HRP931046B1 - New phospholipid derivatives - Google Patents

New phospholipid derivatives

Info

Publication number
HRP931046B1
HRP931046B1 HR931046A HRP931046A HRP931046B1 HR P931046 B1 HRP931046 B1 HR P931046B1 HR 931046 A HR931046 A HR 931046A HR P931046 A HRP931046 A HR P931046A HR P931046 B1 HRP931046 B1 HR P931046B1
Authority
HR
Croatia
Prior art keywords
phospholipid derivatives
new phospholipid
new
derivatives
medicaments
Prior art date
Application number
HR931046A
Other languages
English (en)
Inventor
Gerhard Noessner
Bernhard Kutscher
Juergen Engel
Wolfgang Schumacher
Jurij Stekar
Peter Hilgard
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of HRP931046A2 publication Critical patent/HRP931046A2/xx
Publication of HRP931046B1 publication Critical patent/HRP931046B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532—Seven-(or more) membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • AIDS & HIV (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Saccharide Compounds (AREA)
HR931046A 1992-07-11 1993-07-09 New phospholipid derivatives HRP931046B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4222910A DE4222910A1 (de) 1992-07-11 1992-07-11 Neue Phospholipidderivate

Publications (2)

Publication Number Publication Date
HRP931046A2 HRP931046A2 (en) 1997-04-30
HRP931046B1 true HRP931046B1 (en) 2000-06-30

Family

ID=6463031

Family Applications (1)

Application Number Title Priority Date Filing Date
HR931046A HRP931046B1 (en) 1992-07-11 1993-07-09 New phospholipid derivatives

Country Status (31)

Country Link
EP (1) EP0579939B1 (xx)
JP (1) JP3311431B2 (xx)
KR (1) KR100297180B1 (xx)
CN (1) CN1039012C (xx)
AT (1) ATE176477T1 (xx)
AU (1) AU664101B2 (xx)
BR (1) BR9302809A (xx)
CA (2) CA2100228C (xx)
CZ (1) CZ290863B6 (xx)
DE (2) DE4222910A1 (xx)
DK (1) DK0579939T3 (xx)
EE (1) EE03140B1 (xx)
ES (1) ES2129053T3 (xx)
FI (1) FI111262B (xx)
GR (1) GR3029602T3 (xx)
HR (1) HRP931046B1 (xx)
HU (1) HU218783B (xx)
IL (1) IL106289A (xx)
LT (1) LT3113B (xx)
LV (1) LV10870B (xx)
MX (1) MX9304133A (xx)
NO (1) NO306468B1 (xx)
PL (3) PL177811B1 (xx)
RU (1) RU2108336C1 (xx)
SG (1) SG46249A1 (xx)
SI (1) SI9300365B (xx)
SK (1) SK283827B6 (xx)
TW (1) TW304956B (xx)
UA (1) UA40567C2 (xx)
YU (1) YU49079B (xx)
ZA (1) ZA934971B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0606480A (pt) 2005-01-21 2008-03-11 Astex Therapeutics Ltd compostos farmacêuticos
EP1800684A1 (en) * 2005-12-20 2007-06-27 Zentaris GmbH Novel alkyl phospholipid derivatives and uses thereof
KR101378005B1 (ko) 2005-12-19 2014-03-27 아에테르나 젠타리스 게엠베하 세포독성이 감소된 알킬 인지질 유도체 및 이의 용도
EP1869981A1 (de) * 2006-06-21 2007-12-26 Staatliches Weinbauinstitut Freiburg Alkylphospholipide und Lyso-Phospholipide zur Bekämpfung von Pflanzenpathogenen
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444766A (en) * 1980-10-21 1984-04-24 Boehringer Mannheim Gmbh Sulfur-containing phospholipid compounds and therapeutic compositions
JPS5984824A (ja) * 1982-11-08 1984-05-16 Takeda Chem Ind Ltd 抗腫瘍剤
DE3530767A1 (de) * 1985-08-28 1987-03-12 Max Planck Gesellschaft Mittel gegen multiple sklerose
IE59778B1 (en) * 1985-12-04 1994-04-06 Max Planck Gesellschaft Medicament with anti-tumour action containing hexadecylphosphocholine
JP2512311B2 (ja) * 1986-07-14 1996-07-03 日本ケミファ株式会社 新規なグリセリン誘導体及び血圧降下剤
ES2058260T3 (es) * 1987-03-24 1994-11-01 Nippon Chemiphar Co Un proceso para la preparacion de un derivado del glicerol.
DE3906952A1 (de) * 1989-03-04 1990-09-06 Boehringer Mannheim Gmbh (3-(c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)6(pfeil abwaerts)-c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)8(pfeil abwaerts))alkansulfinyl- und sulfonyl-2-methoxymethyl-propyl)-(2-trimethylammonio-ethyl) phosphate, verfahren zu deren herstellung diese verbindungen enthaltende arzneimittel
DE3942933A1 (de) * 1989-12-23 1991-06-27 Boehringer Mannheim Gmbh Verwendung von alkylphospholipiden als antivirale arzneimittel und neue phospholipid-derivate
DE4114586A1 (de) * 1991-05-04 1992-11-05 Boehringer Mannheim Gmbh Arzneimittel enthaltend azacyclodiphosphonsaeurederivate, neue azacyclodiphosphonsaeurederivate sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
JPH0733791A (ja) 1995-02-03
PL173388B1 (pl) 1998-02-27
IL106289A0 (en) 1994-04-12
AU4186493A (en) 1994-01-13
LTIP620A (en) 1994-07-15
HU218783B (hu) 2000-12-28
LV10870B (en) 1996-06-20
GR3029602T3 (en) 1999-06-30
NO932502L (no) 1994-01-12
SK67093A3 (en) 1995-03-08
SI9300365B (sl) 2002-02-28
CA2511753A1 (en) 1994-01-12
UA40567C2 (uk) 2001-08-15
TW304956B (xx) 1997-05-11
ATE176477T1 (de) 1999-02-15
FI111262B (fi) 2003-06-30
BR9302809A (pt) 1994-03-15
LT3113B (en) 1994-12-27
SI9300365A (en) 1994-03-31
CA2100228C (en) 2006-01-24
EP0579939A1 (de) 1994-01-26
RU2108336C1 (ru) 1998-04-10
EE03140B1 (et) 1998-12-15
NO932502D0 (no) 1993-07-08
MX9304133A (es) 1994-04-29
HUT64548A (en) 1994-01-28
YU47393A (sh) 1997-08-22
PL299624A1 (en) 1994-02-21
DE59309355D1 (de) 1999-03-18
ZA934971B (en) 1994-02-01
IL106289A (en) 2000-06-01
FI933165A0 (fi) 1993-07-09
CZ290863B6 (cs) 2002-11-13
YU49079B (sh) 2003-08-29
CA2511753C (en) 2007-09-25
CA2100228A1 (en) 1994-01-12
FI933165A (fi) 1994-01-12
AU664101B2 (en) 1995-11-02
LV10870A (lv) 1995-10-20
KR940002265A (ko) 1994-02-17
EP0579939B1 (de) 1999-02-03
CN1039012C (zh) 1998-07-08
PL175607B1 (pl) 1999-01-29
HU9301992D0 (en) 1993-09-28
ES2129053T3 (es) 1999-06-01
CZ124993A3 (en) 1995-03-15
SK283827B6 (sk) 2004-02-03
CN1084175A (zh) 1994-03-23
DK0579939T3 (da) 1999-09-20
PL177811B1 (pl) 2000-01-31
DE4222910A1 (de) 1994-01-13
KR100297180B1 (ko) 2001-11-30
HRP931046A2 (en) 1997-04-30
NO306468B1 (no) 1999-11-08
SG46249A1 (en) 1998-02-20
JP3311431B2 (ja) 2002-08-05

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
PPPP Transfer of rights

Owner name: ZENTARIS AG, DE

PNAN Change of the applicant name, address/residence

Owner name: ZENTARIS GMBH, DE

PNAN Change of the applicant name, address/residence

Owner name: ZENTARIS GMBH, DE

PNAN Change of the applicant name, address/residence

Owner name: ÆTERNA ZENTARIS GMBH, DE

ODRP Renewal fee for the maintenance of a patent

Payment date: 20120626

Year of fee payment: 20

PB20 Patent expired after termination of 20 years

Effective date: 20130710