ES2154727T3 - Tiazolidinas y oxazolidinas sustituidas por una piridina ciclica y utilizacion como principios hipoglicemicos. - Google Patents

Tiazolidinas y oxazolidinas sustituidas por una piridina ciclica y utilizacion como principios hipoglicemicos.

Info

Publication number
ES2154727T3
ES2154727T3 ES95913343T ES95913343T ES2154727T3 ES 2154727 T3 ES2154727 T3 ES 2154727T3 ES 95913343 T ES95913343 T ES 95913343T ES 95913343 T ES95913343 T ES 95913343T ES 2154727 T3 ES2154727 T3 ES 2154727T3
Authority
ES
Spain
Prior art keywords
group
alkyl
cycloalkyl
hypoglycemic
thiazolidins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95913343T
Other languages
English (en)
Inventor
Yoshio Ohara
Mikio Suzuki
Nobuhide Miyachi
Katsuhiro Kato
Keisuke Ohdoi
Tetsuya Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Original Assignee
Nissan Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp filed Critical Nissan Chemical Corp
Application granted granted Critical
Publication of ES2154727T3 publication Critical patent/ES2154727T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA NUEVAS TIAZOLIDINAS TIPO PIRIDINAS Y SUS SALES, EXPRESADAS POR LA FORMULA (I) (EN DONDE X{SUP,1} ES S O O; X{SUP,2} ES S, O O NH; Y ES CR{SUP,6}R{SUP,7}; R{SUP,6} ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO C{SUB,1}-C{SUB,7} O UN GRUPO CICLOALQUILO C{SUB,3}C{SUB,7}, Y R{SUP,7} ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO C{SUB,1}-C{SUB,7} O UN GRUPO CICLOALQUILO C{SUB,3}-C{SUB,7} O FORMAN JUNTOS UN ENLACE CON R{SUP,4}), O SO{SUB,2}; Z ES UN GRUPO ALQUILO C{SUB,1}-C{SUB,10}, UN GRUPO ALQUENILO C{SUB,2}C{SUB,10}, UN GRUPO ALQUINILO C{SUB,2}-C{SUB,10}, UN GRUPO CICLOALQUILO C{SUB,3}-C{SUB,7}, UN GRUPPO CICLOALQUENILO C{SUB,3}-C{SUB,7} (CADA UNO DE LOS GRUPO ALQUILO, ALQUENILO, ALQUINILO, CICLOALQUILO Y CICLOALQUENILO DICHOS PUEDE ESTAR SUSTITUIDO CON A LO SUMO 3 DE LOS GRUPOS HIDROXILO, OXO, ALQUILO C{SUB,1}-C{SUB,7} Y ALCOXI C{SUB,1}-C{SUB,7}), UN GRUPO FENILO, UN GRUPO BIFENILO, UN GRUPO {AL}-NAFTILO, UN GRUPO {BE}-NAFTILO, UN GRUPO BENZILO O UN GRUPO HETEROCICLICO.ESTOS COMPUESTOS TIENEN EFECTOS HIPOGLICEMICOS.
ES95913343T 1994-03-28 1995-03-27 Tiazolidinas y oxazolidinas sustituidas por una piridina ciclica y utilizacion como principios hipoglicemicos. Expired - Lifetime ES2154727T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP5719294 1994-03-28
JP29517794 1994-11-29

Publications (1)

Publication Number Publication Date
ES2154727T3 true ES2154727T3 (es) 2001-04-16

Family

ID=26398213

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95913343T Expired - Lifetime ES2154727T3 (es) 1994-03-28 1995-03-27 Tiazolidinas y oxazolidinas sustituidas por una piridina ciclica y utilizacion como principios hipoglicemicos.

Country Status (19)

Country Link
EP (1) EP0751944B1 (es)
KR (1) KR100340615B1 (es)
CN (1) CN1045776C (es)
AT (1) ATE198200T1 (es)
AU (1) AU683739B2 (es)
CA (1) CA2186381A1 (es)
CZ (1) CZ282096A3 (es)
DE (1) DE69519666T2 (es)
DK (1) DK0751944T3 (es)
ES (1) ES2154727T3 (es)
GR (1) GR3035277T3 (es)
HU (1) HUT76062A (es)
IL (1) IL113112A (es)
MX (1) MX9604430A (es)
NZ (1) NZ282893A (es)
PT (1) PT751944E (es)
RU (1) RU2125053C1 (es)
TW (1) TW420669B (es)
WO (1) WO1995026347A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69511683T2 (de) * 1994-03-08 2000-03-02 American Home Prod Thiazolidine-dion-derivate als antihyperglykemische mittel
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5889032A (en) * 1996-05-06 1999-03-30 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5889025A (en) * 1996-05-06 1999-03-30 Reddy's Research Foundation Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US6114526A (en) * 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
BR9711098B1 (pt) * 1996-07-01 2011-10-04 compostos heterocìclicos, processo para sua preparação e composições farmacêuticas contendo os mesmos e seu uso no tratamento de diabetes e doenças relacionadas.
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) * 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6313113B1 (en) 1997-04-15 2001-11-06 Reddy-Cheminor, Inc. Heterocyclic compounds having antidiabetic, hypolipidemic and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US6011031A (en) * 1997-05-30 2000-01-04 Dr. Reddy's Research Foundation Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them
US6756360B1 (en) 1998-12-24 2004-06-29 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
IL155368A0 (en) 2000-11-27 2003-11-23 Pfizer Prod Inc Ep4 receptor selective agonists in the treatment of osteoporosis
WO2007117381A2 (en) * 2006-03-24 2007-10-18 Array Biopharma Inc. 2 -aminopyridine analogs as glucokinase activators
CN101311167B (zh) * 2007-05-25 2011-04-06 天津药物研究院 1-苯基咪唑烷-2,4-二酮类衍生物及其用途
JP5793505B2 (ja) 2009-12-23 2015-10-14 ジャスコ ファーマシューティカルズ， エルエルシー アミノピリミジンキナーゼ阻害薬
CA2832865C (en) 2011-04-22 2021-05-11 Jasco Pharmaceuticals, LLC Aminopyrimidine kinase inhibitors
JP6215832B2 (ja) 2011-11-04 2017-10-18 ジャスコ ファーマスーティカルズ エルエルシーＪａｓｃｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， ＬＬＣ アミノピリミジンキナーゼ阻害剤
KR20160004272U (ko) 2015-06-04 2016-12-14 심명보 걸이구가 구비된 케이블행거
KR200488728Y1 (ko) 2017-06-15 2019-03-11 심명보 걸이구가 구비된 케이블행거
US11590131B2 (en) 2017-07-28 2023-02-28 Applied Therapeutics, Inc. Compositions and methods for treating galactosemia
KR102433164B1 (ko) * 2020-06-29 2022-08-18 한국전력공사 길이와 각도 조절이 가능한 케이블 행거

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5564586A (en) * 1978-11-09 1980-05-15 Takeda Chem Ind Ltd Thiazolidine derivative
WO1989008651A1 (en) * 1988-03-08 1989-09-21 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
US5061717A (en) * 1988-03-08 1991-10-29 Pfizer Inc. Thiazolidinedione hypoglycemic agents
JPH065228A (ja) * 1992-06-18 1994-01-14 Mitsubishi Electric Corp 偏向デバイス
TW245716B (es) * 1992-12-28 1995-04-21 Takeda Pharm Industry Co
KR960002625A (ko) * 1994-06-17 1996-01-26 제임스 조셉 드롱 다층 레지스트의 플라즈마 에칭을 위한 방법 및 장치

Also Published As

Publication number Publication date
MX9604430A (es) 1997-12-31
EP0751944B1 (en) 2000-12-20
WO1995026347A1 (en) 1995-10-05
CN1045776C (zh) 1999-10-20
PT751944E (pt) 2001-03-30
CZ282096A3 (en) 1997-03-12
KR100340615B1 (ko) 2002-10-18
CA2186381A1 (en) 1995-10-05
ATE198200T1 (de) 2001-01-15
RU2125053C1 (ru) 1999-01-20
KR970701716A (ko) 1997-04-12
AU2083395A (en) 1995-10-17
IL113112A (en) 2000-06-01
DK0751944T3 (da) 2001-01-08
NZ282893A (en) 1997-07-27
HUT76062A (en) 1997-06-30
DE69519666T2 (de) 2001-04-26
DE69519666D1 (de) 2001-01-25
IL113112A0 (en) 1995-06-29
AU683739B2 (en) 1997-11-20
TW420669B (en) 2001-02-01
EP0751944A1 (en) 1997-01-08
GR3035277T3 (en) 2001-04-30
CN1144526A (zh) 1997-03-05
HU9602645D0 (en) 1996-11-28

Similar Documents

Publication Publication Date Title
ES2154727T3 (es) Tiazolidinas y oxazolidinas sustituidas por una piridina ciclica y utilizacion como principios hipoglicemicos.
DE122006000027I2 (de) Aminderivate
MX9709951A (es) Derivados de benzamida y su uso como antagonistas de vasopresina.
GR3034398T3 (en) 2-[1',2',4'-triazol-3'-yloxymethylene]-anilides and their use as pest-control agents
ES2124545T3 (es) Azolidindionas como agentes antihiperglucemicos.
ATE175661T1 (de) Benzamid-derivate als vasopressin-antagonisten
WO2003048130A3 (en) Peroxisome proliferator activated receptor agonists
BR8500007A (pt) Processo para a preparacao de 5-halogenoalquil-1,3,4-tiadiazol-2-iloxiacetamidas,composicoes herbicidas,aplicacao,composicoes fungicidas processo para a preparacao de composicoes
MX9703807A (es) Carboxilatos de aminoguanidina para el tratamiento de la diabetes mellitus no dependiente de la insulina.
ES8506655A1 (es) Procedimiento para la obtencion de un derivado de fenilsulfonilguanidina
ES8506647A1 (es) Procedimiento para la obtencion de derivados de fenilsulfonilguanidina sustituidos de efecto herbicida
TW200505446A (en) Inhibitor of cox
NZ336091A (en) Aqueous disinfecting cleaning composition
MX9302388A (es) Oxazolidinonas fungicidas y composicion fungicida que las contiene
BR0113978A (pt) Derivados de tiazol de 2-metoxiimino-2-(piridiniloximetil)-fenil-acetamidas úteis como fungicidas
ZA824820B (en) A synergistic composition and a process for selectively combating weeds, especially in cereal crops
DE60211686D1 (de) Pkb-3564-substanz mit die gefässneubildung hemmender wirkung
EP0293839A3 (en) Substituted phenyl (or pyridyl) urea compound and herbicidal composition containing the same as active ingredient
TH19998EX (th) สารแก้โรคเบาหวาน
DK0446873T3 (da) Aminer med fungicid virkning
ES463857A1 (es) Procedimiento para la preparacion de diuretanos.
ES2166681B1 (es) Compuestos de uracilo opticamente activos.
SU820186A1 (ru) 1-[4-(3',4'-диоксифенил)-тиазолил-2]-3-алкил-5-тетрафторэтилпиразолы, обладающие акарицидной активностью
FI912828A0 (fi) N-oxi-imidsyraderivat.
ATE404548T1 (de) Cyclisches hemiacetalderivat und dessen anwendung

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 751944

Country of ref document: ES