ES2154727T3 - Tiazolidinas y oxazolidinas sustituidas por una piridina ciclica y utilizacion como principios hipoglicemicos. - Google Patents
Tiazolidinas y oxazolidinas sustituidas por una piridina ciclica y utilizacion como principios hipoglicemicos.Info
- Publication number
- ES2154727T3 ES2154727T3 ES95913343T ES95913343T ES2154727T3 ES 2154727 T3 ES2154727 T3 ES 2154727T3 ES 95913343 T ES95913343 T ES 95913343T ES 95913343 T ES95913343 T ES 95913343T ES 2154727 T3 ES2154727 T3 ES 2154727T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl
- cycloalkyl
- hypoglycemic
- thiazolidins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA PRESENTE INVENCION PROPORCIONA NUEVAS TIAZOLIDINAS TIPO PIRIDINAS Y SUS SALES, EXPRESADAS POR LA FORMULA (I) (EN DONDE X{SUP,1} ES S O O; X{SUP,2} ES S, O O NH; Y ES CR{SUP,6}R{SUP,7}; R{SUP,6} ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO C{SUB,1}-C{SUB,7} O UN GRUPO CICLOALQUILO C{SUB,3}C{SUB,7}, Y R{SUP,7} ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO C{SUB,1}-C{SUB,7} O UN GRUPO CICLOALQUILO C{SUB,3}-C{SUB,7} O FORMAN JUNTOS UN ENLACE CON R{SUP,4}), O SO{SUB,2}; Z ES UN GRUPO ALQUILO C{SUB,1}-C{SUB,10}, UN GRUPO ALQUENILO C{SUB,2}C{SUB,10}, UN GRUPO ALQUINILO C{SUB,2}-C{SUB,10}, UN GRUPO CICLOALQUILO C{SUB,3}-C{SUB,7}, UN GRUPPO CICLOALQUENILO C{SUB,3}-C{SUB,7} (CADA UNO DE LOS GRUPO ALQUILO, ALQUENILO, ALQUINILO, CICLOALQUILO Y CICLOALQUENILO DICHOS PUEDE ESTAR SUSTITUIDO CON A LO SUMO 3 DE LOS GRUPOS HIDROXILO, OXO, ALQUILO C{SUB,1}-C{SUB,7} Y ALCOXI C{SUB,1}-C{SUB,7}), UN GRUPO FENILO, UN GRUPO BIFENILO, UN GRUPO {AL}-NAFTILO, UN GRUPO {BE}-NAFTILO, UN GRUPO BENZILO O UN GRUPO HETEROCICLICO.ESTOS COMPUESTOS TIENEN EFECTOS HIPOGLICEMICOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5719294 | 1994-03-28 | ||
JP29517794 | 1994-11-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2154727T3 true ES2154727T3 (es) | 2001-04-16 |
Family
ID=26398213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95913343T Expired - Lifetime ES2154727T3 (es) | 1994-03-28 | 1995-03-27 | Tiazolidinas y oxazolidinas sustituidas por una piridina ciclica y utilizacion como principios hipoglicemicos. |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0751944B1 (es) |
KR (1) | KR100340615B1 (es) |
CN (1) | CN1045776C (es) |
AT (1) | ATE198200T1 (es) |
AU (1) | AU683739B2 (es) |
CA (1) | CA2186381A1 (es) |
CZ (1) | CZ282096A3 (es) |
DE (1) | DE69519666T2 (es) |
DK (1) | DK0751944T3 (es) |
ES (1) | ES2154727T3 (es) |
GR (1) | GR3035277T3 (es) |
HU (1) | HUT76062A (es) |
IL (1) | IL113112A (es) |
MX (1) | MX9604430A (es) |
NZ (1) | NZ282893A (es) |
PT (1) | PT751944E (es) |
RU (1) | RU2125053C1 (es) |
TW (1) | TW420669B (es) |
WO (1) | WO1995026347A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2126395C1 (ru) * | 1994-03-08 | 1999-02-20 | Американ Хоум Продактс Корпорейшн | Производные тиазолидиндиона или их фармацевтически приемлемые соли, способ лечения гипергликемии у млекопитающего, фармацевтическая композиция |
US5889032A (en) * | 1996-05-06 | 1999-03-30 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
US5889025A (en) * | 1996-05-06 | 1999-03-30 | Reddy's Research Foundation | Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
CZ298812B6 (cs) * | 1996-07-01 | 2008-02-13 | Dr. Reddy's Laboratories Limited | Azolidindionové deriváty, způsob jejich přípravy, farmaceutické kompozice s jejich obsahem a jejich použití v léčbě diabetu a příbuzných nemocí |
US6372750B2 (en) | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
USRE39266E1 (en) * | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
US6114526A (en) | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
US6011036A (en) * | 1997-04-15 | 2000-01-04 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them |
US6011031A (en) * | 1997-05-30 | 2000-01-04 | Dr. Reddy's Research Foundation | Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them |
US6756360B1 (en) | 1998-12-24 | 2004-06-29 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes |
EP1339678B1 (en) | 2000-11-27 | 2007-09-26 | Pfizer Products Inc. | Ep4 receptor selective agonists in the treatment of osteoporosis |
MY148985A (en) * | 2006-03-24 | 2013-06-28 | Array Biopharma Inc | 2-aminopyridine analogs as glucokinase activators |
CN101311167B (zh) * | 2007-05-25 | 2011-04-06 | 天津药物研究院 | 1-苯基咪唑烷-2,4-二酮类衍生物及其用途 |
CA2783575C (en) | 2009-12-23 | 2018-06-05 | Jasco Pharmaceuticals, LLC | Aminopyrimidine kinase inhibitors |
US8901145B2 (en) | 2011-04-22 | 2014-12-02 | Jasco Pharmaceuticals, LLC | Aminopyrimidine kinase inhibitors |
ES2629690T3 (es) | 2011-11-04 | 2017-08-14 | Jasco Pharmaceuticals, LLC | Inhibidores de aminopirimidina quinasa |
KR20160004272U (ko) | 2015-06-04 | 2016-12-14 | 심명보 | 걸이구가 구비된 케이블행거 |
KR200488728Y1 (ko) | 2017-06-15 | 2019-03-11 | 심명보 | 걸이구가 구비된 케이블행거 |
EP4417260A2 (en) | 2017-07-28 | 2024-08-21 | Applied Therapeutics, Inc. | Compositions and methods for treating galactosemia |
AU2020268368A1 (en) | 2019-05-07 | 2022-01-06 | Ucl Business Ltd | Treatment and detection of inherited neuropathies and associated disorders |
KR102433164B1 (ko) * | 2020-06-29 | 2022-08-18 | 한국전력공사 | 길이와 각도 조절이 가능한 케이블 행거 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5564586A (en) * | 1978-11-09 | 1980-05-15 | Takeda Chem Ind Ltd | Thiazolidine derivative |
MX15171A (es) * | 1988-03-08 | 1993-05-01 | Pfizer | Derivados de tiazolidinodiona hipoglicemicos |
WO1989008650A1 (en) * | 1988-03-08 | 1989-09-21 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
JPH065228A (ja) * | 1992-06-18 | 1994-01-14 | Mitsubishi Electric Corp | 偏向デバイス |
TW245716B (es) * | 1992-12-28 | 1995-04-21 | Takeda Pharm Industry Co | |
KR960002625A (ko) * | 1994-06-17 | 1996-01-26 | 제임스 조셉 드롱 | 다층 레지스트의 플라즈마 에칭을 위한 방법 및 장치 |
-
1995
- 1995-03-23 TW TW084102837A patent/TW420669B/zh not_active IP Right Cessation
- 1995-03-23 IL IL11311295A patent/IL113112A/xx not_active IP Right Cessation
- 1995-03-27 AT AT95913343T patent/ATE198200T1/de not_active IP Right Cessation
- 1995-03-27 DE DE69519666T patent/DE69519666T2/de not_active Expired - Fee Related
- 1995-03-27 CZ CZ962820A patent/CZ282096A3/cs unknown
- 1995-03-27 ES ES95913343T patent/ES2154727T3/es not_active Expired - Lifetime
- 1995-03-27 NZ NZ282893A patent/NZ282893A/en unknown
- 1995-03-27 KR KR1019960705283A patent/KR100340615B1/ko not_active IP Right Cessation
- 1995-03-27 WO PCT/JP1995/000560 patent/WO1995026347A1/en not_active Application Discontinuation
- 1995-03-27 CN CN95192264A patent/CN1045776C/zh not_active Expired - Fee Related
- 1995-03-27 EP EP95913343A patent/EP0751944B1/en not_active Expired - Lifetime
- 1995-03-27 RU RU96119770A patent/RU2125053C1/ru not_active IP Right Cessation
- 1995-03-27 AU AU20833/95A patent/AU683739B2/en not_active Ceased
- 1995-03-27 PT PT95913343T patent/PT751944E/pt unknown
- 1995-03-27 MX MX9604430A patent/MX9604430A/es unknown
- 1995-03-27 HU HU9602645A patent/HUT76062A/hu unknown
- 1995-03-27 CA CA002186381A patent/CA2186381A1/en not_active Abandoned
- 1995-03-27 DK DK95913343T patent/DK0751944T3/da active
-
2001
- 2001-01-18 GR GR20010400094T patent/GR3035277T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TW420669B (en) | 2001-02-01 |
ATE198200T1 (de) | 2001-01-15 |
AU2083395A (en) | 1995-10-17 |
PT751944E (pt) | 2001-03-30 |
WO1995026347A1 (en) | 1995-10-05 |
EP0751944A1 (en) | 1997-01-08 |
NZ282893A (en) | 1997-07-27 |
IL113112A0 (en) | 1995-06-29 |
DE69519666T2 (de) | 2001-04-26 |
DK0751944T3 (da) | 2001-01-08 |
IL113112A (en) | 2000-06-01 |
DE69519666D1 (de) | 2001-01-25 |
EP0751944B1 (en) | 2000-12-20 |
RU2125053C1 (ru) | 1999-01-20 |
CZ282096A3 (en) | 1997-03-12 |
KR970701716A (ko) | 1997-04-12 |
KR100340615B1 (ko) | 2002-10-18 |
CN1144526A (zh) | 1997-03-05 |
HUT76062A (en) | 1997-06-30 |
MX9604430A (es) | 1997-12-31 |
CN1045776C (zh) | 1999-10-20 |
HU9602645D0 (en) | 1996-11-28 |
CA2186381A1 (en) | 1995-10-05 |
GR3035277T3 (en) | 2001-04-30 |
AU683739B2 (en) | 1997-11-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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