AR081681A1 - METODOS Y COMPOSICIONES PARA LA ADMINISTRACION INTRATECAL DE b-GALACTOCEREBROSIDASA - Google Patents

METODOS Y COMPOSICIONES PARA LA ADMINISTRACION INTRATECAL DE b-GALACTOCEREBROSIDASA

Info

Publication number
AR081681A1
AR081681A1 ARP110102245A ARP110102245A AR081681A1 AR 081681 A1 AR081681 A1 AR 081681A1 AR P110102245 A ARP110102245 A AR P110102245A AR P110102245 A ARP110102245 A AR P110102245A AR 081681 A1 AR081681 A1 AR 081681A1
Authority
AR
Argentina
Prior art keywords
galactocerebrosidasa
compositions
methods
administration
intratecal
Prior art date
Application number
ARP110102245A
Other languages
English (en)
Original Assignee
Shire Human Genetic Therapies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45352777&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR081681(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shire Human Genetic Therapies filed Critical Shire Human Genetic Therapies
Publication of AR081681A1 publication Critical patent/AR081681A1/es

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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06008—Cerebroside-sulfatase (3.1.6.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
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    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01046—Galactosylceramidase (3.2.1.46)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0105—Alpha-N-acetylglucosaminidase (3.2.1.50)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y310/00—Hydrolases acting on sulfur-nitrogen bonds (3.10)
    • C12Y310/01—Hydrolases acting on sulfur-nitrogen bonds (3.10) acting on sulfur-nitrogen bonds (3.10.1)
    • C12Y310/01001—N-Sulfoglucosamine sulfohydrolase (3.10.1.1)

Abstract

Administración por vía intratecal de enzimas lisosomales para el tratamiento eficaz de enfermedades producidas por almacenamiento lisosomal. Formulaciones estables para la administración por vía IT de b-Galactocerebrosidasa.
ARP110102245A 2010-06-25 2011-06-27 METODOS Y COMPOSICIONES PARA LA ADMINISTRACION INTRATECAL DE b-GALACTOCEREBROSIDASA AR081681A1 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US35885710P 2010-06-25 2010-06-25
US36078610P 2010-07-01 2010-07-01
US38786210P 2010-09-29 2010-09-29
US201161435710P 2011-01-24 2011-01-24
US201161442115P 2011-02-11 2011-02-11
US201161476210P 2011-04-15 2011-04-15
US201161495268P 2011-06-09 2011-06-09

Publications (1)

Publication Number Publication Date
AR081681A1 true AR081681A1 (es) 2012-10-10

Family

ID=45352777

Family Applications (6)

Application Number Title Priority Date Filing Date
ARP110102244A AR081680A1 (es) 2010-06-25 2011-06-27 METODOS Y COMPOSICIONES PARA LA ADMINISTRACION INTRATECAL DEL a N-ACETIL GLUCOSAMINIDASA
ARP110102242A AR081678A1 (es) 2010-06-25 2011-06-27 Metodos y composiciones para administracion intratecal de arisulfatasa a
ARP110102245A AR081681A1 (es) 2010-06-25 2011-06-27 METODOS Y COMPOSICIONES PARA LA ADMINISTRACION INTRATECAL DE b-GALACTOCEREBROSIDASA
ARP110102243A AR081679A1 (es) 2010-06-25 2011-06-27 Metodos y composiciones para la administracion intratecal de heparan n-sulfatasa, envase
ARP110102241A AR081677A1 (es) 2010-06-25 2011-06-27 Metodos y composiciones para la administracion intratecal de iduronato-2-sulfatasa, recipiente, sistema para administracion intratecal
ARP110102246A AR082025A1 (es) 2010-06-25 2011-06-27 Administracion intratecal de enzimas lisosomicas y sus usos terapeuticos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ARP110102244A AR081680A1 (es) 2010-06-25 2011-06-27 METODOS Y COMPOSICIONES PARA LA ADMINISTRACION INTRATECAL DEL a N-ACETIL GLUCOSAMINIDASA
ARP110102242A AR081678A1 (es) 2010-06-25 2011-06-27 Metodos y composiciones para administracion intratecal de arisulfatasa a

Family Applications After (3)

Application Number Title Priority Date Filing Date
ARP110102243A AR081679A1 (es) 2010-06-25 2011-06-27 Metodos y composiciones para la administracion intratecal de heparan n-sulfatasa, envase
ARP110102241A AR081677A1 (es) 2010-06-25 2011-06-27 Metodos y composiciones para la administracion intratecal de iduronato-2-sulfatasa, recipiente, sistema para administracion intratecal
ARP110102246A AR082025A1 (es) 2010-06-25 2011-06-27 Administracion intratecal de enzimas lisosomicas y sus usos terapeuticos

Country Status (24)

Country Link
US (14) US9814764B2 (es)
JP (21) JP6250616B2 (es)
CN (4) CN104857504A (es)
AR (6) AR081680A1 (es)
BR (1) BR112012033214B1 (es)
CA (1) CA3171308A1 (es)
CL (7) CL2012003656A1 (es)
DK (3) DK3626257T3 (es)
ES (3) ES2895655T3 (es)
HK (2) HK1214149A1 (es)
HR (3) HRP20211660T1 (es)
HU (6) HUE031036T2 (es)
LT (3) LT3626257T (es)
MX (1) MX354776B (es)
NZ (2) NZ702803A (es)
PE (8) PE20130579A1 (es)
PL (1) PL2588130T3 (es)
PT (6) PT3626257T (es)
RS (3) RS61683B1 (es)
RU (1) RU2761342C2 (es)
SI (3) SI3626257T1 (es)
SM (1) SMT201600385B (es)
TW (8) TWI609694B (es)
UA (2) UA125060C2 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008022349A2 (en) 2006-08-18 2008-02-21 Armagen Technologies, Inc. Agents for blood-brain barrier delivery
US8974791B2 (en) 2007-07-27 2015-03-10 Armagen Technologies, Inc. Methods and compositions for increasing α-L-iduronidase activity in the CNS
EP2485761B1 (en) 2009-10-09 2019-02-27 Armagen, Inc. Methods and compositions for increasing iduronate 2-sulfatase activity in the cns
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