CO7000773A2 - Composiciones intranasales de dexmedetomidina y métodos de uso de ellas - Google Patents

Composiciones intranasales de dexmedetomidina y métodos de uso de ellas

Info

Publication number
CO7000773A2
CO7000773A2 CO14143289A CO14143289A CO7000773A2 CO 7000773 A2 CO7000773 A2 CO 7000773A2 CO 14143289 A CO14143289 A CO 14143289A CO 14143289 A CO14143289 A CO 14143289A CO 7000773 A2 CO7000773 A2 CO 7000773A2
Authority
CO
Colombia
Prior art keywords
methods
dexmedetomidine compositions
intranasal dexmedetomidine
intranasal
compositions
Prior art date
Application number
CO14143289A
Other languages
English (en)
Inventor
Geraldine A Henwood
Randall J Mack
Jr John Joseph Koleng
Christopher T Sharr
Charles Alexander Freyer
Original Assignee
Recro Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48613351&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO7000773(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Recro Pharma Inc filed Critical Recro Pharma Inc
Publication of CO7000773A2 publication Critical patent/CO7000773A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/0007—Special media to be introduced, removed or treated introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0618—Nose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Dispersion Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CO14143289A 2011-12-11 2014-07-03 Composiciones intranasales de dexmedetomidina y métodos de uso de ellas CO7000773A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161569255P 2011-12-11 2011-12-11

Publications (1)

Publication Number Publication Date
CO7000773A2 true CO7000773A2 (es) 2014-07-21

Family

ID=48613351

Family Applications (1)

Application Number Title Priority Date Filing Date
CO14143289A CO7000773A2 (es) 2011-12-11 2014-07-03 Composiciones intranasales de dexmedetomidina y métodos de uso de ellas

Country Status (21)

Country Link
US (2) US9795559B2 (es)
EP (2) EP3406247A1 (es)
JP (2) JP6268100B2 (es)
KR (1) KR102190009B1 (es)
CN (1) CN104470516A (es)
AU (2) AU2012352528B9 (es)
BR (1) BR112014019171A8 (es)
CA (1) CA2858721C (es)
CL (1) CL2014001515A1 (es)
CO (1) CO7000773A2 (es)
CR (1) CR20140318A (es)
DO (1) DOP2014000123A (es)
EC (1) ECSP14007644A (es)
HK (1) HK1203049A1 (es)
IL (1) IL232977B (es)
MX (1) MX367286B (es)
PE (1) PE20142314A1 (es)
PH (1) PH12014501273A1 (es)
RU (1) RU2692245C2 (es)
SG (2) SG10201604653TA (es)
WO (1) WO2013090278A2 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2582766A1 (en) 2010-06-16 2013-04-24 Cargill, Incorporated Starch-based compositions for latex replacement
SG10201604653TA (en) * 2011-12-11 2016-07-28 Recro Pharma Inc Intranasal dexmedetomidine compositions and methods of use thereof
ES2904570T3 (es) * 2013-09-24 2022-04-05 Satsuma Pharmaceuticals Inc Formulación de DHE intranasal para el tratamiento del dolor de cabeza
KR101827980B1 (ko) 2013-10-07 2018-02-13 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 전달 장치 및 이의 사용 방법
ES2856189T3 (es) 2013-10-07 2021-09-27 Teikoku Pharma Usa Inc Métodos y composiciones para el tratamiento del trastorno de hiperactividad por déficit de atención, ansiedad e insomnio utilizando composiciones transdérmicas de dexmedetomidina
CA2924236C (en) 2013-10-07 2020-01-07 Teikoku Pharma Usa, Inc. Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine
CN105682650B (zh) * 2013-10-07 2020-09-25 帝国制药美国公司 用于使用非镇静性右旋美托咪啶经皮组合物治疗戒断综合征的方法和组合物
MA41689A (fr) * 2014-10-15 2017-08-22 Bioxcel Corp Prévention ou traitement de troubles du sommeil au moyen d'une formulation de dexmédétomidine
EP3562486B1 (en) 2016-12-31 2024-03-13 Bioxcel Therapeutics, Inc. Use of sublingual dexmedetomidine for the treatment of agitation
EP3813802A4 (en) 2018-06-27 2022-06-08 Bioxcel Therapeutics, Inc. FILM FORMULATIONS CONTAINING DEXMEDETOMIDINE AND METHODS OF PRODUCING THEM
CN109620802A (zh) * 2018-12-05 2019-04-16 杜皓 一种麻醉用鼻喷剂及其制备方法
CN111481506B (zh) * 2019-01-25 2023-01-24 江苏恒瑞医药股份有限公司 一种包含经鼻给药的右美托咪定组合物的药物制品
CN116474219A (zh) * 2019-06-28 2023-07-25 四川普锐特药业有限公司 保持给药均一度的药物流体分配器及右美托咪定鼻喷器
CN112107544A (zh) * 2019-06-28 2020-12-22 四川普锐特药业有限公司 右美托咪定鼻喷剂、其制备方法及应用
MX2022000709A (es) 2019-07-19 2022-05-19 Bioxcel Therapeutics Inc Regimenes de tratamiento con dexmedetomidina no sedante.
CN113827590A (zh) * 2020-06-08 2021-12-24 四川普锐特药业有限公司 右美托咪定在助眠药物制备中的应用
IL304016A (en) * 2021-01-04 2023-08-01 Bioxcel Therapeutics Inc Treatment regimens of dexmedetomidine
CN115137699B (zh) * 2021-03-29 2024-05-03 四川普锐特药业有限公司 一种增效防腐的右美托咪定鼻喷剂
CN113876776A (zh) * 2021-11-04 2022-01-04 江苏大学附属医院 一种复方鼻喷镇痛药剂及其制备方法
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2206880B (en) 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative
US5124157A (en) 1989-08-18 1992-06-23 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
US5217718A (en) 1989-08-18 1993-06-08 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
FI894911A0 (fi) 1989-10-17 1989-10-17 Farmos Oy En terapeutiskt vaerdefull foerening.
DE69133584T4 (de) 1990-12-05 2009-11-19 The General Hospital Corp., Boston Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma
GB9111732D0 (en) 1991-05-31 1991-07-24 Orion Yhtymae Oy The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs
US5571840A (en) 1993-06-22 1996-11-05 The Regents Of The University Of Michigan Method for treating central nervous system ischemia
GB2281206A (en) 1993-08-25 1995-03-01 Orion Yhtymae Oy Use of dexmedetomidine
US5713907A (en) 1995-07-20 1998-02-03 Endotex Interventional Systems, Inc. Apparatus and method for dilating a lumen and for inserting an intraluminal graft
GB9520150D0 (en) 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
EE03758B1 (et) 1996-05-29 2002-06-17 Orion Corporation Lahustuvad oksiidid bioloogiliseks kasutamiseks
US20050281752A1 (en) 1997-10-01 2005-12-22 Dugger Harry A Iii Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
US20030077227A1 (en) 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
DE19758564A1 (de) 1997-11-11 1999-08-26 Gruenenthal Gmbh Formulierung einer Kombination aus Morphin und einem alpha¶2¶-adrenergem Agonisten und deren Verwendung
AR015744A1 (es) 1998-04-01 2001-05-16 Orion Corp Uso de dexmedetomidina para sedacion en terapia intensiva
US6716867B1 (en) 1998-04-01 2004-04-06 Orion Corporation Use of dexmedetomidine for ICU sedation
US7001609B1 (en) 1998-10-02 2006-02-21 Regents Of The University Of Minnesota Mucosal originated drug delivery systems and animal applications
DE69924536T2 (de) 1998-10-20 2006-02-16 Omeros Corp., Seattle Spülende lösung und methoden zur hemmung von schmerzen und entzündungen
GB9913677D0 (en) 1999-06-11 1999-08-11 Imperial College Formulation
US20040115133A1 (en) * 2000-05-10 2004-06-17 Wermeling Daniel P. Intranasal opioid compositions
GB0029111D0 (en) * 2000-11-29 2001-01-10 Novartis Ag Organic compounds
AUPR184500A0 (en) 2000-12-01 2001-01-04 Drug Delivery Solutions Pty Ltd Dispensing device
US6582457B2 (en) 2001-02-15 2003-06-24 Radiant Medical, Inc. Method of controlling body temperature while reducing shivering
US20030022926A1 (en) 2001-05-07 2003-01-30 Lavand'homme Patricia Method for treating neuropathic pain and pharmaceutical preparation therefor
FR2834212B1 (fr) 2001-12-27 2004-07-09 Besins Int Belgique Utilisation d'une poudre a liberation immediate dans des compositions pharmaceutiques et nutraceutiques
IL147921A0 (en) 2002-01-31 2002-08-14 Abdulrazik Mohammad A method for treating central nervous system disorders by ocular dosing
US6864271B2 (en) 2002-11-12 2005-03-08 The Foundation For The Lsu Health Sciences Center Synergistic combinations including N-acylated 4-hydroxyphenylamine derivatives
EP1581245A2 (en) * 2002-12-17 2005-10-05 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of y2 receptor-binding peptides and methods for treating and preventing obesity
US7439241B2 (en) 2003-05-27 2008-10-21 Galderma Laboratories, Inc. Compounds, formulations, and methods for treating or preventing rosacea
US20050058696A1 (en) 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
US20090117054A1 (en) 2005-03-29 2009-05-07 University Of Kentucky Research Foundation Sublingual spray for the treatment of pain
EP1986642B1 (en) 2006-02-13 2013-11-13 Orient Pharma (Samoa) Co, Ltd Combination of alpha-2 receptor agonist (clonidine) and an anti-muscarinic agent (oxybutynin) for the treatment of sialorrhoea
GB0611241D0 (en) 2006-06-07 2006-07-19 Daniolabs Ltd The treatment of increased sebum production
WO2008003093A2 (en) 2006-06-29 2008-01-03 Questcor Pharmaceuticals, Inc. Pharmaceutical compositions and related methods of treatment
TW200824693A (en) * 2006-08-28 2008-06-16 Jazz Pharmaceuticals Inc Pharmaceutical compositions of clonazepam and methods of use thereof
CN101057830A (zh) 2007-05-10 2007-10-24 北京天川军威医药技术开发有限公司 盐酸纳洛酮舌下喷雾给药系统或组合物及其制备方法
RU2010129833A (ru) * 2007-12-21 2012-01-27 Шеринг-Плау Хельскер Продактс, Инк. (Us) Повышение светоустойчивости оксиметазолина
CN106511273A (zh) * 2009-05-15 2017-03-22 瑞克欧制药有限公司 舌下右美托咪定组合物及其使用方法
JP5863650B2 (ja) * 2009-07-27 2016-02-16 ノシセプタ エルエルシー 疼痛を処置するための方法
AU2011204315A1 (en) 2010-01-08 2012-08-02 Recro Pharma, Inc. Topical transdermal dexmedetomidine compositions and methods of use thereof
SG10201604653TA (en) * 2011-12-11 2016-07-28 Recro Pharma Inc Intranasal dexmedetomidine compositions and methods of use thereof

Also Published As

Publication number Publication date
KR102190009B1 (ko) 2020-12-15
JP6268100B2 (ja) 2018-01-24
US20130178465A1 (en) 2013-07-11
SG11201403094TA (en) 2014-10-30
AU2018200591B2 (en) 2018-11-29
CR20140318A (es) 2014-10-28
ECSP14007644A (es) 2015-11-30
EP2787970A4 (en) 2015-10-28
MX2014006961A (es) 2014-09-22
RU2692245C2 (ru) 2019-06-24
DOP2014000123A (es) 2014-12-31
CA2858721A1 (en) 2013-06-20
KR20140107329A (ko) 2014-09-04
CA2858721C (en) 2021-03-16
US9795559B2 (en) 2017-10-24
CL2014001515A1 (es) 2014-12-05
EP2787970B1 (en) 2018-04-11
AU2018200591A1 (en) 2018-02-15
AU2012352528B2 (en) 2017-10-26
EP2787970A2 (en) 2014-10-15
IL232977B (en) 2019-01-31
US20180055764A1 (en) 2018-03-01
JP6505177B2 (ja) 2019-04-24
CN104470516A (zh) 2015-03-25
SG10201604653TA (en) 2016-07-28
JP2018030850A (ja) 2018-03-01
PE20142314A1 (es) 2015-01-23
WO2013090278A3 (en) 2014-12-24
AU2012352528A1 (en) 2014-07-10
BR112014019171A2 (es) 2017-06-20
HK1203049A1 (en) 2015-10-16
JP2015513309A (ja) 2015-05-07
AU2012352528B9 (en) 2017-11-02
MX367286B (es) 2019-08-13
IL232977A0 (en) 2014-07-31
US10682311B2 (en) 2020-06-16
WO2013090278A2 (en) 2013-06-20
PH12014501273A1 (en) 2014-09-08
EP3406247A1 (en) 2018-11-28
RU2014128343A (ru) 2016-01-27
NZ626999A (en) 2016-07-29
BR112014019171A8 (pt) 2017-07-11

Similar Documents

Publication Publication Date Title
CO7000773A2 (es) Composiciones intranasales de dexmedetomidina y métodos de uso de ellas
LTPA2018516I1 (lt) Testosterono kompozicijos
BR112013032426A2 (pt) composições probióticas e métodos
BR112014016798A8 (pt) método de uso de aditivos tensoativos
BR112014008590A2 (pt) métodos de uso de antagonistas de scd1
CO7010824A2 (es) Inhibidores de aplicación viral
CO7020870A2 (es) Anticuerpos anti-htra1 y métodos de uso
DK2791160T3 (da) Modificerede mrna-sammensætninger
DK3495392T3 (da) Anti-cgrp-sammensætninger og anvendelse deraf
EP2675471A4 (en) HSA-RELATED COMPOSITIONS AND USE PROCESSES
BR112013006016A2 (pt) compostos de azabenzotiazol, composições e métodos de uso
BR112014002716A2 (pt) anticorpos anti-poliubiquitina e métodos de uso
BR112014010450A2 (pt) composição e método
CO6980141A1 (es) Compuestos y composiciones de poliglicerilo catónicos
BR112013010331A2 (pt) composições adesivas crepadas e métodos de uso dessas composições
DK2800572T3 (da) Sammensætning af ellagitannin-rige ekstrakter
CR20130133A (es) Composiciones de anticuerpo y mètodos de uso
CO6940436A2 (es) Composicion de control de fitoenfermedades y su uso
DK2661274T3 (da) Sammensætninger og fremgangsmåder med aloepolysaccharider
IL227924B (en) Preparations and methods of use for determining a4he
BR112014010774A2 (pt) anticorpos anti-kdr e métodos de uso
BR112014010860A2 (pt) composição e método
FI20115310A (fi) Proteaasientsyymi ja sen käytöt
BR112013031545A2 (pt) composições cosméticas
CR20140186A (es) Composiciones mejoradas