YU47393A - Novi derivati fosfolipida - Google Patents

Novi derivati fosfolipida

Info

Publication number
YU47393A
YU47393A YU47393A YU47393A YU47393A YU 47393 A YU47393 A YU 47393A YU 47393 A YU47393 A YU 47393A YU 47393 A YU47393 A YU 47393A YU 47393 A YU47393 A YU 47393A
Authority
YU
Yugoslavia
Prior art keywords
phospholipid derivatives
new phospholipid
new
derivatives
medicaments
Prior art date
Application number
YU47393A
Other languages
English (en)
Other versions
YU49079B (sh
Inventor
G. Nossner
B. Kutscher
J. Engel
W. Schumacher
J. Stekar
P. Hilgard
Original Assignee
Asta Medica Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag. filed Critical Asta Medica Ag.
Publication of YU47393A publication Critical patent/YU47393A/sh
Publication of YU49079B publication Critical patent/YU49079B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532—Seven-(or more) membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • AIDS & HIV (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)

Abstract

Pronalazak je iz oblasti farmaceutske hemije i odnosi se na nove derivate fosfolipida opšte formule I u kojoj je R alkil sa 10 do 24C atoma, a R1 i R2 su vodonik ili alkil sa 1-6 C atoma, A je jednostruka veza ili jedna od grupa sledećih formula -CH2-CH2-CH2-0- (II) -CH2-CH-0- (IV) CH3; -CH2-CH2-0- (III) -S-(CH2)8-0- (V); -CH - CH-CHo-O- H2C (VI); u je O ili l-3,aminsuOili prirodni brojevi s tim što m+n=2 do 8, kao i na postupak za proizvodnju tog jedinjenja reakcijom jedinjenja formule R-X-A-H (VII) sa fosforoksitrihloridom i reakcijom dobijenog jedinjenja sa jedinjenjem formule gde R, X, A, R1, R2, y, m i n imaju isto značenje kao u formuli I, a u je halogenid, mesilat ili tosilat.
YU47393A 1992-07-11 1993-07-06 Novi derivati fosfolipida i postupak za njihovu proizvodnju YU49079B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4222910A DE4222910A1 (de) 1992-07-11 1992-07-11 Neue Phospholipidderivate

Publications (2)

Publication Number Publication Date
YU47393A true YU47393A (sh) 1997-08-22
YU49079B YU49079B (sh) 2003-08-29

Family

ID=6463031

Family Applications (1)

Application Number Title Priority Date Filing Date
YU47393A YU49079B (sh) 1992-07-11 1993-07-06 Novi derivati fosfolipida i postupak za njihovu proizvodnju

Country Status (31)

Country Link
EP (1) EP0579939B1 (sh)
JP (1) JP3311431B2 (sh)
KR (1) KR100297180B1 (sh)
CN (1) CN1039012C (sh)
AT (1) ATE176477T1 (sh)
AU (1) AU664101B2 (sh)
BR (1) BR9302809A (sh)
CA (2) CA2511753C (sh)
CZ (1) CZ290863B6 (sh)
DE (2) DE4222910A1 (sh)
DK (1) DK0579939T3 (sh)
EE (1) EE03140B1 (sh)
ES (1) ES2129053T3 (sh)
FI (1) FI111262B (sh)
GR (1) GR3029602T3 (sh)
HR (1) HRP931046B1 (sh)
HU (1) HU218783B (sh)
IL (1) IL106289A (sh)
LT (1) LT3113B (sh)
LV (1) LV10870B (sh)
MX (1) MX9304133A (sh)
NO (1) NO306468B1 (sh)
PL (3) PL173388B1 (sh)
RU (1) RU2108336C1 (sh)
SG (1) SG46249A1 (sh)
SI (1) SI9300365B (sh)
SK (1) SK283827B6 (sh)
TW (1) TW304956B (sh)
UA (1) UA40567C2 (sh)
YU (1) YU49079B (sh)
ZA (1) ZA934971B (sh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0606480A (pt) 2005-01-21 2008-03-11 Astex Therapeutics Ltd compostos farmacêuticos
EP1800684A1 (en) * 2005-12-20 2007-06-27 Zentaris GmbH Novel alkyl phospholipid derivatives and uses thereof
UY30042A1 (es) * 2005-12-19 2007-07-31 Zentaris Gmbh Nuevos derivados de alquilfosfolípidos con citotoxicidad reducida y usos de los mismos.
EP1869981A1 (de) * 2006-06-21 2007-12-26 Staatliches Weinbauinstitut Freiburg Alkylphospholipide und Lyso-Phospholipide zur Bekämpfung von Pflanzenpathogenen
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444766A (en) * 1980-10-21 1984-04-24 Boehringer Mannheim Gmbh Sulfur-containing phospholipid compounds and therapeutic compositions
JPS5984824A (ja) * 1982-11-08 1984-05-16 Takeda Chem Ind Ltd 抗腫瘍剤
DE3530767A1 (de) * 1985-08-28 1987-03-12 Max Planck Gesellschaft Mittel gegen multiple sklerose
CA1338627C (en) * 1985-12-04 1996-10-01 Hansjorg Eibl Pharmaceuticals based on phosphoric acid esters for use in tumor therapy, and process for their preparation
ES2036210T3 (es) * 1986-07-14 1993-05-16 Nippon Chemiphar Co., Ltd. Un procedimiento para la preparacion de un derivado de glicerol.
EP0284395B1 (en) * 1987-03-24 1993-06-23 Nippon Chemiphar Co., Ltd. Novel glycerol derivative and anti-hypertensive agent
DE3906952A1 (de) * 1989-03-04 1990-09-06 Boehringer Mannheim Gmbh (3-(c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)6(pfeil abwaerts)-c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)8(pfeil abwaerts))alkansulfinyl- und sulfonyl-2-methoxymethyl-propyl)-(2-trimethylammonio-ethyl) phosphate, verfahren zu deren herstellung diese verbindungen enthaltende arzneimittel
DE3942933A1 (de) * 1989-12-23 1991-06-27 Boehringer Mannheim Gmbh Verwendung von alkylphospholipiden als antivirale arzneimittel und neue phospholipid-derivate
DE4114586A1 (de) * 1991-05-04 1992-11-05 Boehringer Mannheim Gmbh Arzneimittel enthaltend azacyclodiphosphonsaeurederivate, neue azacyclodiphosphonsaeurederivate sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
ES2129053T3 (es) 1999-06-01
CZ124993A3 (en) 1995-03-15
SG46249A1 (en) 1998-02-20
UA40567C2 (uk) 2001-08-15
MX9304133A (es) 1994-04-29
CN1039012C (zh) 1998-07-08
CA2100228A1 (en) 1994-01-12
HUT64548A (en) 1994-01-28
JPH0733791A (ja) 1995-02-03
NO932502L (no) 1994-01-12
CA2511753A1 (en) 1994-01-12
FI111262B (fi) 2003-06-30
CZ290863B6 (cs) 2002-11-13
EP0579939A1 (de) 1994-01-26
SI9300365A (en) 1994-03-31
LTIP620A (en) 1994-07-15
NO932502D0 (no) 1993-07-08
LT3113B (en) 1994-12-27
CA2100228C (en) 2006-01-24
GR3029602T3 (en) 1999-06-30
NO306468B1 (no) 1999-11-08
YU49079B (sh) 2003-08-29
PL173388B1 (pl) 1998-02-27
ATE176477T1 (de) 1999-02-15
EE03140B1 (et) 1998-12-15
EP0579939B1 (de) 1999-02-03
FI933165A0 (fi) 1993-07-09
FI933165A (fi) 1994-01-12
HU218783B (hu) 2000-12-28
PL177811B1 (pl) 2000-01-31
DE4222910A1 (de) 1994-01-13
HRP931046A2 (en) 1997-04-30
JP3311431B2 (ja) 2002-08-05
CN1084175A (zh) 1994-03-23
CA2511753C (en) 2007-09-25
AU664101B2 (en) 1995-11-02
RU2108336C1 (ru) 1998-04-10
LV10870B (en) 1996-06-20
HRP931046B1 (en) 2000-06-30
BR9302809A (pt) 1994-03-15
HU9301992D0 (en) 1993-09-28
KR940002265A (ko) 1994-02-17
SK283827B6 (sk) 2004-02-03
IL106289A0 (en) 1994-04-12
IL106289A (en) 2000-06-01
PL175607B1 (pl) 1999-01-29
DE59309355D1 (de) 1999-03-18
TW304956B (sh) 1997-05-11
DK0579939T3 (da) 1999-09-20
SK67093A3 (en) 1995-03-08
AU4186493A (en) 1994-01-13
ZA934971B (en) 1994-02-01
SI9300365B (sl) 2002-02-28
PL299624A1 (en) 1994-02-21
KR100297180B1 (ko) 2001-11-30
LV10870A (lv) 1995-10-20

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