AR024523A1 - Metodo para aumentar la sobrevida de un injerto por modulacion de la actividad de hemo oxigenasa - Google Patents
Metodo para aumentar la sobrevida de un injerto por modulacion de la actividad de hemo oxigenasaInfo
- Publication number
- AR024523A1 AR024523A1 ARP990106547A ARP990106547A AR024523A1 AR 024523 A1 AR024523 A1 AR 024523A1 AR P990106547 A ARP990106547 A AR P990106547A AR P990106547 A ARP990106547 A AR P990106547A AR 024523 A1 AR024523 A1 AR 024523A1
- Authority
- AR
- Argentina
- Prior art keywords
- activity
- oxygenase
- heme
- oxigenasa
- hemo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Se proveen métodos con los cuales se aumenta la sobrevida de un transplante de organos por medio de la introduccion en células del transplante de unamolécula de ácido nucleico que modula la actividad de hemo oxigenasa-I en las mismas. Las moléculas de ácido nucleico que modulan la actividad de la hemo-I-oxigenasa y por lo tanto tienen utilidad en los métodos descriptos incluyen, por ejemplo, moléculas que codifican un polipéptido que presenta de por síactividad de hemo oxigenasa-I, o bien oligonucleotidos antisentido que actuan como inhibidores de la actividad de hemo-oxigenasa-I en las células.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21600598A | 1998-12-17 | 1998-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR024523A1 true AR024523A1 (es) | 2002-10-16 |
Family
ID=22805290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106547A AR024523A1 (es) | 1998-12-17 | 1999-12-17 | Metodo para aumentar la sobrevida de un injerto por modulacion de la actividad de hemo oxigenasa |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6861414B1 (es) |
| EP (1) | EP1141319A2 (es) |
| JP (1) | JP2003500335A (es) |
| AR (1) | AR024523A1 (es) |
| AU (1) | AU2366900A (es) |
| CA (1) | CA2355066A1 (es) |
| WO (1) | WO2000036113A2 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1141319A2 (en) * | 1998-12-17 | 2001-10-10 | Sangstat Medical Corporation | Extending graft survival by heme oxygenase-i expression induced immunomodulation |
| GB0111872D0 (en) * | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
| WO2002098432A1 (en) * | 2001-06-01 | 2002-12-12 | The Brigham And Women's Hospital, Inc. | Methods of treating cardiac disorders |
| US20080026984A1 (en) * | 2002-02-04 | 2008-01-31 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
| WO2003066067A2 (en) * | 2002-02-04 | 2003-08-14 | Alfama - Investigaçao E Desenvolvimento De Produtos Farmaceuticos Lda. | Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases |
| US7968605B2 (en) * | 2002-02-04 | 2011-06-28 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
| CA2482260A1 (en) * | 2002-04-15 | 2003-10-30 | Beth Israel Deaconess Medical Center Inc. | Use of heme oxygenase-1 and products of heme degradation |
| FR2842738B1 (fr) * | 2002-07-23 | 2006-02-10 | Negma Lerads | Utilisation d'une rheine pour la preparation d'un medicament pour le traitement de l'inflammation chronique, la prevention et le traitement du rejet des transplantations d'organes et de tissus |
| GB2395432B (en) * | 2002-11-20 | 2005-09-14 | Northwick Park Inst For Medica | Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs |
| GB0601394D0 (en) | 2006-01-24 | 2006-03-01 | Hemocorm Ltd | Therapeutic delivery of carbon monoxide |
| ES2656237T3 (es) | 2011-04-19 | 2018-02-26 | Alfama, Inc. | Moléculas liberadoras de monóxido de carbono y usos de las mismas |
| ES2628634T3 (es) | 2011-07-21 | 2017-08-03 | Alfama, Inc. | Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4829984A (en) | 1983-12-15 | 1989-05-16 | Gordon Robert T | Method for the improvement of transplantation techniques and for the preservation of tissue |
| US5563132A (en) | 1994-06-21 | 1996-10-08 | Bodaness; Richard S. | Two-step cancer treatment method |
| CA2132690A1 (en) | 1994-09-22 | 1996-03-23 | Dean Willis | Control and modulation of inflammatory response in humans in need of such control and modulation |
| US6013641A (en) * | 1995-09-28 | 2000-01-11 | Sangstat Medical Corporation | Use of hyaluronic acid as an immunosuppressant |
| US5756492A (en) * | 1996-09-09 | 1998-05-26 | Sangstat Medical Corporation | Graft survival prolongation with porphyrins |
| WO1999023215A2 (en) * | 1997-10-31 | 1999-05-14 | University Of Florida | Materials and methods for preventing cellular injury in humans and animals |
| AU6022999A (en) * | 1998-08-28 | 2000-03-21 | Mu-En Lee | Inhibiting cardiomyocyte death |
| EP1141319A2 (en) * | 1998-12-17 | 2001-10-10 | Sangstat Medical Corporation | Extending graft survival by heme oxygenase-i expression induced immunomodulation |
-
1999
- 1999-12-17 EP EP99967381A patent/EP1141319A2/en not_active Ceased
- 1999-12-17 AR ARP990106547A patent/AR024523A1/es unknown
- 1999-12-17 WO PCT/US1999/030089 patent/WO2000036113A2/en active Application Filing
- 1999-12-17 AU AU23669/00A patent/AU2366900A/en not_active Abandoned
- 1999-12-17 JP JP2000588362A patent/JP2003500335A/ja active Pending
- 1999-12-17 CA CA002355066A patent/CA2355066A1/en not_active Abandoned
-
2000
- 2000-02-29 US US09/515,582 patent/US6861414B1/en not_active Expired - Fee Related
-
2004
- 2004-02-18 US US10/782,260 patent/US7151090B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000036113A3 (en) | 2000-08-31 |
| WO2000036113A2 (en) | 2000-06-22 |
| AU2366900A (en) | 2000-07-03 |
| CA2355066A1 (en) | 2000-06-22 |
| EP1141319A2 (en) | 2001-10-10 |
| US7151090B2 (en) | 2006-12-19 |
| US6861414B1 (en) | 2005-03-01 |
| JP2003500335A (ja) | 2003-01-07 |
| US20040131602A1 (en) | 2004-07-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |