ES2529453T3 - Nuevas composiciones de liposomas - Google Patents
Nuevas composiciones de liposomas Download PDFInfo
- Publication number
- ES2529453T3 ES2529453T3 ES06737793.7T ES06737793T ES2529453T3 ES 2529453 T3 ES2529453 T3 ES 2529453T3 ES 06737793 T ES06737793 T ES 06737793T ES 2529453 T3 ES2529453 T3 ES 2529453T3
- Authority
- ES
- Spain
- Prior art keywords
- phosphatidyl ethanolamine
- derivatized
- dicarboxylic acid
- lipid
- liposome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000002502 liposome Substances 0.000 title claims abstract description 691
- 239000000203 mixture Substances 0.000 title claims description 439
- 150000002632 lipids Chemical class 0.000 claims abstract description 624
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims abstract description 506
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims abstract description 447
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 350
- 239000003814 drug Substances 0.000 claims abstract description 276
- 229940079593 drug Drugs 0.000 claims abstract description 268
- 230000008685 targeting Effects 0.000 claims abstract description 209
- 235000012000 cholesterol Nutrition 0.000 claims abstract description 175
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 174
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims abstract description 147
- 150000001875 compounds Chemical class 0.000 claims abstract description 123
- 239000003446 ligand Substances 0.000 claims abstract description 99
- 125000002252 acyl group Chemical group 0.000 claims abstract description 75
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 61
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 53
- 150000001841 cholesterols Chemical class 0.000 claims abstract description 32
- -1 vinrodisin Chemical compound 0.000 claims description 165
- 238000000034 method Methods 0.000 claims description 148
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- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims description 122
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- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims description 65
- 238000004519 manufacturing process Methods 0.000 claims description 65
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 64
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- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims description 37
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 21
- 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 21
- 235000019152 folic acid Nutrition 0.000 claims description 19
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
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- Chemical & Material Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005067469A JP2006248978A (ja) | 2005-03-10 | 2005-03-10 | 新規なリポソーム製剤 |
| JP2005067469 | 2005-03-10 | ||
| PCT/US2006/008650 WO2006099169A2 (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions |
Publications (1)
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|---|---|
| ES2529453T3 true ES2529453T3 (es) | 2015-02-20 |
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| ES06737793.7T Active ES2529453T3 (es) | 2005-03-10 | 2006-03-08 | Nuevas composiciones de liposomas |
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- 2005-03-10 JP JP2005067469A patent/JP2006248978A/ja active Pending
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2006
- 2006-03-08 ES ES06737793.7T patent/ES2529453T3/es active Active
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- 2006-03-08 EP EP06737793.7A patent/EP1863448B1/en active Active
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| MX2007010996A (es) | 2007-11-07 |
| HUE024290T2 (en) | 2016-01-28 |
| AU2006223329A1 (en) | 2006-09-21 |
| JP5438317B2 (ja) | 2014-03-12 |
| RU2454229C2 (ru) | 2012-06-27 |
| CN101170995A (zh) | 2008-04-30 |
| NO20075136L (no) | 2007-12-07 |
| EP1863448B1 (en) | 2014-11-26 |
| EP1863448A2 (en) | 2007-12-12 |
| WO2006099169A3 (en) | 2007-02-22 |
| SI1863448T1 (sl) | 2015-03-31 |
| CA2600446A1 (en) | 2006-09-21 |
| AU2006223329B2 (en) | 2011-11-17 |
| CY1116075T1 (el) | 2017-02-08 |
| JP2008538105A (ja) | 2008-10-09 |
| CN101170995B (zh) | 2013-01-16 |
| WO2006099169A2 (en) | 2006-09-21 |
| NZ561569A (en) | 2011-03-31 |
| ZA200708600B (en) | 2009-01-28 |
| BRPI0608297A2 (pt) | 2009-12-08 |
| JP2006248978A (ja) | 2006-09-21 |
| US7829113B2 (en) | 2010-11-09 |
| US8758810B2 (en) | 2014-06-24 |
| RU2007137492A (ru) | 2009-04-20 |
| DK1863448T3 (en) | 2015-02-16 |
| KR101352490B1 (ko) | 2014-02-04 |
| US20110081404A1 (en) | 2011-04-07 |
| PT1863448E (pt) | 2015-02-10 |
| PL1863448T3 (pl) | 2015-05-29 |
| HK1111625A1 (en) | 2008-08-15 |
| KR20080002819A (ko) | 2008-01-04 |
| US20060222696A1 (en) | 2006-10-05 |
| US20140363491A1 (en) | 2014-12-11 |
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