DE60031419D1 - Zusammensetzungen und verfahren für verbesserte zellkultur - Google Patents
Zusammensetzungen und verfahren für verbesserte zellkulturInfo
- Publication number
- DE60031419D1 DE60031419D1 DE60031419T DE60031419T DE60031419D1 DE 60031419 D1 DE60031419 D1 DE 60031419D1 DE 60031419 T DE60031419 T DE 60031419T DE 60031419 T DE60031419 T DE 60031419T DE 60031419 D1 DE60031419 D1 DE 60031419D1
- Authority
- DE
- Germany
- Prior art keywords
- cell culture
- methods
- compositions
- improved cell
- igf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004113 cell culture Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 abstract 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
- 230000014616 translation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0043—Medium free of human- or animal-derived components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/005—Protein-free medium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/105—Insulin-like growth factors [IGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15064599P | 1999-08-25 | 1999-08-25 | |
US150645P | 1999-08-25 | ||
US16894899P | 1999-12-03 | 1999-12-03 | |
US168948P | 1999-12-03 | ||
US17194999P | 1999-12-23 | 1999-12-23 | |
US171949P | 1999-12-23 | ||
PCT/US2000/023483 WO2001014529A1 (en) | 1999-08-25 | 2000-08-25 | Compositions and methods for improved cell culture |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60031419D1 true DE60031419D1 (de) | 2006-11-30 |
DE60031419T2 DE60031419T2 (de) | 2007-09-27 |
Family
ID=27387011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2000631419 Expired - Lifetime DE60031419T2 (de) | 1999-08-25 | 2000-08-25 | Zusammensetzungen und verfahren für verbesserte zellkultur |
Country Status (14)
Country | Link |
---|---|
US (3) | US6413744B1 (de) |
EP (1) | EP1210411B1 (de) |
JP (1) | JP2003507058A (de) |
AT (1) | ATE342962T1 (de) |
AU (1) | AU784506B2 (de) |
CA (1) | CA2383073A1 (de) |
CY (1) | CY1105772T1 (de) |
DE (1) | DE60031419T2 (de) |
DK (1) | DK1210411T3 (de) |
ES (1) | ES2272318T3 (de) |
IL (2) | IL148060A0 (de) |
NZ (2) | NZ529329A (de) |
PT (1) | PT1210411E (de) |
WO (1) | WO2001014529A1 (de) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6475725B1 (en) | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
US7115231B1 (en) | 1998-06-09 | 2006-10-03 | Symyx Technologies, Inc. | Parallel reactor with knife-edge seal |
AT409379B (de) | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
PT1210411E (pt) * | 1999-08-25 | 2006-12-29 | Immunex Corp | Composições e métodos para cultura celular melhorada |
IL136232A0 (en) * | 2000-05-18 | 2001-05-20 | Bar Ilan University Res Author | Measurements of enzymatic activity in a single, individual cell in population |
US6439036B1 (en) | 2000-06-13 | 2002-08-27 | Symyx Technologics, Inc. | Method for evaluating a test fluid |
US6455007B1 (en) | 2000-06-13 | 2002-09-24 | Symyx Technologies, Inc. | Apparatus and method for testing compositions in contact with a porous medium |
US7018589B1 (en) | 2000-07-19 | 2006-03-28 | Symyx Technologies, Inc. | High pressure parallel reactor |
US7091004B1 (en) | 2001-06-08 | 2006-08-15 | Immunex Corporation | Regulation of translation for recombinant protein production |
US20050271663A1 (en) * | 2001-06-28 | 2005-12-08 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
US20060073141A1 (en) * | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
ES2344070T3 (es) * | 2001-07-04 | 2010-08-17 | Chromagenics B.V. | Secuencias de adn con actividad anti-represora. |
EP1438385A1 (de) * | 2001-10-25 | 2004-07-21 | Bar-Ilan University | Interaktiver transparenter biochip-prozessor für einzeln adressierbare zellen |
US20030166147A1 (en) * | 2001-12-14 | 2003-09-04 | Lee Chichang | Clonal myeloma cell lines useful for manufacturing proteins in chemically defined media |
EP1520008B1 (de) | 2002-07-09 | 2012-09-05 | Baxter International Inc. | Tierproteinfreies zellkulturmedium |
EP1572994B1 (de) * | 2002-12-20 | 2007-02-21 | Chromagenics B.V. | Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können |
IL154677A0 (en) * | 2003-02-27 | 2003-09-17 | Univ Bar Ilan | A method and apparatus for manipulating an individual cell |
US7888110B2 (en) * | 2003-06-26 | 2011-02-15 | Seng Enterprises Ltd. | Pico liter well holding device and method of making the same |
US9200245B2 (en) | 2003-06-26 | 2015-12-01 | Seng Enterprises Ltd. | Multiwell plate |
US8597597B2 (en) * | 2003-06-26 | 2013-12-03 | Seng Enterprises Ltd. | Picoliter well holding device and method of making the same |
WO2004113492A1 (en) * | 2003-06-26 | 2004-12-29 | Molecular Cytomics Ltd. | Improved materials for constructing cell-chips, cell-chip covers, cell-chip coats, processed cell-chips and uses thereof |
US7982751B2 (en) * | 2003-07-11 | 2011-07-19 | The University Of North Carolina | Methods and systems for controlling a computer using a video image and for combining the video image with a computer desktop |
US20050064524A1 (en) * | 2003-08-11 | 2005-03-24 | Mordechai Deutsch | Population of cells utilizable for substance detection and methods and devices using same |
JP2007520546A (ja) * | 2004-02-03 | 2007-07-26 | ケマジス リミティド | モンテルカストナトリウムの安定な非晶質性形態 |
US7403647B2 (en) * | 2004-09-13 | 2008-07-22 | Seng Enterprises Ltd. | Method for identifying an image of a well in an image of a well-bearing component |
EP1763665A1 (de) * | 2004-07-07 | 2007-03-21 | Seng Enterprises Limited | Verfahren und vorrichtung zur identifizierung eines vertiefungsbildes auf einem bild einer komponente mit vertiefungen |
US20080009051A1 (en) * | 2004-08-25 | 2008-01-10 | Seng Enterprises Ltd. | Method and Device for Isolating Cells |
EP1833961B1 (de) * | 2004-10-15 | 2011-07-20 | Monell Chemical Senses Center | Verfahren zur kultivierung von geschmackszellen aus säugern |
US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
JP5291341B2 (ja) * | 2004-11-08 | 2013-09-18 | クロマジェニックス ベー ヴェー | タンパク質を高レベルで発現する宿主細胞の選定 |
US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US8999667B2 (en) * | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US20100136616A1 (en) * | 2004-11-08 | 2010-06-03 | Chromagenics B.V. | Selection of Host Cells Expressing Protein at High Levels |
SI1809750T1 (sl) | 2004-11-08 | 2012-08-31 | Chromagenics Bv | Izbira gostiteljskih celic, ki imajo visok nivo izraĹľanja proteina |
ES2352344T3 (es) * | 2005-01-25 | 2011-02-17 | Seng Enterprises Limited | Dispositivo de microfluido para estudio de células. |
EP1844068A4 (de) * | 2005-01-25 | 2009-09-30 | Apollo Life Sciences Ltd | Moleküle und chimere moleküle davon |
EP1707634A1 (de) | 2005-03-29 | 2006-10-04 | Octapharma AG | Verfahren zur Isolierung von rekombinant hergestellten Proteinen |
US20060232821A1 (en) * | 2005-04-15 | 2006-10-19 | Sridharan Ranganathan | Parallel architecture for vector color error diffusion |
WO2007002210A2 (en) * | 2005-06-20 | 2007-01-04 | Bresagen, Inc. | Embryonic stem cell culture compositions and methods of use thereof |
EP1739179A1 (de) | 2005-06-30 | 2007-01-03 | Octapharma AG | Serumfreie stabile Transfektion und Produktion von rekombinanten humanen Proteinen in humanen Zelllinien |
DE102005034043B4 (de) * | 2005-07-18 | 2019-12-12 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Gemisch, enthaltend L-Carnitin und Trehalulose, sowie Produkt enthaltend das Gemisch |
US20070141555A1 (en) * | 2005-10-11 | 2007-06-21 | Mordechai Deutsch | Current damper for the study of cells |
WO2007052245A1 (en) * | 2005-11-03 | 2007-05-10 | Seng Enterprises Ltd. | Method and device for studying floating, living cells |
PL3121266T3 (pl) | 2006-01-04 | 2020-07-13 | Baxalta Incorporated | Wolne od oligopeptydów pożywki do hodowli komórkowej |
US20060223999A1 (en) * | 2006-05-10 | 2006-10-05 | Chemagis Ltd. | Process for preparing montelukast and precursors thereof |
US7655191B2 (en) | 2007-05-14 | 2010-02-02 | Symyx Solutions, Inc. | Methods for chemical reactions in a parallel batch reactor |
US7807109B2 (en) | 2007-05-14 | 2010-10-05 | Freeslate, Inc. | Parallel batch reactor with pressure monitoring |
CA2683801A1 (en) * | 2007-06-06 | 2008-12-11 | Domantis Limited | Polypeptides, antibody variable domains and antagonists |
AU2008271657A1 (en) * | 2007-06-29 | 2009-01-08 | F. Hoffmann-La Roche Ag | CHO cell |
EP2207881A1 (de) * | 2007-10-12 | 2010-07-21 | F. Hoffmann-Roche AG | Proteinexpression aus mehreren nukleinsäuren |
US9145540B1 (en) | 2007-11-15 | 2015-09-29 | Seng Enterprises Ltd. | Device for the study of living cells |
US9975118B2 (en) | 2007-11-15 | 2018-05-22 | Seng Enterprises Ltd. | Device for the study of living cells |
WO2009115495A1 (de) * | 2008-03-19 | 2009-09-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Methode zur steigerung der reklonierungseffizienz |
CA2737580A1 (en) * | 2008-09-26 | 2010-04-01 | Schering Corporation | High titer antibody production |
JP2013512674A (ja) * | 2009-12-02 | 2013-04-18 | アクセルロン ファーマ, インコーポレイテッド | Fc融合タンパク質の血清半減期を増加させるための組成物および方法 |
CA2826158A1 (en) | 2011-02-07 | 2012-08-16 | Rose ACKERMANN | Lipoprotein complexes and manufacturing and uses thereof |
EP2718328A4 (de) | 2011-06-08 | 2014-12-24 | Acceleron Pharma Inc | Zusammensetzungen und verfahren zur erhöhung der halbwertszeit von serum |
WO2014062535A1 (en) | 2012-10-15 | 2014-04-24 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
WO2015010088A1 (en) * | 2013-07-19 | 2015-01-22 | Technical University Of Denmark | Methods for modeling chinese hamster ovary (cho) cell metabolism |
US9644032B2 (en) | 2015-05-29 | 2017-05-09 | Bristol-Myers Squibb Company | Antibodies against OX40 and uses thereof |
CN113493770A (zh) * | 2020-03-18 | 2021-10-12 | 苏州大学 | 人源glut5稳定转染细胞株及其在筛选glut5抑制剂中的应用 |
JP2024503239A (ja) | 2020-12-22 | 2024-01-25 | アムジェン インコーポレイテッド | 細胞培養法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL87737A (en) | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
WO1991003554A1 (en) * | 1989-09-01 | 1991-03-21 | Genentech, Inc. | Cells transfected with nucleic acid encoding gtp |
US5605690A (en) | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
US5283173A (en) * | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
EP0496453A1 (de) | 1991-01-23 | 1992-07-29 | Merck & Co. Inc. | Menschlicher glut4 Genpromotor |
US5262308A (en) * | 1992-01-28 | 1993-11-16 | Thomas Jefferson University | Cell lines which constitutively express IGF-1 and IGF-1 R |
WO1993020200A1 (en) | 1992-04-02 | 1993-10-14 | Imperial Cancer Research Technology Limited | Modified cells and method of treatment |
US5663314A (en) | 1992-11-20 | 1997-09-02 | The Board Of Regents Of The University Of Washington | Human signal transduction MAPK kinase |
EP0666312A1 (de) | 1994-02-08 | 1995-08-09 | Wolfgang A. Renner | Verfahren zur Förderung des Wachstums von Säugetierzellen |
US5597719A (en) * | 1994-07-14 | 1997-01-28 | Onyx Pharmaceuticals, Inc. | Interaction of RAF-1 and 14-3-3 proteins |
AUPN442295A0 (en) | 1995-07-26 | 1995-08-17 | Commonwealth Scientific And Industrial Research Organisation | Regulated autocrine growth of mammalian cells |
CN1276832A (zh) | 1997-09-26 | 2000-12-13 | 昂尼克斯药物公司 | 鉴定pkb激酶抑制剂的组合物及方法 |
PT1210411E (pt) * | 1999-08-25 | 2006-12-29 | Immunex Corp | Composições e métodos para cultura celular melhorada |
-
2000
- 2000-08-25 PT PT00959455T patent/PT1210411E/pt unknown
- 2000-08-25 AU AU70778/00A patent/AU784506B2/en not_active Ceased
- 2000-08-25 CA CA 2383073 patent/CA2383073A1/en not_active Abandoned
- 2000-08-25 DE DE2000631419 patent/DE60031419T2/de not_active Expired - Lifetime
- 2000-08-25 DK DK00959455T patent/DK1210411T3/da active
- 2000-08-25 WO PCT/US2000/023483 patent/WO2001014529A1/en active IP Right Grant
- 2000-08-25 IL IL14806000A patent/IL148060A0/xx unknown
- 2000-08-25 US US09/648,667 patent/US6413744B1/en not_active Expired - Lifetime
- 2000-08-25 NZ NZ529329A patent/NZ529329A/en unknown
- 2000-08-25 EP EP00959455A patent/EP1210411B1/de not_active Expired - Lifetime
- 2000-08-25 JP JP2001518843A patent/JP2003507058A/ja active Pending
- 2000-08-25 NZ NZ517215A patent/NZ517215A/en unknown
- 2000-08-25 ES ES00959455T patent/ES2272318T3/es not_active Expired - Lifetime
- 2000-08-25 AT AT00959455T patent/ATE342962T1/de not_active IP Right Cessation
-
2002
- 2002-02-06 IL IL148060A patent/IL148060A/en not_active IP Right Cessation
- 2002-03-29 US US10/109,971 patent/US6897040B2/en not_active Expired - Lifetime
-
2005
- 2005-02-28 US US11/069,122 patent/US7166445B2/en not_active Expired - Lifetime
-
2006
- 2006-11-13 CY CY20061101630T patent/CY1105772T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2272318T3 (es) | 2007-05-01 |
DE60031419T2 (de) | 2007-09-27 |
ATE342962T1 (de) | 2006-11-15 |
PT1210411E (pt) | 2006-12-29 |
WO2001014529A9 (en) | 2002-09-06 |
EP1210411B1 (de) | 2006-10-18 |
US7166445B2 (en) | 2007-01-23 |
IL148060A0 (en) | 2002-09-12 |
IL148060A (en) | 2009-07-20 |
CA2383073A1 (en) | 2001-03-01 |
NZ517215A (en) | 2004-01-30 |
AU784506B2 (en) | 2006-04-13 |
US6413744B1 (en) | 2002-07-02 |
CY1105772T1 (el) | 2011-02-02 |
US6897040B2 (en) | 2005-05-24 |
WO2001014529A1 (en) | 2001-03-01 |
NZ529329A (en) | 2005-06-24 |
US20050170462A1 (en) | 2005-08-04 |
US20020160455A1 (en) | 2002-10-31 |
JP2003507058A (ja) | 2003-02-25 |
DK1210411T3 (da) | 2007-02-19 |
AU7077800A (en) | 2001-03-19 |
EP1210411A1 (de) | 2002-06-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: IMMUNEX CORP., THOUSAND OAKS, CALIF., US |
|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: DF-MP, 80333 MUENCHEN |