CN102686221B - 治疗疼痛的方法 - Google Patents
治疗疼痛的方法 Download PDFInfo
- Publication number
- CN102686221B CN102686221B CN201080042858.4A CN201080042858A CN102686221B CN 102686221 B CN102686221 B CN 102686221B CN 201080042858 A CN201080042858 A CN 201080042858A CN 102686221 B CN102686221 B CN 102686221B
- Authority
- CN
- China
- Prior art keywords
- pain
- analgesic
- ofq
- administration
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Abstract
Description
Claims (11)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22894609P | 2009-07-27 | 2009-07-27 | |
US61/228,946 | 2009-07-27 | ||
PCT/US2010/043430 WO2011017122A1 (en) | 2009-07-27 | 2010-07-27 | Methods for treatment of pain |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102686221A CN102686221A (zh) | 2012-09-19 |
CN102686221B true CN102686221B (zh) | 2018-04-17 |
Family
ID=43497852
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201080042858.4A Active CN102686221B (zh) | 2009-07-27 | 2010-07-27 | 治疗疼痛的方法 |
Country Status (17)
Country | Link |
---|---|
US (2) | US8551949B2 (zh) |
EP (1) | EP2459183B1 (zh) |
JP (1) | JP5863650B2 (zh) |
KR (2) | KR20180052610A (zh) |
CN (1) | CN102686221B (zh) |
AU (1) | AU2010281436B2 (zh) |
BR (1) | BR112012001819A2 (zh) |
CA (1) | CA2769347C (zh) |
DK (1) | DK2459183T3 (zh) |
HK (1) | HK1169804A1 (zh) |
IL (1) | IL217777A (zh) |
MX (1) | MX2012001139A (zh) |
NZ (1) | NZ597763A (zh) |
RU (1) | RU2012106820A (zh) |
SG (2) | SG177752A1 (zh) |
WO (1) | WO2011017122A1 (zh) |
ZA (1) | ZA201200584B (zh) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG177752A1 (en) | 2009-07-27 | 2012-03-29 | Trigemina Inc | Methods for treatment of pain |
AU2011346749A1 (en) | 2010-12-22 | 2013-05-02 | Purdue Pharma L.P. | Phosphorus-substituted quinoxaline-type piperidine compounds and uses thereof |
RS59491B1 (sr) | 2011-03-04 | 2019-12-31 | Gruenenthal Gmbh | Vodena farmaceutska formulacija tapentadola za oralnu primenu |
CN103906522B (zh) * | 2011-11-07 | 2017-04-12 | 尼克塔治疗公司 | 阿片激动剂化合物和止痛化合物的组合物、剂型以及共给药 |
US10525054B2 (en) | 2011-11-07 | 2020-01-07 | Inheris Biopharma, Inc. | Compositions, dosage forms, and co-administration of an opioid agonist compound and an analgesic compound |
EP2797912B1 (en) | 2011-12-01 | 2016-05-25 | Purdue Pharma L.P. | Azetidine-substituted quinoxaline-type piperidine compounds and uses thereof |
EP3406247A1 (en) | 2011-12-11 | 2018-11-28 | Recro Pharma, Inc. | Intranasal dexmedetomidine compositions and methods of use thereof |
JP2015503592A (ja) * | 2012-01-05 | 2015-02-02 | ビーチ ツリー ラボ、インコーポレイテッド | 神経成長因子の投与による疼痛処置方法 |
US9085561B2 (en) | 2012-07-30 | 2015-07-21 | Purdue Pharma L.P. | Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators |
WO2014102589A1 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Quinazolin-4(3h)-one-type piperidine compounds and uses thereof |
US10639439B2 (en) | 2013-01-30 | 2020-05-05 | Midwest Pharmaceuticals, Llc | Smokeless THC and administration method thereof |
AP2015008732A0 (en) | 2013-03-15 | 2015-09-30 | Amgen Inc | Human pac1 antibodies |
CA2960756C (en) | 2014-09-15 | 2023-08-01 | Amgen Inc. | Bi-specific anti-cgrp receptor/pac1 receptor antigen binding proteins and uses thereof |
EP3226972A4 (en) * | 2014-12-01 | 2018-08-08 | Achelios Therapeutics, Inc. | Methods and compositions for treating migraine and conditions associated with pain |
PT3242676T (pt) | 2015-01-07 | 2023-12-06 | TONIX Pharmaceuticals Holding Corp | Formulações de ocitocina que contém magnésio e métodos de uso |
US10851378B2 (en) * | 2015-07-16 | 2020-12-01 | Saint Louis University | Methods of treating pain using anti-GPR160 antibodies |
MA43567A (fr) | 2015-12-15 | 2018-11-14 | Amgen Inc | Anticorps pacap et leurs utilisations |
US10398760B2 (en) * | 2016-06-30 | 2019-09-03 | Gabriel Rusanescu | Method of treating pain using agents that promote neuronal differentiation |
MX2020006976A (es) | 2018-01-12 | 2020-10-05 | Amgen Inc | Anticuerpos del receptor de tipo i del polipeptido activador de la adenilato?ciclasa hipofisaria (pac1) y sus usos. |
RU2713133C1 (ru) * | 2018-12-18 | 2020-02-03 | Федеральное государственное автономное учреждение "Национальный медицинский исследовательский центр "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Фёдорова Министерства здравоохранения РФ | Способ обезболивания при витреоретинальной и эписклеральной хирургии |
WO2021016190A1 (en) * | 2019-07-19 | 2021-01-28 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Compositions and methods for modulating drug-use disorders |
US11854085B1 (en) | 2023-07-19 | 2023-12-26 | Anesthesia and Pain Physicians of Florida, LLC | Display tool |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1634980A (zh) * | 2004-10-10 | 2005-07-06 | 兰州大学 | 孤啡肽的类似物 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5837809A (en) | 1995-08-11 | 1998-11-17 | Oregon Health Sciences University | Mammalian opioid receptor ligand and uses |
WO1999003491A1 (en) | 1997-07-15 | 1999-01-28 | Novo Nordisk A/S | New use of nociceptin |
IL138214A0 (en) | 1998-03-09 | 2001-10-31 | Zealand Pharmaceuticals As | Pharmacolgically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
US6262066B1 (en) * | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
US7163921B1 (en) | 2000-04-14 | 2007-01-16 | Nippon Shinyaku Co., Ltd. | Peptide derivatives and medicinal compositions |
IL137820A (en) | 2000-08-10 | 2009-06-15 | S I S Shulov Inst For Science | Pharmaceutical composition for topical administration comprising an analgesic peptide |
US7666876B2 (en) * | 2002-03-19 | 2010-02-23 | Vernalis (R&D) Limited | Buprenorphine formulations for intranasal delivery |
AU2003237119A1 (en) | 2002-04-29 | 2003-11-17 | Euro-Celtique S.A. | Conformationally constrained peptides that bind the orl-1 receptor |
ITMI20022022A1 (it) | 2002-09-24 | 2004-03-25 | Girolamo Calo' | Analoghi di nocicettina. |
AU2004213019B2 (en) * | 2003-02-19 | 2010-06-10 | University Of Rochester | Treatment of pain through expression of opioid receptors |
US20050228023A1 (en) | 2003-12-19 | 2005-10-13 | Sri International | Agonist and antagonist ligands of the nociceptin receptor |
WO2006059105A2 (en) | 2004-12-01 | 2006-06-08 | Health Protection Agency | Non-cytotoxic Protein Conjugates |
WO2007025249A2 (en) * | 2005-08-26 | 2007-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treatment of headaches by administration of oxytocin |
WO2008134071A1 (en) * | 2007-04-26 | 2008-11-06 | Theraquest Biosciences, Inc. | Multimodal abuse resistant extended release formulations |
EP1897543A1 (en) * | 2006-08-30 | 2008-03-12 | Euro-Celtique S.A. | Buprenorphine- wafer for drug substitution therapy |
WO2008154337A1 (en) | 2007-06-08 | 2008-12-18 | Healthpartners Research Foundation | Pharmaceutical compositions and methods for enhancing targeting of therapeutic compounds to the central nervous system |
SG177752A1 (en) | 2009-07-27 | 2012-03-29 | Trigemina Inc | Methods for treatment of pain |
AU2011264416A1 (en) | 2010-06-07 | 2013-01-10 | The University Of Queensland | Nociceptin mimetics |
-
2010
- 2010-07-27 SG SG2012005419A patent/SG177752A1/en unknown
- 2010-07-27 NZ NZ597763A patent/NZ597763A/en unknown
- 2010-07-27 SG SG10201406930UA patent/SG10201406930UA/en unknown
- 2010-07-27 RU RU2012106820/15A patent/RU2012106820A/ru not_active Application Discontinuation
- 2010-07-27 WO PCT/US2010/043430 patent/WO2011017122A1/en active Application Filing
- 2010-07-27 KR KR1020187004786A patent/KR20180052610A/ko not_active Application Discontinuation
- 2010-07-27 EP EP10806903.0A patent/EP2459183B1/en active Active
- 2010-07-27 US US12/844,721 patent/US8551949B2/en active Active
- 2010-07-27 AU AU2010281436A patent/AU2010281436B2/en active Active
- 2010-07-27 JP JP2012522979A patent/JP5863650B2/ja not_active Expired - Fee Related
- 2010-07-27 CA CA2769347A patent/CA2769347C/en active Active
- 2010-07-27 CN CN201080042858.4A patent/CN102686221B/zh active Active
- 2010-07-27 MX MX2012001139A patent/MX2012001139A/es active IP Right Grant
- 2010-07-27 BR BR112012001819A patent/BR112012001819A2/pt not_active Application Discontinuation
- 2010-07-27 KR KR1020127004766A patent/KR20120100887A/ko not_active Application Discontinuation
- 2010-07-27 DK DK10806903.0T patent/DK2459183T3/en active
-
2012
- 2012-01-24 ZA ZA2012/00584A patent/ZA201200584B/en unknown
- 2012-01-26 IL IL217777A patent/IL217777A/en not_active IP Right Cessation
- 2012-10-23 HK HK12110525.9A patent/HK1169804A1/zh unknown
-
2013
- 2013-03-13 US US13/802,075 patent/US9238053B2/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1634980A (zh) * | 2004-10-10 | 2005-07-06 | 兰州大学 | 孤啡肽的类似物 |
Non-Patent Citations (2)
Title |
---|
孤啡肽在脑内对抗电针镇痛在脊髓加强电针镇痛;许伟,田令华,张伟,韩济生;《北京医科大学学报》;19961018;第28卷(第05期);327-329 * |
孤啡肽的研究及进展;薛彩萍;《国外医学.生理.病理科学与临床分册》;20030430;第23卷(第02期);158-160 * |
Also Published As
Publication number | Publication date |
---|---|
AU2010281436A1 (en) | 2012-02-16 |
RU2012106820A (ru) | 2013-09-10 |
JP2013500348A (ja) | 2013-01-07 |
SG10201406930UA (en) | 2014-11-27 |
BR112012001819A2 (pt) | 2019-09-24 |
JP5863650B2 (ja) | 2016-02-16 |
US20110021426A1 (en) | 2011-01-27 |
MX2012001139A (es) | 2012-07-30 |
HK1169804A1 (zh) | 2013-02-08 |
EP2459183A4 (en) | 2013-08-21 |
AU2010281436B2 (en) | 2016-03-24 |
US20130196908A1 (en) | 2013-08-01 |
WO2011017122A1 (en) | 2011-02-10 |
CN102686221A (zh) | 2012-09-19 |
CA2769347A1 (en) | 2011-02-10 |
CA2769347C (en) | 2022-03-29 |
DK2459183T3 (en) | 2016-01-18 |
EP2459183B1 (en) | 2015-10-07 |
US8551949B2 (en) | 2013-10-08 |
ZA201200584B (en) | 2014-03-26 |
US9238053B2 (en) | 2016-01-19 |
IL217777A (en) | 2017-04-30 |
EP2459183A1 (en) | 2012-06-06 |
IL217777A0 (en) | 2012-03-29 |
KR20120100887A (ko) | 2012-09-12 |
SG177752A1 (en) | 2012-03-29 |
KR20180052610A (ko) | 2018-05-18 |
NZ597763A (en) | 2014-07-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102686221B (zh) | 治疗疼痛的方法 | |
US8258096B2 (en) | Therapy procedure for drug delivery for trigeminal pain | |
US10357533B2 (en) | Drug for the effective control of acute and or chronic pain and a method for its administration | |
EA040799B1 (ru) | Средство для эффективного купирования острого и/или хронического болевого синдрома и способ его применения | |
AU2013201158A1 (en) | Methods for treatment of headaches by administration of oxytocin |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1176287 Country of ref document: HK |
|
C41 | Transfer of patent application or patent right or utility model | ||
CB02 | Change of applicant information |
Address after: Wilmington, Newcastle County of the U.S. state of Delaware Applicant after: Nocicepta LLC Address before: Wilmington, Newcastle County of the U.S. state of Delaware Applicant before: Nokia Saiputing LLC |
|
COR | Change of bibliographic data | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20161013 Address after: Wilmington, Newcastle County of the U.S. state of Delaware Applicant after: Nokia Saiputing LLC Address before: California, USA Applicant before: Trigemina Inc. |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1176287 Country of ref document: HK |