YU49079B - Novi derivati fosfolipida i postupak za njihovu proizvodnju - Google Patents

Novi derivati fosfolipida i postupak za njihovu proizvodnju

Info

Publication number
YU49079B
YU49079B YU47393A YU47393A YU49079B YU 49079 B YU49079 B YU 49079B YU 47393 A YU47393 A YU 47393A YU 47393 A YU47393 A YU 47393A YU 49079 B YU49079 B YU 49079B
Authority
YU
Yugoslavia
Prior art keywords
preration
phospholipid derivatives
new phospholipid
new
derivatives
Prior art date
Application number
YU47393A
Other languages
English (en)
Other versions
YU47393A (sh
Inventor
Gerhard Dr. Nössner
Bernhard Dr. Kutscher
Jürgen Prof.Dr.Engel
Schumacher Wolfgang Dr.
Jurij Dr. Stekar
Peter Dr. Hilgard
Original Assignee
Zentaris Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Ag. filed Critical Zentaris Ag.
Publication of YU47393A publication Critical patent/YU47393A/sh
Publication of YU49079B publication Critical patent/YU49079B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532—Seven-(or more) membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

Jedinjenja, naznačena time, što imaju opštu formulu I u kojoj R označava alkilni ostatak u obliku pravog ili razgranatog lanca od 10 do 24 ugljenikova atoma, koji može sadržavati i jednu do tri dvostruke ili trostruke veze, R1 i R2 označavaju nezavisno jedan od drugog, vodonik ili zasićeni ili nezasićeni alkilni ostatak u vidu pravog ili razgranatog lanca, sa jednim do šest ugljenikova atoma, koji može sadržati i jednu Cl, OH- ili NH2-grupu, pri čemu dva ovakva ostatka mogu biti vezani u jedan prsten, A označava jednostruku vezu ili jednu od grupa formule pri čemu su grupe od (II) do (VI) tako orijentisane, da je kiseonikov atom vezan za atom fosfora jedinjenja (I), a X označava atom kiseonika ili sumpora ili NH kada je A jednostruka veza, ili atom kiseonika ili sumpora kada A označava jednu od grupa (II) do (VI); y je 0 ili jedan prirodan broj između 1 i 3, m + n nezavisno jedan od drugog znače 0 ili prirodne brojeve pod uslovom da je m + n = 2 do 8. Prijava sadrži još 10 zavisnih i 11 nezavisnih zahteva.
YU47393A 1992-07-11 1993-07-06 Novi derivati fosfolipida i postupak za njihovu proizvodnju YU49079B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4222910A DE4222910A1 (de) 1992-07-11 1992-07-11 Neue Phospholipidderivate

Publications (2)

Publication Number Publication Date
YU47393A YU47393A (sh) 1997-08-22
YU49079B true YU49079B (sh) 2003-08-29

Family

ID=6463031

Family Applications (1)

Application Number Title Priority Date Filing Date
YU47393A YU49079B (sh) 1992-07-11 1993-07-06 Novi derivati fosfolipida i postupak za njihovu proizvodnju

Country Status (31)

Country Link
EP (1) EP0579939B1 (sh)
JP (1) JP3311431B2 (sh)
KR (1) KR100297180B1 (sh)
CN (1) CN1039012C (sh)
AT (1) ATE176477T1 (sh)
AU (1) AU664101B2 (sh)
BR (1) BR9302809A (sh)
CA (2) CA2511753C (sh)
CZ (1) CZ290863B6 (sh)
DE (2) DE4222910A1 (sh)
DK (1) DK0579939T3 (sh)
EE (1) EE03140B1 (sh)
ES (1) ES2129053T3 (sh)
FI (1) FI111262B (sh)
GR (1) GR3029602T3 (sh)
HR (1) HRP931046B1 (sh)
HU (1) HU218783B (sh)
IL (1) IL106289A (sh)
LT (1) LT3113B (sh)
LV (1) LV10870B (sh)
MX (1) MX9304133A (sh)
NO (1) NO306468B1 (sh)
PL (3) PL173388B1 (sh)
RU (1) RU2108336C1 (sh)
SG (1) SG46249A1 (sh)
SI (1) SI9300365B (sh)
SK (1) SK283827B6 (sh)
TW (1) TW304956B (sh)
UA (1) UA40567C2 (sh)
YU (1) YU49079B (sh)
ZA (1) ZA934971B (sh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080161251A1 (en) 2005-01-21 2008-07-03 Astex Therapeutics Limited Pharmaceutical Compounds
EP1962862B1 (en) 2005-12-19 2013-09-04 Æterna Zentaris GmbH Alkyl phospholipid derivatives with reduced cytotoxicity and uses therof
EP1800684A1 (en) * 2005-12-20 2007-06-27 Zentaris GmbH Novel alkyl phospholipid derivatives and uses thereof
EP1869981A1 (de) * 2006-06-21 2007-12-26 Staatliches Weinbauinstitut Freiburg Alkylphospholipide und Lyso-Phospholipide zur Bekämpfung von Pflanzenpathogenen
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3164332D1 (en) * 1980-10-21 1984-07-26 Boehringer Mannheim Gmbh Phospholipids that contain sulphur, process for their preparation and medicines containing these compounds
JPS5984824A (ja) * 1982-11-08 1984-05-16 Takeda Chem Ind Ltd 抗腫瘍剤
DE3530767A1 (de) * 1985-08-28 1987-03-12 Max Planck Gesellschaft Mittel gegen multiple sklerose
CA1338627C (en) * 1985-12-04 1996-10-01 Hansjorg Eibl Pharmaceuticals based on phosphoric acid esters for use in tumor therapy, and process for their preparation
JP2512311B2 (ja) * 1986-07-14 1996-07-03 日本ケミファ株式会社 新規なグリセリン誘導体及び血圧降下剤
CN1017435B (zh) * 1987-03-24 1992-07-15 日本化学医药株式会社 新的甘油衍生物的制备方法
DE3906952A1 (de) * 1989-03-04 1990-09-06 Boehringer Mannheim Gmbh (3-(c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)6(pfeil abwaerts)-c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)8(pfeil abwaerts))alkansulfinyl- und sulfonyl-2-methoxymethyl-propyl)-(2-trimethylammonio-ethyl) phosphate, verfahren zu deren herstellung diese verbindungen enthaltende arzneimittel
DE3942933A1 (de) * 1989-12-23 1991-06-27 Boehringer Mannheim Gmbh Verwendung von alkylphospholipiden als antivirale arzneimittel und neue phospholipid-derivate
DE4114586A1 (de) * 1991-05-04 1992-11-05 Boehringer Mannheim Gmbh Arzneimittel enthaltend azacyclodiphosphonsaeurederivate, neue azacyclodiphosphonsaeurederivate sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
JPH0733791A (ja) 1995-02-03
CA2100228A1 (en) 1994-01-12
CA2511753C (en) 2007-09-25
SK283827B6 (sk) 2004-02-03
KR100297180B1 (ko) 2001-11-30
HRP931046A2 (en) 1997-04-30
CN1039012C (zh) 1998-07-08
FI933165A (fi) 1994-01-12
TW304956B (sh) 1997-05-11
EP0579939B1 (de) 1999-02-03
HUT64548A (en) 1994-01-28
NO932502D0 (no) 1993-07-08
SK67093A3 (en) 1995-03-08
FI111262B (fi) 2003-06-30
NO932502L (no) 1994-01-12
SI9300365A (en) 1994-03-31
UA40567C2 (uk) 2001-08-15
PL175607B1 (pl) 1999-01-29
DE59309355D1 (de) 1999-03-18
MX9304133A (es) 1994-04-29
ZA934971B (en) 1994-02-01
HU218783B (hu) 2000-12-28
ES2129053T3 (es) 1999-06-01
DK0579939T3 (da) 1999-09-20
NO306468B1 (no) 1999-11-08
JP3311431B2 (ja) 2002-08-05
BR9302809A (pt) 1994-03-15
HU9301992D0 (en) 1993-09-28
LTIP620A (en) 1994-07-15
CA2100228C (en) 2006-01-24
SG46249A1 (en) 1998-02-20
HRP931046B1 (en) 2000-06-30
AU664101B2 (en) 1995-11-02
PL177811B1 (pl) 2000-01-31
PL299624A1 (en) 1994-02-21
LV10870B (en) 1996-06-20
AU4186493A (en) 1994-01-13
CZ124993A3 (en) 1995-03-15
ATE176477T1 (de) 1999-02-15
GR3029602T3 (en) 1999-06-30
SI9300365B (sl) 2002-02-28
KR940002265A (ko) 1994-02-17
IL106289A0 (en) 1994-04-12
LT3113B (en) 1994-12-27
CN1084175A (zh) 1994-03-23
EP0579939A1 (de) 1994-01-26
RU2108336C1 (ru) 1998-04-10
FI933165A0 (fi) 1993-07-09
CA2511753A1 (en) 1994-01-12
CZ290863B6 (cs) 2002-11-13
YU47393A (sh) 1997-08-22
IL106289A (en) 2000-06-01
DE4222910A1 (de) 1994-01-13
LV10870A (lv) 1995-10-20
EE03140B1 (et) 1998-12-15
PL173388B1 (pl) 1998-02-27

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