BR112014019171A8 - Composições intranasais de dexdetomida e seus métodos de uso - Google Patents

Composições intranasais de dexdetomida e seus métodos de uso

Info

Publication number
BR112014019171A8
BR112014019171A8 BR112014019171A BR112014019171A BR112014019171A8 BR 112014019171 A8 BR112014019171 A8 BR 112014019171A8 BR 112014019171 A BR112014019171 A BR 112014019171A BR 112014019171 A BR112014019171 A BR 112014019171A BR 112014019171 A8 BR112014019171 A8 BR 112014019171A8
Authority
BR
Brazil
Prior art keywords
methods
dexdetomide
intranasal compositions
intranasal
compositions
Prior art date
Application number
BR112014019171A
Other languages
English (en)
Other versions
BR112014019171A2 (pt
Inventor
Geraldine A Henwood
Randall J Mack
Jr John Joseph Koleng
Christopher T Sharr
Charles Alexander Freyer
Original Assignee
Recro Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48613351&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014019171(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Recro Pharma Inc filed Critical Recro Pharma Inc
Publication of BR112014019171A2 publication Critical patent/BR112014019171A2/pt
Publication of BR112014019171A8 publication Critical patent/BR112014019171A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/0007—Special media to be introduced, removed or treated introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0618—Nose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Dispersion Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPOSIÇÕES INTRANASAIS DE DEXMEDETOMIDINA E SEUS MÉTODOS DE USO. A presente invenção provê formulações intranasais compreendendo dexmedetomidina, ou um sal farmaceuticamente aceitável da mesma, e usos da mesma.
BR112014019171A 2011-12-11 2012-12-11 Composições intranasais de dexdetomida e seus métodos de uso BR112014019171A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161569255P 2011-12-11 2011-12-11
PCT/US2012/068988 WO2013090278A2 (en) 2011-12-11 2012-12-11 Intranasal dexmedetomidine compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
BR112014019171A2 BR112014019171A2 (pt) 2017-06-20
BR112014019171A8 true BR112014019171A8 (pt) 2017-07-11

Family

ID=48613351

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014019171A BR112014019171A8 (pt) 2011-12-11 2012-12-11 Composições intranasais de dexdetomida e seus métodos de uso

Country Status (21)

Country Link
US (2) US9795559B2 (pt)
EP (2) EP3406247A1 (pt)
JP (2) JP6268100B2 (pt)
KR (1) KR102190009B1 (pt)
CN (1) CN104470516A (pt)
AU (2) AU2012352528B9 (pt)
BR (1) BR112014019171A8 (pt)
CA (1) CA2858721C (pt)
CL (1) CL2014001515A1 (pt)
CO (1) CO7000773A2 (pt)
CR (1) CR20140318A (pt)
DO (1) DOP2014000123A (pt)
EC (1) ECSP14007644A (pt)
HK (1) HK1203049A1 (pt)
IL (1) IL232977B (pt)
MX (1) MX367286B (pt)
PE (1) PE20142314A1 (pt)
PH (1) PH12014501273A1 (pt)
RU (1) RU2692245C2 (pt)
SG (2) SG10201604653TA (pt)
WO (1) WO2013090278A2 (pt)

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CA2802757A1 (en) 2010-06-16 2012-01-05 Stephane Biltresse Starch-based compositions for latex replacement
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DK3049059T3 (da) * 2013-09-24 2022-01-31 Satsuma Pharmaceuticals Inc Intranasal dhe formulering til behandlingen af hovedpine
TWI629066B (zh) 2013-10-07 2018-07-11 帝國製藥美國股份有限公司 使用右美托咪啶經皮組成物用於治療注意力不足過動症、焦慮及失眠的方法及組成物
RU2646512C2 (ru) 2013-10-07 2018-03-05 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Устройства для трансдермальной доставки дексмедетомидина и способы их применения
ES2847936T3 (es) 2013-10-07 2021-08-04 Teikoku Pharma Usa Inc Métodos y composiciones para el suministro transdérmico de una cantidad no sedante de dexmedetomidina
WO2015054063A1 (en) * 2013-10-07 2015-04-16 Teikoku Pharma Usa, Inc. Methods and compositions for treating withdrawal syndromes using non-sedative dexmedetomidine transdermal compositions
MA41689A (fr) * 2014-10-15 2017-08-22 Bioxcel Corp Prévention ou traitement de troubles du sommeil au moyen d'une formulation de dexmédétomidine
EP4371554A2 (en) 2016-12-31 2024-05-22 BioXcel Therapeutics, Inc. Use of sublingual dexmedetomidine for the treatment of agitation
CN115154440A (zh) 2018-06-27 2022-10-11 比奥克斯塞尔医疗股份有限公司 含右美托咪定的膜制剂及其制造方法
CN109620802A (zh) * 2018-12-05 2019-04-16 杜皓 一种麻醉用鼻喷剂及其制备方法
CN111481506B (zh) * 2019-01-25 2023-01-24 江苏恒瑞医药股份有限公司 一种包含经鼻给药的右美托咪定组合物的药物制品
WO2020259440A1 (zh) * 2019-06-28 2020-12-30 四川普锐特药业有限公司 右美托咪定鼻喷剂、其制备方法及应用
CN116474219A (zh) * 2019-06-28 2023-07-25 四川普锐特药业有限公司 保持给药均一度的药物流体分配器及右美托咪定鼻喷器
CA3145388A1 (en) 2019-07-19 2021-01-28 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
CN113827590A (zh) * 2020-06-08 2021-12-24 四川普锐特药业有限公司 右美托咪定在助眠药物制备中的应用
KR20230136612A (ko) * 2021-01-04 2023-09-26 바이오엑셀 테라퓨틱스 인코포레이티드 덱스메데토미딘 치료 용법
CN115137699B (zh) * 2021-03-29 2024-05-03 四川普锐特药业有限公司 一种增效防腐的右美托咪定鼻喷剂
CN113876776A (zh) * 2021-11-04 2022-01-04 江苏大学附属医院 一种复方鼻喷镇痛药剂及其制备方法
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Also Published As

Publication number Publication date
SG10201604653TA (en) 2016-07-28
IL232977A0 (en) 2014-07-31
US20130178465A1 (en) 2013-07-11
RU2014128343A (ru) 2016-01-27
CL2014001515A1 (es) 2014-12-05
CN104470516A (zh) 2015-03-25
AU2018200591B2 (en) 2018-11-29
JP6505177B2 (ja) 2019-04-24
MX2014006961A (es) 2014-09-22
JP2018030850A (ja) 2018-03-01
RU2692245C2 (ru) 2019-06-24
AU2012352528B9 (en) 2017-11-02
US9795559B2 (en) 2017-10-24
DOP2014000123A (es) 2014-12-31
IL232977B (en) 2019-01-31
PH12014501273A1 (en) 2014-09-08
NZ626999A (en) 2016-07-29
ECSP14007644A (es) 2015-11-30
CA2858721A1 (en) 2013-06-20
HK1203049A1 (en) 2015-10-16
CO7000773A2 (es) 2014-07-21
PE20142314A1 (es) 2015-01-23
MX367286B (es) 2019-08-13
AU2012352528B2 (en) 2017-10-26
EP2787970A2 (en) 2014-10-15
WO2013090278A3 (en) 2014-12-24
EP3406247A1 (en) 2018-11-28
CA2858721C (en) 2021-03-16
CR20140318A (es) 2014-10-28
WO2013090278A2 (en) 2013-06-20
JP6268100B2 (ja) 2018-01-24
KR102190009B1 (ko) 2020-12-15
KR20140107329A (ko) 2014-09-04
US10682311B2 (en) 2020-06-16
AU2012352528A1 (en) 2014-07-10
EP2787970B1 (en) 2018-04-11
US20180055764A1 (en) 2018-03-01
JP2015513309A (ja) 2015-05-07
AU2018200591A1 (en) 2018-02-15
EP2787970A4 (en) 2015-10-28
BR112014019171A2 (pt) 2017-06-20
SG11201403094TA (en) 2014-10-30

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