CA2511753A1 - Phospholipid derivatives - Google Patents

Phospholipid derivatives Download PDF

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Publication number
CA2511753A1
CA2511753A1 CA002511753A CA2511753A CA2511753A1 CA 2511753 A1 CA2511753 A1 CA 2511753A1 CA 002511753 A CA002511753 A CA 002511753A CA 2511753 A CA2511753 A CA 2511753A CA 2511753 A1 CA2511753 A1 CA 2511753A1
Authority
CA
Canada
Prior art keywords
phospholipid derivatives
derivatives
phospholipid
medicaments
preparation processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002511753A
Other languages
French (fr)
Other versions
CA2511753C (en
Inventor
Gerhard Noessner
Bernhard Kutscher
Juergen Engel
Wolfgang Schumacher
Jurij Stekar
Peter Hilgard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aeterna Zentaris GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2511753A1 publication Critical patent/CA2511753A1/en
Application granted granted Critical
Publication of CA2511753C publication Critical patent/CA2511753C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532—Seven-(or more) membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • AIDS & HIV (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)

Abstract

Novel phospholipid derivatives, preparation processes therefor and their use as medicaments are described.
CA002511753A 1992-07-11 1993-07-09 Phospholipid derivatives Expired - Lifetime CA2511753C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP4222910.3 1992-07-11
DE4222910A DE4222910A1 (en) 1992-07-11 1992-07-11 New phospholipid derivatives
CA002100228A CA2100228C (en) 1992-07-11 1993-07-09 Phospholipid derivatives

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002100228A Division CA2100228C (en) 1992-07-11 1993-07-09 Phospholipid derivatives

Publications (2)

Publication Number Publication Date
CA2511753A1 true CA2511753A1 (en) 1994-01-12
CA2511753C CA2511753C (en) 2007-09-25

Family

ID=6463031

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002100228A Expired - Lifetime CA2100228C (en) 1992-07-11 1993-07-09 Phospholipid derivatives
CA002511753A Expired - Lifetime CA2511753C (en) 1992-07-11 1993-07-09 Phospholipid derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002100228A Expired - Lifetime CA2100228C (en) 1992-07-11 1993-07-09 Phospholipid derivatives

Country Status (31)

Country Link
EP (1) EP0579939B1 (en)
JP (1) JP3311431B2 (en)
KR (1) KR100297180B1 (en)
CN (1) CN1039012C (en)
AT (1) ATE176477T1 (en)
AU (1) AU664101B2 (en)
BR (1) BR9302809A (en)
CA (2) CA2100228C (en)
CZ (1) CZ290863B6 (en)
DE (2) DE4222910A1 (en)
DK (1) DK0579939T3 (en)
EE (1) EE03140B1 (en)
ES (1) ES2129053T3 (en)
FI (1) FI111262B (en)
GR (1) GR3029602T3 (en)
HR (1) HRP931046B1 (en)
HU (1) HU218783B (en)
IL (1) IL106289A (en)
LT (1) LT3113B (en)
LV (1) LV10870B (en)
MX (1) MX9304133A (en)
NO (1) NO306468B1 (en)
PL (3) PL177811B1 (en)
RU (1) RU2108336C1 (en)
SG (1) SG46249A1 (en)
SI (1) SI9300365B (en)
SK (1) SK283827B6 (en)
TW (1) TW304956B (en)
UA (1) UA40567C2 (en)
YU (1) YU49079B (en)
ZA (1) ZA934971B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101146532B (en) 2005-01-21 2012-05-09 阿斯泰克斯治疗有限公司 Pharmaceutical compounds
EP1800684A1 (en) * 2005-12-20 2007-06-27 Zentaris GmbH Novel alkyl phospholipid derivatives and uses thereof
PL1962862T3 (en) * 2005-12-19 2014-01-31 Aeterna Zentaris Gmbh Alkyl phospholipid derivatives with reduced cytotoxicity and uses therof
EP1869981A1 (en) * 2006-06-21 2007-12-26 Staatliches Weinbauinstitut Freiburg Alkylphospholipids and lysophospholipids for controlling plant pathogens
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3164332D1 (en) * 1980-10-21 1984-07-26 Boehringer Mannheim Gmbh Phospholipids that contain sulphur, process for their preparation and medicines containing these compounds
JPS5984824A (en) * 1982-11-08 1984-05-16 Takeda Chem Ind Ltd Antitumor agent
DE3530767A1 (en) * 1985-08-28 1987-03-12 Max Planck Gesellschaft AGENT AGAINST MULTIPLE Sclerosis
IE59777B1 (en) * 1985-12-04 1994-04-06 Max Planck Gesellschaft Medicaments
EP0257762B1 (en) * 1986-07-14 1990-10-10 Nippon Chemiphar Co., Ltd. Novel glycerol derivative and anti-hypertensive agent
DE3881925T2 (en) * 1987-03-24 1994-01-27 Nippon Chemiphar Co Glycerol derivatives and anti-hypertensive agent.
DE3906952A1 (en) * 1989-03-04 1990-09-06 Boehringer Mannheim Gmbh (3- (C (DOWN ARROW)) (DOWN ARROW) (DOWN ARROW) 6 (DOWN ARROW) -C (DOWN ARROW) 1 (DOWN ARROW) (DOWN ARROW) 8 (DOWN ARROW)) ALKANSULFINYL AND 2 SULPHONE -METHOXYMETHYL-PROPYL) - (2-TRIMETHYLAMMONIO-ETHYL) PHOSPHATES, METHOD FOR PRODUCING THE MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE3942933A1 (en) * 1989-12-23 1991-06-27 Boehringer Mannheim Gmbh USE OF ALKYLPHOSPHOLIPIDES AS ANTIVIRAL MEDICINAL PRODUCTS AND NEW PHOSPHOLIPID DERIVATIVES
DE4114586A1 (en) * 1991-05-04 1992-11-05 Boehringer Mannheim Gmbh MEDICINAL PRODUCTS CONTAINING AZACYCLODIPHOSPHONIC ACID DERIVATIVES, NEW AZACYCLODIPHOSPHONIC ACID DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
JP3311431B2 (en) 2002-08-05
YU47393A (en) 1997-08-22
EP0579939B1 (en) 1999-02-03
CZ290863B6 (en) 2002-11-13
CA2100228A1 (en) 1994-01-12
LTIP620A (en) 1994-07-15
ZA934971B (en) 1994-02-01
UA40567C2 (en) 2001-08-15
SI9300365B (en) 2002-02-28
SG46249A1 (en) 1998-02-20
DE4222910A1 (en) 1994-01-13
RU2108336C1 (en) 1998-04-10
PL173388B1 (en) 1998-02-27
FI933165A (en) 1994-01-12
HRP931046A2 (en) 1997-04-30
BR9302809A (en) 1994-03-15
CA2511753C (en) 2007-09-25
PL177811B1 (en) 2000-01-31
NO306468B1 (en) 1999-11-08
GR3029602T3 (en) 1999-06-30
MX9304133A (en) 1994-04-29
FI933165A0 (en) 1993-07-09
YU49079B (en) 2003-08-29
DE59309355D1 (en) 1999-03-18
EP0579939A1 (en) 1994-01-26
DK0579939T3 (en) 1999-09-20
SI9300365A (en) 1994-03-31
LV10870B (en) 1996-06-20
CN1039012C (en) 1998-07-08
AU4186493A (en) 1994-01-13
ES2129053T3 (en) 1999-06-01
PL175607B1 (en) 1999-01-29
JPH0733791A (en) 1995-02-03
CA2100228C (en) 2006-01-24
NO932502L (en) 1994-01-12
EE03140B1 (en) 1998-12-15
CN1084175A (en) 1994-03-23
SK283827B6 (en) 2004-02-03
KR940002265A (en) 1994-02-17
HU218783B (en) 2000-12-28
LT3113B (en) 1994-12-27
IL106289A0 (en) 1994-04-12
KR100297180B1 (en) 2001-11-30
ATE176477T1 (en) 1999-02-15
FI111262B (en) 2003-06-30
SK67093A3 (en) 1995-03-08
HU9301992D0 (en) 1993-09-28
TW304956B (en) 1997-05-11
AU664101B2 (en) 1995-11-02
HRP931046B1 (en) 2000-06-30
LV10870A (en) 1995-10-20
NO932502D0 (en) 1993-07-08
PL299624A1 (en) 1994-02-21
CZ124993A3 (en) 1995-03-15
HUT64548A (en) 1994-01-28
IL106289A (en) 2000-06-01

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