FI3562486T3 - Kielenalaisen deksmedetomidiinin käyttö agitaation hoidossa - Google Patents

Kielenalaisen deksmedetomidiinin käyttö agitaation hoidossa Download PDF

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Publication number
FI3562486T3
FI3562486T3 FIEP17885750.4T FI17885750T FI3562486T3 FI 3562486 T3 FI3562486 T3 FI 3562486T3 FI 17885750 T FI17885750 T FI 17885750T FI 3562486 T3 FI3562486 T3 FI 3562486T3
Authority
FI
Finland
Prior art keywords
dexmedetomidine
use according
agitation
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
FIEP17885750.4T
Other languages
English (en)
Finnish (fi)
Inventor
Krishnan Nandabalan
Frank Yocca
Sameer Sharma
Original Assignee
Bioxcel Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioxcel Therapeutics Inc filed Critical Bioxcel Therapeutics Inc
Application granted granted Critical
Publication of FI3562486T3 publication Critical patent/FI3562486T3/fi

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
FIEP17885750.4T 2016-12-31 2017-12-29 Kielenalaisen deksmedetomidiinin käyttö agitaation hoidossa FI3562486T3 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662441164P 2016-12-31 2016-12-31
US201762471393P 2017-03-15 2017-03-15
US201762542323P 2017-08-08 2017-08-08
PCT/US2017/069030 WO2018126182A1 (en) 2016-12-31 2017-12-29 Use of sublingual dexmedetomidine for the treatment of agitation

Publications (1)

Publication Number Publication Date
FI3562486T3 true FI3562486T3 (fi) 2024-06-04

Family

ID=62710955

Family Applications (1)

Application Number Title Priority Date Filing Date
FIEP17885750.4T FI3562486T3 (fi) 2016-12-31 2017-12-29 Kielenalaisen deksmedetomidiinin käyttö agitaation hoidossa

Country Status (20)

Country Link
US (7) US11839604B2 (enExample)
EP (3) EP3562486B1 (enExample)
JP (5) JP6868698B2 (enExample)
KR (2) KR102793584B1 (enExample)
CN (1) CN110337290A (enExample)
AU (3) AU2017388759B2 (enExample)
BR (1) BR112019013503A2 (enExample)
CA (1) CA3045043A1 (enExample)
DK (1) DK3562486T3 (enExample)
ES (1) ES2980126T3 (enExample)
FI (1) FI3562486T3 (enExample)
HU (1) HUE067266T2 (enExample)
IL (1) IL267689B2 (enExample)
MX (3) MX2019007923A (enExample)
PL (1) PL3562486T3 (enExample)
PT (1) PT3562486T (enExample)
SG (1) SG10202107367SA (enExample)
TW (3) TWI833550B (enExample)
WO (1) WO2018126182A1 (enExample)
ZA (1) ZA202006636B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018126182A1 (en) 2016-12-31 2018-07-05 Bioxcel Therapeutics, Inc. Use of sublingual dexmedetomidine for the treatment of agitation
WO2020006119A1 (en) * 2018-06-27 2020-01-02 Bioxcel Therapeutics, Inc. Methods for treating agitation using dexmedetomidine hydrochloride
CN114983979A (zh) 2018-06-27 2022-09-02 比奥克斯塞尔医疗股份有限公司 含右美托咪定的膜制剂及其制造方法
RU2692247C1 (ru) * 2018-12-06 2019-06-24 федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени В.А. Алмазова" Министерства здравоохранения Российской Федерации Способ лечения послеоперационного делирия
KR20220049526A (ko) * 2019-07-19 2022-04-21 바이오엑셀 테라퓨틱스 인코포레이티드 비-진정성 덱스메데토미딘 치료 양생법
JP2022549142A (ja) * 2019-09-18 2022-11-24 バイオエクセル セラピューティクス，インコーポレイテッド 激越の出現を検出及び防止するためのシステム及び方法
WO2021158059A1 (ko) * 2020-02-07 2021-08-12 건국대학교 글로컬산학협력단 릴메니딘 화합물을 유효성분으로 포함하는 취약 x 증후군 또는 관련 발달 장애 치료용 조성물
CA3167994A1 (en) * 2020-02-14 2021-08-19 Bioxcel Therapeutics, Inc. Systems and methods for detection and prevention of emergence of agitation
TW202228682A (zh) * 2020-10-08 2022-08-01 美商百歐克斯賽爾治療公司 使用右美托咪啶(dexmedetomidine)鹽酸鹽治療躁鬱症及精神病
TW202241416A (zh) * 2021-01-04 2022-11-01 美商百歐克斯賽爾治療公司 右美托咪啶（ｄｅｘｍｅｄｅｔｏｍｉｄｉｎｅ）治療方案
CN117412747A (zh) * 2021-02-26 2024-01-16 比奥克斯塞尔医疗股份有限公司 用于治疗激越的方法和组合物
CN117157070A (zh) * 2021-03-19 2023-12-01 奥赖恩公司 他西匹啶(tasipimidine)制剂及其用途
JP2024524434A (ja) * 2021-07-02 2024-07-05 バイオエクセル セラピューティクス，インコーポレイテッド うつ状態を処置するための方法
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JP2025526428A (ja) 2022-07-27 2025-08-13 ウニヴェルジテート・チューリッヒ 睡眠障害を治療するためのデクスメデトミジン
TW202421126A (zh) * 2022-09-11 2024-06-01 美商百歐克斯賽爾治療公司 治療在社區環境中躁動的方法
WO2024145347A1 (en) * 2022-12-27 2024-07-04 Alceptor Therapeutics, Inc. (s)-(3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol for treatment of agitation
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
WO2024263973A1 (en) * 2023-06-23 2024-12-26 Bioxcel Therapeutics, Inc. Dexmedetomidine treatment regimens
CN119139275B (zh) * 2024-11-05 2025-08-22 中国人民解放军军事科学院军事医学研究院 一种盐酸右美托咪定口溶膜及其制备方法和其应用

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