ES2598140T3 - Procedimiento para la preparación de sales cuaternarias de alcaloides de N-alquil morfinano - Google Patents

Procedimiento para la preparación de sales cuaternarias de alcaloides de N-alquil morfinano Download PDF

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Publication number
ES2598140T3
ES2598140T3 ES09013952.8T ES09013952T ES2598140T3 ES 2598140 T3 ES2598140 T3 ES 2598140T3 ES 09013952 T ES09013952 T ES 09013952T ES 2598140 T3 ES2598140 T3 ES 2598140T3
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ES
Spain
Prior art keywords
naltrexone
solvent
positions
substituted
methobromide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09013952.8T
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English (en)
Spanish (es)
Inventor
Peter X Wang
Robert E Halvachs
Kevin R Roesch
Henry J Buehler
Joseph P Haar
Gary L Cantrell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt LLC
Original Assignee
Mallinckrodt LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt LLC filed Critical Mallinckrodt LLC
Application granted granted Critical
Publication of ES2598140T3 publication Critical patent/ES2598140T3/es
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
ES09013952.8T 2007-03-06 2008-03-06 Procedimiento para la preparación de sales cuaternarias de alcaloides de N-alquil morfinano Active ES2598140T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US89316307P 2007-03-06 2007-03-06
US893163P 2007-03-06
US95324807P 2007-08-01 2007-08-01
US953248P 2007-08-01

Publications (1)

Publication Number Publication Date
ES2598140T3 true ES2598140T3 (es) 2017-01-25

Family

ID=39720102

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09013952.8T Active ES2598140T3 (es) 2007-03-06 2008-03-06 Procedimiento para la preparación de sales cuaternarias de alcaloides de N-alquil morfinano
ES08726581.5T Active ES2540534T3 (es) 2007-03-06 2008-03-06 Procedimiento para la preparación de sales cuaternarias de alcaloides de N-alquil morfinano

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES08726581.5T Active ES2540534T3 (es) 2007-03-06 2008-03-06 Procedimiento para la preparación de sales cuaternarias de alcaloides de N-alquil morfinano

Country Status (10)

Country Link
US (1) US8669366B2 (enExample)
EP (2) EP2147920B1 (enExample)
JP (5) JP5875748B2 (enExample)
CN (1) CN101781303A (enExample)
AU (2) AU2008223328B2 (enExample)
CA (2) CA2707757C (enExample)
ES (2) ES2598140T3 (enExample)
NZ (2) NZ580536A (enExample)
PL (2) PL2137189T3 (enExample)
WO (1) WO2008109156A2 (enExample)

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PL2137189T3 (pl) * 2007-03-06 2015-12-31 SpecGx LLC Sposób wytwarzania czwartorzędowych N-alkilowych soli alkaloidu morfinanowego
EP2134718A2 (en) * 2007-03-29 2009-12-23 Progenics Pharmaceuticals, Inc. Crystal forms of (r)-n-methylnaltrexone bromide and uses thereof
WO2009009292A2 (en) * 2007-07-11 2009-01-15 Mallinckrodt Inc. Crystalline forms of naltrexone methobromide
CA2713568C (en) * 2008-02-06 2016-09-20 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
UA102128C2 (en) 2008-12-05 2013-06-10 Х. Луннбек А/С Nalmefene hydrochloride dihydrate
TWI630208B (zh) 2008-12-08 2018-07-21 歐陸斯迪公司 二氫羥戊甲嗎啡
CN102325776A (zh) * 2009-02-23 2012-01-18 马林克罗特公司 (+)-吗啡喃*季盐及其制备方法
WO2010121369A1 (en) 2009-04-24 2010-10-28 Brock University Processes for the preparation of morphinane and morphinone compounds
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN101845047B (zh) * 2009-12-31 2011-12-07 南京臣功制药有限公司 一种溴甲基纳曲酮的制备方法
WO2011154826A1 (en) 2010-06-11 2011-12-15 Rhodes Technologies Process for n-dealkylation of tertiary amines
ES2645725T3 (es) 2010-06-11 2017-12-07 Rhodes Technologies Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
CN102558188B (zh) * 2010-12-17 2014-07-23 北大方正集团有限公司 一种溴甲纳曲酮的制备方法
GB201309654D0 (en) 2013-05-30 2013-07-17 Euro Celtique Sa Method
EP3077398B1 (en) 2013-12-05 2020-03-11 The University of Bath Novel opioid compounds and their uses
CN103626782B (zh) * 2013-12-13 2016-07-13 山东新华制药股份有限公司 溴甲纳曲酮的制备方法
EP3094634A1 (en) * 2014-01-15 2016-11-23 Rhodes Technologies Process for improved oxycodone synthesis
CN105753874A (zh) * 2014-12-15 2016-07-13 北大方正集团有限公司 一种Delta-7甲基纳曲酮甲酸盐及其制备方法
CN105753875A (zh) * 2014-12-15 2016-07-13 北大方正集团有限公司 一种乙酰化Delta-7甲基纳曲酮甲酸盐及其制备方法
CN105777766B (zh) * 2014-12-15 2017-11-24 北大方正集团有限公司 Delta‑7溴甲纳曲酮的制备方法
CN106317064B (zh) * 2015-06-30 2018-06-19 北大方正集团有限公司 溴甲纳曲酮的制备方法
CN116103348A (zh) * 2018-03-16 2023-05-12 江苏瑞科医药科技有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法

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Also Published As

Publication number Publication date
JP5957180B2 (ja) 2016-07-27
EP2147920B1 (en) 2016-08-31
EP2147920A3 (en) 2010-03-24
EP2137189A2 (en) 2009-12-30
CA2707757A1 (en) 2008-09-12
NZ579469A (en) 2011-02-25
PL2137189T3 (pl) 2015-12-31
JP2015052019A (ja) 2015-03-19
CN101781303A (zh) 2010-07-21
AU2009227892B2 (en) 2012-09-27
US8669366B2 (en) 2014-03-11
CA2680205A1 (en) 2008-09-12
WO2008109156A3 (en) 2008-11-20
CA2707757C (en) 2017-01-03
JP2011098988A (ja) 2011-05-19
WO2008109156A2 (en) 2008-09-12
AU2009227892A1 (en) 2009-11-12
EP2147920A2 (en) 2010-01-27
JP5875748B2 (ja) 2016-03-02
CA2680205C (en) 2015-06-30
AU2008223328A1 (en) 2008-09-12
JP2010520288A (ja) 2010-06-10
ES2540534T3 (es) 2015-07-10
PL2147920T3 (pl) 2017-02-28
NZ580536A (en) 2010-11-26
JP2013216687A (ja) 2013-10-24
US20110082297A1 (en) 2011-04-07
AU2008223328B2 (en) 2012-10-11
JP2016210815A (ja) 2016-12-15
EP2137189B1 (en) 2015-05-06

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