) 1988-08-31
DK133388A (da) 1988-09-15
FI881185A (fi) 1988-09-15
IE71940B1 (en) 1997-03-12
PT86955B (pt) 1992-06-30
GR3019091T3 (en) 1996-05-31
DK133388D0 (da) 1988-03-11
AU618526B2 (en) 1992-01-02
NO176884C (no) 1995-06-14
JPS6463383A (en) 1989-03-09
EP0676472A1 (de) 1995-10-11
IE880717L (en) 1988-09-14
NO881089L (no) 1988-09-15
JP2860100B2 (ja) 1999-02-24
NO881089D0 (no) 1988-03-11
US5240847A (en) 1993-08-31
KR880011339A (ko) 1988-10-27
HU212920B (en) 1996-12-30
EP0282899B1 (de) 1996-01-10
PT86955A (pt) 1988-04-01
US5436162A (en) 1995-07-25
FI881185A0 (fi) 1988-03-14
HUT46739A (en) 1988-11-28
ATE132902T1 (de) 1996-01-15
MX9203619A (es) 1992-09-01
AU1302788A (en) 1988-09-15
US5589371A (en) 1996-12-31
EP0282899A2 (de) 1988-09-21
IE960190L (en) 1988-09-14
EP0282899A3 (en) 1989-11-15
DE3854872D1 (de) 1996-02-22

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