NO881089D0 - Human mangan-superoksyddismutase (hmn-sod). - Google Patents

Human mangan-superoksyddismutase (hmn-sod).

Info

Publication number
NO881089D0
NO881089D0 NO881089A NO881089A NO881089D0 NO 881089 D0 NO881089 D0 NO 881089D0 NO 881089 A NO881089 A NO 881089A NO 881089 A NO881089 A NO 881089A NO 881089 D0 NO881089 D0 NO 881089D0
Authority
NO
Norway
Prior art keywords
hmn
sod
human
dismutase
superoxyd
Prior art date
Application number
NO881089A
Other languages
English (en)
Other versions
NO176884C (no
NO176884B (no
NO881089L (no
Inventor
Konrad Heckl
Walter Spevak
Elinborg Ostermann
Andreas Zoephel
Edeltraud Krystek
Ingrid Maurer-Fogy
Maria Josefa Wiche-Castanon
Christian Stratowa
Rudolf Hauptmann
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19873708306 external-priority patent/DE3708306A1/de
Priority claimed from DE19873717695 external-priority patent/DE3717695A1/de
Priority claimed from DE19873722884 external-priority patent/DE3722884A1/de
Priority claimed from DE19873744038 external-priority patent/DE3744038A1/de
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of NO881089D0 publication Critical patent/NO881089D0/no
Publication of NO881089L publication Critical patent/NO881089L/no
Publication of NO176884B publication Critical patent/NO176884B/no
Publication of NO176884C publication Critical patent/NO176884C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/07—Fusion polypeptide containing a localisation/targetting motif containing a mitochondrial localisation signal

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Peptides Or Proteins (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
NO881089A 1987-03-14 1988-03-11 DNA-sekvens kodende for human Mangansuperoksyddismutase (hMn-SOD), vektorer inneholdende dette genet og rekombinant framstilling av hMn-SOD NO176884C (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19873708306 DE3708306A1 (de) 1987-03-14 1987-03-14 Humane mangan-superoxiddismutase (hmn-sod)
DE19873717695 DE3717695A1 (de) 1987-05-26 1987-05-26 Humane mangan-superoxiddismutase (hmn-sod)
DE19873722884 DE3722884A1 (de) 1987-07-10 1987-07-10 Humane mangan-superoxiddismutase (hmn-sod)
DE19873744038 DE3744038A1 (de) 1987-12-24 1987-12-24 Humane mangan-superoxiddismutase (hmn-sod)

Publications (4)

Publication Number Publication Date
NO881089D0 true NO881089D0 (no) 1988-03-11
NO881089L NO881089L (no) 1988-09-15
NO176884B NO176884B (no) 1995-03-06
NO176884C NO176884C (no) 1995-06-14

Family

ID=27433860

Family Applications (1)

Application Number Title Priority Date Filing Date
NO881089A NO176884C (no) 1987-03-14 1988-03-11 DNA-sekvens kodende for human Mangansuperoksyddismutase (hMn-SOD), vektorer inneholdende dette genet og rekombinant framstilling av hMn-SOD

Country Status (18)

Country Link
US (3) US5240847A (no)
EP (2) EP0282899B1 (no)
JP (1) JP2860100B2 (no)
KR (1) KR880011339A (no)
AT (1) ATE132902T1 (no)
AU (1) AU618526B2 (no)
CA (1) CA1341387C (no)
DE (1) DE3854872D1 (no)
DK (1) DK133388A (no)
ES (1) ES2083357T3 (no)
FI (1) FI881185A (no)
GR (1) GR3019091T3 (no)
HU (1) HU212920B (no)
IE (2) IE960190L (no)
IL (1) IL85701A0 (no)
MX (1) MX9203619A (no)
NO (1) NO176884C (no)
PT (1) PT86955B (no)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714362A (en) * 1983-04-29 1998-02-03 Yeda Research And Development Co. Ltd. Human superoxide dismutase cDNA
US6610520B1 (en) * 1985-11-22 2003-08-26 Bio-Technology General Corp. Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby
US6326003B1 (en) 1986-10-14 2001-12-04 Chiron Corporation Manganese superoxide dismutase cloning and expression in microorganisms
ATE132902T1 (de) * 1987-03-14 1996-01-15 Boehringer Ingelheim Int Humane mangan-superoxiddismutase (hmn-sod)
DE3854678T2 (de) * 1987-03-27 1996-06-13 Bio Technology General Corp Menschliches Mangansuperoxiddismutase und Behandlungsverfahren.
JP2500543B2 (ja) * 1991-05-24 1996-05-29 住友化学工業株式会社 キメラｐ４５０産生菌株
EP0587055B1 (de) * 1992-09-09 2001-12-05 Bio-Technology General Corporation Verwendung von Mangan-Superoxiddismutase (Mn-SOD) zur Herstellung von Arzneimitteln zur Behandlung von Erkrankungen in niedriger Dosierung
US5843641A (en) * 1993-02-26 1998-12-01 Massachusetts Institute Of Technology Methods for the daignosis, of familial amyotrophic lateral sclerosis
AU6491394A (en) * 1993-03-24 1994-10-11 Boehringer Ingelheim Pharmaceuticals, Inc. Method for inhibiting pulmonary oxygen toxicity using manganese superoxide dismutase
US6887856B1 (en) * 1993-10-15 2005-05-03 University Of Pittsburgh Protection from ionizing irradiation or chemotherapeutic drug damage by in vivo gene therapy
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
US6127356A (en) * 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US5994339A (en) * 1993-10-15 1999-11-30 University Of Alabama At Birmingham Research Foundation Oxidant scavengers
US5506133A (en) 1994-04-11 1996-04-09 Human Genome Sciences, Inc. Superoxide dismutase-4
JP2517894B2 (ja) * 1994-08-12 1996-07-24 住友化学工業株式会社 フェレドキシン及びフェレドキシン還元酵素を同時に発現させるキメラｐ４５０産生菌株
WO1996009053A1 (en) * 1994-09-20 1996-03-28 Duke University Oxidoreductase activity of manganic porphyrins
US5834248A (en) * 1995-02-10 1998-11-10 Millennium Pharmaceuticals Inc. Compositions and methods using rchd534, a gene uregulated by shear stress
US6359194B1 (en) 1995-02-10 2002-03-19 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease
AU725192B2 (en) * 1996-02-16 2000-10-05 Brigham And Women's Hospital Compositions and methods for the treatment and diagnosis of cardiovascular disease
US6099823A (en) * 1996-02-16 2000-08-08 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease
US6171856B1 (en) 1997-07-30 2001-01-09 Board Of Regents, The University Of Texas System Methods and compositions relating to no-mediated cytotoxicity
WO1999006059A2 (en) * 1997-07-30 1999-02-11 Board Of Regents, The University Of Texas System Methods and compositions relating to no-mediated cytotoxicity
IL135949A0 (en) 1997-11-03 2001-05-20 Univ Duke Substituted porphyrins
AU3311699A (en) * 1998-02-25 1999-09-15 Board Of Regents Of The University And Community College System Of Nevada, The Manganese superoxide dismutase exon 3-deleted isoforms and nucleic acid molecules encoding the isoforms
US6737506B1 (en) * 1998-02-25 2004-05-18 Paul Anziano Manganese superoxide dismutase exon 3-deleted isoforms and nucleic acid molecules encoding the isoforms
WO1999055388A1 (en) 1998-04-24 1999-11-04 Duke University Substituted porphyrins
US6190658B1 (en) 1998-05-08 2001-02-20 Webb-Waring Institute For Biomedical Research Genetically modified manganese superoxide dismutase for treating oxidative damage
US6221848B1 (en) 1998-05-11 2001-04-24 University Of Pittsburgh Protection of the esophagus from chemotherapeutic or irradiation damage by gene therapy
GB9824282D0 (en) * 1998-11-05 1998-12-30 Microbiological Research Agenc Delivery of superoxide dismutase to neuronal cells
JP4501128B2 (ja) 1999-01-25 2010-07-14 ナショナル ジュウィッシュ ヘルス 置換ポルフィリン
US6265172B1 (en) * 1999-02-08 2001-07-24 University Of Kentucky Diagnostic test and therapy for manganese superoxide dismutate (mNsod) associated diseases
FR2806911B1 (fr) * 2000-03-28 2003-01-10 Univ Rene Descartes Utilisation de mimetiques de la sod dans le traitement d'insuffisances hepatocellulaires
CN1322825A (zh) * 2000-05-09 2001-11-21 上海博德基因开发有限公司 一种新的多肽——超氧化物歧化酶11和编码这种多肽的多核苷酸
US20030050297A1 (en) 2001-01-19 2003-03-13 Crapo James D. Cancer therapy
WO2002098431A1 (en) 2001-06-01 2002-12-12 National Jewish Medical And Research Center Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
US20030027745A1 (en) * 2001-06-13 2003-02-06 Repine John E. Diagnostic and prognostic method for evaluating ocular inflammation and oxidative stress and the treatment of the same
EP1513537A4 (en) 2002-06-07 2006-09-06 Univ Duke SUBSTITUTED PORPHYRINS
US8258105B2 (en) * 2003-10-07 2012-09-04 Isis Pharmaceuticals, Inc. Antisense oligonucleotides optimized for kidney targeting
US20050191653A1 (en) * 2003-11-03 2005-09-01 Freier Susan M. Modulation of SGLT2 expression
WO2006017559A1 (en) * 2004-08-02 2006-02-16 University Of Iowa Research Foundation Methods of inhibiting manganese-containing superoxide dismutase 2 (mnsod)
US9546312B2 (en) * 2007-08-31 2017-01-17 Hayes & Associates Endotherm systems and methods utilizing carbohydrate in non-oxidizing environment
CN102105146A (zh) 2008-05-23 2011-06-22 国立犹太保健医院 用于治疗与暴露于烷化物质有关的损伤的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE813485A (fr) * 1973-04-16 1974-10-09 Superoxyde dismutases et leur application comme inhibiteurs d'oxydation
FR2240277B2 (no) * 1973-08-10 1976-12-17 Anvar
FR2225443B1 (no) * 1973-04-16 1976-11-12 Anvar
US4029819A (en) * 1973-04-16 1977-06-14 Etablissement Public Det: Agence Nationale De Valorisation De La Recherche Anver Superoxide dismutase and its application as an oxidation inhibitor
JPS5816685A (ja) * 1981-07-22 1983-01-31 Takeda Chem Ind Ltd 固定化酵素，その製造法および製剤
US5196335A (en) * 1983-04-29 1993-03-23 Yeda Research And Development Co., Ltd. Human superoxide dismutase cDNA
US5066591A (en) * 1983-10-03 1991-11-19 Chiron Corporation Polypeptides of human copper/zinc superoxide dimutase
DE3486452T2 (de) * 1983-10-03 1997-11-06 Chiron Corp Superoxiddismutase und deren Expression in Mikroorganismen
US4751180A (en) * 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
DK402785D0 (da) * 1985-09-03 1985-09-03 Syn Tek Ab Fremgangsmaade til fremstilling af et enzym
IE59498B1 (en) * 1985-11-22 1994-03-09 Bio Technology General Corp Human manganese superoxide dismutase analog, plasmid for its expression and method of recovering it in enzymatically active form
US5270195A (en) * 1985-11-22 1993-12-14 Bio-Technology General Corp. Plasmids for expression and method of producing a human manganese superoxide dimutase analog
US5246847A (en) * 1985-11-22 1993-09-21 Bio-Technology General Corp. Polypeptide analogs of human manganese superoxide dismutase and compositions and complexes thereof
US5260204A (en) * 1987-03-14 1993-11-09 Boehringer Ingelheim International Gmbh Human manganese superoxide dismutase (hMn-SOD)
ATE132902T1 (de) * 1987-03-14 1996-01-15 Boehringer Ingelheim Int Humane mangan-superoxiddismutase (hmn-sod)
DE3854678T2 (de) * 1987-03-27 1996-06-13 Bio Technology General Corp Menschliches Mangansuperoxiddismutase und Behandlungsverfahren.
US5223538A (en) * 1987-03-31 1993-06-29 Duke University Superoxide dismutase mimic
NZ225760A (en) * 1987-08-14 1991-02-26 Bio Technology General Corp Expression plasmids containing the deo promoter and bacterial hosts containing these plasmids
JPH0283398A (ja) * 1988-09-21 1990-03-23 Ube Ind Ltd 合成ペプチド、それを用いたヒトＭｎ−スーパーオキシドジスムターゼの測定キットおよび測定法
EP0462836A3 (en) * 1990-06-20 1992-08-26 Mitsui Toatsu Chemicals, Inc. Recombinant vector plasmid capable of expressing human manganese superoxide dismutase, and process of producing this enzyme

Also Published As

Publication number Publication date
DK133388A (da) 1988-09-15
ES2083357T3 (es) 1996-04-16
DE3854872D1 (de) 1996-02-22
GR3019091T3 (en) 1996-05-31
KR880011339A (ko) 1988-10-27
DK133388D0 (da) 1988-03-11
EP0282899B1 (de) 1996-01-10
IE960190L (en) 1988-09-14
JP2860100B2 (ja) 1999-02-24
CA1341387C (en) 2002-09-03
PT86955B (pt) 1992-06-30
JPS6463383A (en) 1989-03-09
ATE132902T1 (de) 1996-01-15
MX9203619A (es) 1992-09-01
PT86955A (pt) 1988-04-01
IE71940B1 (en) 1997-03-12
NO176884C (no) 1995-06-14
NO176884B (no) 1995-03-06
US5589371A (en) 1996-12-31
FI881185A0 (fi) 1988-03-14
HUT46739A (en) 1988-11-28
US5240847A (en) 1993-08-31
AU618526B2 (en) 1992-01-02
EP0282899A2 (de) 1988-09-21
IE880717L (en) 1988-09-14
US5436162A (en) 1995-07-25
EP0282899A3 (en) 1989-11-15
NO881089L (no) 1988-09-15
AU1302788A (en) 1988-09-15
EP0676472A1 (de) 1995-10-11
FI881185A (fi) 1988-09-15
HU212920B (en) 1996-12-30
IL85701A0 (en) 1988-08-31

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Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN SEPTEMBER 2003