FI84230B - Foerfarande foer laddning av vattensvaellbara, vattenoloesliga polymerer med medroxiprogesteronacetat. - Google Patents

Foerfarande foer laddning av vattensvaellbara, vattenoloesliga polymerer med medroxiprogesteronacetat. Download PDF

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Publication number
FI84230B
FI84230B FI850455A FI850455A FI84230B FI 84230 B FI84230 B FI 84230B FI 850455 A FI850455 A FI 850455A FI 850455 A FI850455 A FI 850455A FI 84230 B FI84230 B FI 84230B
Authority
FI
Finland
Prior art keywords
map
polymer
swellable
mixture
water
Prior art date
Application number
FI850455A
Other languages
English (en)
Finnish (fi)
Other versions
FI84230C (sv
FI850455A0 (fi
FI850455L (fi
Inventor
Fabio Carli
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of FI850455A0 publication Critical patent/FI850455A0/fi
Publication of FI850455L publication Critical patent/FI850455L/fi
Application granted granted Critical
Publication of FI84230B publication Critical patent/FI84230B/fi
Publication of FI84230C publication Critical patent/FI84230C/sv

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Claims (4)

1. Förfarande för laddning av en vattensvällbar, vatteno-löslig polymer eller en blandning av tvä eller flera vatten-olösliga polymerer med metylhydroxiprogesteronacetat (MAP), kännetecknat av, (a) att man bereder och finfördelar en blandning av polyme-ren och MAP; och/eller (b) att (i) man bereder en blandning av polymeren, som är stabil när blandningen värms upp i steg (ii), och MAP och (ii) värmer upp blandningen till MAPs smältpunkt; och/eller (c) att man sväller polymeren med en MAP-lösning som är kapabel till detta och sedan torkar det erhällna svullna polymer-/MAP-systemet.
2. Förfarande enligt patentkravet 1, kännetecknat av, att viktförhällandet mellan MAP och den svällbara polymeren, uttryckt i viktdelar, ligger i intervallet 1 : 0,1 - 1 ; 100.
3. Förfarande enligt patentkravet 1 eller 2, kännetecknat av, att den svällbara, vattenolösliga polymeren är en tvärbunden polyvinylpyrrolidon.
4. Förfarande enligt vilket som heist av de föregäende patentkraven, kännetecknat av, att den svällbara, vattenolösliga polymeren är en tvärbunden natriumkar-boxymetylcellulosa.
FI850455A 1984-02-08 1985-02-04 Förfarande för laddning av vattensvällbara, vattenolösliga polymerer m ed medroxiprogesteronacetat FI84230C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848403360A GB8403360D0 (en) 1984-02-08 1984-02-08 Pharmaceutical compositions
GB8403360 1984-02-08

Publications (4)

Publication Number Publication Date
FI850455A0 FI850455A0 (fi) 1985-02-04
FI850455L FI850455L (fi) 1985-08-09
FI84230B true FI84230B (fi) 1991-07-31
FI84230C FI84230C (sv) 1991-11-11

Family

ID=10556300

Family Applications (1)

Application Number Title Priority Date Filing Date
FI850455A FI84230C (sv) 1984-02-08 1985-02-04 Förfarande för laddning av vattensvällbara, vattenolösliga polymerer m ed medroxiprogesteronacetat

Country Status (32)

Country Link
US (1) US4632828A (sv)
JP (1) JPS60181017A (sv)
KR (1) KR930009897B1 (sv)
AT (1) AT388869B (sv)
AU (1) AU577351B2 (sv)
BE (1) BE901664A (sv)
BG (1) BG60524B2 (sv)
CA (1) CA1240928A (sv)
CH (1) CH664693A5 (sv)
CZ (1) CZ277728B6 (sv)
DE (1) DE3503679A1 (sv)
DK (1) DK164149C (sv)
ES (3) ES8607984A1 (sv)
FI (1) FI84230C (sv)
FR (1) FR2559065B1 (sv)
GB (2) GB8403360D0 (sv)
GR (1) GR850312B (sv)
HK (1) HK94290A (sv)
HU (1) HU194050B (sv)
IE (1) IE58230B1 (sv)
IL (1) IL74241A (sv)
IT (1) IT1209615B (sv)
NL (1) NL192780C (sv)
NO (1) NO170568C (sv)
NZ (1) NZ211058A (sv)
PT (1) PT79933B (sv)
SE (2) SE8500553L (sv)
SG (1) SG80390G (sv)
SK (1) SK278084B6 (sv)
SU (1) SU1605926A3 (sv)
UA (1) UA6028A1 (sv)
ZA (1) ZA85943B (sv)

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KR880701098A (ko) * 1986-04-01 1988-07-25 로버어트 에이 아미테이지 메틸프레드니솔론/소디움 카르복시메틸 전분 정제 조성물
US5019562A (en) * 1988-01-19 1991-05-28 The Trustees Of The University Of Pennsylvania/Childrens Hospital Corporation Growth inhibiting agent and the use thereof
GB8806367D0 (en) * 1988-03-17 1988-04-13 Erba Carlo Spa Siloxane matrices with internal non-uniform drug distribution
IE60458B1 (en) * 1989-10-26 1994-07-13 Elan Corp Plc Enhanced bioavailability adsorbates
HU222501B1 (hu) * 1991-06-28 2003-07-28 Endorecherche Inc. MPA-t vagy MGA-t tartalmazó nyújtott hatóanyag-felszabadulású gyógyászati készítmény és eljárás előállítására
US5547948A (en) * 1995-01-17 1996-08-20 American Home Products Corporation Controlled release of steroids from sugar coatings
US5759577A (en) * 1995-01-17 1998-06-02 American Home Products Corporation Controlled release of steroids from sugar coatings
UA65607C2 (uk) 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
DE19847252B4 (de) * 1998-10-02 2004-02-12 Jenapharm Gmbh & Co. Kg Bukkal applizierbare bioadhäsive Systeme mit zeitlich gesteuerter Wirkstofffreisetzung enthaltend Testosteronester und fakultativ zusätzlich Testosteron
WO2000050041A1 (en) * 1999-02-24 2000-08-31 Akzo Nobel N.V. Pharmaceutical compositions containing a crystalline form of the progestagen-(17alpha)-17-hydroxy-11-methylene-19-nor-pregna-4,15-dien-20-yn-3-one (org 30659) and lactose
US20020132839A1 (en) * 2000-06-22 2002-09-19 Ganter Sabina Maria Tablet formulations comprising valsartan
AUPS244002A0 (en) * 2002-05-20 2002-06-13 John Kohnke Products Pty Ltd Agent delivery system
DE10247037A1 (de) * 2002-10-09 2004-04-22 Abbott Gmbh & Co. Kg Herstellung von festen Dosierungsformen unter Verwendung eines vernetzten nichtthermoplastischen Trägers
JP2005094910A (ja) * 2003-09-17 2005-04-07 Aruze Corp モータ停止制御装置

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Publication number Priority date Publication date Assignee Title
US3545439A (en) * 1968-01-04 1970-12-08 Upjohn Co Medicated devices and methods
AU454482B2 (en) * 1970-11-05 1974-10-15 Alza Corporation Drug-delivery system
DE2200778B2 (de) * 1971-01-13 1974-04-18 Sandoz Ag, Basel (Schweiz) Verwendung von hochmolekularem, unlöslichem, quervernetztem Polyvinylpyrrolidon als Sprengmittel in festen Arzneiformen
US4038389A (en) * 1975-05-07 1977-07-26 The Upjohn Company Medroxyprogesterone acetate compositions
DE2634004B2 (de) * 1976-07-29 1978-08-10 Bernhard Dr. 8000 Muenchen Lippold Verfahren zur Beschleunigung der Auflösung und Verbesserung der Löslichkeit von schlechtlöslichen zur peroralen Verabreichung bestimmten Arzneistoffen
CA1098443A (en) * 1977-05-20 1981-03-31 Namassivaya Doddi Absorbable p-dioxanone polymer-drug compositions
SE431821B (sv) * 1979-01-29 1984-03-05 Perstorp Ab Lagringsstabilt, prostaglandininnehallande medicinskt preparat
GB2042888B (en) * 1979-03-05 1983-09-28 Teijin Ltd Preparation for administration to the mucosa of the oral or nasal cavity
GB2067900B (en) * 1980-01-25 1983-06-22 Ddsa Pharmaceuticals Ltd Medicinal tablets
DE3006635A1 (de) * 1980-02-22 1981-08-27 Basf Ag, 6700 Ludwigshafen Verwendung von mikronisiertem vernetztem, unloeslichem polyvinylpyrrolidon zur stabilisierung von suspensionen
DE3045135A1 (de) * 1980-11-29 1982-06-09 Sandoz-Patent-GmbH, 7850 Lörrach Pharmazeutische kompositionen enthaltende bioabbaubare polymere
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Also Published As

Publication number Publication date
HUT37890A (en) 1986-03-28
IE850261L (en) 1985-08-08
ZA85943B (en) 1985-10-30
DE3503679A1 (de) 1985-08-08
DE3503679C2 (sv) 1992-05-07
GB8503033D0 (en) 1985-03-06
KR930009897B1 (ko) 1993-10-13
KR850005858A (ko) 1985-09-26
ES539874A0 (es) 1986-06-01
GB2153677B (en) 1988-04-13
DK164149C (da) 1992-10-12
ES8607984A1 (es) 1986-06-01
IE58230B1 (en) 1993-08-11
GB8403360D0 (en) 1984-03-14
ES8703278A1 (es) 1987-02-16
FI84230C (sv) 1991-11-11
ES550614A0 (es) 1987-02-16
JPS60181017A (ja) 1985-09-14
UA6028A1 (uk) 1994-12-29
AU3848885A (en) 1985-08-15
AU577351B2 (en) 1988-09-22
CA1240928A (en) 1988-08-23
IT1209615B (it) 1989-08-30
PT79933B (en) 1987-02-02
US4632828A (en) 1986-12-30
NL192780B (nl) 1997-10-01
ATA31685A (de) 1989-02-15
NZ211058A (en) 1988-09-29
SK278084B6 (en) 1995-12-06
IT8519385A0 (it) 1985-02-05
ES8703277A1 (es) 1987-02-16
DK164149B (da) 1992-05-18
NL192780C (nl) 1998-02-03
HU194050B (en) 1988-01-28
JPH0415769B2 (sv) 1992-03-19
FR2559065B1 (fr) 1988-09-09
IL74241A0 (en) 1985-05-31
SG80390G (en) 1990-11-23
CH664693A5 (de) 1988-03-31
PT79933A (en) 1985-03-01
CS78485A3 (en) 1992-11-18
BE901664A (fr) 1985-08-06
NL8500323A (nl) 1985-09-02
FI850455A0 (fi) 1985-02-04
GB2153677A (en) 1985-08-29
NO850477L (no) 1985-08-09
DK57085A (da) 1985-08-09
FI850455L (fi) 1985-08-09
FR2559065A1 (fr) 1985-08-09
CZ277728B6 (en) 1993-04-14
AT388869B (de) 1989-09-11
GR850312B (sv) 1985-06-05
IL74241A (en) 1988-12-30
SE8500553L (sv) 1985-08-09
ES550613A0 (es) 1987-02-16
NO170568C (no) 1992-11-04
SE462547B (sv) 1990-07-16
SE8500553D0 (sv) 1985-02-06
BG60524B2 (bg) 1995-07-28
NO170568B (no) 1992-07-27
SU1605926A3 (ru) 1990-11-07
HK94290A (en) 1990-11-23
DK57085D0 (da) 1985-02-07

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Owner name: PHARMACIA ITALIA S.P.A.

MA Patent expired