ES2704641T3 - Compuestos N-hidroxiamidinoheterocíclicos como moduladores de la indoleamina 2,3-dioxigenasa - Google Patents
Compuestos N-hidroxiamidinoheterocíclicos como moduladores de la indoleamina 2,3-dioxigenasa Download PDFInfo
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- ES2704641T3 ES2704641T3 ES07842681T ES07842681T ES2704641T3 ES 2704641 T3 ES2704641 T3 ES 2704641T3 ES 07842681 T ES07842681 T ES 07842681T ES 07842681 T ES07842681 T ES 07842681T ES 2704641 T3 ES2704641 T3 ES 2704641T3
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- alkynyl
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- alkenyl
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- C07—ORGANIC CHEMISTRY
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
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- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
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- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84571106P | 2006-09-19 | 2006-09-19 | |
| PCT/US2007/078759 WO2008036653A2 (en) | 2006-09-19 | 2007-09-18 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2704641T3 true ES2704641T3 (es) | 2019-03-19 |
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| ES07842681T Active ES2704641T3 (es) | 2006-09-19 | 2007-09-18 | Compuestos N-hidroxiamidinoheterocíclicos como moduladores de la indoleamina 2,3-dioxigenasa |
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| Country | Link |
|---|---|
| US (2) | US20080214546A1 (enExample) |
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| CL (1) | CL2007002650A1 (enExample) |
| ES (1) | ES2704641T3 (enExample) |
| TW (1) | TW200819445A (enExample) |
| WO (1) | WO2008036653A2 (enExample) |
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| CN100406567C (zh) * | 2002-01-22 | 2008-07-30 | 生物材料公司 | 生物可降解聚合物的干燥方法 |
| PL1879573T3 (pl) | 2005-05-10 | 2013-05-31 | Incyte Holdings Corp | Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania |
| US8450351B2 (en) * | 2005-12-20 | 2013-05-28 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| WO2008036642A2 (en) * | 2006-09-19 | 2008-03-27 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| JP5465720B2 (ja) | 2008-07-08 | 2014-04-09 | インサイト・コーポレイション | インドールアミン２，３−ジオキシゲナーゼの阻害剤としての１，２，５−オキサジアゾール |
| CN102558084A (zh) * | 2010-12-22 | 2012-07-11 | 上海药明康德新药开发有限公司 | N,n-双取代-3-氨基异噁唑-5-羧酸化合物的合成方法 |
| CN102558083B (zh) * | 2010-12-22 | 2015-07-01 | 无锡药明康德生物技术有限公司 | N,n-双取代-3-氨基异噁唑-5-甲醇化合物的合成方法 |
| GB201120860D0 (en) | 2011-12-05 | 2012-01-18 | Cambridge Entpr Ltd | Cancer immunotherapy |
| KR20150087400A (ko) | 2012-11-20 | 2015-07-29 | 버텍스 파마슈티칼스 인코포레이티드 | 인돌아민 2,3-디옥시게나제의 억제제로서 유용한 화합물 |
| ES2799582T3 (es) | 2013-11-08 | 2020-12-18 | Incyte Holdings Corp | Proceso para la síntesis de un inhibidor de indoleamina 2,3-dioxigenasa |
| KR102457145B1 (ko) | 2013-12-24 | 2022-10-19 | 브리스톨-마이어스 스큅 컴퍼니 | 항암제로서의 트리시클릭 화합물 |
| PE20170441A1 (es) | 2014-06-06 | 2017-04-26 | Bristol Myers Squibb Co | Anticuerpos contra el receptor del factor de necrosis tumoral inducido por glucocorticoides (gitr) y sus usos |
| RU2016149812A (ru) * | 2014-06-06 | 2018-07-17 | Флексус Байосайенсиз, Инк. | Иммунорегулирующие средства |
| AU2015349878A1 (en) | 2014-11-21 | 2017-05-25 | Bristol-Myers Squibb Company | Antibodies against CD73 and uses thereof |
| US10525035B2 (en) | 2014-12-18 | 2020-01-07 | Lankenau Institute For Medical Research | Methods and compositions for the treatment of retinopathy and other ocular diseases |
| AR103232A1 (es) | 2014-12-22 | 2017-04-26 | Bristol Myers Squibb Co | ANTAGONISTAS DE TGFbR |
| JP6180663B2 (ja) | 2014-12-23 | 2017-08-16 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｔｉｇｉｔに対する抗体 |
| US10983128B2 (en) | 2015-02-05 | 2021-04-20 | Bristol-Myers Squibb Company | CXCL11 and SMICA as predictive biomarkers for efficacy of anti-CTLA4 immunotherapy |
| EA037112B1 (ru) | 2015-03-02 | 2021-02-08 | Ригель Фармасьютикалс, Инк. | Ингибиторы tgf- |
| KR20170134981A (ko) | 2015-04-03 | 2017-12-07 | 브리스톨-마이어스 스큅 컴퍼니 | 암의 치료를 위한 인돌아민-2,3-디옥시게나제의 억제제 |
| TW201642897A (zh) | 2015-04-08 | 2016-12-16 | Ｆ 星生物科技有限公司 | Ｈｅｒ２結合劑治療 |
| AU2016249981B2 (en) | 2015-04-13 | 2022-02-17 | Five Prime Therapeutics, Inc. | Combination therapy for cancer |
| US10683290B2 (en) | 2015-05-11 | 2020-06-16 | Bristol-Myers Squibb Company | Tricyclic compounds as anticancer agents |
| ES2770349T3 (es) | 2015-05-12 | 2020-07-01 | Bristol Myers Squibb Co | Compuestos de 5H-pirido[3,2-b]indol como agentes antineoplásicos |
| US9725449B2 (en) | 2015-05-12 | 2017-08-08 | Bristol-Myers Squibb Company | Tricyclic compounds as anticancer agents |
| DK3303396T5 (da) | 2015-05-29 | 2024-10-07 | Bristol Myers Squibb Co | Antistoffer mod ox40 og anvendelser deraf |
| CN107922500A (zh) | 2015-06-29 | 2018-04-17 | 洛克菲勒大学 | 具有增强的激动剂活性的抗cd40抗体 |
| US10399987B2 (en) | 2015-07-28 | 2019-09-03 | Bristol-Myer Squibb Company | TGF beta receptor antagonists |
| CN108349976A (zh) | 2015-08-25 | 2018-07-31 | 百时美施贵宝公司 | TGFβ受体拮抗剂 |
| US10273281B2 (en) | 2015-11-02 | 2019-04-30 | Five Prime Therapeutics, Inc. | CD80 extracellular domain polypeptides and their use in cancer treatment |
| AU2016356780A1 (en) | 2015-11-19 | 2018-06-28 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof |
| MX2018006181A (es) | 2015-11-23 | 2018-09-24 | Five Prime Therapeutics Inc | Inhibidores de fgfr2 solos o en combinacion con agentes que estimulan el sistema inmunitario en el tratamiento contra el cancer. |
| JP6856648B2 (ja) | 2015-12-15 | 2021-04-07 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｃｘｃｒ４受容体アンタゴニスト |
| WO2017140835A1 (en) | 2016-02-19 | 2017-08-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of obesity |
| RU2638530C2 (ru) * | 2016-02-29 | 2017-12-14 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | ПРОИЗВОДНЫЕ 5-АМИНОИЗОКСАЗОЛА - КОНФОРМАЦИОННО-ЖЕСТКИЕ АНАЛОГИ γ-АМИНОМАСЛЯНОЙ КИСЛОТЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
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-
2007
- 2007-09-12 CL CL200702650A patent/CL2007002650A1/es unknown
- 2007-09-18 WO PCT/US2007/078759 patent/WO2008036653A2/en not_active Ceased
- 2007-09-18 AR ARP070104118A patent/AR062881A1/es unknown
- 2007-09-18 ES ES07842681T patent/ES2704641T3/es active Active
- 2007-09-18 EP EP07842681.4A patent/EP2064194B1/en active Active
- 2007-09-18 CA CA2662773A patent/CA2662773C/en active Active
- 2007-09-18 JP JP2009529343A patent/JP5432715B2/ja not_active Expired - Fee Related
- 2007-09-18 US US11/856,982 patent/US20080214546A1/en not_active Abandoned
- 2007-09-19 TW TW096135025A patent/TW200819445A/zh unknown
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2011
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Also Published As
| Publication number | Publication date |
|---|---|
| US20080214546A1 (en) | 2008-09-04 |
| CA2662773A1 (en) | 2008-03-27 |
| US8507541B2 (en) | 2013-08-13 |
| JP5432715B2 (ja) | 2014-03-05 |
| EP2064194A2 (en) | 2009-06-03 |
| JP2010504347A (ja) | 2010-02-12 |
| CA2662773C (en) | 2015-11-24 |
| AR062881A1 (es) | 2008-12-10 |
| US20110165188A1 (en) | 2011-07-07 |
| CL2007002650A1 (es) | 2008-02-08 |
| WO2008036653A2 (en) | 2008-03-27 |
| EP2064194B1 (en) | 2018-11-07 |
| TW200819445A (en) | 2008-05-01 |
| WO2008036653A3 (en) | 2008-07-31 |
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