NZ580536A - Process for the preparation of quaternary N-alkyl morphinan alkaloid salts - Google Patents

Process for the preparation of quaternary N-alkyl morphinan alkaloid salts

Info

Publication number
NZ580536A
NZ580536A NZ580536A NZ58053608A NZ580536A NZ 580536 A NZ580536 A NZ 580536A NZ 580536 A NZ580536 A NZ 580536A NZ 58053608 A NZ58053608 A NZ 58053608A NZ 580536 A NZ580536 A NZ 580536A
Authority
NZ
New Zealand
Prior art keywords
tertiary
derivative
hydroxy
protected
naltrexone
Prior art date
Application number
NZ580536A
Other languages
English (en)
Inventor
Peter X Wang
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Priority to NZ579469A priority Critical patent/NZ579469A/en
Publication of NZ580536A publication Critical patent/NZ580536A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
NZ580536A 2007-03-06 2008-03-06 Process for the preparation of quaternary N-alkyl morphinan alkaloid salts NZ580536A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ579469A NZ579469A (en) 2007-03-06 2008-03-06 Process for the preparation of quaternary n-alkyl morphinan alkaloid salts

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89316307P 2007-03-06 2007-03-06
US95324807P 2007-08-01 2007-08-01

Publications (1)

Publication Number Publication Date
NZ580536A true NZ580536A (en) 2010-11-26

Family

ID=39720102

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ580536A NZ580536A (en) 2007-03-06 2008-03-06 Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
NZ579469A NZ579469A (en) 2007-03-06 2008-03-06 Process for the preparation of quaternary n-alkyl morphinan alkaloid salts

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ579469A NZ579469A (en) 2007-03-06 2008-03-06 Process for the preparation of quaternary n-alkyl morphinan alkaloid salts

Country Status (10)

Country Link
US (1) US8669366B2 (enExample)
EP (2) EP2147920B1 (enExample)
JP (5) JP5875748B2 (enExample)
CN (1) CN101781303A (enExample)
AU (2) AU2008223328B2 (enExample)
CA (2) CA2707757C (enExample)
ES (2) ES2598140T3 (enExample)
NZ (2) NZ580536A (enExample)
PL (2) PL2137189T3 (enExample)
WO (1) WO2008109156A2 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2137189T3 (pl) * 2007-03-06 2015-12-31 SpecGx LLC Sposób wytwarzania czwartorzędowych N-alkilowych soli alkaloidu morfinanowego
EP2134718A2 (en) * 2007-03-29 2009-12-23 Progenics Pharmaceuticals, Inc. Crystal forms of (r)-n-methylnaltrexone bromide and uses thereof
WO2009009292A2 (en) * 2007-07-11 2009-01-15 Mallinckrodt Inc. Crystalline forms of naltrexone methobromide
CA2713568C (en) * 2008-02-06 2016-09-20 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
UA102128C2 (en) 2008-12-05 2013-06-10 Х. Луннбек А/С Nalmefene hydrochloride dihydrate
TWI630208B (zh) 2008-12-08 2018-07-21 歐陸斯迪公司 二氫羥戊甲嗎啡
CN102325776A (zh) * 2009-02-23 2012-01-18 马林克罗特公司 (+)-吗啡喃*季盐及其制备方法
WO2010121369A1 (en) 2009-04-24 2010-10-28 Brock University Processes for the preparation of morphinane and morphinone compounds
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN101845047B (zh) * 2009-12-31 2011-12-07 南京臣功制药有限公司 一种溴甲基纳曲酮的制备方法
WO2011154826A1 (en) 2010-06-11 2011-12-15 Rhodes Technologies Process for n-dealkylation of tertiary amines
ES2645725T3 (es) 2010-06-11 2017-12-07 Rhodes Technologies Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
CN102558188B (zh) * 2010-12-17 2014-07-23 北大方正集团有限公司 一种溴甲纳曲酮的制备方法
GB201309654D0 (en) 2013-05-30 2013-07-17 Euro Celtique Sa Method
EP3077398B1 (en) 2013-12-05 2020-03-11 The University of Bath Novel opioid compounds and their uses
CN103626782B (zh) * 2013-12-13 2016-07-13 山东新华制药股份有限公司 溴甲纳曲酮的制备方法
EP3094634A1 (en) * 2014-01-15 2016-11-23 Rhodes Technologies Process for improved oxycodone synthesis
CN105753874A (zh) * 2014-12-15 2016-07-13 北大方正集团有限公司 一种Delta-7甲基纳曲酮甲酸盐及其制备方法
CN105753875A (zh) * 2014-12-15 2016-07-13 北大方正集团有限公司 一种乙酰化Delta-7甲基纳曲酮甲酸盐及其制备方法
CN105777766B (zh) * 2014-12-15 2017-11-24 北大方正集团有限公司 Delta‑7溴甲纳曲酮的制备方法
CN106317064B (zh) * 2015-06-30 2018-06-19 北大方正集团有限公司 溴甲纳曲酮的制备方法
CN116103348A (zh) * 2018-03-16 2023-05-12 江苏瑞科医药科技有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3101339A (en) * 1958-10-30 1963-08-20 Boehringer Sohn Ingelheim Quaternary salts of normorphine and its acylated derivatives
US4141897A (en) * 1976-12-20 1979-02-27 Research Corporation N-dealkylation of N-alkyl-14-hydroxymorphinans and derivatives thereof
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
FR2469413B1 (fr) 1979-11-13 1986-04-25 Urpha Derives de la 6h-dibenzo(a,g) 5,8,13,13a-tetrahydroquinolizine, procede d'obtention et compositions pharmaceutiques les contenant
US4322426A (en) * 1980-04-28 1982-03-30 E. I. Du Pont De Nemours And Company 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists
US4727146A (en) * 1980-07-03 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Synthesis of chiral 1-benzyl-1,2,3,4-tetra-hydroisoquinolines by asymmetric reduction
US4556712A (en) * 1981-05-20 1985-12-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines
US4368326A (en) * 1980-07-03 1983-01-11 Rice Kenner C Short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydroccodeinone
US4410700A (en) * 1980-07-03 1983-10-18 The United States Of America As Represented By The Department Of Health And Human Services Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution
US4521601A (en) * 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
US4535157A (en) * 1983-11-01 1985-08-13 Key Pharmaceuticals, Inc. Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone
JPS60132983A (ja) * 1983-12-21 1985-07-16 Tanabe Seiyaku Co Ltd チアゾ−ル酢酸誘導体及びその製法
US4613668A (en) * 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
US5352780A (en) * 1989-07-20 1994-10-04 Ecosorb International, Inc. Absorbent material and litter from ground cellulose
DE4132159A1 (de) * 1991-09-27 1993-04-01 Boehringer Ingelheim Kg 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5574159A (en) 1992-02-03 1996-11-12 Delta Pharmaceuticals, Inc. Opioid compounds and methods for making therefor
US5352680A (en) 1992-07-15 1994-10-04 Regents Of The University Of Minnesota Delta opioid receptor antagonists to block opioid agonist tolerance and dependence
WO1994008599A1 (en) * 1992-10-14 1994-04-28 The Regents Of The University Of Colorado Ion-pairing of drugs for improved efficacy and delivery
DE4333892A1 (de) * 1993-10-05 1995-04-06 Brose Fahrzeugteile Manuell betätigbare mechanische Memory-Vorrichtung
SE9401728D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds II
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
US5756851A (en) * 1996-10-21 1998-05-26 Albemarle Corporation Production of nabumetone or precursors thereof
ES2215158T3 (es) * 1996-11-25 2004-10-01 Toray Industries, Inc. Agente antipruritico.
ES2121554B1 (es) 1996-12-23 1999-06-16 Univ Santiago Compostela Procedimiento de obtencion de 14-hidroximofinonas mediante fotooxidac ion de alcaloides morfinicos con sistema alcoxidienico en el anillo c.
GB9713703D0 (en) * 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
ES2172376B1 (es) 2000-01-28 2003-11-16 Servier Lab Nuevos derivados de isoquinoleinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
DE10229842A1 (de) * 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
AU2003272642B2 (en) * 2002-09-25 2009-07-09 Euro-Celtique S.A. N-substituted hydromorphones and the use thereof
WO2004043964A2 (en) * 2002-11-08 2004-05-27 Mallinckrodt Inc. Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
HRP20080618T3 (hr) * 2004-02-06 2009-01-31 Euro-Celtique S.A. Postupci za pripravljanje 3-o-zaštićenih morfinona i 3-o-zaštićenih morfinon dienol karboksilata
WO2006084389A1 (de) * 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
AR057035A1 (es) * 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) * 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
DE602006019246D1 (de) * 2005-06-16 2011-02-10 Mallinckrodt Inc Synthetische route zu 14-hydroxylopiaten über 1-halogenthebain oder analoga
CA2670136A1 (en) * 2006-11-22 2008-05-29 Progenics Pharmaceuticals, Inc. 7,8-saturated-4,5-epoxy-morphinanium analogs
PL2137189T3 (pl) * 2007-03-06 2015-12-31 SpecGx LLC Sposób wytwarzania czwartorzędowych N-alkilowych soli alkaloidu morfinanowego

Also Published As

Publication number Publication date
JP5957180B2 (ja) 2016-07-27
EP2147920B1 (en) 2016-08-31
EP2147920A3 (en) 2010-03-24
EP2137189A2 (en) 2009-12-30
CA2707757A1 (en) 2008-09-12
NZ579469A (en) 2011-02-25
PL2137189T3 (pl) 2015-12-31
ES2598140T3 (es) 2017-01-25
JP2015052019A (ja) 2015-03-19
CN101781303A (zh) 2010-07-21
AU2009227892B2 (en) 2012-09-27
US8669366B2 (en) 2014-03-11
CA2680205A1 (en) 2008-09-12
WO2008109156A3 (en) 2008-11-20
CA2707757C (en) 2017-01-03
JP2011098988A (ja) 2011-05-19
WO2008109156A2 (en) 2008-09-12
AU2009227892A1 (en) 2009-11-12
EP2147920A2 (en) 2010-01-27
JP5875748B2 (ja) 2016-03-02
CA2680205C (en) 2015-06-30
AU2008223328A1 (en) 2008-09-12
JP2010520288A (ja) 2010-06-10
ES2540534T3 (es) 2015-07-10
PL2147920T3 (pl) 2017-02-28
JP2013216687A (ja) 2013-10-24
US20110082297A1 (en) 2011-04-07
AU2008223328B2 (en) 2012-10-11
JP2016210815A (ja) 2016-12-15
EP2137189B1 (en) 2015-05-06

Similar Documents

Publication Publication Date Title
AU2008223328B2 (en) Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
US9415044B2 (en) Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
JP2010520288A5 (enExample)
EP1562953B1 (en) Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
AU2009300390B2 (en) Processes for the production of buprenorphine with reduced impurity formation
EP2344506B1 (en) Processes for the alkylation of secondary amine groups of morphinan derivatives
WO2010096788A1 (en) (+)-morphinanium quaternary salts and processes for their production
EP2342207B1 (en) Processes for the alkylation of norbuprenorphine with reduced impurity formation
AU2009300384B2 (en) Processes for increasing the yield of opiate alkaloid derivatives
CN101646675A (zh) 季n-烷基吗啡喃生物碱盐的制备方法
EP2344508B1 (en) Processes for the synthesis of opiate alkaloids with reduced impurity formation
AU2014348256B2 (en) Preparation of normorphinans

Legal Events

Date Code Title Description
PSEA Patent sealed