JP2006248978A - 新規なリポソーム製剤 - Google Patents
新規なリポソーム製剤 Download PDFInfo
- Publication number
- JP2006248978A JP2006248978A JP2005067469A JP2005067469A JP2006248978A JP 2006248978 A JP2006248978 A JP 2006248978A JP 2005067469 A JP2005067469 A JP 2005067469A JP 2005067469 A JP2005067469 A JP 2005067469A JP 2006248978 A JP2006248978 A JP 2006248978A
- Authority
- JP
- Japan
- Prior art keywords
- liposome preparation
- preparation according
- liposome
- dicarboxylic acid
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002502 liposome Substances 0.000 title claims abstract description 157
- 238000002360 preparation method Methods 0.000 title claims abstract description 57
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims abstract description 35
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims abstract description 35
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 32
- 239000003446 ligand Substances 0.000 claims abstract description 25
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 22
- 235000012000 cholesterol Nutrition 0.000 claims abstract description 16
- 239000003814 drug Substances 0.000 claims description 33
- 102000004338 Transferrin Human genes 0.000 claims description 32
- 108090000901 Transferrin Proteins 0.000 claims description 32
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- 229940079593 drug Drugs 0.000 claims description 27
- 229960001756 oxaliplatin Drugs 0.000 claims description 22
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims description 22
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 18
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- 229930006000 Sucrose Natural products 0.000 claims description 13
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 13
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- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims description 6
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- NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (25)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005067469A JP2006248978A (ja) | 2005-03-10 | 2005-03-10 | 新規なリポソーム製剤 |
| RU2007137492/15A RU2454229C2 (ru) | 2005-03-10 | 2006-03-08 | Новые композиции липосом |
| JP2008500977A JP5438317B2 (ja) | 2005-03-10 | 2006-03-08 | 新規リポソーム組成物 |
| NZ561569A NZ561569A (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions comprising SuccNomegaPE:NomegaPE:additional lipids and TF-NomegaPE:NomegaPE:additional lipids |
| AU2006223329A AU2006223329B2 (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions |
| US11/371,586 US7829113B2 (en) | 2005-03-10 | 2006-03-08 | Liposome compositions |
| PL06737793T PL1863448T3 (pl) | 2005-03-10 | 2006-03-08 | Nowe kompozycje liposomowe |
| ZA200708600A ZA200708600B (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions |
| DK06737793.7T DK1863448T3 (en) | 2005-03-10 | 2006-03-08 | NEW LIPOSOM COMPOSITIONS |
| BRPI0608297-1A BRPI0608297A2 (pt) | 2005-03-10 | 2006-03-08 | composições de lipossomos |
| ES06737793.7T ES2529453T3 (es) | 2005-03-10 | 2006-03-08 | Nuevas composiciones de liposomas |
| HUE06737793A HUE024290T2 (en) | 2005-03-10 | 2006-03-08 | New liposome compositions |
| KR1020077023219A KR101352490B1 (ko) | 2005-03-10 | 2006-03-08 | 신규 리포좀 조성물 |
| CN2006800159670A CN101170995B (zh) | 2005-03-10 | 2006-03-08 | 新颖的脂质体组合物 |
| PCT/US2006/008650 WO2006099169A2 (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions |
| MX2007010996A MX2007010996A (es) | 2005-03-10 | 2006-03-08 | Nuevas composiciones de liposomas. |
| HK08105936.8A HK1111625B (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions |
| CA002600446A CA2600446A1 (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions |
| EP06737793.7A EP1863448B1 (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions |
| SI200631892T SI1863448T1 (sl) | 2005-03-10 | 2006-03-08 | Novi liposomski sestavki |
| PT67377937T PT1863448E (pt) | 2005-03-10 | 2006-03-08 | Novas composições de lipossomas |
| NO20075136A NO20075136L (no) | 2005-03-10 | 2007-10-09 | Nye liposompreparater |
| US12/891,568 US8758810B2 (en) | 2005-03-10 | 2010-09-27 | Liposome compositions |
| US14/274,377 US20140363491A1 (en) | 2005-03-10 | 2014-05-09 | Novel liposome compositions |
| CY20151100123T CY1116075T1 (el) | 2005-03-10 | 2015-02-06 | Νεες συνθεσεις λιποσωματων |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005067469A JP2006248978A (ja) | 2005-03-10 | 2005-03-10 | 新規なリポソーム製剤 |
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| JP2006248978A true JP2006248978A (ja) | 2006-09-21 |
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| JP2005067469A Pending JP2006248978A (ja) | 2005-03-10 | 2005-03-10 | 新規なリポソーム製剤 |
| JP2008500977A Expired - Fee Related JP5438317B2 (ja) | 2005-03-10 | 2006-03-08 | 新規リポソーム組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008500977A Expired - Fee Related JP5438317B2 (ja) | 2005-03-10 | 2006-03-08 | 新規リポソーム組成物 |
Country Status (21)
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|---|---|
| US (3) | US7829113B2 (enExample) |
| EP (1) | EP1863448B1 (enExample) |
| JP (2) | JP2006248978A (enExample) |
| KR (1) | KR101352490B1 (enExample) |
| CN (1) | CN101170995B (enExample) |
| AU (1) | AU2006223329B2 (enExample) |
| BR (1) | BRPI0608297A2 (enExample) |
| CA (1) | CA2600446A1 (enExample) |
| CY (1) | CY1116075T1 (enExample) |
| DK (1) | DK1863448T3 (enExample) |
| ES (1) | ES2529453T3 (enExample) |
| HU (1) | HUE024290T2 (enExample) |
| MX (1) | MX2007010996A (enExample) |
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Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2424792C2 (ru) | 2004-05-03 | 2011-07-27 | Хермес Байесайенсиз, Инк. | Липосомы, используемые для доставки лекарственных средств |
| JP2006248978A (ja) | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| CN101209243B (zh) * | 2006-12-29 | 2010-12-08 | 石药集团中奇制药技术（石家庄）有限公司 | 一种脂质体药物及其制备方法 |
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| US9849173B2 (en) * | 2009-07-06 | 2017-12-26 | Variation Biotechnologies Inc. | Methods for preparing vesicles and formulations produced therefrom |
| US8956600B2 (en) * | 2009-08-10 | 2015-02-17 | Taiwan Liposome Co. Ltd. | Ophthalmic drug delivery system containing phospholipid and cholesterol |
| WO2011038073A1 (en) * | 2009-09-23 | 2011-03-31 | Formatech, Inc. | Methods for the preparation of liposomes comprising docetaxel |
| US10143652B2 (en) * | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
| WO2011102904A1 (en) * | 2010-02-19 | 2011-08-25 | Robert Shorr | Imageable lipid-oil-water nanoemulsion therapeutic delivery system |
| US11400058B2 (en) * | 2010-03-12 | 2022-08-02 | Berg Llc | Intravenous formulations of coenzyme Q10 (CoQ10) and methods of use thereof |
| CN103025159A (zh) | 2010-03-19 | 2013-04-03 | 波士顿生物医学公司 | 靶向癌症干细胞的新方法 |
| EP2558108A1 (en) * | 2010-04-12 | 2013-02-20 | Ramot at Tel-Aviv University Ltd | Iron oxide nanoparticles for use in treating non-infectious inflammatory disorders |
| JP5909745B2 (ja) | 2010-11-12 | 2016-04-27 | クール ファーマシューティカルズ ディベロップメント カンパニー | 炎症性疾患の治療薬、ならびにウイルスまたは細菌感染疾患の治療薬 |
| WO2012153616A1 (ja) * | 2011-05-10 | 2012-11-15 | 国立大学法人北海道大学 | 標的細胞移行能を有する脂質膜構造体、その製造方法および標的細胞において効果を示す物質のスクリーニング方法 |
| US20140161876A1 (en) * | 2011-07-15 | 2014-06-12 | Konica Minolta, Inc. | Liposome-containing preparation utilizing dissolution aid, and method for producing same |
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| KR20250052503A (ko) * | 2012-06-21 | 2025-04-18 | 노쓰웨스턴유니버시티 | 펩티드 접합된 입자 |
| AU2013360302C1 (en) * | 2012-12-12 | 2019-01-24 | Temple University - Of The Commonwealth System Of Higher Education | Compositions and methods for treatment of cancer |
| CN103083239B (zh) * | 2012-12-26 | 2015-11-25 | 中国人民解放军第四军医大学 | 一种蟾毒灵脂质体及其制备方法和应用 |
| TWI718086B (zh) | 2013-01-07 | 2021-02-11 | 英屬維爾京群島商遠東超級實驗室有限公司 | 通過干擾素的經皮和/或經粘膜給藥治療骨癌、皮膚癌、皮下癌、粘膜癌和/或粘膜下癌的方法和組合物 |
| US9468681B2 (en) | 2013-03-01 | 2016-10-18 | California Institute Of Technology | Targeted nanoparticles |
| CN105209017A (zh) * | 2013-03-13 | 2015-12-30 | 马林克罗特有限公司 | 用于癌症疗法的脂质体顺铂组合物 |
| HK1220368A1 (zh) | 2013-03-13 | 2017-05-05 | Cour Pharmaceuticals Development Company | 用於治疗炎症的免疫修饰性颗粒 |
| JP6433085B2 (ja) | 2013-04-09 | 2018-12-05 | ボストン バイオメディカル， インコーポレイテッド | がんの処置に使用するための２−アセチルナフト［２，３−ｂ］フラン−４，９−ジオン |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| JP6553033B2 (ja) | 2013-08-13 | 2019-07-31 | ノースウェスタン ユニバーシティ | ペプチドコンジュゲート粒子 |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
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| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
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| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| AU2016284156B2 (en) | 2015-06-24 | 2020-01-30 | Nippon Kayaku Kabushiki Kaisha | Novel platinum (IV) complex |
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| JP6725520B2 (ja) | 2015-09-14 | 2020-07-22 | 日本化薬株式会社 | ６配位白金錯体の高分子結合体 |
| BR112018006922B1 (pt) | 2015-10-16 | 2023-11-21 | Ipsen Biopharm Ltd | Composições de irinotecano lipossômico estabilizado para armazenamento |
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| CN110590855B (zh) * | 2016-01-25 | 2023-05-12 | 沈阳药科大学 | 铂类配合物的制备方法及其含有该铂类配合物的脂质体与制备方法 |
| CN109069817B (zh) * | 2016-04-15 | 2021-07-13 | 富士胶片株式会社 | 微针阵列 |
| KR20190019121A (ko) * | 2016-06-17 | 2019-02-26 | 오사카 유니버시티 | 종양 내 정맥 형성 촉진제 |
| WO2018026794A1 (en) * | 2016-08-02 | 2018-02-08 | Curirx Inc. | Methods for the preparation of liposomes |
| KR20250103795A (ko) | 2016-08-03 | 2025-07-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| CN109804066A (zh) | 2016-08-09 | 2019-05-24 | 哈佛大学的校长及成员们 | 可编程cas9-重组酶融合蛋白及其用途 |
| EP3496757A4 (en) | 2016-08-12 | 2020-04-15 | L.E.A.F Holdings Group LLC | POLYGLUTAMATE ANTIFOLATES AND USES THEREOF. |
| US20180236098A1 (en) | 2016-08-12 | 2018-08-23 | L.E.A.F. Holdings Group Llc | Alpha and gamma-d polyglutamated antifolates and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| AU2017342543B2 (en) | 2016-10-14 | 2024-06-27 | President And Fellows Of Harvard College | AAV delivery of nucleobase editors |
| CN110402163A (zh) | 2016-11-02 | 2019-11-01 | 易普森生物制药有限公司 | 使用包括脂质体伊立替康、奥沙利铂、5-氟尿嘧啶(和甲酰四氢叶酸)的组合疗法治疗胃癌 |
| US11339209B2 (en) | 2016-11-14 | 2022-05-24 | Novartis Ag | Compositions, methods, and therapeutic uses related to fusogenic protein minion |
| US11299469B2 (en) | 2016-11-29 | 2022-04-12 | Sumitomo Dainippon Pharma Oncology, Inc. | Naphthofuran derivatives, preparation, and methods of use thereof |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| CN110869006A (zh) * | 2017-05-12 | 2020-03-06 | 库里纳尔克斯有限公司 | 制备含药脂质体的方法 |
| WO2018213424A1 (en) | 2017-05-17 | 2018-11-22 | Boston Biomedical, Inc. | Methods for treating cancer |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| EP3724214A4 (en) | 2017-12-15 | 2021-09-01 | The Broad Institute Inc. | SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING |
| US12246019B2 (en) | 2018-02-07 | 2025-03-11 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated lometrexol and uses thereof |
| US12246015B2 (en) | 2018-02-07 | 2025-03-11 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated raltitrexed and uses thereof |
| JP7491573B2 (ja) | 2018-02-07 | 2024-05-28 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | アルファポリグルタミン酸化メトトレキセートおよびその使用 |
| WO2019157145A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pemetrexed and uses thereof |
| CA3090506A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated tetrahydrofolates and uses thereof |
| EP3749318A4 (en) | 2018-02-07 | 2022-07-06 | L.E.A.F Holdings Group LLC | GAMMA-POLYGLUTAMATED RALTITREXED AND ITS USES |
| US12076402B2 (en) | 2018-02-07 | 2024-09-03 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated antifolates and uses thereof |
| US12310966B2 (en) | 2018-02-07 | 2025-05-27 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated aminopterin and uses thereof |
| US11730738B2 (en) | 2018-02-07 | 2023-08-22 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated pralatrexate and uses thereof |
| EP3749317A4 (en) | 2018-02-07 | 2022-06-22 | L.E.A.F Holdings Group LLC | PEMETREXED ALPHA-POLYGLUTAMATE AND ASSOCIATED USES |
| WO2019160735A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated tetrahydrofolates and uses thereof |
| CA3090753A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pralatrexate and uses thereof |
| WO2019160734A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated lometrexol and uses thereof |
| CA3090989A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated methotrexate and uses thereof |
| EP3752158A4 (en) | 2018-02-14 | 2022-03-09 | L.E.A.F Holdings Group LLC | GAMMA-POLYGLUTAMATED AMINOPTERINE AND USES THEREOF |
| CN108524450A (zh) * | 2018-04-16 | 2018-09-14 | 温州医科大学 | 基于磁性热敏阳离子脂质体的奥沙利铂和mdc1-as共传递药物载体的制备及应用 |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| US20190381188A1 (en) | 2018-06-13 | 2019-12-19 | California Institute Of Technology | Nanoparticles For Crossing The Blood Brain Barrier And Methods Of Treatment Using The Same |
| AU2019347666B2 (en) | 2018-09-28 | 2025-10-02 | President And Fellows Of Harvard College | Cellular reprogramming to reverse aging and promote organ and tissue regeneration |
| KR20210093232A (ko) | 2018-10-09 | 2021-07-27 | 더 유니버시티 오브 브리티시 콜롬비아 | 유기용매와 세제가 없는 형질감염 적격 소포를 포함하는 조성물과 시스템 및 관련 방법 |
| US12281338B2 (en) | 2018-10-29 | 2025-04-22 | The Broad Institute, Inc. | Nucleobase editors comprising GeoCas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| CN111721841B (zh) * | 2019-03-19 | 2022-07-12 | 海南长安国际制药有限公司 | 与洛铂有关物质的检测 |
| DE112020001306T5 (de) | 2019-03-19 | 2022-01-27 | Massachusetts Institute Of Technology | Verfahren und zusammensetzungen zur editierung von nukleotidsequenzen |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| CN110292563B (zh) * | 2019-06-12 | 2021-07-16 | 兰州大学 | 基于叶酸热敏脂质体的阴离子载体诱导癌细胞凋亡的方法 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| EP4114968A4 (en) * | 2020-03-04 | 2023-07-19 | Siemens Healthcare Diagnostics, Inc. | COMPOSITIONS AND METHODS OF USE OF MODIFIED LIPOSOMES |
| JP2023525304A (ja) | 2020-05-08 | 2023-06-15 | ザ ブロード インスティテュート，インコーポレーテッド | 標的二本鎖ヌクレオチド配列の両鎖同時編集のための方法および組成物 |
| CN112129871B (zh) * | 2020-09-04 | 2021-06-15 | 斯微(上海)生物科技有限公司 | 复合磷脂脂质体中dope和m5两种磷脂含量的检测方法 |
| CN112870164B (zh) * | 2021-01-25 | 2021-12-17 | 山东大学 | 一种双靶向载药脂质体及其制备方法和应用 |
| JP2025511883A (ja) | 2022-04-06 | 2025-04-16 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 中枢神経系の加齢を逆行させること |
| KR20250146635A (ko) | 2024-04-01 | 2025-10-13 | 고려대학교 산학협력단 | 리포좀 폴록사머 복합체를 포함하는 통증 질환 치료 조성물 |
Family Cites Families (156)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6041077B2 (ja) | 1976-09-06 | 1985-09-13 | 喜徳 喜谷 | １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体 |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| GR75598B (enExample) * | 1980-04-29 | 1984-08-01 | Sanofi Sa | |
| US4534899A (en) * | 1981-07-20 | 1985-08-13 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
| US4565696A (en) * | 1983-08-03 | 1986-01-21 | The Regents Of The University Of California | Production of immunogens by antigen conjugation to liposomes |
| US4789633A (en) | 1984-04-19 | 1988-12-06 | University Of Tennessee Research Corporation | Fused liposome and acid induced method for liposome fusion |
| US4925661A (en) * | 1984-04-19 | 1990-05-15 | Leaf Huang | Target-specific cytotoxic liposomes |
| US5736155A (en) * | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US4762915A (en) * | 1985-01-18 | 1988-08-09 | Liposome Technology, Inc. | Protein-liposome conjugates |
| WO1986004232A1 (en) * | 1985-01-18 | 1986-07-31 | Cooper-Lipotech, Inc. | Liposome composition and method |
| US5026651A (en) * | 1985-04-25 | 1991-06-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the production of human transferrin |
| PH26160A (en) * | 1985-08-19 | 1992-03-18 | Univ Texas | Pharmaceutical compositions consisting of acylated phospholipids |
| US4983397A (en) * | 1985-08-19 | 1991-01-08 | Board Of Regents, University Of Texas System | Pharmaceutical compositions consisting of acylated phospholipids |
| US5384127A (en) * | 1985-10-18 | 1995-01-24 | Board Of Regents, The University Of Texas System | Stable liposomal formulations of lipophilic platinum compounds |
| JPH0714865B2 (ja) * | 1986-10-28 | 1995-02-22 | 武田薬品工業株式会社 | リポソ−ム製剤およびその製造法 |
| US5049390A (en) * | 1987-09-02 | 1991-09-17 | Allergy Immuno Technologies, Inc. | Liposome containing immunotherapy agents for treating IgE mediated allergies |
| US4853224A (en) | 1987-12-22 | 1989-08-01 | Visionex | Biodegradable ocular implants |
| FR2631826B1 (fr) * | 1988-05-27 | 1992-06-19 | Centre Nat Rech Scient | Vecteur particulaire utile notamment pour le transport de molecules a activite biologique et procede pour sa preparation |
| JPH0720857B2 (ja) | 1988-08-11 | 1995-03-08 | テルモ株式会社 | リポソームおよびその製法 |
| DE69034042T2 (de) * | 1989-08-02 | 2003-07-17 | Mitra Medical Technology Ab, Lund | System zur verwendung in einem verfahren zur therapeutischen und diagnostischen behandlung |
| US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| ATE119767T1 (de) * | 1990-10-09 | 1995-04-15 | Vestar Inc | Vesikel aus phospholipidderivaten mit einem succinimidylsubstituenten. |
| US5554728A (en) * | 1991-07-23 | 1996-09-10 | Nexstar Pharmaceuticals, Inc. | Lipid conjugates of therapeutic peptides and protease inhibitors |
| US6509032B1 (en) | 1991-08-28 | 2003-01-21 | Mcmaster University | Cationic amphiphiles |
| US5292524A (en) * | 1991-09-06 | 1994-03-08 | California Institute Of Technology | Blood platelet loaded with diagnostic or therapeutic-containing liposome or reconstituted Sendai virus |
| JPH0776230B2 (ja) * | 1992-01-13 | 1995-08-16 | 田中貴金属工業株式会社 | 白金化合物の製造方法 |
| JP2673331B2 (ja) * | 1993-01-12 | 1997-11-05 | 田中貴金属工業 株式会社 | 光学的に高純度なシス―オキザラート（トランス―１―１，２―シクロヘキサンジアミン）白金（▲ｉｉ▼） |
| JPH06287021A (ja) * | 1992-04-22 | 1994-10-11 | Tanaka Kikinzoku Kogyo Kk | 光学活性な白金錯化合物の光学的分割方法 |
| US20030190638A1 (en) | 1992-05-13 | 2003-10-09 | Board Of Regents, The University Of Texas System | Methods of screening for compounds that derepress or increase telomerase activity |
| US5962316A (en) * | 1992-10-16 | 1999-10-05 | Cold Spring Harbor Laboratory | Cell-cycle regulatory proteins, and uses related thereto |
| US20030100489A1 (en) * | 1992-10-16 | 2003-05-29 | Beach David H. | Cell-cycle regulatory proteins, and uses related thereto |
| WO1994026254A1 (en) | 1993-05-17 | 1994-11-24 | The Liposome Company, Inc. | Incorporation of taxol into liposomes and gels |
| JP3025602B2 (ja) * | 1993-05-21 | 2000-03-27 | デビオファーム エス．アー． | 光学的に高純度なシス−オキザラート（トランス−ｌ−１，２−シクロヘキサンジアミン）白金（ＩＩ）錯体の製造方法 |
| US5534241A (en) * | 1993-07-23 | 1996-07-09 | Torchilin; Vladimir P. | Amphipathic polychelating compounds and methods of use |
| HUT72326A (en) * | 1993-10-06 | 1996-04-29 | Amgen Inc | Stable protein phospholipid compositions and methods |
| CA2179014C (en) * | 1993-12-17 | 2003-07-29 | Spinal Cord Society | Method for inducing dna synthesis in neurons |
| US5830686A (en) * | 1994-01-13 | 1998-11-03 | Calydon | Tissue-specific enhancer active in prostate |
| US6057299A (en) * | 1994-01-13 | 2000-05-02 | Calydon, Inc. | Tissue-specific enhancer active in prostate |
| AU2076895A (en) | 1994-03-28 | 1995-10-17 | Daiichi Pharmaceutical Co., Ltd. | Liposomes |
| EP0773921B1 (en) | 1994-07-29 | 1999-12-01 | Abbott Laboratories | Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane |
| KR100365171B1 (ko) | 1994-08-08 | 2003-02-19 | 드바이오팜 에스.아. | 약학적으로안정한옥살리플라티늄제제 |
| EP0785773B1 (en) * | 1994-10-14 | 2001-01-03 | The Liposome Company, Inc. | Ether lipid liposomes and their therapeutic use |
| DE69531722T2 (de) * | 1994-11-11 | 2004-07-01 | Debiopharm S.A. | Karzinostatische Zusammensetzungen, welche Cis-Oxaliplatin und eine oder mehrere andere verträgliche Karzinostatika enthalten |
| US5786214A (en) * | 1994-12-15 | 1998-07-28 | Spinal Cord Society | pH-sensitive immunoliposomes and method of gene delivery to the mammalian central nervous system |
| US5580899A (en) * | 1995-01-09 | 1996-12-03 | The Liposome Company, Inc. | Hydrophobic taxane derivatives |
| US6008202A (en) | 1995-01-23 | 1999-12-28 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| TW319763B (enExample) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| US5780052A (en) * | 1995-04-24 | 1998-07-14 | Northeastern University | Compositions and methods useful for inhibiting cell death and for delivering an agent into a cell |
| US5834012A (en) * | 1995-05-03 | 1998-11-10 | Roman Perez-Soler | Lipid complexed topoisomerase I inhibitors |
| US20020022264A1 (en) | 1995-05-26 | 2002-02-21 | Sullivan Sean M. | Delivery vehicles comprising stable lipid/nucleic acid complexes |
| US6825174B2 (en) * | 1995-06-07 | 2004-11-30 | East Carolina University | Composition, formulations & method for prevention & treatment of diseases and conditions associated with bronchoconstriction, allergy(ies) & inflammation |
| JP3154399B2 (ja) | 1996-07-04 | 2001-04-09 | デビオファーム エス．アー． | 白金化合物の製造方法 |
| JPH09278785A (ja) | 1996-04-10 | 1997-10-28 | Tanaka Kikinzoku Kogyo Kk | 白金化合物の製造方法 |
| FR2740686B1 (fr) | 1995-11-03 | 1998-01-16 | Sanofi Sa | Formulation pharmaceutique lyophilisee stable |
| US6428977B1 (en) | 1995-12-20 | 2002-08-06 | Curis, Inc. | Signalin family of TGFβ signal transduction proteins, and uses related thereto |
| JP3735921B2 (ja) * | 1996-02-07 | 2006-01-18 | 三菱ウェルファーマ株式会社 | ＧＰＩｂ・脂質複合体およびその用途 |
| AU2112697A (en) * | 1996-02-09 | 1997-08-28 | Pi-Wan Cheng | Receptor ligand-facilitated delivery of biologically active molecules |
| EP0897389B1 (fr) | 1996-03-11 | 2002-07-03 | Yoshinori Kidani | Complexes de platine dinucleaires, procede pour leur preparation et compositions pharmaceutiques en contenant |
| EP0914094A4 (en) * | 1996-03-28 | 2000-03-01 | Univ Illinois | MATERIALS AND METHOD FOR PRODUCING IMPROVED LIPOSOMAL AGENTS |
| JP3919227B2 (ja) * | 1996-05-02 | 2007-05-23 | テルモ株式会社 | アミジン誘導体及びそれを構成成分とする薬物担体 |
| WO1998007409A1 (en) | 1996-08-23 | 1998-02-26 | Sequus Pharmaceuticals, Inc. | Liposomes containing a cisplatin compound |
| TW520297B (en) * | 1996-10-11 | 2003-02-11 | Sequus Pharm Inc | Fusogenic liposome composition and method |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| DK0964690T3 (da) * | 1996-10-15 | 2003-10-20 | Liposome Co Inc | Peptid-lipidkonjugater, liposomer og liposomal lægemiddeladministration |
| NZ336538A (en) | 1996-10-15 | 2001-11-30 | Liposome Co Inc | N-acyl phosphatidylethanolamine-mediated liposomal drug delivery |
| AU5729898A (en) | 1996-12-18 | 1998-07-15 | Emory University | Polycationic oligomers |
| AU6178198A (en) * | 1997-03-07 | 1998-09-22 | Sanofi Pharmaceuticals, Inc. | Method of treating a tumor |
| DE19709704C2 (de) * | 1997-03-10 | 1999-11-04 | Michael Georgieff | Verwendung einer flüssigen Präparation von Xenon zur intravenösen Verabreichung bei Einleitung und/oder Aufrechterhaltung der Anaesthesie |
| JPH10253632A (ja) * | 1997-03-10 | 1998-09-25 | Nissui Pharm Co Ltd | 分析方法、キット及び装置 |
| US6120751A (en) * | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| US6060082A (en) * | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
| US6524613B1 (en) * | 1997-04-30 | 2003-02-25 | Regents Of The University Of Minnesota | Hepatocellular chimeraplasty |
| US6272370B1 (en) * | 1998-08-07 | 2001-08-07 | The Regents Of University Of Minnesota | MR-visible medical device for neurological interventions using nonlinear magnetic stereotaxis and a method imaging |
| AU7984498A (en) | 1997-06-25 | 1999-01-04 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Serum-free cell growth medium |
| AU742407B2 (en) * | 1997-07-15 | 2002-01-03 | Regents Of The University Of California, The | Isolated DNA encoding human calcium activated potassium channel |
| EP1002103B1 (en) | 1997-08-04 | 2007-10-17 | Cell Genesys, Inc. | A human glandular kallikrein enhancer, vectors comprising the enhancer and methods of use thereof |
| DE69819925T2 (de) * | 1997-10-02 | 2004-09-02 | Epix Medical, Inc., Cambridge | Kontrastverstärktes Diagnosebildererzeugungsverfahren zur Überwachung von therapeutischen Eingriffen |
| US6749863B1 (en) * | 1997-11-19 | 2004-06-15 | Georgetown University | Targeted liposome gene delivery |
| US6320017B1 (en) * | 1997-12-23 | 2001-11-20 | Inex Pharmaceuticals Corp. | Polyamide oligomers |
| WO1999041403A1 (en) * | 1998-02-12 | 1999-08-19 | The Regents Of The University Of California | Compositions for receptor/liposome mediated transfection and methods of using same |
| GB9804013D0 (en) | 1998-02-25 | 1998-04-22 | Sanofi Sa | Formulations |
| US6245427B1 (en) * | 1998-07-06 | 2001-06-12 | DüZGüNES NEJAT | Non-ligand polypeptide and liposome complexes as intracellular delivery vehicles |
| WO2000021527A2 (fr) | 1998-10-14 | 2000-04-20 | Debiopharm S.A. | Conditionnement d'une preparation d'oxaliplatine |
| US7311924B2 (en) * | 1999-04-01 | 2007-12-25 | Hana Biosciences, Inc. | Compositions and methods for treating cancer |
| US6723338B1 (en) * | 1999-04-01 | 2004-04-20 | Inex Pharmaceuticals Corporation | Compositions and methods for treating lymphoma |
| EP1183275B1 (en) | 1999-05-17 | 2006-08-09 | Avi Biopharma, Inc. | Specific antibodies against human chorionic gonadotropin and their use in therapy and diagnostic |
| JP2001002592A (ja) | 1999-06-18 | 2001-01-09 | Dai Ichi Seiyaku Co Ltd | 遺伝子導入用組成物 |
| US6280054B1 (en) * | 1999-07-02 | 2001-08-28 | Zight Corporation | Image generator having an improved illumination system |
| US6242188B1 (en) * | 1999-07-30 | 2001-06-05 | Applied Gene Technologies, Inc. | Sample processing to release nucleic acids for direct detection |
| EP1204241A1 (en) * | 1999-08-09 | 2002-05-08 | Fujitsu Limited | Package control device and method |
| BRPI0013613B8 (pt) | 1999-08-30 | 2021-05-25 | Debiopharm Sa | composição farmacêuticamente estável de oxaliplatina para administração parenteral. |
| CN101041079A (zh) | 1999-12-30 | 2007-09-26 | 诺瓦提斯公司 | 用于基因治疗的新的胶体合成载体 |
| CA2394717C (en) | 1999-12-30 | 2011-05-17 | Judith K. Gwathmey | Iron chelator delivery system |
| CA2397016C (en) * | 2000-01-10 | 2011-03-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of disease |
| US6530944B2 (en) * | 2000-02-08 | 2003-03-11 | Rice University | Optically-active nanoparticles for use in therapeutic and diagnostic methods |
| US7001735B2 (en) * | 2000-03-01 | 2006-02-21 | Albert Einstein College Of Medicine Of Yeshiva University | Glucose transporter/sensor protein and uses thereof |
| AU2001236062A1 (en) * | 2000-03-02 | 2001-09-12 | Yasuo Ikeda | Gpib-lipid bond construct and use thereof |
| JP4449147B2 (ja) | 2000-03-22 | 2010-04-14 | 日油株式会社 | ホスファチジルエタノールアミン誘導体の製造方法 |
| FR2806727A1 (fr) | 2000-03-23 | 2001-09-28 | Pf Medicament | Molecule d'interet pharmaceutique comprotant en son extremite n-terminale un acide glutamique ou une glutamine sous forme de sel d'addition d'acide fort physiologiquement acceptable |
| ES2280355T3 (es) | 2000-04-12 | 2007-09-16 | Liplasome Pharma A/S | Sistema de administracion de medicamentos basados en lipidos para su utilizacion en la piel. |
| WO2001082899A2 (en) * | 2000-05-03 | 2001-11-08 | Mbt Munich Biotechnology Ag | Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites |
| US20030059461A1 (en) * | 2000-06-06 | 2003-03-27 | Sibtech, Inc. | Molecular delivery vehicle for delivery of selected compounds to targets |
| US20030072794A1 (en) * | 2000-06-09 | 2003-04-17 | Teni Boulikas | Encapsulation of plasmid DNA (lipogenes™) and therapeutic agents with nuclear localization signal/fusogenic peptide conjugates into targeted liposome complexes |
| WO2002020570A2 (en) * | 2000-09-11 | 2002-03-14 | Institut Pasteur | Mitochondrial membrane permeabilization bv hiv-1 vpr and methods of screening |
| US20040234588A1 (en) | 2000-09-21 | 2004-11-25 | University Of Georgia Research Foundation, Inc. | Artificial lipoprotein carrier system for bioactive materials |
| DE60108405D1 (de) * | 2000-10-03 | 2005-02-17 | Debiopharm Sa | Plga/pla-typ mikrokugeln enthaltend eine wasserlösliche verbindung und herstellungsverfahren dafür |
| US20030129223A1 (en) * | 2000-10-11 | 2003-07-10 | Targesome, Inc. | Targeted multivalent macromolecules |
| EP1209469A1 (en) * | 2000-11-22 | 2002-05-29 | Vectron Therapeutics AG | Production and use of a targeted diagnostic system |
| JP2004524516A (ja) * | 2000-12-12 | 2004-08-12 | オーストラリアン インスティチュート オブ マリーン サイエンス | 麻痺性貝毒のアッセイ |
| EP1341555A2 (fr) | 2000-12-12 | 2003-09-10 | Debiopharm S.A. | Preparation pharmaceutique d'oxaliplatine pour administration par voie parenterale et procede d'obtention de ladite preparation |
| US6897196B1 (en) * | 2001-02-07 | 2005-05-24 | The Regents Of The University Of California | pH sensitive lipids based on ortho ester linkers, composition and method |
| US6703524B2 (en) * | 2001-02-20 | 2004-03-09 | Lkt Laboratories, Inc. | Organoselenium compounds for cancer chemoprevention |
| DE60220766T2 (de) | 2001-03-02 | 2008-03-06 | Debiopharm S.A. | Verwendung eines eine oxaliplatinlösung beinhaltenden fläschchens |
| FI113840B (fi) | 2001-03-26 | 2004-06-30 | Ctt Cancer Targeting Tech Oy | Matriisi-metalloproteinaasi-inhibiittorien käyttö liposomien kohdentamisessa |
| US20040049022A1 (en) * | 2001-04-24 | 2004-03-11 | Nyce Jonathan W. | Composition & methods for treatment and screening |
| AU2002256398A2 (en) | 2001-04-30 | 2002-11-11 | Targeted Genetics Corporation | Lipid-comprising drug delivery complexes and methods for their production |
| WO2002089772A1 (en) * | 2001-05-09 | 2002-11-14 | Inex Pharmaceuticals Corporation | Anti-angiogenic therapy using liposome-encapsulated chemotherapeutic agents |
| US20030108986A1 (en) * | 2001-06-21 | 2003-06-12 | Euroscreen, S.A. | Compositions and methods comprising G-protein coupled receptors |
| US20040186172A1 (en) | 2001-07-02 | 2004-09-23 | Houssam Ibrahim | Oxaliplatin active substance with a very low content of oxalic acid |
| US20030096299A1 (en) * | 2001-07-09 | 2003-05-22 | Valerie Wittamer | Natural ligand of G protein coupled receptor ChemR23 and uses thereof |
| EP1424898A4 (en) * | 2001-08-20 | 2008-04-02 | Transave Inc | TREATMENT OF CANCER BY INHALATION OF STABLE FORMULATIONS CONTAINING PLATINUM |
| DE10144252A1 (de) | 2001-08-31 | 2003-03-27 | Fraunhofer Ges Forschung | Nanopartikel mit daran immobilisiertem biologisch aktivem TNF |
| WO2003028640A2 (en) * | 2001-10-03 | 2003-04-10 | Vanderbilt University | In vivo panning for ligands to radiation-induced molecules |
| US7101985B2 (en) | 2001-11-20 | 2006-09-05 | Baylor College Of Medicine | Methods and compositions in checkpoint signaling |
| JP4468617B2 (ja) | 2001-12-04 | 2010-05-26 | デビオファーム エス．アー． | 抗癌剤の併用投与方法及び併用可能な抗癌剤 |
| US6476068B1 (en) | 2001-12-06 | 2002-11-05 | Pharmacia Italia, S.P.A. | Platinum derivative pharmaceutical formulations |
| EP1463759B8 (en) | 2002-01-07 | 2013-07-10 | Euroscreen S.A. | Ligand for g-protein coupled receptor gpr43 and uses thereof |
| US20030220284A1 (en) | 2002-02-22 | 2003-11-27 | Patricia Yotnda | Delivery of adenoviral DNA in a liposomal formulation for treatment of disease |
| EP1587944A4 (en) * | 2002-03-01 | 2007-03-21 | Dyax Corp | KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES |
| WO2003074567A2 (en) * | 2002-03-01 | 2003-09-12 | Immunomedics, Inc. | Internalizing anti-cd74 antibodies and methods of use |
| AU2003221533A1 (en) | 2002-03-29 | 2003-10-13 | Euroscreen Sa | Ligands for g protein coupled receptor gpr7 and uses thereof |
| CA2391438A1 (en) * | 2002-05-01 | 2003-11-01 | Procyon Biopharma Inc. | Psp94 diagnostic reagents and assays |
| US20030228285A1 (en) | 2002-05-03 | 2003-12-11 | Mien-Chie Hung | Bipartite T-cell factor (Tcf)-responsive promoter |
| US7460960B2 (en) | 2002-05-10 | 2008-12-02 | Epitome Biosystems, Inc. | Proteome epitope tags and methods of use thereof in protein modification analysis |
| JP3415131B1 (ja) | 2002-06-03 | 2003-06-09 | メビオファーム株式会社 | リポソーム製剤 |
| US20040022842A1 (en) * | 2002-06-03 | 2004-02-05 | Mebiopharm Co., Ltd. | Liposome preparations containing oxaliplatin |
| FR2840236B1 (fr) | 2002-06-03 | 2005-02-04 | Inst Francais Du Petrole | Membrane zeolithique de faible epaisseur, sa preparation et son utilisation en separation |
| EP1511518A2 (en) * | 2002-06-07 | 2005-03-09 | Immunomedics, Inc. | Neutrophil imaging methods in cystic fibrosis |
| EP1519958B1 (en) * | 2002-06-14 | 2014-10-15 | Immunomedics, Inc. | Humanized monoclonal antibody hpam4 |
| KR101228124B1 (ko) * | 2002-06-14 | 2013-01-31 | 이뮤노메딕스, 인코오포레이티드 | 단클론 항체 ｐａｍ4 및 췌장암의 진단 및 치료를 위한이들의 용도 |
| US6790632B2 (en) | 2002-06-17 | 2004-09-14 | Stephen Eliot Zweig | Membrane receptor reagent and assay |
| US7901708B2 (en) * | 2002-06-28 | 2011-03-08 | Protiva Biotherapeutics, Inc. | Liposomal apparatus and manufacturing methods |
| KR101115797B1 (ko) | 2002-08-01 | 2012-07-27 | 이뮤노메딕스, 인코오포레이티드 | 알파 태아 단백질 Ｉｍｍｕ31 항체 및 융합단백질, 및이들의 이용 방법 |
| US20040132652A1 (en) * | 2002-08-30 | 2004-07-08 | Shire Biochem Inc. | Pharmaceutical compositions |
| US20040197770A1 (en) | 2002-11-14 | 2004-10-07 | Mount Sinai School Of Medicine | Induction of apoptosis by HIV-1 infected monocytic cells |
| CN1711074B (zh) | 2002-11-15 | 2010-10-06 | 尼普洛株式会社 | 脂质体 |
| MXPA05008687A (es) | 2003-02-17 | 2005-10-05 | Mebiopharm Co Ltd | Remedio para cancer. |
| EP1618181B1 (en) * | 2003-04-22 | 2014-10-15 | IBC Pharmaceuticals | Polyvalent protein complex |
| US7172751B2 (en) * | 2003-06-13 | 2007-02-06 | Immunomedics, Inc. | D-amino acid peptides |
| EP1648512A4 (en) * | 2003-07-31 | 2009-01-21 | Immunomedics Inc | ANTI-CD19 ANTIBODIES |
| JP2005154282A (ja) | 2003-11-20 | 2005-06-16 | Mebiopharm Co Ltd | ガス封入リポソームの製造法 |
| US7582430B2 (en) * | 2004-01-20 | 2009-09-01 | United States Of America As Represented By The Secretary Of The Army | Immunoliposome-nucleic acid amplification (ILNAA) assay |
| US7212869B2 (en) * | 2004-02-04 | 2007-05-01 | Medtronic, Inc. | Lead retention means |
| EP1579850A3 (en) | 2004-03-15 | 2009-12-16 | Nipro Corporation | A pharmaceutical composition containing liposomes for treating a cancer |
| JP2006248978A (ja) | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| WO2008030818A2 (en) | 2006-09-05 | 2008-03-13 | Mebiopharm Co., Ltd. | Novel liposome compositions |
-
2005
- 2005-03-10 JP JP2005067469A patent/JP2006248978A/ja active Pending
-
2006
- 2006-03-08 ES ES06737793.7T patent/ES2529453T3/es active Active
- 2006-03-08 ZA ZA200708600A patent/ZA200708600B/xx unknown
- 2006-03-08 AU AU2006223329A patent/AU2006223329B2/en not_active Ceased
- 2006-03-08 EP EP06737793.7A patent/EP1863448B1/en active Active
- 2006-03-08 US US11/371,586 patent/US7829113B2/en not_active Expired - Fee Related
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- 2006-03-08 BR BRPI0608297-1A patent/BRPI0608297A2/pt not_active IP Right Cessation
- 2006-03-08 CA CA002600446A patent/CA2600446A1/en not_active Abandoned
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- 2006-03-08 CN CN2006800159670A patent/CN101170995B/zh not_active Expired - Fee Related
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- 2006-03-08 WO PCT/US2006/008650 patent/WO2006099169A2/en not_active Ceased
- 2006-03-08 RU RU2007137492/15A patent/RU2454229C2/ru not_active IP Right Cessation
-
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- 2007-10-09 NO NO20075136A patent/NO20075136L/no not_active Application Discontinuation
-
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- 2010-09-27 US US12/891,568 patent/US8758810B2/en not_active Expired - Fee Related
-
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- 2014-05-09 US US14/274,377 patent/US20140363491A1/en not_active Abandoned
-
2015
- 2015-02-06 CY CY20151100123T patent/CY1116075T1/el unknown
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| WO2009096487A1 (ja) | 2008-01-30 | 2009-08-06 | The University Of Tokushima | オキサリプラチンリポソーム製剤からなる抗腫瘍効果増強剤及び当該リポソーム製剤を含有する抗腫瘍剤 |
| JP5419716B2 (ja) * | 2008-01-30 | 2014-02-19 | 国立大学法人徳島大学 | オキサリプラチンリポソーム製剤からなる抗腫瘍効果増強剤及び当該リポソーム製剤を含有する抗腫瘍剤 |
| US8940327B2 (en) | 2008-01-30 | 2015-01-27 | The University Of Tokushima | Agent for enhancing anti-tumor effect comprising oxaliplatin liposome preparation, and anti-tumor agent comprising the liposome preparation |
| JP2015509085A (ja) * | 2012-01-01 | 2015-03-26 | キュービーアイ エンタープライゼズ リミテッドＱｂｉ Ｅｎｔｅｒｐｒｉｓｅｓ Ｌｔｄ． | 治療剤および診断剤の選択的送達のためのｅｎｄｏ１８０を標的とする粒子 |
| JPWO2014025042A1 (ja) * | 2012-08-10 | 2016-07-25 | 大鵬薬品工業株式会社 | 安定なオキサリプラチン封入リポソーム水分散液及びその安定化方法 |
| WO2014025042A1 (ja) | 2012-08-10 | 2014-02-13 | 大鵬薬品工業株式会社 | 安定なオキサリプラチン封入リポソーム水分散液及びその安定化方法 |
| US10383822B2 (en) | 2012-08-10 | 2019-08-20 | Taiho Pharmaceutical Co., Ltd. | Stable oxaliplatin-encapsulating liposome aqueous dispersion and method for stabilizing same |
| US10993913B2 (en) | 2012-08-10 | 2021-05-04 | Taiho Pharmaceutical Co., Ltd | Stable oxaliplatin-encapsulating liposome aqueous dispersion and method for stabilizing same |
| JP2016512550A (ja) * | 2013-03-13 | 2016-04-28 | マリンクロッド エルエルシー | がん治療のためのリポソームオキサリプラチン組成物 |
| JP2019512489A (ja) * | 2016-03-07 | 2019-05-16 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | マイクロｒｎａおよびその使用方法 |
| US11655469B2 (en) | 2016-03-07 | 2023-05-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | MicroRNAs and methods of their use |
| JP2021521279A (ja) * | 2018-04-11 | 2021-08-26 | ニュー メキシコ テック ユニバーシティ リサーチ パーク コーポレーション | 薬物送達における使用のための脂質プロドラッグ |
| US11597930B2 (en) | 2020-04-02 | 2023-03-07 | Mirecule, Inc. | Targeted inhibition using engineered oligonucleotides |
| US11795459B2 (en) | 2020-04-02 | 2023-10-24 | Mirecule, Inc. | Targeted inhibition using engineered oligonucleotides |
| US12104157B2 (en) | 2020-04-02 | 2024-10-01 | Mirecule, Inc. | Targeted inhibition using engineered oligonucleotides |
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| MX2007010996A (es) | 2007-11-07 |
| HUE024290T2 (en) | 2016-01-28 |
| AU2006223329A1 (en) | 2006-09-21 |
| JP5438317B2 (ja) | 2014-03-12 |
| RU2454229C2 (ru) | 2012-06-27 |
| CN101170995A (zh) | 2008-04-30 |
| NO20075136L (no) | 2007-12-07 |
| EP1863448B1 (en) | 2014-11-26 |
| EP1863448A2 (en) | 2007-12-12 |
| WO2006099169A3 (en) | 2007-02-22 |
| SI1863448T1 (sl) | 2015-03-31 |
| CA2600446A1 (en) | 2006-09-21 |
| AU2006223329B2 (en) | 2011-11-17 |
| CY1116075T1 (el) | 2017-02-08 |
| JP2008538105A (ja) | 2008-10-09 |
| CN101170995B (zh) | 2013-01-16 |
| WO2006099169A2 (en) | 2006-09-21 |
| NZ561569A (en) | 2011-03-31 |
| ZA200708600B (en) | 2009-01-28 |
| BRPI0608297A2 (pt) | 2009-12-08 |
| US7829113B2 (en) | 2010-11-09 |
| US8758810B2 (en) | 2014-06-24 |
| RU2007137492A (ru) | 2009-04-20 |
| DK1863448T3 (en) | 2015-02-16 |
| KR101352490B1 (ko) | 2014-02-04 |
| US20110081404A1 (en) | 2011-04-07 |
| PT1863448E (pt) | 2015-02-10 |
| PL1863448T3 (pl) | 2015-05-29 |
| HK1111625A1 (en) | 2008-08-15 |
| KR20080002819A (ko) | 2008-01-04 |
| US20060222696A1 (en) | 2006-10-05 |
| US20140363491A1 (en) | 2014-12-11 |
| ES2529453T3 (es) | 2015-02-20 |
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