BR112014019171A8 - Composições intranasais de dexdetomida e seus métodos de uso - Google Patents

Composições intranasais de dexdetomida e seus métodos de uso

Info

Publication number
BR112014019171A8
BR112014019171A8 BR112014019171A BR112014019171A BR112014019171A8 BR 112014019171 A8 BR112014019171 A8 BR 112014019171A8 BR 112014019171 A BR112014019171 A BR 112014019171A BR 112014019171 A BR112014019171 A BR 112014019171A BR 112014019171 A8 BR112014019171 A8 BR 112014019171A8
Authority
BR
Brazil
Prior art keywords
methods
dexdetomide
intranasal compositions
intranasal
compositions
Prior art date
Application number
BR112014019171A
Other languages
English (en)
Other versions
BR112014019171A2 (pt
Inventor
Geraldine A Henwood
Randall J Mack
Jr John Joseph Koleng
Christopher T Sharr
Charles Alexander Freyer
Original Assignee
Recro Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48613351&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014019171(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Recro Pharma Inc filed Critical Recro Pharma Inc
Publication of BR112014019171A2 publication Critical patent/BR112014019171A2/pt
Publication of BR112014019171A8 publication Critical patent/BR112014019171A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/0007—Special media to be introduced, removed or treated introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0618—Nose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Dispersion Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPOSIÇÕES INTRANASAIS DE DEXMEDETOMIDINA E SEUS MÉTODOS DE USO. A presente invenção provê formulações intranasais compreendendo dexmedetomidina, ou um sal farmaceuticamente aceitável da mesma, e usos da mesma.
BR112014019171A 2011-12-11 2012-12-11 Composições intranasais de dexdetomida e seus métodos de uso BR112014019171A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161569255P 2011-12-11 2011-12-11
PCT/US2012/068988 WO2013090278A2 (en) 2011-12-11 2012-12-11 Intranasal dexmedetomidine compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
BR112014019171A2 BR112014019171A2 (pt) 2017-06-20
BR112014019171A8 true BR112014019171A8 (pt) 2017-07-11

Family

ID=48613351

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014019171A BR112014019171A8 (pt) 2011-12-11 2012-12-11 Composições intranasais de dexdetomida e seus métodos de uso

Country Status (21)

Country Link
US (2) US9795559B2 (pt)
EP (2) EP2787970B1 (pt)
JP (2) JP6268100B2 (pt)
KR (1) KR102190009B1 (pt)
CN (1) CN104470516A (pt)
AU (2) AU2012352528B9 (pt)
BR (1) BR112014019171A8 (pt)
CA (1) CA2858721C (pt)
CL (1) CL2014001515A1 (pt)
CO (1) CO7000773A2 (pt)
CR (1) CR20140318A (pt)
DO (1) DOP2014000123A (pt)
EC (1) ECSP14007644A (pt)
HK (1) HK1203049A1 (pt)
IL (1) IL232977B (pt)
MX (1) MX367286B (pt)
PE (1) PE20142314A1 (pt)
PH (1) PH12014501273A1 (pt)
RU (1) RU2692245C2 (pt)
SG (2) SG10201604653TA (pt)
WO (1) WO2013090278A2 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012031720A2 (pt) 2010-06-16 2016-12-06 Cargill Inc composições a base de amido para substituição por látex
BR112014019171A8 (pt) * 2011-12-11 2017-07-11 Recro Pharma Inc Composições intranasais de dexdetomida e seus métodos de uso
WO2015044782A2 (en) * 2013-09-24 2015-04-02 Shin Nippon Biomedical Laboratories, Ltd. Intranasal dhe for the treatment of headache
CN105764494A (zh) 2013-10-07 2016-07-13 帝国制药美国公司 右旋美托咪啶经皮递送装置及其使用方法
KR101881791B1 (ko) * 2013-10-07 2018-07-25 테이코쿠 팔마 유에스에이, 인코포레이티드 비진정성 덱스메데토미딘 경피 조성물을 사용하여 금단 증후군을 치료하기 위한 방법 및 조성물
RU2658463C2 (ru) 2013-10-07 2018-06-21 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Способы и композиции для лечения синдрома дефицита внимания и гиперактивности, тревожности и бессонницы с применением трансдермальных композиций на основе дексмедетомидина
JP6188933B2 (ja) 2013-10-07 2017-08-30 テイコク ファーマ ユーエスエー インコーポレーテッド 非鎮静量のデクスメデトミジンの経皮送達用方法及び組成物
MA41689A (fr) * 2014-10-15 2017-08-22 Bioxcel Corp Prévention ou traitement de troubles du sommeil au moyen d'une formulation de dexmédétomidine
MX2019007923A (es) 2016-12-31 2019-09-10 Bioxcel Therapeutics Inc Uso de dexmedetomidina sublingual para el tratamiento de la agitacion.
CN114983979A (zh) * 2018-06-27 2022-09-02 比奥克斯塞尔医疗股份有限公司 含右美托咪定的膜制剂及其制造方法
CN109620802A (zh) * 2018-12-05 2019-04-16 杜皓 一种麻醉用鼻喷剂及其制备方法
CN111481506B (zh) * 2019-01-25 2023-01-24 江苏恒瑞医药股份有限公司 一种包含经鼻给药的右美托咪定组合物的药物制品
CN112138250B (zh) * 2019-06-28 2023-04-14 四川普锐特药业有限公司 保持给药均一度的药物流体分配器及右美托咪定鼻喷器
CN112107544A (zh) * 2019-06-28 2020-12-22 四川普锐特药业有限公司 右美托咪定鼻喷剂、其制备方法及应用
CN114375191A (zh) 2019-07-19 2022-04-19 比奥克斯塞尔医疗股份有限公司 非镇静的右美托咪定治疗方案
CN113827590A (zh) * 2020-06-08 2021-12-24 四川普锐特药业有限公司 右美托咪定在助眠药物制备中的应用
TW202241416A (zh) * 2021-01-04 2022-11-01 美商百歐克斯賽爾治療公司 右美托咪啶（ｄｅｘｍｅｄｅｔｏｍｉｄｉｎｅ）治療方案
CN115137699B (zh) * 2021-03-29 2024-05-03 四川普锐特药业有限公司 一种增效防腐的右美托咪定鼻喷剂
CN113876776A (zh) * 2021-11-04 2022-01-04 江苏大学附属医院 一种复方鼻喷镇痛药剂及其制备方法
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2206880B (en) 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative
US5124157A (en) 1989-08-18 1992-06-23 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
US5217718A (en) 1989-08-18 1993-06-08 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
FI894911A0 (fi) 1989-10-17 1989-10-17 Farmos Oy En terapeutiskt vaerdefull foerening.
DE122007000103I1 (de) 1990-12-05 2008-04-03 Gen Hospital Corp Verwendung von NO zur Behandlung der persistenten pulmonalen Hypertonie des Neugeborenen
GB9111732D0 (en) 1991-05-31 1991-07-24 Orion Yhtymae Oy The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs
US5571840A (en) 1993-06-22 1996-11-05 The Regents Of The University Of Michigan Method for treating central nervous system ischemia
GB2281206A (en) 1993-08-25 1995-03-01 Orion Yhtymae Oy Use of dexmedetomidine
US5713907A (en) 1995-07-20 1998-02-03 Endotex Interventional Systems, Inc. Apparatus and method for dilating a lumen and for inserting an intraluminal graft
GB9520150D0 (en) 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
CA2257172C (en) 1996-05-29 2005-04-12 Orion Corporation Dissolvable oxides for biological applications
US20050281752A1 (en) 1997-10-01 2005-12-22 Dugger Harry A Iii Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
US20030077227A1 (en) 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
DE19749724A1 (de) 1997-11-11 1999-06-10 Gruenenthal Gmbh Verwendung einer Kombination aus Opioid und alpha-adrenergem Agonisten in Schmerzmitteln
AR015744A1 (es) 1998-04-01 2001-05-16 Orion Corp Uso de dexmedetomidina para sedacion en terapia intensiva
US6716867B1 (en) 1998-04-01 2004-04-06 Orion Corporation Use of dexmedetomidine for ICU sedation
US7001609B1 (en) 1998-10-02 2006-02-21 Regents Of The University Of Minnesota Mucosal originated drug delivery systems and animal applications
ATE291907T1 (de) 1998-10-20 2005-04-15 Omeros Corp Spülende lösung und methoden zur hemmung von schmerzen und entzündungen
GB9913677D0 (en) 1999-06-11 1999-08-11 Imperial College Formulation
US20040115133A1 (en) * 2000-05-10 2004-06-17 Wermeling Daniel P. Intranasal opioid compositions
GB0029111D0 (en) * 2000-11-29 2001-01-10 Novartis Ag Organic compounds
AUPR184500A0 (en) 2000-12-01 2001-01-04 Drug Delivery Solutions Pty Ltd Dispensing device
US6582457B2 (en) 2001-02-15 2003-06-24 Radiant Medical, Inc. Method of controlling body temperature while reducing shivering
US20030022926A1 (en) 2001-05-07 2003-01-30 Lavand'homme Patricia Method for treating neuropathic pain and pharmaceutical preparation therefor
FR2834212B1 (fr) 2001-12-27 2004-07-09 Besins Int Belgique Utilisation d'une poudre a liberation immediate dans des compositions pharmaceutiques et nutraceutiques
IL147921A0 (en) 2002-01-31 2002-08-14 Abdulrazik Mohammad A method for treating central nervous system disorders by ocular dosing
US6864271B2 (en) 2002-11-12 2005-03-08 The Foundation For The Lsu Health Sciences Center Synergistic combinations including N-acylated 4-hydroxyphenylamine derivatives
EP1581245A2 (en) * 2002-12-17 2005-10-05 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of y2 receptor-binding peptides and methods for treating and preventing obesity
US7439241B2 (en) 2003-05-27 2008-10-21 Galderma Laboratories, Inc. Compounds, formulations, and methods for treating or preventing rosacea
US20050058696A1 (en) 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
WO2006105205A1 (en) 2005-03-29 2006-10-05 University Of Kentucky Research Foundation Sublingual spray for the treatment of pain
US8481583B2 (en) 2006-02-13 2013-07-09 Orient Pharma (Samoa) Co., Ltd. Combination of alpha-2 receptor agonist (clonidin) and anti-muscarinic agent (oxybutynin) for the treatment of sialorrhoea
GB0611241D0 (en) 2006-06-07 2006-07-19 Daniolabs Ltd The treatment of increased sebum production
US20080021074A1 (en) 2006-06-29 2008-01-24 Questcor Pharmaceuticals, Inc. Pharmaceutical Compositions and Related Methods of Treatment
TW200824693A (en) * 2006-08-28 2008-06-16 Jazz Pharmaceuticals Inc Pharmaceutical compositions of clonazepam and methods of use thereof
CN101057830A (zh) 2007-05-10 2007-10-24 北京天川军威医药技术开发有限公司 盐酸纳洛酮舌下喷雾给药系统或组合物及其制备方法
JP2011507895A (ja) 2007-12-21 2011-03-10 シェーリング−プラウ ヘルスケア プロダクツ，インコーポレイテッド オキシメタゾリンの増強された光安定化
RU2572692C2 (ru) * 2009-05-15 2016-01-20 Рекро Фарма, Инк. Сублингвальные композиции дексмедетомидина и способы их применения
SG10201406930UA (en) * 2009-07-27 2014-11-27 Nocicepta Llc Methods For Treatment Of Pain
NZ601195A (en) * 2010-01-08 2015-02-27 Recro Pharma Inc Topical transdermal dexmedetomidine compositions and methods of use thereof
BR112014019171A8 (pt) * 2011-12-11 2017-07-11 Recro Pharma Inc Composições intranasais de dexdetomida e seus métodos de uso

Also Published As

Publication number Publication date
AU2012352528A1 (en) 2014-07-10
CO7000773A2 (es) 2014-07-21
JP2018030850A (ja) 2018-03-01
IL232977A0 (en) 2014-07-31
JP2015513309A (ja) 2015-05-07
RU2014128343A (ru) 2016-01-27
IL232977B (en) 2019-01-31
BR112014019171A2 (pt) 2017-06-20
CN104470516A (zh) 2015-03-25
EP2787970B1 (en) 2018-04-11
AU2018200591A1 (en) 2018-02-15
EP2787970A4 (en) 2015-10-28
US20130178465A1 (en) 2013-07-11
JP6268100B2 (ja) 2018-01-24
PE20142314A1 (es) 2015-01-23
CR20140318A (es) 2014-10-28
KR20140107329A (ko) 2014-09-04
KR102190009B1 (ko) 2020-12-15
AU2012352528B2 (en) 2017-10-26
US9795559B2 (en) 2017-10-24
JP6505177B2 (ja) 2019-04-24
SG11201403094TA (en) 2014-10-30
EP2787970A2 (en) 2014-10-15
MX2014006961A (es) 2014-09-22
CA2858721A1 (en) 2013-06-20
PH12014501273A1 (en) 2014-09-08
DOP2014000123A (es) 2014-12-31
MX367286B (es) 2019-08-13
NZ626999A (en) 2016-07-29
AU2018200591B2 (en) 2018-11-29
AU2012352528B9 (en) 2017-11-02
WO2013090278A3 (en) 2014-12-24
SG10201604653TA (en) 2016-07-28
US10682311B2 (en) 2020-06-16
US20180055764A1 (en) 2018-03-01
HK1203049A1 (en) 2015-10-16
RU2692245C2 (ru) 2019-06-24
EP3406247A1 (en) 2018-11-28
ECSP14007644A (es) 2015-11-30
CL2014001515A1 (es) 2014-12-05
WO2013090278A2 (en) 2013-06-20
CA2858721C (en) 2021-03-16

Similar Documents

Publication Publication Date Title
BR112014019171A8 (pt) Composições intranasais de dexdetomida e seus métodos de uso
CY1121843T1 (el) Σκευασματα ετανερσεπτης σταθεροποιημενα με ιοντα μαγνησιου
CY1122853T1 (el) Σταθερα σκευασματα λινακλοτιδης
BR112015010663A8 (pt) formas de dosagem oral de liberação sustentada, e uso de ruxolitinib ou de sal farmaceuticamente aceitável do mesmo
BR112014014769A2 (pt) Composto, composição farmacêutica, e, uso de um composto ou sal.
BR112015003376A2 (pt) composto ou sal farmaceuticamente aceitável do mesmo , composição farmacêutica e usos de quantidade eficiente
EA201400838A1 (ru) ЗАМЕЩЕННЫЕ АМИДИНОМ β-ЛАКТАМЫ, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В КАЧЕСТВЕ АНТИБАКТЕРИАЛЬНЫХ СРЕДСТВ
TR201813877T4 (tr) Spi̇nal müsküler atrofi̇ni̇n tedavi̇ edi̇lmesi̇ne yöneli̇k bi̇leşi̇kler.
CO6741203A2 (es) Derivados de biciclo[3,2,1]octilamida y sus usos
BR112013000607A2 (pt) 5-cloro-4-hidroxi-1-metil-2-oxo-n-fenil-1,2-di-hidroquinolina-3-carboxamida, os sais e suas utilizações
AR081681A1 (es) METODOS Y COMPOSICIONES PARA LA ADMINISTRACION INTRATECAL DE b-GALACTOCEREBROSIDASA
PL2768937T3 (pl) Preparaty, ich zastosowanie jako środków do mycia naczyń lub do wytwarzania środków do mycia naczyń i ich wytwarzanie
UY34350A (es) Derivados de pirazolquinolinona, su preparación y su uso terapéutico.
IN2014DN10670A (pt)
BR112014025041B8 (pt) Composição farmacêutica
BR112014008555A2 (pt) r(+)-n-formil-propargil-aminoindano
BR112014002845A2 (pt) “composto, sal farmaceuticamente aceitável, composição farmacêutica, e, uso de um composto”
BR112014030720A8 (pt) composto, composição farmacêutica e usos de inibidores de fbx03
BR112015012443A2 (pt) composição de limpeza, método de limpeza do corpo humano, uso da composição e método para prover limpeza
BR112013023575A2 (pt) “derivado de octaidrotienoquinolina, composição farmacêutica compreendendo o derivado, e uso destes”
WO2012138731A3 (en) Activated nucleoside analog conjugates and methods of use thereof
UA109804C2 (xx) 2-метоксипіридин-4-ільні похідні
BR112019000988A2 (pt) derivado de triazolopirazinona útil como inibidor de pde1 humana
CY1118277T1 (el) Σταθερη φαρμακοτεχνικη μορφη πεξιγανανης
WO2012116992A3 (en) Oral use of a composition comprising steviol or isosteviol

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements