FI111262B - Menetelmä terapeuttisesti käyttökelpoisten fosfolipidijohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten fosfolipidijohdannaisten valmistamiseksi Download PDF

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Publication number
FI111262B
FI111262B FI933165A FI933165A FI111262B FI 111262 B FI111262 B FI 111262B FI 933165 A FI933165 A FI 933165A FI 933165 A FI933165 A FI 933165A FI 111262 B FI111262 B FI 111262B
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FI
Finland
Prior art keywords
methanol
mmol
compounds
general formula
mol
Prior art date
Application number
FI933165A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI933165A7 (fi
FI933165A0 (fi
Inventor
Juergen Engel
Peter Hilgard
Wolfgang Schumacher
Gerhard Noessner
Bernhard Kutscher
Jurij Stekar
Original Assignee
Zentaris Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Ag filed Critical Zentaris Ag
Publication of FI933165A0 publication Critical patent/FI933165A0/fi
Publication of FI933165A7 publication Critical patent/FI933165A7/fi
Application granted granted Critical
Publication of FI111262B publication Critical patent/FI111262B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532—Seven-(or more) membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI933165A 1992-07-11 1993-07-09 Menetelmä terapeuttisesti käyttökelpoisten fosfolipidijohdannaisten valmistamiseksi FI111262B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4222910A DE4222910A1 (de) 1992-07-11 1992-07-11 Neue Phospholipidderivate
DE4222910 1992-07-11

Publications (3)

Publication Number Publication Date
FI933165A0 FI933165A0 (fi) 1993-07-09
FI933165A7 FI933165A7 (fi) 1994-01-12
FI111262B true FI111262B (fi) 2003-06-30

Family

ID=6463031

Family Applications (1)

Application Number Title Priority Date Filing Date
FI933165A FI111262B (fi) 1992-07-11 1993-07-09 Menetelmä terapeuttisesti käyttökelpoisten fosfolipidijohdannaisten valmistamiseksi

Country Status (31)

Country Link
EP (1) EP0579939B1 (cs)
JP (1) JP3311431B2 (cs)
KR (1) KR100297180B1 (cs)
CN (1) CN1039012C (cs)
AT (1) ATE176477T1 (cs)
AU (1) AU664101B2 (cs)
BR (1) BR9302809A (cs)
CA (2) CA2100228C (cs)
CZ (1) CZ290863B6 (cs)
DE (2) DE4222910A1 (cs)
DK (1) DK0579939T3 (cs)
EE (1) EE03140B1 (cs)
ES (1) ES2129053T3 (cs)
FI (1) FI111262B (cs)
GR (1) GR3029602T3 (cs)
HR (1) HRP931046B1 (cs)
HU (1) HU218783B (cs)
IL (1) IL106289A (cs)
LT (1) LT3113B (cs)
LV (1) LV10870B (cs)
MX (1) MX9304133A (cs)
NO (1) NO306468B1 (cs)
PL (3) PL177811B1 (cs)
RU (1) RU2108336C1 (cs)
SG (1) SG46249A1 (cs)
SI (1) SI9300365B (cs)
SK (1) SK283827B6 (cs)
TW (1) TW304956B (cs)
UA (1) UA40567C2 (cs)
YU (1) YU49079B (cs)
ZA (1) ZA934971B (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101146532B (zh) 2005-01-21 2012-05-09 阿斯泰克斯治疗有限公司 药物化合物
EP1800684A1 (en) * 2005-12-20 2007-06-27 Zentaris GmbH Novel alkyl phospholipid derivatives and uses thereof
AU2006328479B2 (en) * 2005-12-19 2012-03-08 Aeterna Zentaris Gmbh Alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof
EP1869981A1 (de) * 2006-06-21 2007-12-26 Staatliches Weinbauinstitut Freiburg Alkylphospholipide und Lyso-Phospholipide zur Bekämpfung von Pflanzenpathogenen
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444766A (en) * 1980-10-21 1984-04-24 Boehringer Mannheim Gmbh Sulfur-containing phospholipid compounds and therapeutic compositions
JPS5984824A (ja) * 1982-11-08 1984-05-16 Takeda Chem Ind Ltd 抗腫瘍剤
DE3530767A1 (de) * 1985-08-28 1987-03-12 Max Planck Gesellschaft Mittel gegen multiple sklerose
CA1338627C (en) * 1985-12-04 1996-10-01 Hansjorg Eibl Pharmaceuticals based on phosphoric acid esters for use in tumor therapy, and process for their preparation
JP2512311B2 (ja) * 1986-07-14 1996-07-03 日本ケミファ株式会社 新規なグリセリン誘導体及び血圧降下剤
CN1017435B (zh) * 1987-03-24 1992-07-15 日本化学医药株式会社 新的甘油衍生物的制备方法
DE3906952A1 (de) * 1989-03-04 1990-09-06 Boehringer Mannheim Gmbh (3-(c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)6(pfeil abwaerts)-c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)8(pfeil abwaerts))alkansulfinyl- und sulfonyl-2-methoxymethyl-propyl)-(2-trimethylammonio-ethyl) phosphate, verfahren zu deren herstellung diese verbindungen enthaltende arzneimittel
DE3942933A1 (de) * 1989-12-23 1991-06-27 Boehringer Mannheim Gmbh Verwendung von alkylphospholipiden als antivirale arzneimittel und neue phospholipid-derivate
DE4114586A1 (de) * 1991-05-04 1992-11-05 Boehringer Mannheim Gmbh Arzneimittel enthaltend azacyclodiphosphonsaeurederivate, neue azacyclodiphosphonsaeurederivate sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
LT3113B (en) 1994-12-27
AU4186493A (en) 1994-01-13
CZ290863B6 (cs) 2002-11-13
SI9300365A (en) 1994-03-31
AU664101B2 (en) 1995-11-02
PL175607B1 (pl) 1999-01-29
IL106289A (en) 2000-06-01
HUT64548A (en) 1994-01-28
GR3029602T3 (en) 1999-06-30
UA40567C2 (uk) 2001-08-15
SK283827B6 (sk) 2004-02-03
HU218783B (hu) 2000-12-28
LV10870A (lv) 1995-10-20
CN1084175A (zh) 1994-03-23
CZ124993A3 (en) 1995-03-15
KR100297180B1 (ko) 2001-11-30
DE4222910A1 (de) 1994-01-13
NO306468B1 (no) 1999-11-08
RU2108336C1 (ru) 1998-04-10
YU49079B (sh) 2003-08-29
ATE176477T1 (de) 1999-02-15
TW304956B (cs) 1997-05-11
BR9302809A (pt) 1994-03-15
PL177811B1 (pl) 2000-01-31
CA2511753C (en) 2007-09-25
NO932502L (no) 1994-01-12
YU47393A (sh) 1997-08-22
FI933165A7 (fi) 1994-01-12
SK67093A3 (en) 1995-03-08
ZA934971B (en) 1994-02-01
HRP931046B1 (en) 2000-06-30
CA2100228A1 (en) 1994-01-12
CA2100228C (en) 2006-01-24
KR940002265A (ko) 1994-02-17
JPH0733791A (ja) 1995-02-03
FI933165A0 (fi) 1993-07-09
DK0579939T3 (da) 1999-09-20
JP3311431B2 (ja) 2002-08-05
DE59309355D1 (de) 1999-03-18
LV10870B (en) 1996-06-20
ES2129053T3 (es) 1999-06-01
EP0579939A1 (de) 1994-01-26
PL299624A1 (en) 1994-02-21
MX9304133A (es) 1994-04-29
NO932502D0 (no) 1993-07-08
EP0579939B1 (de) 1999-02-03
HRP931046A2 (en) 1997-04-30
PL173388B1 (pl) 1998-02-27
LTIP620A (en) 1994-07-15
CN1039012C (zh) 1998-07-08
CA2511753A1 (en) 1994-01-12
IL106289A0 (en) 1994-04-12
SI9300365B (sl) 2002-02-28
SG46249A1 (en) 1998-02-20
HU9301992D0 (en) 1993-09-28
EE03140B1 (et) 1998-12-15

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