MX9604430A - Tiazolidinas del tipo piridina. - Google Patents
Tiazolidinas del tipo piridina.Info
- Publication number
- MX9604430A MX9604430A MX9604430A MX9604430A MX9604430A MX 9604430 A MX9604430 A MX 9604430A MX 9604430 A MX9604430 A MX 9604430A MX 9604430 A MX9604430 A MX 9604430A MX 9604430 A MX9604430 A MX 9604430A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- alkyl
- cycloalkyl
- thiazolidines
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invencion provee tiazolidinas del tipo piridina, novedosas y sus sales, expresadas pro la siguiente formula (I): (Ver Formula) (en donde X1 es 5 u 0; X2 es 5, O o NH; Y es CR6R7 (R6 es un átomo de hidrogeno, un grupo alquilo de 1 a 7 átomos de carbono o un grupo cicloalqulo de 3 a 7 átomos de carbono; y R7 es un átomo de hidrogeno, un grupo alquilo de 1 a 7 átomos de carbono o un grupo cicloaqluilo de 3 a 7 átomos de carbono; o juntos forman una ligadura con R4), o SO2, Z es un grupo alquilo de 1 a 10 átomos de carbono, un grupo alquenilo de 2 a 10 átomos de carbono, un grupo alquenilo de 2 a 10átomos de carbono, un grupo cicloalquilo de 3 a 7 átomos de carbono, un grupo cicloalquenilo de 3 a 7 átomos de carbono (cada uno de los grupos alquilo, alquenilo, alquinilo, cicloalquilo y cicloaquenilo puede estar sustituido con a lo sumo tres grupos hidroxilo, oxo alquilo de 1 a 7 átomos de carbono y alcoxi de 1 a 7 átomos de carbono); un grupo fenilo, un grupo bifenilo, un grupo alfa-naftilo, un grupo beta-naftilo, un grupo bencilo, un grupo piridilo, un grupo pirimidinilo, un grupo piridazinilo, un grupo furanilo, un grupo tienilo, un grupo pirrolilo, un grupo pirazolilo, un grupo imidazolilo, un grupo piranilo (cada uno de dichos grupos fenilo, bifenilo, alfa-naftilo, beta-naftilo, bencilo, piridilo, pirimidinilo, piridazinilo, furanilo, tienilo, pirrolilo, pirazolilo, imidazolilo y piranilo puede estar sustituido con a lo sumo tres grupos hidroxi, alquilo de 1 a 7 átomos de carbono y alcoxi de 1 a 7 átomos de carbono, y un átomo de halogeno); un grupo sililo sustituido, un grupo acilo alifático de 1 a 14 átomos de carbono, un grupo acilo aromático de 6 a 10 átomos de carbono o un grupo -A-B (A es un grupo de hidrocarburo divalente saturado, de 1 a 6 átomos de carbono, o insaturado de 2 a 6 átomos de carbono, que puede estar sustituido con a lo sumo tres grupos hidroxilo, oxo y alquilo de 1 a 7 átomos de carbono; y B es los grupos cicloalquilo de 3 a 10 átomos de carbono, cicloalquenilo de 3 a 7 átomos de carbono, aromático de 6 a 14 átomos de carbono y aromático heterociclico de 4 a 12 átomos de carbono, que pueden tener a lo sumo cinco sustituyentes en total (dicho grupo aromático heterociclico puede contener a lo sumo cinco heteroátomos seleccionados del grupo que consiste de un átomo de oxígeno, un átomo de azufre y un átomo de nitrogeno como constituyentes para el anillo heterociclico); o un grupo heterocicloalifático de 4 a 5 átomos de carbono (dicho grupo heterocicloalifático puede contener a lo sumo tres heteroátomos seleccionados del grupo que consiste de un átomo de oxígeno, un átomo de azufre y un átomo de nitrogeno, como constituyentes para el anillo heterociclico)); cada uno de R1, R2 y R3 es independientemente un átomo de hidrogeno, un grupo alquilo de 1 a 7 átomos de carbono (que puede estar sustituido con un grupo hidroxilo), un grupo cicloalquilo de 3 a 7 átomos de carbono, un grupo hidroxilo o un átomo de halogeno; R4 es un átomo de hidrogeno o un grupo alquilo de 1 a 7 átomos de carbono, o forma junto con R7 una ligadura; y n es 0 o 1).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5719294 | 1994-03-28 | ||
| JP29517794 | 1994-11-29 | ||
| PCT/JP1995/000560 WO1995026347A1 (en) | 1994-03-28 | 1995-03-27 | Thiazolidines and oxazolidines substituted by a pyridine ring and their use as hypoglycemic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9604430A true MX9604430A (es) | 1997-12-31 |
Family
ID=26398213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9604430A MX9604430A (es) | 1994-03-28 | 1995-03-27 | Tiazolidinas del tipo piridina. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0751944B1 (es) |
| KR (1) | KR100340615B1 (es) |
| CN (1) | CN1045776C (es) |
| AT (1) | ATE198200T1 (es) |
| AU (1) | AU683739B2 (es) |
| CA (1) | CA2186381A1 (es) |
| CZ (1) | CZ282096A3 (es) |
| DE (1) | DE69519666T2 (es) |
| DK (1) | DK0751944T3 (es) |
| ES (1) | ES2154727T3 (es) |
| GR (1) | GR3035277T3 (es) |
| HU (1) | HUT76062A (es) |
| IL (1) | IL113112A (es) |
| MX (1) | MX9604430A (es) |
| NZ (1) | NZ282893A (es) |
| PT (1) | PT751944E (es) |
| RU (1) | RU2125053C1 (es) |
| TW (1) | TW420669B (es) |
| WO (1) | WO1995026347A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0749430T3 (da) * | 1994-03-08 | 2000-02-07 | American Home Prod | Thiazolidindion-derivater som antihyperglykæmiske midler |
| US5889025A (en) * | 1996-05-06 | 1999-03-30 | Reddy's Research Foundation | Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| ZA973848B (en) * | 1996-05-06 | 1997-12-02 | Reddy Research Foundation | Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them. |
| US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| BR9711098B1 (pt) * | 1996-07-01 | 2011-10-04 | compostos heterocìclicos, processo para sua preparação e composições farmacêuticas contendo os mesmos e seu uso no tratamento de diabetes e doenças relacionadas. | |
| US6114526A (en) * | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6372750B2 (en) | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
| USRE39266E1 (en) * | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6313113B1 (en) * | 1997-04-15 | 2001-11-06 | Reddy-Cheminor, Inc. | Heterocyclic compounds having antidiabetic, hypolipidemic and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US6011031A (en) * | 1997-05-30 | 2000-01-04 | Dr. Reddy's Research Foundation | Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them |
| US6756360B1 (en) | 1998-12-24 | 2004-06-29 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes |
| PT1339678E (pt) | 2000-11-27 | 2007-11-30 | Pfizer Prod Inc | Agonistas selectivos do receptor ep4 no tratamento de osteoporose |
| MY148985A (en) * | 2006-03-24 | 2013-06-28 | Array Biopharma Inc | 2-aminopyridine analogs as glucokinase activators |
| CN101311167B (zh) * | 2007-05-25 | 2011-04-06 | 天津药物研究院 | 1-苯基咪唑烷-2,4-二酮类衍生物及其用途 |
| CN102884062B (zh) | 2009-12-23 | 2016-08-03 | 嘉世高制药公司 | 氨基嘧啶激酶抑制剂 |
| AU2012245344B2 (en) | 2011-04-22 | 2017-11-09 | Jasco Pharmaceuticals, LLC | Aminopyrimidine kinase inhibitors |
| KR101990605B1 (ko) * | 2011-11-04 | 2019-06-18 | 자스코 파머수티컬스, 엘엘씨 | 아미노피리미딘 키나아제 억제제 |
| KR20160004272U (ko) | 2015-06-04 | 2016-12-14 | 심명보 | 걸이구가 구비된 케이블행거 |
| KR200488728Y1 (ko) | 2017-06-15 | 2019-03-11 | 심명보 | 걸이구가 구비된 케이블행거 |
| EP3658142B1 (en) | 2017-07-28 | 2024-04-17 | Applied Therapeutics, Inc. | Compositions and methods for treating galactosemia |
| EP3966320A4 (en) | 2019-05-07 | 2023-10-25 | University of Miami | TREATMENT AND DETECTION OF HEREDITARY NEUROPATHIES AND ASSOCIATED DISORDERS |
| KR102433164B1 (ko) * | 2020-06-29 | 2022-08-18 | 한국전력공사 | 길이와 각도 조절이 가능한 케이블 행거 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5564586A (en) * | 1978-11-09 | 1980-05-15 | Takeda Chem Ind Ltd | Thiazolidine derivative |
| WO1989008651A1 (en) * | 1988-03-08 | 1989-09-21 | Pfizer Inc. | Hypoglycemic thiazolidinedione derivatives |
| US5061717A (en) * | 1988-03-08 | 1991-10-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| JPH065228A (ja) * | 1992-06-18 | 1994-01-14 | Mitsubishi Electric Corp | 偏向デバイス |
| TW245716B (es) * | 1992-12-28 | 1995-04-21 | Takeda Pharm Industry Co | |
| KR960002625A (ko) * | 1994-06-17 | 1996-01-26 | 제임스 조셉 드롱 | 다층 레지스트의 플라즈마 에칭을 위한 방법 및 장치 |
-
1995
- 1995-03-23 TW TW084102837A patent/TW420669B/zh not_active IP Right Cessation
- 1995-03-23 IL IL11311295A patent/IL113112A/xx not_active IP Right Cessation
- 1995-03-27 PT PT95913343T patent/PT751944E/pt unknown
- 1995-03-27 KR KR1019960705283A patent/KR100340615B1/ko not_active IP Right Cessation
- 1995-03-27 NZ NZ282893A patent/NZ282893A/en unknown
- 1995-03-27 HU HU9602645A patent/HUT76062A/hu unknown
- 1995-03-27 EP EP95913343A patent/EP0751944B1/en not_active Expired - Lifetime
- 1995-03-27 DK DK95913343T patent/DK0751944T3/da active
- 1995-03-27 WO PCT/JP1995/000560 patent/WO1995026347A1/en not_active Application Discontinuation
- 1995-03-27 ES ES95913343T patent/ES2154727T3/es not_active Expired - Lifetime
- 1995-03-27 CZ CZ962820A patent/CZ282096A3/cs unknown
- 1995-03-27 DE DE69519666T patent/DE69519666T2/de not_active Expired - Fee Related
- 1995-03-27 MX MX9604430A patent/MX9604430A/es unknown
- 1995-03-27 RU RU96119770A patent/RU2125053C1/ru not_active IP Right Cessation
- 1995-03-27 AU AU20833/95A patent/AU683739B2/en not_active Ceased
- 1995-03-27 CN CN95192264A patent/CN1045776C/zh not_active Expired - Fee Related
- 1995-03-27 AT AT95913343T patent/ATE198200T1/de not_active IP Right Cessation
- 1995-03-27 CA CA002186381A patent/CA2186381A1/en not_active Abandoned
-
2001
- 2001-01-18 GR GR20010400094T patent/GR3035277T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK0751944T3 (da) | 2001-01-08 |
| IL113112A0 (en) | 1995-06-29 |
| KR100340615B1 (ko) | 2002-10-18 |
| PT751944E (pt) | 2001-03-30 |
| EP0751944B1 (en) | 2000-12-20 |
| DE69519666D1 (de) | 2001-01-25 |
| WO1995026347A1 (en) | 1995-10-05 |
| EP0751944A1 (en) | 1997-01-08 |
| CN1144526A (zh) | 1997-03-05 |
| TW420669B (en) | 2001-02-01 |
| AU2083395A (en) | 1995-10-17 |
| KR970701716A (ko) | 1997-04-12 |
| HU9602645D0 (en) | 1996-11-28 |
| IL113112A (en) | 2000-06-01 |
| AU683739B2 (en) | 1997-11-20 |
| CZ282096A3 (en) | 1997-03-12 |
| NZ282893A (en) | 1997-07-27 |
| ES2154727T3 (es) | 2001-04-16 |
| CA2186381A1 (en) | 1995-10-05 |
| RU2125053C1 (ru) | 1999-01-20 |
| HUT76062A (en) | 1997-06-30 |
| DE69519666T2 (de) | 2001-04-26 |
| ATE198200T1 (de) | 2001-01-15 |
| CN1045776C (zh) | 1999-10-20 |
| GR3035277T3 (en) | 2001-04-30 |
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