ES2628634T3 - Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas - Google Patents
Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas Download PDFInfo
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- ES2628634T3 ES2628634T3 ES12815454.9T ES12815454T ES2628634T3 ES 2628634 T3 ES2628634 T3 ES 2628634T3 ES 12815454 T ES12815454 T ES 12815454T ES 2628634 T3 ES2628634 T3 ES 2628634T3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/08—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium
- C07H5/10—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium to sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/08—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161510136P | 2011-07-21 | 2011-07-21 | |
| US201161510136P | 2011-07-21 | ||
| PCT/US2012/047661 WO2013013179A1 (en) | 2011-07-21 | 2012-07-20 | Ruthenium carbon monoxide releasing molecules and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2628634T3 true ES2628634T3 (es) | 2017-08-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12815454.9T Active ES2628634T3 (es) | 2011-07-21 | 2012-07-20 | Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9062089B2 (https=) |
| EP (1) | EP2734235B1 (https=) |
| JP (1) | JP6134710B2 (https=) |
| ES (1) | ES2628634T3 (https=) |
| WO (1) | WO2013013179A1 (https=) |
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| US9163044B2 (en) | 2011-04-19 | 2015-10-20 | Alfama, Inc. | Carbon monoxide releasing molecules and uses thereof |
| ES2628634T3 (es) * | 2011-07-21 | 2017-08-03 | Alfama, Inc. | Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas |
| ES2718548T3 (es) | 2014-03-21 | 2019-07-02 | Univ Paris Val De Marne | Híbridos de molécula de liberación de CO-fumarato, su utilización en el tratamiento de enfermedades inflamatorias o cardiovasculares y su procedimiento de preparación |
| DK3383846T3 (da) * | 2015-11-30 | 2022-08-15 | Otago Innovation Ltd | Kuliltefrigivende norbornenonforbindelser |
| CN105906667B (zh) * | 2016-04-26 | 2018-06-29 | 中国科学院长春应用化学研究所 | 一种具有抗癌活性的化学物质及其制备方法与应用 |
| US11253495B2 (en) * | 2018-11-21 | 2022-02-22 | Yanming Wang | Pharmaceutical composition for treating excessive lactate production and acidemia |
| CN110437285B (zh) * | 2019-07-16 | 2022-06-10 | 中国中医科学院中药研究所 | 青蒿素钌金属配合物及其制备方法和医药用途 |
| GB202004514D0 (en) | 2020-03-27 | 2020-05-13 | Inst De Medicina Molecular Joaeo Lobo Antunes | Treatment of Immunosuppressive Cancer |
| EP4275682A1 (en) * | 2022-05-12 | 2023-11-15 | Institut National De La Sante Et De La Recherche Medicale - Inserm | Carbon monoxide-releasing molecule (corm) or composition thereof for use in the treatment or the prevention of an intestinal dysbiosis in a subject |
| LU506390B1 (en) * | 2024-02-09 | 2025-08-11 | L2R Sas | Oil-in-water jellified emulsion for use in anti-malarial treatment |
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| US2870180A (en) | 1955-10-13 | 1959-01-20 | Ethyl Corp | Process for the preparation of hydrocarbon manganese carbonyl compounds |
| US3065250A (en) | 1960-05-13 | 1962-11-20 | Hercules Powder Co Ltd | Nitrile-metal carbonyl complexes |
| US3278570A (en) | 1961-04-11 | 1966-10-11 | Ethyl Corp | Molybdenum pentacarbonyl compounds and process for preparing same |
| US3452079A (en) | 1964-06-15 | 1969-06-24 | Merck & Co Inc | Acetic acid type compounds |
| GB1118728A (en) | 1966-04-28 | 1968-07-03 | James Kaye | Improvements in or relating to the shaping of thermoplastic sheeting |
| CH536294A (de) | 1968-09-13 | 1973-04-30 | Schering Ag | Verfahren zur Herstellung von racemischen und optisch aktiven 4,6-Dichlor-4,6-östradienen |
| US3829504A (en) | 1970-06-04 | 1974-08-13 | Int Flavors & Fragrances Inc | Novel di-lower alkyl and lower alkylene acetals of 2-and 3-phenyl-pentenals |
| US3694232A (en) | 1970-06-04 | 1972-09-26 | Int Flavors & Fragrances Inc | Flavoring methods and compositions containing 3-phenyl pentenals |
| US3980583A (en) | 1974-02-19 | 1976-09-14 | Mobil Oil Corporation | Complexed metals bonded to inorganic oxides |
| US4096250A (en) * | 1977-02-25 | 1978-06-20 | Smithkline Corporation | Tri-substituted phosphinegold(I) 1-thio-β-D-glucopyranosides |
| NL7802482A (nl) | 1977-03-17 | 1978-09-19 | Klosa Josef | Preparaat voor de profylaxis en therapie van acne vulgaris en werkwijze voor de profylaxis en therapie van acne vulgaris met behulp van pyridinaldehyden. |
| US4312989A (en) | 1979-08-21 | 1982-01-26 | The United States Of America As Represented By The Secretary Of The Army | Pharmacologically active amine boranes |
| EP0034238B1 (en) | 1979-12-21 | 1985-04-17 | Duke University | Pharmacologically active amine-carboxyboranes |
| US4322411A (en) | 1980-04-25 | 1982-03-30 | Burroughs Wellcome Co. | Anti-inflammatory nucleosides |
| US4613621A (en) | 1981-09-18 | 1986-09-23 | Hoerrmann Wilhelm | Fatty aldehydes and acids in the treatment of neurological and inflammatory diseases |
| DE3139358C2 (de) | 1981-10-02 | 1984-06-07 | Dragoco Gerberding & Co Gmbh, 3450 Holzminden | Verwendung von 1,1-Di(C↓1↓-C↓6↓-alkyl)-2-phenyl-ethan-Derivaten als Riechstoffe |
| US4535167A (en) | 1981-12-14 | 1985-08-13 | Merck & Co. Inc. | Chiral, N-protected, N-substituted α-amino acids |
| US4649151A (en) | 1982-09-27 | 1987-03-10 | Health Research, Inc. | Drugs comprising porphyrins |
| JPS59190999A (ja) * | 1983-04-14 | 1984-10-29 | リチヤ−ド・エフ・ストツケル | セレン含有白金化合物 |
| GB8407557D0 (en) | 1984-03-23 | 1984-05-02 | Hayward J A | Polymeric lipsomes |
| US4647555A (en) | 1984-10-25 | 1987-03-03 | The United States Of America As Represented By The Secretary Of The Army | Esters of boron analogues of amino acids |
| US4657902A (en) | 1985-03-25 | 1987-04-14 | The Rockefeller University | Therapeutic use of tin mesoporphyrin |
| US4709083A (en) | 1986-05-19 | 1987-11-24 | The United States Of America As Represented By The Secretary Of The Army | Method of making boron analogues |
| US4699903A (en) | 1986-06-20 | 1987-10-13 | The Rockefeller University | Therapeutic use of tin diiododeuteroporphyrin |
| US4668670A (en) | 1986-06-20 | 1987-05-26 | The Rockefeller University | Tin diiododeuteroporphyrin and therapeutic use thereof |
| US4792452A (en) | 1987-07-28 | 1988-12-20 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| JPH0670025B2 (ja) | 1987-08-07 | 1994-09-07 | 鐘紡株式会社 | ベンゾチアゾ−ル誘導体および該化合物を有効成分とする抗リウマチ剤 |
| US5350767A (en) | 1987-11-19 | 1994-09-27 | Aktiebolaget Draco | Derivatives of cysteine |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| KR920700612A (ko) | 1989-07-25 | 1992-08-10 | 제이. 제프리 헐리 | 광선에 의해 노화된 피부를 재생시키기 위한 치료 방법 |
| US5086060A (en) | 1989-07-25 | 1992-02-04 | Eastman Kodak Company | Compound and method for treating skin for acne or psoriasis |
| US5010073A (en) | 1989-10-05 | 1991-04-23 | The Rockefeller University | Use of liposomes as carriers for metalloporphyrins |
| US5362732A (en) | 1989-12-20 | 1994-11-08 | University Of North Carolina At Chapel Hill | Boronated compounds |
| HU211084B (en) | 1990-04-20 | 1995-10-30 | Brezo | Process for producing oral pharmaceutical composition of bone strengthening activity |
| DE4014762A1 (de) | 1990-05-05 | 1991-11-07 | Martin Prof Dr Wenzel | Verbindungen zur strahlentherapie oder diagnostik durch absorption von moessbauer-strahlung |
| WO1992003402A1 (fr) | 1990-08-24 | 1992-03-05 | Firmenich Sa | Compose cetonique polycyclique et son utilisation a titre d'ingredient parfumant |
| US5102670A (en) | 1990-09-14 | 1992-04-07 | Abraham Nader G | Method for treating eye disorders by reducing 12(r)-hydroxyeicosatetraenoic acid and 12(r)-dihydroxyeicosatrienoic acid levels |
| US5254706A (en) | 1991-05-10 | 1993-10-19 | Boron Biologicals, Inc. | Process of making phosphite-borane compounds |
| WO1993005795A1 (en) | 1991-09-13 | 1993-04-01 | Boron Biologicals, Inc. | Method of combatting osteoporosis and other disease states in mammalian subjects, utilizing organic boron compounds |
| GB2271351A (en) | 1992-10-08 | 1994-04-13 | Merck Patent Gmbh | Carbocyclyl-phenyl-pyrazines and liquid crystalline media |
| GB9221327D0 (en) | 1992-10-10 | 1992-11-25 | Harden Richard C | Letter receptacle |
| IT1256450B (it) | 1992-11-26 | 1995-12-05 | Soldato Piero Del | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione |
| AU6523194A (en) | 1993-03-26 | 1994-10-24 | Biorelease Technologies, Inc. | Compositions including heme-containing proteins and methods relating thereto |
| FR2707085B1 (fr) | 1993-06-30 | 1995-08-18 | Adir | Nouveaux dérivés d'alpha amino acides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| US6284752B1 (en) | 1993-08-25 | 2001-09-04 | Anormed Inc. | Pharmaceutical compositions comprising metal complexes |
| US6417182B1 (en) | 1993-08-25 | 2002-07-09 | Anormed Inc. | Pharmaceutical compositions comprising metal complexes |
| GB9317686D0 (en) | 1993-08-25 | 1993-10-13 | Johnson Matthey Plc | Pharmaceutical compositions |
| US5811463A (en) | 1993-10-06 | 1998-09-22 | University Of British Columbia | Compositions and method for relaxing smooth muscles |
| US5631284A (en) | 1993-10-06 | 1997-05-20 | University Of British Columbia | Compositions and methods for relaxing smooth muscles |
| DE69412109T2 (de) | 1993-10-06 | 1999-01-21 | Nicox S.A., Paris | Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung |
| US6051576A (en) | 1994-01-28 | 2000-04-18 | University Of Kentucky Research Foundation | Means to achieve sustained release of synergistic drugs by conjugation |
| US5891689A (en) | 1994-04-12 | 1999-04-06 | Innovir Laboratories, Inc. | Heme-bearing microparticles for targeted delivery of drugs |
| SI0759899T1 (en) | 1994-05-10 | 1999-12-31 | Nicox S.A. | Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities |
| DE4421433C1 (de) | 1994-06-18 | 1995-06-08 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit Wirkstoffen, die Kohlenmonoxid-Quellen darstellen, Verfahren zu seiner Herstellung und seine Verwendung |
| US6338963B1 (en) | 1994-07-25 | 2002-01-15 | Neotherapeutics, Inc. | Use of carbon monoxide dependent guanylyl cyclase modifiers to stimulate neuritogenesis |
| US5447939A (en) | 1994-07-25 | 1995-09-05 | Glasky; Alvin J. | Carbon monoxide dependent guanylyl cyclase modifiers and methods of use |
| FI970302L (fi) | 1994-07-25 | 1997-01-24 | Alvin J Glasky | Hiilimonoksidista riippuvaisia guanylyylisyklaasin modifikaattoreita |
| US5801184A (en) | 1994-07-25 | 1998-09-01 | Glasky; Alvin J. | Carbon monoxide dependent guanylyl cyclase modifiers and methods of use |
| WO1997034589A1 (en) | 1996-03-20 | 1997-09-25 | President And Fellows Of Harvard College | Triaryl methane compounds for sickle cell disease |
| CA2132690A1 (en) | 1994-09-22 | 1996-03-23 | Dean Willis | Control and modulation of inflammatory response in humans in need of such control and modulation |
| US6066333A (en) | 1994-09-22 | 2000-05-23 | William Harvey Research Limited | Pharmaceutical control of inflammation |
| US5664563A (en) | 1994-12-09 | 1997-09-09 | Cardiopulmonary Corporation | Pneumatic system |
| US5670664A (en) | 1995-09-08 | 1997-09-23 | University Of Maryland Biotechnology Institute | Photosensitive organic compounds that release carbon monoxide upon illumination |
| DE19540475A1 (de) | 1995-10-20 | 1997-04-24 | Schering Ag | Chirale Methylphenyloxazolidinone |
| US5767157A (en) | 1996-01-16 | 1998-06-16 | Van Moerkerken; Arthur | Arthritic pain prevention method and compositions |
| IT1276071B1 (it) | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
| US20020193363A1 (en) | 1996-02-26 | 2002-12-19 | Bridger Gary J. | Use of nitric oxide scavengers to modulate inflammation and matrix metalloproteinase activity |
| US5888982A (en) | 1996-04-01 | 1999-03-30 | President And Fellows Of Harvard College | Regulation of vascular smooth muscle cell heme oxygenase-1 |
| ATE331505T1 (de) | 1996-04-05 | 2006-07-15 | Gen Hospital Corp | Behandlung einer hämoglobinstörung |
| US5756492A (en) | 1996-09-09 | 1998-05-26 | Sangstat Medical Corporation | Graft survival prolongation with porphyrins |
| US8128963B2 (en) | 1996-09-27 | 2012-03-06 | The Trustees Of Columbia University In The City Of New York | Methods for treating ischemic disorders using carbon monoxide |
| ATE358492T1 (de) | 1996-09-27 | 2007-04-15 | Univ Columbia | Behandlung einer ischämischen störung und zur verbesserung des infarktergebnis |
| IT1295694B1 (it) | 1996-11-14 | 1999-05-27 | Nicox Sa | Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica |
| TR199902063T2 (xx) | 1997-02-26 | 1999-12-21 | Glaxo Group Limited | Metalloproteaz inhibitörleri olarak ters hidroksamat türevleri. |
| US6344178B1 (en) | 1997-04-25 | 2002-02-05 | Mallinckrodt Inc. | Method for the preparation of facial metal tricarbonyl compounds and their use in the labelling of biologically active substrates |
| EP0879606A1 (en) | 1997-04-25 | 1998-11-25 | Paul Scherrer Institut | Method for the preparation of facial metal tricarbonyl compounds and their use in the labelling of biologically active substrates |
| IT1292377B1 (it) | 1997-06-19 | 1999-02-08 | Nicox Sa | Composizioni farmaceutiche a base di prostaglandine |
| IT1292426B1 (it) | 1997-06-27 | 1999-02-08 | Nicox Sa | Sali nitrati di ace-inibitori |
| IT1301759B1 (it) | 1998-06-19 | 2000-07-07 | Nicox Sa | Sali nitrati di farmaci antiipertensivi |
| US6203991B1 (en) | 1998-08-21 | 2001-03-20 | The Regents Of The University Of Michigan | Inhibition of smooth muscle cell migration by heme oxygenase I |
| US6511971B1 (en) | 1998-10-13 | 2003-01-28 | Brown University Research Foundation | Substituted perhalogenated phthalocyanines |
| EP1123282A2 (en) | 1998-10-23 | 2001-08-16 | The Procter & Gamble Company | Fragrance pro-accords and aldehyde and ketone fragrance libraries |
| WO2000036113A2 (en) | 1998-12-17 | 2000-06-22 | Sangstat Medical Corporation | Extending graft survival by heme oxygenase-i expression induced immunomodulation |
| US6025394A (en) | 1999-01-29 | 2000-02-15 | Cell Pathways, Inc. | Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols |
| US6673908B1 (en) | 1999-02-22 | 2004-01-06 | Nuvelo, Inc. | Tumor necrosis factor receptor 2 |
| KR20010112343A (ko) | 1999-03-19 | 2001-12-20 | 추후제출 | 금속 착화합물을 포함하는 약제학적 조성물 |
| NZ514515A (en) | 1999-03-23 | 2003-11-28 | Global Cardiac Solutions Pty L | Organ arrest, protection and preservation using a potassium channel operator and/or adenosine receptor and a local anaesthetic |
| US7678390B2 (en) | 1999-04-01 | 2010-03-16 | Yale University | Carbon monoxide as a biomarker and therapeutic agent |
| IT1311924B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| US6251927B1 (en) | 1999-04-20 | 2001-06-26 | Medinox, Inc. | Methods for treatment of sickle cell anemia |
| IT1314184B1 (it) | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
| GB9920566D0 (en) | 1999-08-31 | 1999-11-03 | Univ London | Screen for axon viability |
| US7053242B1 (en) | 1999-10-05 | 2006-05-30 | Mallinckrodt Inc. | Carbon monoxide source for preparation of transition-metal-carbonyl-complexes |
| US6484747B2 (en) | 2000-04-05 | 2002-11-26 | Jerry S. Bridgers | Medical gas utility stand |
| US6518269B1 (en) | 2000-07-28 | 2003-02-11 | University Of Arizona Foundation | Cancer treatment |
| US6645938B2 (en) | 2000-10-10 | 2003-11-11 | Zymogenetics, Inc. | Protection against ischemia and reperfusion injury |
| US20040122091A1 (en) | 2000-10-11 | 2004-06-24 | Esperion Therapeutics, Inc. | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
| FR2816212A1 (fr) | 2000-11-03 | 2002-05-10 | Air Liquide Sante Int | Utilisation de monoxyde de carbone (co) dans le traitement des inflammations du systeme cardiovasculaire |
| CA2442457A1 (en) | 2001-03-30 | 2002-10-10 | Roland Buelow | Carbon monoxide generating compounds for treatment of vascular, inflammatory and immune disorders |
| ATE271871T1 (de) | 2001-04-07 | 2004-08-15 | Hans-Guenther Schmalz | Substanzen zur therapie von erkrankungen, die durch hochproliferierende zellen verursacht werden |
| GB0111872D0 (en) | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
| ITMI20010985A1 (it) | 2001-05-15 | 2002-11-15 | Nicox Sa | Farmaci per il morbo di alzheimer |
| EP1404811B1 (en) | 2001-06-21 | 2008-11-12 | Beth Israel Deaconess Medical Center, Inc. | Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis |
| US8246969B2 (en) | 2001-11-16 | 2012-08-21 | Skinmedica, Inc. | Compositions containing aromatic aldehydes and their use in treatments |
| US20030157154A1 (en) | 2002-01-04 | 2003-08-21 | Bryan Fuller | Compositions containing hydroxy aromatic aldehydes and their use in treatments |
| US7011854B2 (en) | 2002-02-04 | 2006-03-14 | Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda | Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof |
| US20080026984A1 (en) | 2002-02-04 | 2008-01-31 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
| US7968605B2 (en) | 2002-02-04 | 2011-06-28 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
| EP1474804A2 (en) | 2002-02-06 | 2004-11-10 | Koninklijke Philips Electronics N.V. | Reading circuit for reading a memory cell |
| SG148850A1 (en) | 2002-02-13 | 2009-01-29 | Beth Israel Hospital | Methods of treating vascular disease |
| AU2003212609A1 (en) | 2002-03-28 | 2003-10-13 | Firmenich Sa | Compounds for the controlled release of active aldehydes |
| US20040143025A1 (en) | 2002-04-01 | 2004-07-22 | Roland Buelow | Carbon monoxide generating compunds for treatment of vascular, inflammatory and immune disorders |
| EA200401365A1 (ru) | 2002-04-15 | 2005-04-28 | Юниверсити Оф Питтсбург Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн | Способы лечения илеуса |
| WO2003088981A1 (en) | 2002-04-15 | 2003-10-30 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods of treating necrotizing enterocolitis |
| ITMI20020960A1 (it) | 2002-05-07 | 2003-11-07 | Univ Degli Studi Milano | Aldeidi lineari poliinsature e loro derivati ad attivita' antiradicalica e antitumorale |
| BR0215717A (pt) | 2002-05-09 | 2005-02-22 | Univ Yale | Monóxido de carbono como um biomarcador e agente terapêutico |
| EA200401525A1 (ru) | 2002-05-17 | 2006-06-30 | Йейл Юниверсити | Способы лечения гепатита (варианты ) |
| JP2005532351A (ja) | 2002-06-05 | 2005-10-27 | イエール ユニバーシティ | 血管形成、腫瘍増殖、および転移を治療する方法 |
| WO2004000368A1 (en) | 2002-06-21 | 2003-12-31 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation |
| US7569214B2 (en) | 2002-09-09 | 2009-08-04 | Nektar Therapeutics Al, Corporation | Method for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid |
| JP4323271B2 (ja) | 2002-09-27 | 2009-09-02 | 花王株式会社 | バレロラクトン化合物及び香料組成物 |
| EP1558084A4 (en) | 2002-11-07 | 2008-04-30 | Univ Pittsburgh | TREATMENT OF HEMORRHAGIC SHOCK |
| GB2395432B (en) | 2002-11-20 | 2005-09-14 | Northwick Park Inst For Medica | Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs |
| GB2395431A (en) | 2002-11-20 | 2004-05-26 | Northwick Park Inst For Medica | Combination of a metal carbonyl compound and a guanylate cyclase stimulant or stabilizer for the therapeutic delivery of carbon monoxide |
| US20070207217A1 (en) | 2003-02-03 | 2007-09-06 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Method for treating a mammal by administration of a compound having the ability to release CO |
| US7670631B2 (en) | 2003-03-12 | 2010-03-02 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Method for the prevention of malaria infection of humans by hepatocyte growth factor antagonists |
| US7709534B2 (en) | 2003-04-28 | 2010-05-04 | University Of The West Indies | Method of treating strongyloides infections and medicaments therefor |
| CA2534415A1 (en) | 2003-08-04 | 2005-02-17 | Northwick Park Institute For Medical Research | Therapeutic delivery of carbon monoxide |
| WO2005090400A1 (en) | 2004-03-18 | 2005-09-29 | The University Court Of The University Of Glasgow | Immunosuppressive cytokine |
| EP1771540A4 (en) | 2004-06-24 | 2007-09-12 | Flexitral Inc | NEW ALDEHYDE MOST AND THEIR DERIVATIVES |
| US8148356B2 (en) | 2005-08-24 | 2012-04-03 | Cumberland Pharmaceuticals, Inc. | Acetylcysteine composition and uses therefor |
| US20070207993A1 (en) | 2005-12-20 | 2007-09-06 | Alfama - Investigacao E Desenvolvimetno De Productos Farmaceuticos Lda | Molybdenum carbonyl complexes for treating rheumatoid arthritis and other inflammatory diseases |
| GB0601394D0 (en) | 2006-01-24 | 2006-03-01 | Hemocorm Ltd | Therapeutic delivery of carbon monoxide |
| GB0613362D0 (en) | 2006-07-05 | 2006-08-16 | Hemocorm Ltd | Therapeutic delivery of carbon monoxide |
| EP2099439A2 (en) | 2006-12-06 | 2009-09-16 | Alfama - Investigação E Desenvolvimento De Produto | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
| WO2008130261A1 (en) | 2007-04-24 | 2008-10-30 | Alfama - Investigaçao E Desenvolvimento De Produtos Farmaceuticos Lda. | Treatment of infections by carbon monoxide |
| JP5563452B2 (ja) | 2007-07-24 | 2014-07-30 | アルファーマ−インベスティガシオ エ デセンボルビメント デ プロデュトス ファルマセウティコス エレデア． | 一酸化炭素による胃潰瘍の予防 |
| CA2792319A1 (en) * | 2010-03-08 | 2011-09-15 | University Of Zuerich | Carbon monoxide releasing rhenium compounds for medical use |
| US9163044B2 (en) | 2011-04-19 | 2015-10-20 | Alfama, Inc. | Carbon monoxide releasing molecules and uses thereof |
| ES2628634T3 (es) | 2011-07-21 | 2017-08-03 | Alfama, Inc. | Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas |
-
2012
- 2012-07-20 ES ES12815454.9T patent/ES2628634T3/es active Active
- 2012-07-20 WO PCT/US2012/047661 patent/WO2013013179A1/en not_active Ceased
- 2012-07-20 EP EP12815454.9A patent/EP2734235B1/en not_active Not-in-force
- 2012-07-20 JP JP2014521837A patent/JP6134710B2/ja not_active Expired - Fee Related
- 2012-07-21 US US14/234,024 patent/US9062089B2/en not_active Expired - Fee Related
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2015
- 2015-05-13 US US14/711,113 patent/US9611286B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014520897A (ja) | 2014-08-25 |
| WO2013013179A1 (en) | 2013-01-24 |
| US9062089B2 (en) | 2015-06-23 |
| EP2734235A4 (en) | 2015-04-08 |
| JP6134710B2 (ja) | 2017-05-24 |
| US20140219996A1 (en) | 2014-08-07 |
| EP2734235A1 (en) | 2014-05-28 |
| EP2734235B1 (en) | 2017-03-22 |
| US9611286B2 (en) | 2017-04-04 |
| US20160237105A9 (en) | 2016-08-18 |
| US20150322105A1 (en) | 2015-11-12 |
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