ES2058260T3 - Un proceso para la preparacion de un derivado del glicerol. - Google Patents

Un proceso para la preparacion de un derivado del glicerol.

Info

Publication number
ES2058260T3
ES2058260T3 ES88302621T ES88302621T ES2058260T3 ES 2058260 T3 ES2058260 T3 ES 2058260T3 ES 88302621 T ES88302621 T ES 88302621T ES 88302621 T ES88302621 T ES 88302621T ES 2058260 T3 ES2058260 T3 ES 2058260T3
Authority
ES
Spain
Prior art keywords
hetero
carbon
glycerol derivative
aryl
rent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88302621T
Other languages
English (en)
Inventor
Mitsuo Masaki
Hiromitsu Takeda
Toshiro Kamishiro
Masao Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6994387A external-priority patent/JP2512304B2/ja
Priority claimed from JP8070587A external-priority patent/JP2512306B2/ja
Priority claimed from JP8070687A external-priority patent/JP2512307B2/ja
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Application granted granted Critical
Publication of ES2058260T3 publication Critical patent/ES2058260T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/60—Quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/5765—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/62—Isoquinoline or hydrogenated isoquinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

UN NUEVO DERIVADO DE GLICEROL QUE ES EFECTIVO PARA REDUCIR LA PRESION DE LA SANGRE TIENE LA FORMULA (I) DONDE R1 ES UN GRUPO ALQUILO CON 10-22 ATOMOS DE CARBONO, R2 ES ACILO INFERIOR, BENZOILO, ARILO, MONO-, DI- O TRIARILALQUILO, ALQUILO, CICLOALQUILO O CICLOALQUILALQUILO; Q ES ALQUILENO SUSTITUIDO O NO SUSTITUIDO CONTENIENDO 1-4 ATOMOS DE CARBONO, L ES 0 O 1; Y ES UN GRUPO HETEROCICLICO CONTENIENDO NITROGENO O UN GRUPO HETEROCICLICO PUENTEADO CONTENIENDO NITROGENO (-(Q)L- ESTA UNIDO A UN ATOMO DE CARBONO CONTENIDO EN UN HETEROANILLO DEL GRUPO HETEROCICLICO) EN EL QUE Y ES EL GRUPO HETEROCICLICO PUENTEADO DONDE L ES O Y CADA UNO DE LOS R5, R6 Y R7 SON HIDROGENO, ALQUILO, ARILO O ARALQUILO INFERIOR.
ES88302621T 1987-03-24 1988-03-24 Un proceso para la preparacion de un derivado del glicerol. Expired - Lifetime ES2058260T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP6994387A JP2512304B2 (ja) 1987-03-24 1987-03-24 新規なグリセリン誘導体及び血圧降下剤
JP6994487 1987-03-24
JP8070587A JP2512306B2 (ja) 1986-09-05 1987-03-31 新規なグリセリン誘導体及び血小板凝集抑制剤
JP8070687A JP2512307B2 (ja) 1987-03-31 1987-03-31 新規なグリセリン誘導体及び血小板凝集抑制剤

Publications (1)

Publication Number Publication Date
ES2058260T3 true ES2058260T3 (es) 1994-11-01

Family

ID=27465194

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88302621T Expired - Lifetime ES2058260T3 (es) 1987-03-24 1988-03-24 Un proceso para la preparacion de un derivado del glicerol.

Country Status (5)

Country Link
US (1) US4962096A (es)
EP (1) EP0284395B1 (es)
CN (1) CN1017435B (es)
DE (1) DE3881925T2 (es)
ES (1) ES2058260T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0336142A3 (en) * 1988-04-04 1991-04-24 American Cyanamid Company Novel antagonists of platelet activating factor
US5144045A (en) * 1990-11-13 1992-09-01 American Cyanamid Company Phosphocholine derivative inhibitors of phospholipase A2
US5208223A (en) * 1990-11-13 1993-05-04 American Cyanamid Company Phosphocholine derivative inhibitors of phospholipase A2
DE4222910A1 (de) * 1992-07-11 1994-01-13 Asta Medica Ag Neue Phospholipidderivate
EP1723127A4 (en) * 2004-02-11 2009-10-28 Univ Ohio State Res Found ANALOGS THAT INHIBIT CELL PROLIFERATION, METHOD FOR THE PRODUCTION THEREOF AND THEIR APPLICATION
EP1800684A1 (en) * 2005-12-20 2007-06-27 Zentaris GmbH Novel alkyl phospholipid derivatives and uses thereof
AR058397A1 (es) 2005-12-19 2008-01-30 Zentaris Gmbh Derivados de alquilfosfolipidos con citotoxicidad reducida y usos de los mismos
WO2022253297A1 (zh) * 2021-06-03 2022-12-08 上海森辉医药有限公司 一种阿尼芬净衍生物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4408052A (en) * 1980-02-27 1983-10-04 Takeda Chemical Industries, Ltd. Phospholipid carbamates
JPS5772914A (en) * 1980-10-22 1982-05-07 Takeda Chem Ind Ltd Antitumor agent
US4493832A (en) * 1981-07-03 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. Certain glycerol-phosphoryl choline derivatives, compositions containing same and method of using same
JPS6081194A (ja) * 1983-10-11 1985-05-09 Takeda Chem Ind Ltd ケトアルキルリン脂質
US4650791A (en) * 1984-01-11 1987-03-17 Takedo Chemical Industries, Ltd. Certain 3-alkoxy-2-cyclic-imido-propyl-phosphate-ethyl-cyclic ammonium hydroxide inner salts which inhibit activities of platelet activating factor
CA1264162A (en) * 1984-03-15 1990-01-02 Manfred Breuninger Glycerol ether phosphatides
US4710579A (en) * 1984-11-09 1987-12-01 Takeda Chemical Industries, Ltd. 2-(acetoacetyloxy)-3-(octadecyloxy)propyl-3-trimethylammoniopropyl phosphate or a pharmaceutically acceptable salt thereof
US4900731A (en) * 1984-12-10 1990-02-13 American Cyanamid Company Antihypertensive phosphate derivatives
ES2036210T3 (es) * 1986-07-14 1993-05-16 Nippon Chemiphar Co., Ltd. Un procedimiento para la preparacion de un derivado de glicerol.

Also Published As

Publication number Publication date
EP0284395A2 (en) 1988-09-28
US4962096A (en) 1990-10-09
EP0284395B1 (en) 1993-06-23
DE3881925D1 (de) 1993-07-29
EP0284395A3 (en) 1989-03-22
CN1030239A (zh) 1989-01-11
CN1017435B (zh) 1992-07-15
DE3881925T2 (de) 1994-01-27

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