TWI791479B - 用於治療激躁之舌下迪美得托咪汀(dexmedetomidine)之用途 - Google Patents

用於治療激躁之舌下迪美得托咪汀(dexmedetomidine)之用途 Download PDF

Info

Publication number
TWI791479B
TWI791479B TW107100113A TW107100113A TWI791479B TW I791479 B TWI791479 B TW I791479B TW 107100113 A TW107100113 A TW 107100113A TW 107100113 A TW107100113 A TW 107100113A TW I791479 B TWI791479 B TW I791479B
Authority
TW
Taiwan
Prior art keywords
micrograms
agitation
pharmaceutically acceptable
sublingual
acceptable salt
Prior art date
Application number
TW107100113A
Other languages
English (en)
Chinese (zh)
Other versions
TW201829018A (zh
Inventor
克里許南 南大巴朗
法蘭克 優卡
薩米爾 莎瑪
Original Assignee
美商百歐克斯賽爾治療公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商百歐克斯賽爾治療公司 filed Critical 美商百歐克斯賽爾治療公司
Publication of TW201829018A publication Critical patent/TW201829018A/zh
Application granted granted Critical
Publication of TWI791479B publication Critical patent/TWI791479B/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
TW107100113A 2016-12-31 2018-01-02 用於治療激躁之舌下迪美得托咪汀(dexmedetomidine)之用途 TWI791479B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662441164P 2016-12-31 2016-12-31
US62/441,164 2016-12-31
US201762471393P 2017-03-15 2017-03-15
US62/471,393 2017-03-15
US201762542323P 2017-08-08 2017-08-08
US62/542,323 2017-08-08

Publications (2)

Publication Number Publication Date
TW201829018A TW201829018A (zh) 2018-08-16
TWI791479B true TWI791479B (zh) 2023-02-11

Family

ID=62710955

Family Applications (3)

Application Number Title Priority Date Filing Date
TW107100113A TWI791479B (zh) 2016-12-31 2018-01-02 用於治療激躁之舌下迪美得托咪汀(dexmedetomidine)之用途
TW112101436A TWI833550B (zh) 2016-12-31 2018-01-02 用於治療激躁之舌下迪美得托咪汀(dexmedetomidine)之用途
TW113107057A TW202423422A (zh) 2016-12-31 2018-01-02 用於治療激躁之舌下迪美得托咪汀(dexmedetomidine)之用途

Family Applications After (2)

Application Number Title Priority Date Filing Date
TW112101436A TWI833550B (zh) 2016-12-31 2018-01-02 用於治療激躁之舌下迪美得托咪汀(dexmedetomidine)之用途
TW113107057A TW202423422A (zh) 2016-12-31 2018-01-02 用於治療激躁之舌下迪美得托咪汀(dexmedetomidine)之用途

Country Status (20)

Country Link
US (7) US11839604B2 (enExample)
EP (3) EP3562486B1 (enExample)
JP (5) JP6868698B2 (enExample)
KR (2) KR102793584B1 (enExample)
CN (1) CN110337290A (enExample)
AU (3) AU2017388759B2 (enExample)
BR (1) BR112019013503A2 (enExample)
CA (1) CA3045043A1 (enExample)
DK (1) DK3562486T3 (enExample)
ES (1) ES2980126T3 (enExample)
FI (1) FI3562486T3 (enExample)
HU (1) HUE067266T2 (enExample)
IL (1) IL267689B2 (enExample)
MX (3) MX2019007923A (enExample)
PL (1) PL3562486T3 (enExample)
PT (1) PT3562486T (enExample)
SG (1) SG10202107367SA (enExample)
TW (3) TWI791479B (enExample)
WO (1) WO2018126182A1 (enExample)
ZA (1) ZA202006636B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3045043A1 (en) 2016-12-31 2018-07-05 Bioxcel Therapeutics, Inc. Use of sublingual dexmedetomidine for the treatment of agitation
CN115154440A (zh) 2018-06-27 2022-10-11 比奥克斯塞尔医疗股份有限公司 含右美托咪定的膜制剂及其制造方法
EP3813828A4 (en) * 2018-06-27 2022-03-30 Bioxcel Therapeutics, Inc. METHOD OF TREATMENT OF AGITATION WITH DEXMEDETOMIDIN HYDROCHLORIDE
RU2692247C1 (ru) * 2018-12-06 2019-06-24 федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени В.А. Алмазова" Министерства здравоохранения Российской Федерации Способ лечения послеоперационного делирия
WO2021016112A2 (en) 2019-07-19 2021-01-28 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
CN114667095A (zh) * 2019-09-18 2022-06-24 比奥克斯塞尔医疗股份有限公司 用于检测并预防激躁发生的系统和方法
WO2021158059A1 (ko) * 2020-02-07 2021-08-12 건국대학교 글로컬산학협력단 릴메니딘 화합물을 유효성분으로 포함하는 취약 x 증후군 또는 관련 발달 장애 치료용 조성물
MX2022009971A (es) * 2020-02-14 2022-11-09 Bioxcel Therapeutics Inc Sistemas y métodos para la detección y prevención de la aparición de la agitación.
MX2023003993A (es) * 2020-10-08 2023-05-24 Bioxcel Therapeutics Inc Tratamiento de trastornos bipolares y psicosis con clorhidrato de dexmedetomidina.
KR20230136612A (ko) * 2021-01-04 2023-09-26 바이오엑셀 테라퓨틱스 인코포레이티드 덱스메데토미딘 치료 용법
US20240139169A1 (en) * 2021-02-26 2024-05-02 Bioxcel Therapeutics, Inc. Methods and compositions for treating agitation
AU2022236605A1 (en) 2021-03-19 2023-11-02 Orion Corporation Tasipimidine formulations and use thereof
WO2023278824A1 (en) * 2021-07-02 2023-01-05 Bioxcel Therapeutics, Inc. Methods for treating depressive states
GB2618810A (en) * 2022-05-17 2023-11-22 Novumgen Ltd Pharmaceutical composition for sublingual administration of clonidine
EP4561573A1 (en) 2022-07-27 2025-06-04 Universität Zürich Dexmedetomidine for the treatment of sleep disorders
EP4583871A1 (en) * 2022-09-11 2025-07-16 BioXcel Therapeutics, Inc. Methods for treating agitation in community settings
EP4642453A1 (en) * 2022-12-27 2025-11-05 Alceptor Therapeutics, Inc. (s)-(3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol for treatment of agitation
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
WO2024263973A1 (en) * 2023-06-23 2024-12-26 Bioxcel Therapeutics, Inc. Dexmedetomidine treatment regimens
CN119139275B (zh) * 2024-11-05 2025-08-22 中国人民解放军军事科学院军事医学研究院 一种盐酸右美托咪定口溶膜及其制备方法和其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016061413A1 (en) * 2014-10-15 2016-04-21 Bioxcel Corporation Prevention or treatment of sleep disorders using dexmedetomidine formulation

Family Cites Families (259)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8295A (en) 1851-08-12 Construction- of roofs
SU1138164A1 (ru) 1963-04-25 1985-02-07 Shadurskij Konstantin S Антигистаминное средство "димебон
US4407957A (en) 1981-03-13 1983-10-04 Damon Corporation Reversible microencapsulation of a core material
FI844786A0 (fi) 1984-12-04 1984-12-04 Farmos Oy Terapeutiskt utnyttjbar foerening.
US4839170A (en) 1985-10-01 1989-06-13 Survival Technology, Inc. Protein absorption enhancing agents
US4760093A (en) 1986-10-21 1988-07-26 American Home Products Corporation (Del.) Spray dried acetaminophen
US4760094A (en) 1986-10-21 1988-07-26 American Home Products Corporation (Del.) Spray dried acetaminophen
US4767789A (en) 1986-10-21 1988-08-30 American Home Products Corporation (Del.) Spray dried acetaminophen
US5039540A (en) 1989-08-14 1991-08-13 Neophore Technologies, Inc. Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
US5217718A (en) 1989-08-18 1993-06-08 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
US5178878A (en) 1989-10-02 1993-01-12 Cima Labs, Inc. Effervescent dosage form with microparticles
US5215756A (en) 1989-12-22 1993-06-01 Gole Dilip J Preparation of pharmaceutical and other matrix systems by solid-state dissolution
US5188825A (en) 1989-12-28 1993-02-23 Iles Martin C Freeze-dried dosage forms and methods for preparing the same
DK0585368T3 (da) 1991-04-25 1998-03-16 Univ Brown Res Found Implanterbart biokompatibelt immunisolatorisk vehikel til afgivelse af udvalgte terapeutiske produkter
US5352456A (en) 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
KR100291620B1 (ko) 1992-09-29 2001-10-24 추후제출 부갑상선호르몬의활성단편의폐를통한전달방법
US5343672A (en) 1992-12-01 1994-09-06 Scherer Ltd R P Method for manufacturing freeze dried dosages in a multilaminate blister pack
JP3233638B2 (ja) 1993-07-09 2001-11-26 アール．ピー． シェーラー コーポレイション 凍結乾燥された薬投与形状物の製造方法
GB2281206A (en) 1993-08-25 1995-03-01 Orion Yhtymae Oy Use of dexmedetomidine
US5457895A (en) 1993-10-01 1995-10-17 R. P. Scherer Corporation Method of identifying freeze-dried dosage forms
US5395907A (en) 1993-11-29 1995-03-07 Adhesive Research, Inc. Water-soluble pressure sensitive adhesive
AU1330895A (en) 1993-11-29 1995-06-13 Adhesives Research, Inc. Water-soluble pressure sensitive adhesive
US5508367A (en) 1993-11-29 1996-04-16 Adhesives Research, Inc. Water-soluble pressure sensitive adhesive
FR2718357B1 (fr) 1994-04-06 1997-10-03 Defarges Alain Moreau Perfectionnements apportés à un dispositif d'injection par jet sans aiguille.
GB2290964A (en) 1994-07-08 1996-01-17 Arto Olavi Urtti Transdermal drug delivery system
US5731387A (en) 1994-07-11 1998-03-24 Adhesives Research, Inc. Ionically-crosslinked water-absorbent graft copolymer
US5726250A (en) 1994-07-11 1998-03-10 Adhesives Research, Inc. Covalently crosslinked water-absorbent graft copolymer
GB9421836D0 (en) 1994-10-28 1994-12-14 Scherer Corp R P Process for preparing solid pharmaceutical dosage forms of hydrophobic substances
US6726928B2 (en) 1994-10-28 2004-04-27 R.P. Scherer Technologies, Inc. Process for preparing solid dosage forms for unpalatable pharmaceuticals
US5837287A (en) 1994-10-28 1998-11-17 R P Scherer Corporation Process for preparing solid pharmaceutical dosage forms
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5605911A (en) 1995-01-31 1997-02-25 Washington University Use of alpha-2 adrenergic drugs to prevent adverse effects of NMDA receptor hypofunction (NRH)
US5700873A (en) 1995-03-07 1997-12-23 Adhesives Research, Inc. Method of preparation of water-soluble copolymer
US5780014A (en) 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
US5654007A (en) 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
GB9616672D0 (en) 1996-08-08 1996-09-25 Scherer Ltd R P Pharmaceutical compositions
US5800832A (en) 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
GB9700624D0 (en) 1997-01-14 1997-03-05 Danbiosyst Uk Drug delivery composition
GB9702799D0 (en) 1997-02-12 1997-04-02 Scherer Corp R P Process for preparing solid pharmaceutical dosage forms
JP4563516B2 (ja) 1997-02-20 2010-10-13 マサチューセッツ インスティテュート オブ テクノロジー 迅速分散性を示す投与剤形、その使用法並びにその製造方法
US5951999A (en) 1997-02-21 1999-09-14 Adhesives Research, Inc. Transdermal pressure sensitive adhesive drug delivery system
CA2276339A1 (en) 1997-02-21 1998-08-27 Michael J. Zajaczkowski Transdermal pressure sensitive adhesive drug delivery system and pressure sensitive adhesive used therein
US6239228B1 (en) 1997-02-21 2001-05-29 Adhesives Research, Inc. Pressure sensitive adhesive containing macromer having repeat hydrophilic moieties
US6024981A (en) 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
US5976577A (en) 1997-07-11 1999-11-02 Rp Scherer Corporation Process for preparing fast dispersing solid oral dosage form
PT1001748E (pt) 1997-07-25 2006-08-31 Alpex Pharma Sa Um processo para a preparacao de um granulado adequado para a preparacao de comprimidos rapidamente desintegraveis na boca
US7632517B2 (en) 1997-10-01 2009-12-15 Novadel Pharma Inc. Buccal, polar and non-polar spray containing zolpidem
GB9802088D0 (en) 1998-01-30 1998-03-25 Scherer Ltd R P Pharmaceutical products
PT1591360E (pt) 1998-03-09 2007-10-09 Cima Labs Inc ''aparelho para manusear e embalar comprimidos quebradiços''
US6200604B1 (en) 1998-03-27 2001-03-13 Cima Labs Inc. Sublingual buccal effervescent
US6716867B1 (en) * 1998-04-01 2004-04-06 Orion Corporation Use of dexmedetomidine for ICU sedation
AU2005201500B2 (en) 1998-06-03 2007-01-04 Scott Laboratories, Inc. Apparatus and method for providing a conscious patient relief from pain and anxiety associated with medical or surgical procedures
US7565905B2 (en) 1998-06-03 2009-07-28 Scott Laboratories, Inc. Apparatuses and methods for automatically assessing and monitoring a patient's responsiveness
WO1999062403A1 (en) 1998-06-03 1999-12-09 Scott Laboratories, Inc. Apparatus and method for providing a conscious patient relief from pain and anxiety associated with medical or surgical procedures
US7001609B1 (en) 1998-10-02 2006-02-21 Regents Of The University Of Minnesota Mucosal originated drug delivery systems and animal applications
HK1042856B (zh) 1998-11-20 2007-07-27 Skyepharma Canada Inc. 可分散的磷脂稳定的微粒
GB9901819D0 (en) 1999-01-27 1999-03-17 Scherer Corp R P Pharmaceutical compositions
GB9908014D0 (en) 1999-04-08 1999-06-02 Scherer Corp R P Pharmaceutical compositions
US6284270B1 (en) 1999-08-04 2001-09-04 Drugtech Corporation Means for creating a mass having structural integrity
DE19940740A1 (de) 1999-08-31 2001-03-01 Gruenenthal Gmbh Pharmazeutische Salze
US6984207B1 (en) 1999-09-14 2006-01-10 Hoana Medical, Inc. Passive physiological monitoring (P2M) system
CA2324967A1 (en) 2000-11-01 2002-05-01 3816133 Canada Inc. System for monitoring patients with alzheimer's disease or related dementia
US6316029B1 (en) 2000-05-18 2001-11-13 Flak Pharma International, Ltd. Rapidly disintegrating solid oral dosage form
DE60142900D1 (de) 2000-07-07 2010-10-07 Corium Internat Inc Herstellung von hydrophilen druckempfindlichen klebstoffen mit optimalen hafteigenschaften
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US6814978B2 (en) 2000-12-29 2004-11-09 Mcneil-Ppc, Inc. Process for preparing a soft tablet
US20030022926A1 (en) 2001-05-07 2003-01-30 Lavand'homme Patricia Method for treating neuropathic pain and pharmaceutical preparation therefor
US7269516B2 (en) 2001-05-15 2007-09-11 Psychogenics, Inc. Systems and methods for monitoring behavior informatics
US6509040B1 (en) 2001-06-22 2003-01-21 R.P. Scherer Corporation Fast dispersing dosage forms essentially free of mammalian gelatin
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US7425292B2 (en) 2001-10-12 2008-09-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US7666337B2 (en) 2002-04-11 2010-02-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
DE60222160T2 (de) 2001-10-12 2008-06-12 Elan Pharma International Ltd., Athlone Zusammensetzungen mit einer kombination aus eigenschaften sofortiger freisetzung und kontrollierter freisetzung
US20140271788A1 (en) 2013-03-15 2014-09-18 Monosol Rx, Llc Sublingual and buccal film compositions
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US8663687B2 (en) 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
FR2832311B1 (fr) 2001-11-21 2004-04-16 Besins Int Belgique Poudre filmogene, compositions la comprenant, leurs procedes de preparation et leurs utilisations
FR2834212B1 (fr) 2001-12-27 2004-07-09 Besins Int Belgique Utilisation d'une poudre a liberation immediate dans des compositions pharmaceutiques et nutraceutiques
AU2003211051A1 (en) 2002-02-13 2003-09-04 Michael K. Weibel Drug dose-form and method of manufacture
WO2004032913A1 (en) 2002-10-08 2004-04-22 Allergan, Inc. Alpha 2b 0r 2b/2c adrenoceptor agonists for the treatment of neurodegeneration
US20040156894A1 (en) 2003-02-07 2004-08-12 Grother Leon Paul Use of edible acids in fast-dispersing pharmaceutical solid dosage forms
CA2544776C (en) 2003-05-28 2014-04-15 Monosolrx Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US7282217B1 (en) 2003-08-29 2007-10-16 Kv Pharmaceutical Company Rapidly disintegrable tablets
US9248146B2 (en) 2003-10-24 2016-02-02 Adhesives Research, Inc. Dissolvable adhesive films for delivery of pharmaceutical or cosmetic agents
WO2005040228A2 (en) 2003-10-24 2005-05-06 Adhesives Research, Inc. Disintegratable films for diagnostic devices
GB0403808D0 (en) 2004-02-20 2004-03-24 Bioprogress Technology Ltd Films for use as dosage forms
US20050222270A1 (en) 2004-02-26 2005-10-06 Olney John W Prolonged administration of NMDA antagonist drug and safener drug to create improved stable neural homeostasis
US7972621B2 (en) 2004-06-03 2011-07-05 R.P. Scherer Technologies, Llc Process for formulating fast dispersing dosage forms comprising at least one fish gelatin selected on the basis of molecular weight
US20060058590A1 (en) 2004-08-24 2006-03-16 Shaw Geoffrey M Method and system for assaying agitation
US20060058700A1 (en) 2004-08-26 2006-03-16 Marro Dominic P Patient sedation monitor
CA2580694A1 (en) 2004-09-23 2006-03-30 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
JP2008532587A (ja) 2005-02-22 2008-08-21 ヘルス−スマート リミテッド 生理学的及び心理学的／生理学的モニタリングのための方法及びシステム並びにその使用
JP2008531714A (ja) 2005-03-04 2008-08-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 不安障害の治療用及び／又は予防用の医薬組成物
WO2007010242A1 (en) 2005-07-18 2007-01-25 Imperial College Innovations Limited Use of a noradrenergic agonist, e.g. guanfacine, for the treatment of cognitive disorders
US20070106126A1 (en) 2005-09-30 2007-05-10 Mannheimer Paul D Patient monitoring alarm escalation system and method
WO2007041697A2 (en) 2005-10-04 2007-04-12 Medivation, Inc. Hydrogenated pyrido-indole compounds for the treatment of huntington ' s disease
US8158152B2 (en) 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
BRPI0620578A2 (pt) 2005-12-27 2011-12-06 Jubilant Organosys Ltd composição farmacêutica que dissolve na boca e processo para o preparo da mesma
EP1986642B1 (en) 2006-02-13 2013-11-13 Orient Pharma (Samoa) Co, Ltd Combination of alpha-2 receptor agonist (clonidine) and an anti-muscarinic agent (oxybutynin) for the treatment of sialorrhoea
US7630758B2 (en) 2006-06-22 2009-12-08 General Electric Company Separation of natural and drug-induced sleep of a subject
US20080026040A1 (en) 2006-07-31 2008-01-31 Isaac Farr Active agent-releasing dosage forms
CN101516331A (zh) 2006-09-20 2009-08-26 莫诺索尔克斯有限公司 含有抗泡沫调味剂的可食用水溶性膜
US8157730B2 (en) 2006-12-19 2012-04-17 Valencell, Inc. Physiological and environmental monitoring systems and methods
US20080153808A1 (en) 2006-12-22 2008-06-26 Allergan, Inc. Alpha-2 receptor pan agonist and serotonin-norepinephrine reuptake inhibitor compositions for treating chronic pain
EP2112923A1 (en) 2007-01-22 2009-11-04 Targacept Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
US8568777B2 (en) 2007-03-30 2013-10-29 Monosol Rx, Llc Packaged film dosage unit containing a complexate
EP2152247A4 (en) 2007-05-10 2012-12-26 Novadel Pharma Inc COMPOSITIONS AND METHODS ANTI-INSOMNIA
US20090099480A1 (en) 2007-05-24 2009-04-16 Peter Salgo System and method for patient monitoring
WO2009002084A2 (en) 2007-06-27 2008-12-31 Hanmi Pharm. Co., Ltd. Method for preparing rapidly disintegrating formulation for oral administration and apparatus for preparing and packing the same
RU2338533C1 (ru) 2007-06-28 2008-11-20 Сергей Олегович Бачурин СРЕДСТВО, ОБЛАДАЮЩЕЕ АНКСИОЛИТИЧЕСКИМ ДЕЙСТВИЕМ, НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
EP2175724A4 (en) 2007-08-01 2010-09-15 Medivation Neurology Inc METHOD AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA USING ANTIPSYCHOTIC COMBINATION THERAPY
MY153890A (en) 2007-10-11 2015-04-15 Philip Morris Products Sa Smokeless tobacco product
US8298583B2 (en) 2007-10-19 2012-10-30 Monosol Rx, Llc Film delivery system for tetrahydrolipstatin
PE20091084A1 (es) 2007-12-07 2009-07-23 Schering Plough Healthcare Formulaciones farmaceuticas de fenilefrina y composiciones para absorcion transmucosal
CN101496801A (zh) 2008-02-02 2009-08-05 四川百利药业有限责任公司 右旋美托咪定及其药用盐的用途
PT2252290T (pt) 2008-02-15 2018-02-14 Bone Therapeutics Sa Composição farmacêutica para utilização no tratamento e/ou prevenção de doenças osteoarticulares
CA2716901C (en) 2008-02-28 2018-07-03 R.P. Scherer Technologies, Llc Process to minimize polymorphism
US20190216389A1 (en) 2008-04-07 2019-07-18 Christopher Scheib Method and system for analyzing a series of electroencephalogram (eeg) signals during altered brain states
US20090275853A1 (en) 2008-04-30 2009-11-05 The General Electric Company Method and apparatus for monitoring physiological state of a subject
US8882684B2 (en) 2008-05-12 2014-11-11 Earlysense Ltd. Monitoring, predicting and treating clinical episodes
US20100029706A1 (en) 2008-07-30 2010-02-04 Edison Parmaceuticals, Inc. a Delaware Corporation HYDROGENATED PYRIDO[4,3-b]INDOLES FOR THE TREATMENT OF OXIDATIVE STRESS
US20110172262A1 (en) 2008-09-15 2011-07-14 Biovista, Inc. Compositions and methods for treating epilepsy
US8731842B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US8256233B2 (en) 2008-10-31 2012-09-04 The Invention Science Fund I, Llc Systems, devices, and methods for making or administering frozen particles
US8470546B2 (en) 2008-11-25 2013-06-25 Albert Einstein College Of Medicine Of Yeshiva University Treatment of autism spectrum disorders with agents that activate the Locus Coeruleus-Noradrenergic system
EP2370136A4 (en) 2008-12-01 2015-12-30 Map Pharmaceuticals Inc INHALATIVE RELEASE PROCEDURES AND DEVICES
US8282954B2 (en) 2008-12-15 2012-10-09 Monosol Rx, Llc Method for manufacturing edible film
TR200903014A1 (tr) 2009-04-17 2010-11-22 Sanovel İlaç San. Ve Ti̇c. A.Ş. Oral yolla dağılan dimebolin bileşimleri.
EP2429521B1 (en) 2009-05-15 2017-10-18 Recro Pharma, Inc. Sublingual dexmedetomidine compositions and methods of use thereof
US8475832B2 (en) 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
US9775819B2 (en) 2009-09-16 2017-10-03 R.P. Scherer Technologies, Llc Oral solid dosage form containing nanoparticles and process of formulating the same using fish gelatin
US8313768B2 (en) 2009-09-24 2012-11-20 Mcneil-Ppc, Inc. Manufacture of tablet having immediate release region and sustained release region
WO2011039686A1 (en) 2009-09-30 2011-04-07 Pfizer Inc. Latrepirdine oral sustained release dosage forms
RU2012133969A (ru) 2010-01-08 2014-02-20 Рекро Фарма, Инк. Локальные трансдермальные композиции дексмедетомидина и способы их применения
US20110245633A1 (en) 2010-03-04 2011-10-06 Neumitra LLC Devices and methods for treating psychological disorders
US10548839B2 (en) 2010-03-16 2020-02-04 Wei Tian Process of manufacturing a lyophilized fast dissolving, multi-phasic dosage form
WO2011127586A1 (en) 2010-04-15 2011-10-20 The Royal Institution For The Advancement Of Learning / Mcgill University Topical treatments for pain
US9572773B2 (en) 2010-04-26 2017-02-21 Novartis A.G. Layered drug delivery device
US20110290694A1 (en) 2010-05-27 2011-12-01 Monosol Rx, Llc Oral film dosage form having indicia thereon
US8529914B2 (en) 2010-06-28 2013-09-10 Richard C. Fuisz Bioactive dose having containing a material for modulating pH of a bodily fluid to help or hinder absorption of a bioactive
WO2012024106A2 (en) 2010-08-17 2012-02-23 University Of Florida Research Foundation, Inc. Central site photoplethysmography, medication administration, and safety
CA2815568C (en) 2010-09-23 2018-10-09 Monosolrx Llc Method and system for forming a pharmaceutical product directly onto a packaging surface
US8383135B2 (en) 2010-12-03 2013-02-26 Richard C. Fuisz Solid dosage form that promotes reliable oral, esophageal and GI transit
EA031156B1 (ru) 2010-12-16 2018-11-30 Суновион Фармасьютикалз Инк. Сублингвальные пленки
EP2670368A4 (en) 2011-02-03 2015-04-15 Pharmedica Ltd NEW ORAL DISSOLUTION FILMS FOR INSULIN DELIVERY FOR THE TREATMENT OF DIABETES
US20140163080A1 (en) 2011-02-03 2014-06-12 Gnt, Llc Compositions and Methods for Treatment of Glaucoma
US8445526B2 (en) 2011-02-03 2013-05-21 Glaucoma & Nasal Therapies Llc Compositions and methods for treatment of glaucoma
US8241661B1 (en) 2011-06-24 2012-08-14 Fuisz Richard C Biocompatible film with variable cross-sectional properties
US8703697B2 (en) 2011-06-24 2014-04-22 Luc QUINTIN Method for treating early severe diffuse acute respiratory distress syndrome
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
US20130116215A1 (en) 2011-10-28 2013-05-09 Mireia Coma Combination therapies for treating neurological disorders
CN104470516A (zh) 2011-12-11 2015-03-25 瑞克欧制药有限公司 鼻内右美托咪定组合物和其使用方法
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
CA2865593A1 (en) 2012-02-27 2013-09-06 Eye Therapies Llc Compositions and methods for the treatment of migraine
JP5921928B2 (ja) 2012-03-28 2016-05-24 テルモ株式会社 既希釈デクスメデトミジン製剤
CN102657635B (zh) 2012-05-04 2013-08-07 上海现代药物制剂工程研究中心有限公司 具有微孔的海绵状的阿塞那平舌下膜剂及其制备方法
WO2013173317A1 (en) 2012-05-14 2013-11-21 Prospire, Llc TREATMENT OF OBSTRUCTIVE SLEEP APNEA WITH α2-ADRENERGIC RECEPTOR AGONISTS
US9549899B2 (en) 2012-07-06 2017-01-24 Egalet Ltd. Abuse deterrent pharmaceutical compositions for controlled release
US10130766B1 (en) 2012-08-08 2018-11-20 Neurowave Systems Inc. Intelligent pharmaceutical delivery system with automatic shutoff and method of using
DK2719376T3 (en) 2012-10-12 2015-06-15 Omya Int Ag Gastroretentiv drug formulation and delivery systems and their method of preparation by the use of functional calcium carbonate
US20140180160A1 (en) 2012-10-12 2014-06-26 Emery N. Brown System and method for monitoring and controlling a state of a patient during and after administration of anesthetic compound
NZ706990A (en) 2012-10-15 2017-12-22 Orion Corp A veterinary method of alleviating noise aversion
GB2510321B (en) 2012-11-12 2018-01-31 Biosurgical S L Agitation apparatus
WO2014116770A1 (en) 2013-01-23 2014-07-31 Arx, Llc Production of unit dose constructs
EP2964270A4 (en) 2013-02-21 2017-03-22 University Of Rochester Methods for evaluating brain-wide paravascular pathway for waste clearance function and methods for treating neurodegenerative disorders based thereon
US20140261990A1 (en) 2013-03-15 2014-09-18 Monosol Rx, Llc Multi-layer films having uniform content
US9303918B2 (en) 2013-03-15 2016-04-05 Monosol Rx, Llc Process for drying a wet film with control of loss on drying
US9346601B2 (en) 2013-03-15 2016-05-24 Monosol Rx, Llc Reduction in stress cracking of films
WO2014144365A1 (en) 2013-03-15 2014-09-18 University Of Maryland, College Park Nano-liposomal formulations and methods of use
WO2014153489A1 (en) 2013-03-22 2014-09-25 Adhesives Research, Inc. Hydrophilic adhesives and tapes and devices containing the same
JP2016520375A (ja) 2013-04-23 2016-07-14 ザ ジェネラル ホスピタル コーポレイション 脳のコヒーレンスおよびシンクロニーの指標を使用して麻酔および鎮静を監視するためのシステムおよび方法
WO2014176436A1 (en) 2013-04-24 2014-10-30 The General Hospital Corporation System and method for estimating high time-frequency resolution eeg spectrograms to monitor patient state
WO2014176441A1 (en) 2013-04-24 2014-10-30 The General Hospital Corporation System and method for monitoring level of dexmedatomidine-induced sedation
CN103284945A (zh) 2013-06-03 2013-09-11 四川百利药业有限责任公司 一种预充式盐酸右美托咪定注射液的制备方法
US9073294B2 (en) 2013-06-04 2015-07-07 Monosol, Llc Method for sealing a water-soluble film by applying a sealing solution
JP6660878B2 (ja) 2013-06-27 2020-03-11 ザ ジェネラル ホスピタル コーポレイション 生理学的データにおける動的構造を追跡するためのシステムおよび該システムの作動方法
US10383574B2 (en) 2013-06-28 2019-08-20 The General Hospital Corporation Systems and methods to infer brain state during burst suppression
EP3043696B1 (en) 2013-09-13 2022-11-02 The General Hospital Corporation Systems and methods for improved brain monitoring during general anesthesia and sedation
KR20180095733A (ko) 2013-10-07 2018-08-27 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 조성물을 포함하는 통증을 관리하기 위한 방법 및 조성물
WO2015054063A1 (en) 2013-10-07 2015-04-16 Teikoku Pharma Usa, Inc. Methods and compositions for treating withdrawal syndromes using non-sedative dexmedetomidine transdermal compositions
TWI709417B (zh) 2013-10-07 2020-11-11 美商帝國製藥美國股份有限公司 使用右美托咪啶經皮組成物用於治療注意力不足過動症、焦慮及失眠的方法及組成物
CN105764496B (zh) 2013-10-07 2020-09-25 帝国制药美国公司 用于经皮递送非镇静量的右旋美托咪啶的方法和组合物
TWI704933B (zh) 2013-10-07 2020-09-21 美商帝國製藥美國股份有限公司 右美托咪啶經皮輸送裝置及使用其之方法
WO2015069778A1 (en) 2013-11-05 2015-05-14 The General Hospital Corporation System and method for determining neural states from physiological measurements
US11033493B2 (en) 2013-12-02 2021-06-15 Intelgenx Corp. Film dosage form with extended release mucoadhesive particles
JP6469587B2 (ja) 2013-12-18 2019-02-13 丸石製薬株式会社 含水型貼付剤
US20170231556A1 (en) 2014-08-22 2017-08-17 The General Hospital Corporation Systems and methods for predicting arousal to consciousness during general anesthesia and sedation
WO2016029226A1 (en) 2014-08-22 2016-02-25 The General Hospital Corporation System and method for administering, monitoring and controlling biomimetic sleep
US20170273611A1 (en) 2014-08-22 2017-09-28 The General Hospital Corporation Systems and methods for discovery and characterization of neuroactive drugs
US9726337B2 (en) * 2014-08-27 2017-08-08 R. W. Swarens Associates, Inc. Light fixture for indirect asymmetric illumination with LEDs
CN104161760A (zh) 2014-09-01 2014-11-26 西北农林科技大学 一种貉用复合麻醉剂及其制备方法和应用
WO2016061554A1 (en) * 2014-10-16 2016-04-21 Bioxcel Corporation Synergistic composition of known, safe pharmaceuticals for use in insomnia and a method of treatment thereof
FI127534B (en) 2014-11-10 2018-08-31 Vetcare Oy Substituted benzoefuroquinolizine and ɑ2-adrenergic agonist comprising compositions
WO2016089997A1 (en) 2014-12-02 2016-06-09 Yale University Methods of preventing neurodegeneration of association cortex in a mammal
JP2016154598A (ja) 2015-02-23 2016-09-01 ニプロ株式会社 デクスメデトミジン注射液を充填したプレフィルドシリンジ
CN104784174A (zh) 2015-03-06 2015-07-22 北京大学第一医院 右美托咪定的药物新用途
WO2016164903A1 (en) 2015-04-10 2016-10-13 Hemcon Medical Technologies, Inc. Bioadhesive chitosan gel for controlling bleeding and for promoting healing with scar reduction without obscuring or interfering with access to a surgical field
CN106038538A (zh) 2015-04-17 2016-10-26 江苏恒瑞医药股份有限公司 一种右美托咪定的预混合制剂
US10179136B2 (en) 2015-06-19 2019-01-15 Imprimis Pharmaceuticals, Inc. Pharmaceutical compositions and methods for anesthesiological applications
US20160374588A1 (en) 2015-06-24 2016-12-29 Microsoft Technology Licensing, Llc Monitoring hydration based on galvanic skin response
CN105168122B (zh) 2015-09-24 2018-11-27 辰欣药业股份有限公司 一种盐酸右美托咪定注射液及其制备工艺
US20170128421A1 (en) 2015-11-11 2017-05-11 Siva Prasad Reddy Sura Premix formulation for parenteral use and packaging thereof
US10632043B2 (en) 2015-11-11 2020-04-28 Aurobindo Pharma Ltd Premix formulation for parenteral use and packaging thereof
US20190290474A1 (en) 2016-01-04 2019-09-26 Jurox Pty Ltd Drug release device and use
CN105534891A (zh) 2016-01-18 2016-05-04 南京正科医药股份有限公司 一种盐酸右美托咪定注射液
US9949934B1 (en) 2016-10-20 2018-04-24 Intelgenx Corp. Device and method of treating conditions associated with neuroinflammation
US9717796B1 (en) 2016-04-20 2017-08-01 Slypharma, Llc Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
CN107412152B (zh) 2016-05-24 2020-12-04 海南合瑞制药股份有限公司 一种盐酸右美托咪定注射液组合物
US20190307762A1 (en) 2016-06-07 2019-10-10 Akhil MEHRA Methods and compositions for the treatment of trauma and stressor-related disorders
CN105997955B (zh) 2016-06-28 2017-09-12 力品药业（厦门）有限公司 一种帕洛诺司琼口腔膜剂及其制备方法
RU2635532C1 (ru) 2016-09-06 2017-11-13 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Способ профилактики ажитационного синдрома у детей с онкологической патологией
EP4241759A1 (en) 2016-10-12 2023-09-13 PS Therapy, Inc. Artificial tear, contact lens and drug vehicle compositions and methods of use thereof
JP7219712B2 (ja) 2016-10-13 2023-02-08 キャタレント・ユーケー・スウィンドン・ザイディス・リミテッド 膣送達のための凍結乾燥医薬組成物
ES2947572T3 (es) 2016-10-25 2023-08-11 Catalent Uk Swindon Zydis Ltd Composiciones de diferentes densidades para comprimidos multicapa de desintegración rápida
WO2018081792A2 (en) 2016-10-31 2018-05-03 Allodynic Therapeutics, Llc Combinations of opioid/tlr4 antagonists and acetaminophen for use in the treatment of emotional pain and insomnia
KR20210113439A (ko) 2016-10-31 2021-09-15 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법
CN106727524A (zh) 2016-11-08 2017-05-31 叶茂 一种药物组合物及其应用
CN106727443A (zh) 2016-12-08 2017-05-31 武汉大学 一种小儿麻醉术前镇静的隐形鼻贴制剂及其制备方法
CN106539778A (zh) 2016-12-08 2017-03-29 武汉大学 一种小儿麻醉术前含服口腔泡腾片及其制备方法
ES2879298T3 (es) 2016-12-13 2021-11-22 Orion Corp Dexmedetomidina o medetomidina para su uso en el tratamiento de la ansiedad por separación en perro
WO2018116202A1 (en) 2016-12-20 2018-06-28 Azista Industries Pvt Ltd Stabilized mouth freshener strips
CA3045043A1 (en) 2016-12-31 2018-07-05 Bioxcel Therapeutics, Inc. Use of sublingual dexmedetomidine for the treatment of agitation
CA3054992A1 (fr) 2017-03-07 2018-09-13 CHILDS, Marc Prevention des risques associes a un allongement de l'intervalle qt d'origine medicamenteuse a l'aide d'un inhibiteur specifique de la production de ros d'origine mitochondriale
CN107693485A (zh) 2017-04-24 2018-02-16 重庆医科大学附属儿童医院 一种用于麻醉的滴鼻液及其制备方法
CN107137399A (zh) 2017-04-24 2017-09-08 徐颖 一种用于麻醉的舌下片及其制备方法
CN107412204A (zh) 2017-04-24 2017-12-01 重庆医科大学附属儿童医院 一种用于麻醉的干粉吸入剂及其制备方法
CN107028880A (zh) 2017-06-09 2017-08-11 安徽赛诺制药有限公司 一种盐酸右美托咪定注射液的生产工艺
US20200368352A1 (en) 2017-08-15 2020-11-26 The Board Of Trustees Of The Leland Stanford Junior University Polymeric perfluorocarbon nanoemulsions for ultrasonic drug uncaging
WO2019038756A1 (en) 2017-08-20 2019-02-28 Solubest Ltd. DRY POWDER COMPOSITIONS FOR INTRANASAL DELIVERY
WO2019070929A1 (en) 2017-10-04 2019-04-11 The General Hospital Corporation SYSTEMS AND METHODS FOR MONITORING A SUBJECT UNDER THE INFLUENCE OF MEDICAMENTS
US20190216345A1 (en) 2017-10-18 2019-07-18 Christoper Scheib Method and system for monitoring and displaying physiological conditions
US11147459B2 (en) 2018-01-05 2021-10-19 CareBand Inc. Wearable electronic device and system for tracking location and identifying changes in salient indicators of patient health
US11406316B2 (en) 2018-02-14 2022-08-09 Cerenion Oy Apparatus and method for electroencephalographic measurement
AU2019229784A1 (en) 2018-03-08 2020-08-13 Catalent U.K. Swindon Zydis Limited Process to reduce endotoxin in gelatin
KR20190109310A (ko) 2018-03-15 2019-09-25 주식회사 바이오홀딩스 레반을 함유하는 염증성 질환 치료용 경비투여형 스프레이 제제
CN108498469A (zh) 2018-05-30 2018-09-07 宁波蒙曼生物科技有限公司 盐酸右美托咪定冻干粉及其制备方法
EP3813828A4 (en) 2018-06-27 2022-03-30 Bioxcel Therapeutics, Inc. METHOD OF TREATMENT OF AGITATION WITH DEXMEDETOMIDIN HYDROCHLORIDE
CN115154440A (zh) 2018-06-27 2022-10-11 比奥克斯塞尔医疗股份有限公司 含右美托咪定的膜制剂及其制造方法
US11648197B2 (en) 2018-06-28 2023-05-16 Arx, Llc Dispensing method for producing dissolvable unit dose film constructs
CN110893186A (zh) 2018-09-12 2020-03-20 宜昌人福药业有限责任公司 一种药物组合物及其制备方法和用途
JP2019048091A (ja) 2018-10-23 2019-03-28 ニプロ株式会社 デクスメデトミジン注射液を充填したプレフィルドシリンジ
KR102183744B1 (ko) 2018-11-26 2020-11-27 연세대학교 산학협력단 섬망 발병 위험도의 예측 방법 및 이를 이용한 디바이스
CN109620802A (zh) 2018-12-05 2019-04-16 杜皓 一种麻醉用鼻喷剂及其制备方法
CN111481506B (zh) 2019-01-25 2023-01-24 江苏恒瑞医药股份有限公司 一种包含经鼻给药的右美托咪定组合物的药物制品
US10900762B2 (en) 2019-02-21 2021-01-26 Aob Products Company Ammunition press and components thereof
WO2020259440A1 (zh) 2019-06-28 2020-12-30 四川普锐特药业有限公司 右美托咪定鼻喷剂、其制备方法及应用
CN116474218A (zh) 2019-06-28 2023-07-25 四川普锐特药业有限公司 保持给药均一度的药物流体分配器及右美托咪定鼻喷器
WO2021016112A2 (en) 2019-07-19 2021-01-28 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
CN114667095A (zh) 2019-09-18 2022-06-24 比奥克斯塞尔医疗股份有限公司 用于检测并预防激躁发生的系统和方法
MX2022009971A (es) 2020-02-14 2022-11-09 Bioxcel Therapeutics Inc Sistemas y métodos para la detección y prevención de la aparición de la agitación.
MX2023003993A (es) 2020-10-08 2023-05-24 Bioxcel Therapeutics Inc Tratamiento de trastornos bipolares y psicosis con clorhidrato de dexmedetomidina.
KR20230136612A (ko) 2021-01-04 2023-09-26 바이오엑셀 테라퓨틱스 인코포레이티드 덱스메데토미딘 치료 용법
US20240139169A1 (en) 2021-02-26 2024-05-02 Bioxcel Therapeutics, Inc. Methods and compositions for treating agitation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016061413A1 (en) * 2014-10-15 2016-04-21 Bioxcel Corporation Prevention or treatment of sleep disorders using dexmedetomidine formulation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
期刊 Michael C. Reade,et al. "Sedation and Delirium in the Intensive Care Unit", N Engl J Med, 2014; 370: 2014, 444-54. *

Also Published As

Publication number Publication date
US20240252470A1 (en) 2024-08-01
AU2017388759A1 (en) 2019-06-13
JP7008153B2 (ja) 2022-02-10
US20250325521A1 (en) 2025-10-23
CA3045043A1 (en) 2018-07-05
CN110337290A (zh) 2019-10-15
JP2024014900A (ja) 2024-02-01
AU2017388759B2 (en) 2021-11-11
KR20240031326A (ko) 2024-03-07
JP2021102654A (ja) 2021-07-15
JP6929479B2 (ja) 2021-09-01
DK3562486T3 (da) 2024-06-10
FI3562486T3 (fi) 2024-06-04
IL267689B1 (en) 2025-01-01
KR20190108104A (ko) 2019-09-23
US11931340B2 (en) 2024-03-19
US11839604B2 (en) 2023-12-12
TW202423422A (zh) 2024-06-16
HUE067266T2 (hu) 2024-10-28
EP3562486A1 (en) 2019-11-06
US20230218580A1 (en) 2023-07-13
US20220031663A1 (en) 2022-02-03
AU2022200892B2 (en) 2024-06-13
US11786508B2 (en) 2023-10-17
SG10202107367SA (en) 2021-08-30
JP6868698B2 (ja) 2021-05-12
ZA202006636B (en) 2023-03-29
EP4368169A3 (en) 2024-08-07
AU2022200892A1 (en) 2022-03-03
EP4371554A3 (en) 2024-08-07
US20190365715A1 (en) 2019-12-05
AU2024219731A1 (en) 2024-10-10
PT3562486T (pt) 2024-06-12
US20230093109A1 (en) 2023-03-23
IL267689B2 (en) 2025-05-01
JP2020503323A (ja) 2020-01-30
EP3562486A4 (en) 2020-08-19
EP3562486B1 (en) 2024-03-13
PL3562486T3 (pl) 2024-09-16
BR112019013503A2 (pt) 2020-01-07
JP2021113203A (ja) 2021-08-05
TW201829018A (zh) 2018-08-16
MX2022010274A (es) 2022-09-19
WO2018126182A1 (en) 2018-07-05
TWI833550B (zh) 2024-02-21
EP4371554A2 (en) 2024-05-22
ES2980126T3 (es) 2024-09-30
JP2022040229A (ja) 2022-03-10
KR102793584B1 (ko) 2025-04-09
EP4368169A2 (en) 2024-05-15
TW202319048A (zh) 2023-05-16
MX2019007923A (es) 2019-09-10
MX2023000213A (es) 2023-02-09
IL267689A (en) 2019-08-29
US20230081503A1 (en) 2023-03-16

Similar Documents

Publication Publication Date Title
TWI791479B (zh) 用於治療激躁之舌下迪美得托咪汀(dexmedetomidine)之用途
JP2025092508A (ja) デクスメデトミジン製剤を使用する睡眠障害の予防または治療
EP1656112A1 (de) Buccale formulierungen des galanthamins und deren anwendungen
HK40014031A (en) Use of sublingual dexmedetomidine for the treatment of agitation
EA042166B1 (ru) Применение сублингвального дексмедетомидина для лечения ажитации
NZ753804A (en) Use of sublingual dexmedetomidine for the treatment of agitation
NZ794535A (en) Use of sublingual Dexmedetomidine for the treatment of agitation