FI883722A - Alfa-amiderande enzymkompositioner och foerfaranden foer deras framstaellning och anvaendning. - Google Patents

Alfa-amiderande enzymkompositioner och foerfaranden foer deras framstaellning och anvaendning. Download PDF

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Publication number
FI883722A
FI883722A FI883722A FI883722A FI883722A FI 883722 A FI883722 A FI 883722A FI 883722 A FI883722 A FI 883722A FI 883722 A FI883722 A FI 883722A FI 883722 A FI883722 A FI 883722A
Authority
FI
Finland
Prior art keywords
och
enzymkompositioner
enzyme
alpha
anvaendning
Prior art date
Application number
FI883722A
Other languages
English (en)
Other versions
FI883722A0 (fi
Inventor
James P Gilligan
Barry N Jones
Arthur H Bertelsen
Nozer M Mehta
Original Assignee
Unigene Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US07/086,161 priority Critical patent/US6319685B1/en
Application filed by Unigene Lab Inc filed Critical Unigene Lab Inc
Publication of FI883722A0 publication Critical patent/FI883722A0/fi
Publication of FI883722A publication Critical patent/FI883722A/fi
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22196693&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI883722(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67General methods for enhancing the expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y114/00Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/17Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced ascorbate as one donor, and incorporation of one atom of oxygen (1.14.17)
    • C12Y114/17003Peptidylglycine monooxygenase (1.14.17.3)
FI883722A 1984-09-27 1988-08-10 Alfa-amiderande enzymkompositioner och foerfaranden foer deras framstaellning och anvaendning. FI883722A (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US07/086,161 US6319685B1 (en) 1984-09-27 1987-08-14 Alpha-amidating enzyme compositions and processes for their production and use

Publications (2)

Publication Number Publication Date
FI883722A0 FI883722A0 (fi) 1988-08-10
FI883722A true FI883722A (fi) 1989-02-15

Family

ID=22196693

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883722A FI883722A (fi) 1984-09-27 1988-08-10 Alfa-amiderande enzymkompositioner och foerfaranden foer deras framstaellning och anvaendning.

Country Status (13)

Country Link
US (1) US6319685B1 (fi)
EP (2) EP0529742B1 (fi)
JP (1) JP2979172B2 (fi)
KR (1) KR0136611B1 (fi)
AT (1) AT198355T (fi)
CA (1) CA1341454C (fi)
DE (1) DE3856446T2 (fi)
DK (1) DK175538B1 (fi)
FI (1) FI883722A (fi)
HU (3) HU213227B (fi)
LT (1) LT4029B (fi)
NO (1) NO883592L (fi)
RU (2) RU2252961C2 (fi)

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US5789234A (en) * 1987-08-14 1998-08-04 Unigene Laboratories, Inc. Expression systems for amidating enzyme
US6319685B1 (en) 1984-09-27 2001-11-20 Unigene Laboratories, Inc. Alpha-amidating enzyme compositions and processes for their production and use
US4708934A (en) * 1984-09-27 1987-11-24 Unigene Laboratories, Inc. α-amidation enzyme
US5871995A (en) * 1989-08-15 1999-02-16 Shiseido Company, Ltd. Purified enzymes participating in C-terminal amidation
ES2079054T3 (es) * 1990-06-01 1996-01-01 Ciba Geigy Ag Peptidilhidroxiglicina n-c-liasa y adn codificante de la misma.
US5580751A (en) * 1990-09-14 1996-12-03 Carlsberg A/S Process for the preparation of C-terminally amidated peptides
DK67691D0 (da) * 1991-03-01 1991-04-15 Carlbiotech Ltd As Enzymatisk fremgangsmaade til c-terminal modificering af peptider og mellemprodukter til brug ved fremgangsmaaden
WO1996017941A2 (en) * 1994-12-07 1996-06-13 Bionebraska, Inc. Production of c-terminal amidated peptides from recombinant protein constructs
US5912014A (en) * 1996-03-15 1999-06-15 Unigene Laboratories, Inc. Oral salmon calcitonin pharmaceutical products
DK1005526T3 (da) 1997-04-16 2011-02-07 Unigene Lab Inc Direkte ekspression af peptider i kulturmedium
WO2004011652A1 (ja) 2002-07-26 2004-02-05 Ajinomoto Co., Inc. トリペプチド以上のペプチドの製造方法
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
US7531518B2 (en) 2004-05-14 2009-05-12 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US7648965B2 (en) * 2004-05-14 2010-01-19 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US20060089723A1 (en) * 2004-10-25 2006-04-27 Murphy Kieran P Method for bone augmentation
US7445911B2 (en) * 2004-11-24 2008-11-04 Unigene Laboratories Inc. Enzymatic reactions in the presence of keto acids
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
US20060293667A1 (en) * 2005-05-19 2006-12-28 Agnes Vignery Bone implant device and methods of using same
US8377863B2 (en) 2007-05-29 2013-02-19 Unigene Laboratories Inc. Peptide pharmaceutical for oral delivery
ES2622877T3 (es) 2009-01-22 2017-07-07 Keybioscience Ag Tratamiento para la obesidad
WO2011063414A1 (en) 2009-11-23 2011-05-26 Amylin Pharmaceuticals, Inc. Polypeptide conjugate
TW201138808A (en) 2010-05-03 2011-11-16 Squibb Bristol Myers Co Serum albumin binding molecules
BR112013007385A2 (pt) 2010-09-28 2021-04-20 Amylin Pharmaceuticals Inc leptinas altamente solúveis
CA2812951A1 (en) 2010-09-28 2012-04-19 Amylin Pharmaceuticals, Llc Engineered polypeptides having enhanced duration of action
ES2712805T3 (es) 2011-06-15 2019-05-14 Resother Pharma Aps Næsseslottet Productos farmacéuticos antiinflamatorios
WO2013009545A1 (en) 2011-07-08 2013-01-17 Amylin Pharmaceuticals, Inc. Engineered polypeptides having enhanced duration of action with reduced immunogenicity
CN103957926B (zh) 2011-07-08 2018-07-03 安米林药品有限责任公司 具有增强的作用持续时间和降低的免疫原性的工程改造的多肽
US9533022B2 (en) 2011-11-02 2017-01-03 KeyBioscience A/S Peptide analogs for treating diseases and disorders
BR112014010701A2 (pt) 2011-11-02 2020-06-23 Keybioscience Ag Uso de um peptídeo
DK2773365T3 (en) 2011-11-02 2016-08-29 Keybioscience Ag Peptide FOR THE TREATMENT OF DISEASES AND DISORDERS
RU2689551C1 (ru) 2013-11-14 2019-05-28 Кибайосайнс Аг Миметик кальцитонина для лечения болезней и нарушений
CN105939759B (zh) 2013-12-02 2020-01-17 康德生物医疗技术公司 用于治疗白癜风的组合物和方法
EP3502132A1 (en) 2014-05-28 2019-06-26 Stealth BioTherapeutics Corp Therapeutic compositions including therapeutic small molecules and uses thereof
WO2015183995A2 (en) 2014-05-28 2015-12-03 Stealth Peptides International, Inc. Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof
WO2015195737A1 (en) 2014-06-17 2015-12-23 Stealth Peptides International, Inc. Methods of identifying and monitoring mitochondrial dysfunction using monocyte screening
GB201500263D0 (en) 2015-01-08 2015-02-25 Keybioscience Ag Calcitonin analogues for treating diseases and disorders
CA2973099A1 (en) 2015-01-12 2016-07-21 Enteris Biopharma, Inc. Solid oral dosage forms
GB201704429D0 (en) 2017-03-21 2017-05-03 Keybioscience Ag Calcitonin mimetics for treating diseases and disorders
GB201707955D0 (en) 2017-05-18 2017-07-05 Keybioscience Ag Dual amylin and calcitonin receptor agonists for treating diseases and disorders
GB201813678D0 (en) 2018-08-22 2018-10-03 Keybioscience Ag Acylated calcitonin mimetics
GB201813677D0 (en) 2018-08-22 2018-10-03 Keybioscience Ag Calcitonin mimetics for treating diseases and disorders

Family Cites Families (15)

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US655366A (en) 1900-05-16 1900-08-07 Simeon C Lawlor Window-cleaner.
US4518693A (en) * 1982-11-01 1985-05-21 Research Corporation Immobilized biocatalysts
GB2141430B (en) 1983-06-15 1987-01-21 Kingdon Craig R Peptides, pharmaceutical compositions, genes, vectors, host organisms, processes for their production and diagnostic reagents
WO1985000043A1 (en) 1983-06-15 1985-01-03 Kingdon Craig R Peptides, pharmaceutical compositions, genes, vectors, host organisms, processes for their production and diagnostic reagents
US4549986A (en) 1983-12-23 1985-10-29 The Salk Institute For Biological Studies Human CGRP
US4708934A (en) * 1984-09-27 1987-11-24 Unigene Laboratories, Inc. α-amidation enzyme
US6319685B1 (en) 1984-09-27 2001-11-20 Unigene Laboratories, Inc. Alpha-amidating enzyme compositions and processes for their production and use
JPH0570433B2 (fi) 1985-04-08 1993-10-05 Sankyo Co
GB8523156D0 (en) 1985-09-19 1985-10-23 Celltech Ltd Polypeptide production
JPH0480988B2 (fi) 1986-01-29 1992-12-21 Toyota Motor Co Ltd
JPH0775541B2 (ja) 1986-06-07 1995-08-16 壽之 松尾 C末端アミド化酵素及びその製造方法
AU7410987A (en) 1986-06-12 1988-01-07 Immunex Corp. Polypeptides devoid of hydrophobic amino acids
JP2598050B2 (ja) 1987-07-17 1997-04-09 サントリー株式会社 C−末端α−アミド化酵素
US6255067B1 (en) 1987-09-15 2001-07-03 The Johns Hopkins University cDNA encoding peptidyl-glycine alpha-amidating monooxygenase (PAM)
JP2845468B2 (ja) 1989-01-17 1999-01-13 サントリー株式会社 ヒト甲状腺由来C―末端α―アミド化酵素

Also Published As

Publication number Publication date
FI883722A0 (fi) 1988-08-10
KR890003947A (ko) 1989-04-19
DK448988D0 (da) 1988-08-11
CA1341454C (en) 2004-04-20
RU2252961C2 (ru) 2005-05-27
RU2080385C1 (ru) 1997-05-27
JPH02104281A (en) 1990-04-17
DK448988A (da) 1989-02-15
AT198355T (de) 2001-01-15
DE3856446T2 (de) 2001-07-12
AU2057688A (en) 1989-02-16
FI883722D0 (fi)
HU213227B (en) 1997-07-28
EP0308067A3 (en) 1989-07-26
EP0529742B1 (en) 2000-12-27
AU629795B2 (en) 1992-10-15
DE3856446D1 (de) 2001-02-01
EP0308067A2 (en) 1989-03-22
US6319685B1 (en) 2001-11-20
NO883592L (no) 1989-02-15
EP0529742A1 (en) 1993-03-03
HU9500552A3 (en) 1995-10-30
LTIP1656A (en) 1995-07-25
HU212071A9 (en) 1996-02-28
LT4029B (en) 1996-08-26
KR0136611B1 (ko) 1998-04-25
DK175538B1 (da) 2004-11-29
JP2979172B2 (ja) 1999-11-15
NO883592D0 (no) 1988-08-12

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Owner name: UNIGENE LABORATORIES, INC.