KR102793584B1 - 불안의 치료를 위한 설하 덱스메데토미딘의 용도 - Google Patents
불안의 치료를 위한 설하 덱스메데토미딘의 용도 Download PDFInfo
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- KR102793584B1 KR102793584B1 KR1020247002837A KR20247002837A KR102793584B1 KR 102793584 B1 KR102793584 B1 KR 102793584B1 KR 1020247002837 A KR1020247002837 A KR 1020247002837A KR 20247002837 A KR20247002837 A KR 20247002837A KR 102793584 B1 KR102793584 B1 KR 102793584B1
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- South Korea
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- micrograms
- anxiety
- dexmedetomidine
- pharmaceutically acceptable
- acceptable salt
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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Landscapes
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| US62/542,323 | 2017-08-08 | ||
| PCT/US2017/069030 WO2018126182A1 (en) | 2016-12-31 | 2017-12-29 | Use of sublingual dexmedetomidine for the treatment of agitation |
| KR1020197018204A KR20190108104A (ko) | 2016-12-31 | 2017-12-29 | 불안의 치료를 위한 설하 덱스메데토미딘의 용도 |
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| KR1020247002837A Active KR102793584B1 (ko) | 2016-12-31 | 2017-12-29 | 불안의 치료를 위한 설하 덱스메데토미딘의 용도 |
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| DK3562486T3 (da) * | 2016-12-31 | 2024-06-10 | Bioxcel Therapeutics Inc | Anvendelse af sublingual dexmedetomidin til behandling af agitation |
| US20210267944A1 (en) * | 2018-06-27 | 2021-09-02 | Bioxcel Therapeutics, Inc. | Methods for treating agitation using dexmedetomidine hydrochloride |
| CA3103431A1 (en) | 2018-06-27 | 2020-01-02 | Bioxcel Therapeutics, Inc. | Film formulations containing dexmedetomidine and methods of producing them |
| RU2692247C1 (ru) * | 2018-12-06 | 2019-06-24 | федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени В.А. Алмазова" Министерства здравоохранения Российской Федерации | Способ лечения послеоперационного делирия |
| MX2022000709A (es) * | 2019-07-19 | 2022-05-19 | Bioxcel Therapeutics Inc | Regimenes de tratamiento con dexmedetomidina no sedante. |
| MX2022003224A (es) * | 2019-09-18 | 2022-06-29 | Bioxcel Therapeutics Inc | Sistemas y metodos para la deteccion y prevencion de la aparicion de la agitacion. |
| JP7412583B2 (ja) | 2020-02-07 | 2024-01-12 | ニューロヴェンティ カンパニー リミテッド | リルメニジン化合物を有効成分として含む脆弱ｘ症候群または関連発達障害を治療するための組成物 |
| CA3167994A1 (en) * | 2020-02-14 | 2021-08-19 | Bioxcel Therapeutics, Inc. | Systems and methods for detection and prevention of emergence of agitation |
| JP2023545372A (ja) * | 2020-10-08 | 2023-10-30 | バイオエクセル セラピューティクス，インコーポレイテッド | デクスメデトミジン塩酸塩を用いた双極性障害及び精神病の治療 |
| US20220226288A1 (en) * | 2021-01-04 | 2022-07-21 | Bioxcel Therapeutics, Inc. | Dexmedetomidine treatment regimens |
| US20240139169A1 (en) * | 2021-02-26 | 2024-05-02 | Bioxcel Therapeutics, Inc. | Methods and compositions for treating agitation |
| WO2022195174A1 (en) | 2021-03-19 | 2022-09-22 | Orion Corporation | Tasipimidine formulations and use thereof |
| US20250319069A1 (en) * | 2021-07-02 | 2025-10-16 | Bioxcel Therapeutics, Inc. | Methods for treating depressive states |
| GB2618810A (en) * | 2022-05-17 | 2023-11-22 | Novumgen Ltd | Pharmaceutical composition for sublingual administration of clonidine |
| JP2025526428A (ja) | 2022-07-27 | 2025-08-13 | ウニヴェルジテート・チューリッヒ | 睡眠障害を治療するためのデクスメデトミジン |
| EP4583871A1 (en) * | 2022-09-11 | 2025-07-16 | BioXcel Therapeutics, Inc. | Methods for treating agitation in community settings |
| EP4642453A1 (en) * | 2022-12-27 | 2025-11-05 | Alceptor Therapeutics, Inc. | (s)-(3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol for treatment of agitation |
| US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
| WO2024263973A1 (en) * | 2023-06-23 | 2024-12-26 | Bioxcel Therapeutics, Inc. | Dexmedetomidine treatment regimens |
| CN119139275B (zh) * | 2024-11-05 | 2025-08-22 | 中国人民解放军军事科学院军事医学研究院 | 一种盐酸右美托咪定口溶膜及其制备方法和其应用 |
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| US4407957A (en) | 1981-03-13 | 1983-10-04 | Damon Corporation | Reversible microencapsulation of a core material |
| FI844786A0 (fi) | 1984-12-04 | 1984-12-04 | Farmos Oy | Terapeutiskt utnyttjbar foerening. |
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