JP2006248978A - 新規なリポソーム製剤 - Google Patents
新規なリポソーム製剤 Download PDFInfo
- Publication number
- JP2006248978A JP2006248978A JP2005067469A JP2005067469A JP2006248978A JP 2006248978 A JP2006248978 A JP 2006248978A JP 2005067469 A JP2005067469 A JP 2005067469A JP 2005067469 A JP2005067469 A JP 2005067469A JP 2006248978 A JP2006248978 A JP 2006248978A
- Authority
- JP
- Japan
- Prior art keywords
- liposome preparation
- preparation according
- liposome
- dicarboxylic acid
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002502 liposome Substances 0.000 title claims abstract description 157
- 238000002360 preparation method Methods 0.000 title claims abstract description 57
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims abstract description 35
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims abstract description 35
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 32
- 239000003446 ligand Substances 0.000 claims abstract description 25
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 22
- 235000012000 cholesterol Nutrition 0.000 claims abstract description 16
- 239000003814 drug Substances 0.000 claims description 33
- 102000004338 Transferrin Human genes 0.000 claims description 32
- 108090000901 Transferrin Proteins 0.000 claims description 32
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- 229940079593 drug Drugs 0.000 claims description 27
- 229960001756 oxaliplatin Drugs 0.000 claims description 22
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims description 22
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 18
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- 229930006000 Sucrose Natural products 0.000 claims description 13
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 13
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- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims description 6
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- NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (25)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005067469A JP2006248978A (ja) | 2005-03-10 | 2005-03-10 | 新規なリポソーム製剤 |
| CA002600446A CA2600446A1 (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions |
| SI200631892T SI1863448T1 (sl) | 2005-03-10 | 2006-03-08 | Novi liposomski sestavki |
| NZ561569A NZ561569A (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions comprising SuccNomegaPE:NomegaPE:additional lipids and TF-NomegaPE:NomegaPE:additional lipids |
| PT67377937T PT1863448E (pt) | 2005-03-10 | 2006-03-08 | Novas composições de lipossomas |
| BRPI0608297-1A BRPI0608297A2 (pt) | 2005-03-10 | 2006-03-08 | composições de lipossomos |
| CN2006800159670A CN101170995B (zh) | 2005-03-10 | 2006-03-08 | 新颖的脂质体组合物 |
| KR1020077023219A KR101352490B1 (ko) | 2005-03-10 | 2006-03-08 | 신규 리포좀 조성물 |
| RU2007137492/15A RU2454229C2 (ru) | 2005-03-10 | 2006-03-08 | Новые композиции липосом |
| US11/371,586 US7829113B2 (en) | 2005-03-10 | 2006-03-08 | Liposome compositions |
| AU2006223329A AU2006223329B2 (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions |
| HUE06737793A HUE024290T2 (en) | 2005-03-10 | 2006-03-08 | New liposome compositions |
| ES06737793.7T ES2529453T3 (es) | 2005-03-10 | 2006-03-08 | Nuevas composiciones de liposomas |
| EP06737793.7A EP1863448B1 (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions |
| ZA200708600A ZA200708600B (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions |
| HK08105936.8A HK1111625B (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions |
| DK06737793.7T DK1863448T3 (en) | 2005-03-10 | 2006-03-08 | NEW LIPOSOM COMPOSITIONS |
| JP2008500977A JP5438317B2 (ja) | 2005-03-10 | 2006-03-08 | 新規リポソーム組成物 |
| MX2007010996A MX2007010996A (es) | 2005-03-10 | 2006-03-08 | Nuevas composiciones de liposomas. |
| PCT/US2006/008650 WO2006099169A2 (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions |
| PL06737793T PL1863448T3 (pl) | 2005-03-10 | 2006-03-08 | Nowe kompozycje liposomowe |
| NO20075136A NO20075136L (no) | 2005-03-10 | 2007-10-09 | Nye liposompreparater |
| US12/891,568 US8758810B2 (en) | 2005-03-10 | 2010-09-27 | Liposome compositions |
| US14/274,377 US20140363491A1 (en) | 2005-03-10 | 2014-05-09 | Novel liposome compositions |
| CY20151100123T CY1116075T1 (el) | 2005-03-10 | 2015-02-06 | Νεες συνθεσεις λιποσωματων |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005067469A JP2006248978A (ja) | 2005-03-10 | 2005-03-10 | 新規なリポソーム製剤 |
Publications (1)
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|---|---|
| JP2006248978A true JP2006248978A (ja) | 2006-09-21 |
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| JP2005067469A Pending JP2006248978A (ja) | 2005-03-10 | 2005-03-10 | 新規なリポソーム製剤 |
| JP2008500977A Expired - Fee Related JP5438317B2 (ja) | 2005-03-10 | 2006-03-08 | 新規リポソーム組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008500977A Expired - Fee Related JP5438317B2 (ja) | 2005-03-10 | 2006-03-08 | 新規リポソーム組成物 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7829113B2 (enExample) |
| EP (1) | EP1863448B1 (enExample) |
| JP (2) | JP2006248978A (enExample) |
| KR (1) | KR101352490B1 (enExample) |
| CN (1) | CN101170995B (enExample) |
| AU (1) | AU2006223329B2 (enExample) |
| BR (1) | BRPI0608297A2 (enExample) |
| CA (1) | CA2600446A1 (enExample) |
| CY (1) | CY1116075T1 (enExample) |
| DK (1) | DK1863448T3 (enExample) |
| ES (1) | ES2529453T3 (enExample) |
| HU (1) | HUE024290T2 (enExample) |
| MX (1) | MX2007010996A (enExample) |
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Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2821167C (en) | 2004-05-03 | 2016-06-28 | Merrimack Pharmaceuticals, Inc. | Drug delivery liposomes containing anionic polyols or anionic sugars |
| JP2006248978A (ja) | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| CN101209243B (zh) * | 2006-12-29 | 2010-12-08 | 石药集团中奇制药技术（石家庄）有限公司 | 一种脂质体药物及其制备方法 |
| EP2187869B1 (en) * | 2007-08-17 | 2015-10-14 | Celator Pharmaceuticals, Inc. | Improved platinum drug formulations |
| JP5688840B2 (ja) | 2007-09-10 | 2015-03-25 | ボストン バイオメディカル， インコーポレイテッド | 新規のＳｔａｔ３経路阻害剤及び癌幹細胞阻害剤 |
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| US8956600B2 (en) | 2009-08-10 | 2015-02-17 | Taiwan Liposome Co. Ltd. | Ophthalmic drug delivery system containing phospholipid and cholesterol |
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| US10143652B2 (en) * | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
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| ES2664793T3 (es) * | 2010-03-12 | 2018-04-23 | Berg Llc | Formulaciones intravenosas de coenzima Q10 (CoQ10) y métodos de uso de las mismas |
| LT2547205T (lt) | 2010-03-19 | 2024-06-10 | 1Globe Biomedical Co., Ltd. | Nauji tikslinio poveikio vėžio kamieninėms ląstelėms būdai |
| WO2011128896A1 (en) * | 2010-04-12 | 2011-10-20 | Ramot At Tel-Aviv University Ltd. | Iron oxide nanoparticles for use in treating non-infectious inflammatory disorders |
| JP5909745B2 (ja) | 2010-11-12 | 2016-04-27 | クール ファーマシューティカルズ ディベロップメント カンパニー | 炎症性疾患の治療薬、ならびにウイルスまたは細菌感染疾患の治療薬 |
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| CN111218447B (zh) | 2013-11-07 | 2024-10-11 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
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| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
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| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| EP3315487B1 (en) | 2015-06-24 | 2020-10-28 | Nippon Kayaku Kabushiki Kaisha | Novel platinum (iv) complex |
| ES2848118T3 (es) | 2015-08-20 | 2021-08-05 | Ipsen Biopharm Ltd | Terapia de combinación que usa irinotecán liposomal y un inhibidor de PARP para el tratamiento del cáncer |
| KR102714060B1 (ko) | 2015-08-21 | 2024-10-08 | 입센 바이오팜 리미티드 | 리포솜 이리노테칸 및 옥살리플라틴을 포함하는 병용 치료를 이용하여 전이성 췌장암을 치료하는 방법 |
| MA42837A (fr) | 2015-09-14 | 2018-07-25 | Nippon Kayaku Kk | Conjugué polymère de complexe de platine hexacoordonné |
| WO2017066726A1 (en) | 2015-10-16 | 2017-04-20 | Merrimack Pharmaceuticals, Inc. | Stabilizing camptothecin pharmaceutical compositions |
| US12043852B2 (en) | 2015-10-23 | 2024-07-23 | President And Fellows Of Harvard College | Evolved Cas9 proteins for gene editing |
| US12364661B2 (en) * | 2015-11-20 | 2025-07-22 | The Regents Of The University Of California | Deformable nano-scale vehicles (DNVS) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery |
| KR20180099734A (ko) | 2015-12-22 | 2018-09-05 | 니폰 가야꾸 가부시끼가이샤 | 설폭사이드 유도체 배위 백금(ii) 착체의 고분자 결합체 |
| CN109678910B (zh) | 2016-01-25 | 2021-09-07 | 沈阳药科大学 | 一种化合物及其应用以及一种铂类配合物及其脂质体 |
| EP3444004B1 (en) * | 2016-04-15 | 2020-12-02 | FUJIFILM Corporation | Microneedle array |
| AU2017284499A1 (en) * | 2016-06-17 | 2019-01-31 | Osaka University | Intratumoral vein formation promoter |
| WO2018026794A1 (en) * | 2016-08-02 | 2018-02-08 | Curirx Inc. | Methods for the preparation of liposomes |
| GB2568182A (en) | 2016-08-03 | 2019-05-08 | Harvard College | Adenosine nucleobase editors and uses thereof |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| WO2018031967A1 (en) | 2016-08-12 | 2018-02-15 | L.E.A.F. Holdings Group Llc | Polyglutamated antifolates and uses thereof |
| EP3496756A4 (en) | 2016-08-12 | 2020-07-22 | L.E.A.F Holdings Group LLC | ALPHA AND GAMMA-D ANTIFOLATES OF POLYGLUTAMATES AND THEIR USES. |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| GB2573062A (en) | 2016-10-14 | 2019-10-23 | Harvard College | AAV delivery of nucleobase editors |
| BR112019007844A2 (pt) | 2016-11-02 | 2019-07-16 | Ipsen Biopharm Ltd | tratamento de câncer gástrico usando terapias de combinação compreendendo irinotecano lipossômico, oxaliplatina, 5-fluoroacila (e leucovorina) |
| CN109996809A (zh) | 2016-11-14 | 2019-07-09 | 诺华股份有限公司 | 与促融合蛋白minion相关的组合物、方法和治疗用途 |
| WO2018102427A1 (en) | 2016-11-29 | 2018-06-07 | Boston Biomedical, Inc. | Naphthofuran derivatives, preparation, and methods of use thereof |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| WO2018165631A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Cancer vaccine |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| US11268082B2 (en) | 2017-03-23 | 2022-03-08 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
| CA3063395A1 (en) * | 2017-05-12 | 2018-11-15 | Curinanorx, Llc | Methods for the preparation of liposomes comprising drugs |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| CA3062656A1 (en) | 2017-05-17 | 2018-11-22 | Boston Biomedical, Inc. | Methods for treating cancer |
| JP2020534795A (ja) | 2017-07-28 | 2020-12-03 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ファージによって支援される連続的進化（ｐａｃｅ）を用いて塩基編集因子を進化させるための方法および組成物 |
| WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3749317A4 (en) | 2018-02-07 | 2022-06-22 | L.E.A.F Holdings Group LLC | PEMETREXED ALPHA-POLYGLUTAMATE AND ASSOCIATED USES |
| US12246015B2 (en) | 2018-02-07 | 2025-03-11 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated raltitrexed and uses thereof |
| CA3090391A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated raltitrexed and uses thereof |
| CN111954529A (zh) | 2018-02-07 | 2020-11-17 | L.E.A.F.控股集团公司 | α聚谷氨酸化氨甲蝶呤及其用途 |
| EP3749319A4 (en) | 2018-02-07 | 2022-06-22 | L.E.A.F Holdings Group LLC | TETRAHYDROFOLATES ALPHA POLYGLUTAMATE AND THEIR USES |
| WO2019157121A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated lometrexol and uses thereof |
| JP7487107B2 (ja) | 2018-02-07 | 2024-05-20 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | アルファポリグルタミン酸化葉酸代謝拮抗薬およびその使用 |
| US11730738B2 (en) | 2018-02-07 | 2023-08-22 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated pralatrexate and uses thereof |
| US12310966B2 (en) | 2018-02-07 | 2025-05-27 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated aminopterin and uses thereof |
| WO2019157145A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pemetrexed and uses thereof |
| WO2019160734A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated lometrexol and uses thereof |
| EP3755335A4 (en) | 2018-02-14 | 2022-06-22 | L.E.A.F Holdings Group LLC | GAMMA POLYGLUTAMIC TETRAHYDROFOLATES AND THEIR USES |
| CA3090943A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated aminopterin and uses thereof |
| EP3752156A4 (en) | 2018-02-14 | 2021-10-27 | L.E.A.F Holdings Group LLC | GAMMA-POLYGLUTAMIZED PRALATREXATE AND USES THEREOF |
| EP3752155A4 (en) | 2018-02-14 | 2022-03-16 | L.E.A.F Holdings Group LLC | GAMMA POLYGLUTAMATE METHOTREXATE AND USES THEREOF |
| CN108524450A (zh) * | 2018-04-16 | 2018-09-14 | 温州医科大学 | 基于磁性热敏阳离子脂质体的奥沙利铂和mdc1-as共传递药物载体的制备及应用 |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| JP7483193B2 (ja) | 2018-06-13 | 2024-05-15 | カリフォルニア・インスティテュート・オブ・テクノロジー | 血脳バリアを越えるためのナノ粒子とそれを用いた治療法 |
| AU2019347666B2 (en) | 2018-09-28 | 2025-10-02 | President And Fellows Of Harvard College | Cellular reprogramming to reverse aging and promote organ and tissue regeneration |
| EA202190688A1 (ru) | 2018-10-09 | 2021-06-07 | Дзе Юниверсити Оф Бритиш Коламбиа | Композиции и системы, содержащие трансфекционно-компетентные везикулы, не содержащие органических растворителей и детергентов, и связанные с ними способы |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| AU2020240109A1 (en) | 2019-03-19 | 2021-09-30 | President And Fellows Of Harvard College | Methods and compositions for editing nucleotide sequences |
| CN111721841B (zh) * | 2019-03-19 | 2022-07-12 | 海南长安国际制药有限公司 | 与洛铂有关物质的检测 |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| CN110292563B (zh) * | 2019-06-12 | 2021-07-16 | 兰州大学 | 基于叶酸热敏脂质体的阴离子载体诱导癌细胞凋亡的方法 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| US20230112563A1 (en) * | 2020-03-04 | 2023-04-13 | Siemens Healthcare Diagnostics Inc. | Compositions and methods of using modified liposomes |
| BR112022022603A2 (pt) | 2020-05-08 | 2023-01-17 | Broad Inst Inc | Métodos e composições para edição simultânea de ambas as fitas de sequência alvo de nucleotídeos de fita dupla |
| CN112129871B (zh) * | 2020-09-04 | 2021-06-15 | 斯微(上海)生物科技有限公司 | 复合磷脂脂质体中dope和m5两种磷脂含量的检测方法 |
| CN112870164B (zh) * | 2021-01-25 | 2021-12-17 | 山东大学 | 一种双靶向载药脂质体及其制备方法和应用 |
| JP2025511883A (ja) | 2022-04-06 | 2025-04-16 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 中枢神経系の加齢を逆行させること |
| KR20250146635A (ko) | 2024-04-01 | 2025-10-13 | 고려대학교 산학협력단 | 리포좀 폴록사머 복합체를 포함하는 통증 질환 치료 조성물 |
Family Cites Families (156)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6041077B2 (ja) | 1976-09-06 | 1985-09-13 | 喜徳 喜谷 | １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体 |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| GR75598B (enExample) | 1980-04-29 | 1984-08-01 | Sanofi Sa | |
| US4534899A (en) | 1981-07-20 | 1985-08-13 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
| US4565696A (en) | 1983-08-03 | 1986-01-21 | The Regents Of The University Of California | Production of immunogens by antigen conjugation to liposomes |
| US4789633A (en) | 1984-04-19 | 1988-12-06 | University Of Tennessee Research Corporation | Fused liposome and acid induced method for liposome fusion |
| US4925661A (en) | 1984-04-19 | 1990-05-15 | Leaf Huang | Target-specific cytotoxic liposomes |
| US5736155A (en) | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| EP0211042A1 (en) * | 1985-01-18 | 1987-02-25 | Cooper-Lipotech, Inc. | Liposome composition and method |
| US4762915A (en) * | 1985-01-18 | 1988-08-09 | Liposome Technology, Inc. | Protein-liposome conjugates |
| US5026651A (en) | 1985-04-25 | 1991-06-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the production of human transferrin |
| PH26160A (en) * | 1985-08-19 | 1992-03-18 | Univ Texas | Pharmaceutical compositions consisting of acylated phospholipids |
| US4983397A (en) | 1985-08-19 | 1991-01-08 | Board Of Regents, University Of Texas System | Pharmaceutical compositions consisting of acylated phospholipids |
| US5384127A (en) | 1985-10-18 | 1995-01-24 | Board Of Regents, The University Of Texas System | Stable liposomal formulations of lipophilic platinum compounds |
| JPH0714865B2 (ja) | 1986-10-28 | 1995-02-22 | 武田薬品工業株式会社 | リポソ−ム製剤およびその製造法 |
| US5049390A (en) | 1987-09-02 | 1991-09-17 | Allergy Immuno Technologies, Inc. | Liposome containing immunotherapy agents for treating IgE mediated allergies |
| US4853224A (en) | 1987-12-22 | 1989-08-01 | Visionex | Biodegradable ocular implants |
| FR2631826B1 (fr) | 1988-05-27 | 1992-06-19 | Centre Nat Rech Scient | Vecteur particulaire utile notamment pour le transport de molecules a activite biologique et procede pour sa preparation |
| JPH0720857B2 (ja) | 1988-08-11 | 1995-03-08 | テルモ株式会社 | リポソームおよびその製法 |
| DE69034042T2 (de) | 1989-08-02 | 2003-07-17 | Mitra Medical Technology Ab, Lund | System zur verwendung in einem verfahren zur therapeutischen und diagnostischen behandlung |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| WO1992005773A1 (en) * | 1990-10-09 | 1992-04-16 | Vestar, Inc. | Phospholipid analogue vesicle with a succinimidyl moiety |
| US5554728A (en) | 1991-07-23 | 1996-09-10 | Nexstar Pharmaceuticals, Inc. | Lipid conjugates of therapeutic peptides and protease inhibitors |
| US6509032B1 (en) | 1991-08-28 | 2003-01-21 | Mcmaster University | Cationic amphiphiles |
| US5292524A (en) | 1991-09-06 | 1994-03-08 | California Institute Of Technology | Blood platelet loaded with diagnostic or therapeutic-containing liposome or reconstituted Sendai virus |
| JPH0776230B2 (ja) | 1992-01-13 | 1995-08-16 | 田中貴金属工業株式会社 | 白金化合物の製造方法 |
| JPH06287021A (ja) | 1992-04-22 | 1994-10-11 | Tanaka Kikinzoku Kogyo Kk | 光学活性な白金錯化合物の光学的分割方法 |
| JP2673331B2 (ja) | 1993-01-12 | 1997-11-05 | 田中貴金属工業 株式会社 | 光学的に高純度なシス―オキザラート（トランス―１―１，２―シクロヘキサンジアミン）白金（▲ｉｉ▼） |
| US20030190638A1 (en) | 1992-05-13 | 2003-10-09 | Board Of Regents, The University Of Texas System | Methods of screening for compounds that derepress or increase telomerase activity |
| US20030100489A1 (en) | 1992-10-16 | 2003-05-29 | Beach David H. | Cell-cycle regulatory proteins, and uses related thereto |
| US5962316A (en) | 1992-10-16 | 1999-10-05 | Cold Spring Harbor Laboratory | Cell-cycle regulatory proteins, and uses related thereto |
| WO1994026254A1 (en) | 1993-05-17 | 1994-11-24 | The Liposome Company, Inc. | Incorporation of taxol into liposomes and gels |
| JP3025602B2 (ja) | 1993-05-21 | 2000-03-27 | デビオファーム エス．アー． | 光学的に高純度なシス−オキザラート（トランス−ｌ−１，２−シクロヘキサンジアミン）白金（ＩＩ）錯体の製造方法 |
| US5534241A (en) | 1993-07-23 | 1996-07-09 | Torchilin; Vladimir P. | Amphipathic polychelating compounds and methods of use |
| WO1995009611A2 (en) * | 1993-10-06 | 1995-04-13 | Amgen Inc. | Stable protein: phospholipid compositions and methods |
| US6087171A (en) | 1993-12-17 | 2000-07-11 | Spinal Cord Society | Method for inducing DNA synthesis in neurons |
| US5830686A (en) | 1994-01-13 | 1998-11-03 | Calydon | Tissue-specific enhancer active in prostate |
| US6057299A (en) | 1994-01-13 | 2000-05-02 | Calydon, Inc. | Tissue-specific enhancer active in prostate |
| AU2076895A (en) | 1994-03-28 | 1995-10-17 | Daiichi Pharmaceutical Co., Ltd. | Liposomes |
| JPH10503772A (ja) | 1994-07-29 | 1998-04-07 | アボツト・ラボラトリーズ | 置換２，５−ジアミノ−３−ヒドロキシヘキサンの製造方法 |
| DE69519300T2 (de) | 1994-08-08 | 2001-05-31 | Debiopharm S.A., Lausanne | Stabiles arzneimittel enthaltend oxaliplatin |
| DK0785773T3 (da) * | 1994-10-14 | 2001-01-29 | Liposome Co Inc | Etherlipidliposomer og deres terapeutiske anvendelse |
| EP1369116A1 (en) | 1994-11-11 | 2003-12-10 | Debiopharm S.A. | Oxalatoplatin and 5-fluorouracil for combination therapy of cancer |
| US5786214A (en) | 1994-12-15 | 1998-07-28 | Spinal Cord Society | pH-sensitive immunoliposomes and method of gene delivery to the mammalian central nervous system |
| US5580899A (en) * | 1995-01-09 | 1996-12-03 | The Liposome Company, Inc. | Hydrophobic taxane derivatives |
| US6008202A (en) | 1995-01-23 | 1999-12-28 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| TW319763B (enExample) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| US5780052A (en) | 1995-04-24 | 1998-07-14 | Northeastern University | Compositions and methods useful for inhibiting cell death and for delivering an agent into a cell |
| US5834012A (en) * | 1995-05-03 | 1998-11-10 | Roman Perez-Soler | Lipid complexed topoisomerase I inhibitors |
| US20020022264A1 (en) | 1995-05-26 | 2002-02-21 | Sullivan Sean M. | Delivery vehicles comprising stable lipid/nucleic acid complexes |
| US6825174B2 (en) | 1995-06-07 | 2004-11-30 | East Carolina University | Composition, formulations & method for prevention & treatment of diseases and conditions associated with bronchoconstriction, allergy(ies) & inflammation |
| JP3154399B2 (ja) | 1996-07-04 | 2001-04-09 | デビオファーム エス．アー． | 白金化合物の製造方法 |
| JPH09278785A (ja) | 1996-04-10 | 1997-10-28 | Tanaka Kikinzoku Kogyo Kk | 白金化合物の製造方法 |
| FR2740686B1 (fr) | 1995-11-03 | 1998-01-16 | Sanofi Sa | Formulation pharmaceutique lyophilisee stable |
| US6428977B1 (en) | 1995-12-20 | 2002-08-06 | Curis, Inc. | Signalin family of TGFβ signal transduction proteins, and uses related thereto |
| JP3735921B2 (ja) | 1996-02-07 | 2006-01-18 | 三菱ウェルファーマ株式会社 | ＧＰＩｂ・脂質複合体およびその用途 |
| EP0904100B1 (en) | 1996-02-09 | 2006-07-26 | Pi-Wan Cheng | Cationic lipid and receptor ligand-facilitated delivery of biologically active molecules |
| US6153646A (en) | 1996-03-11 | 2000-11-28 | Yoshinori Kidani | Binuclear platinum complexes, method for preparing same and pharmaceutical compositions containing said complexes |
| WO1997035560A1 (en) | 1996-03-28 | 1997-10-02 | The Board Of Trustees Of The University Of Illinois | Materials and methods for making improved echogenic liposome compositions |
| WO1997042166A1 (fr) | 1996-05-02 | 1997-11-13 | Terumo Kabushiki Kaisha | Derives amidines et vecteurs de medicaments les contenant |
| ES2208946T3 (es) | 1996-08-23 | 2004-06-16 | Sequus Pharmaceuticals, Inc. | Liposomas que contienen un compuesto de cisplatino. |
| TW520297B (en) * | 1996-10-11 | 2003-02-11 | Sequus Pharm Inc | Fusogenic liposome composition and method |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| AU725376B2 (en) * | 1996-10-15 | 2000-10-12 | Transave, Inc. | Peptide-lipid conjugates, liposomes and liposomal drug delivery |
| EP0966267B1 (en) | 1996-10-15 | 2009-02-25 | Transave, Inc. | N-acyl phosphatidylethanolamine-mediated liposomal drug delivery |
| US6153596A (en) | 1996-12-18 | 2000-11-28 | Emory University | Polycationic oligomers |
| WO1998039009A1 (en) | 1997-03-07 | 1998-09-11 | Sanofi Pharmaceuticals, Inc. | Method of treating a tumor |
| JPH10253632A (ja) | 1997-03-10 | 1998-09-25 | Nissui Pharm Co Ltd | 分析方法、キット及び装置 |
| DE19709704C2 (de) | 1997-03-10 | 1999-11-04 | Michael Georgieff | Verwendung einer flüssigen Präparation von Xenon zur intravenösen Verabreichung bei Einleitung und/oder Aufrechterhaltung der Anaesthesie |
| US6120751A (en) * | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| US6060082A (en) | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
| US6524613B1 (en) | 1997-04-30 | 2003-02-25 | Regents Of The University Of Minnesota | Hepatocellular chimeraplasty |
| US6272370B1 (en) | 1998-08-07 | 2001-08-07 | The Regents Of University Of Minnesota | MR-visible medical device for neurological interventions using nonlinear magnetic stereotaxis and a method imaging |
| WO1998059035A2 (en) | 1997-06-25 | 1998-12-30 | The Goverment Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services, National Institutes Of Health | Serum-free cell growth medium |
| AU742407B2 (en) | 1997-07-15 | 2002-01-03 | Regents Of The University Of California, The | Isolated DNA encoding human calcium activated potassium channel |
| WO1999006576A1 (en) | 1997-08-04 | 1999-02-11 | Calydon, Inc. | A human glandular kallikrein enhancer, vectors comprising the enhancer and methods of use thereof |
| SK4842000A3 (en) | 1997-10-02 | 2000-11-07 | Epix Medical Inc | Contrast-enhanced diagnostic imaging method for monitoring interventional therapies |
| US6749863B1 (en) | 1997-11-19 | 2004-06-15 | Georgetown University | Targeted liposome gene delivery |
| US6320017B1 (en) | 1997-12-23 | 2001-11-20 | Inex Pharmaceuticals Corp. | Polyamide oligomers |
| US6573101B1 (en) | 1998-02-12 | 2003-06-03 | The Regents Of The University Of California | Compositions for receptor/liposome mediated transfection and methods of using same |
| GB9804013D0 (en) | 1998-02-25 | 1998-04-22 | Sanofi Sa | Formulations |
| US6245427B1 (en) | 1998-07-06 | 2001-06-12 | DüZGüNES NEJAT | Non-ligand polypeptide and liposome complexes as intracellular delivery vehicles |
| ES2178474T3 (es) | 1998-10-14 | 2002-12-16 | Debiopharm Sa | Acondicionamiento de una preparacion de oxaliplatino. |
| US7311924B2 (en) | 1999-04-01 | 2007-12-25 | Hana Biosciences, Inc. | Compositions and methods for treating cancer |
| US6723338B1 (en) | 1999-04-01 | 2004-04-20 | Inex Pharmaceuticals Corporation | Compositions and methods for treating lymphoma |
| JP2003502025A (ja) | 1999-05-17 | 2003-01-21 | エイブイアイ バイオファーマ， インコーポレイテッド | ｈｃＧワクチンを用いた癌の処置のための併用アプローチ |
| JP2001002592A (ja) | 1999-06-18 | 2001-01-09 | Dai Ichi Seiyaku Co Ltd | 遺伝子導入用組成物 |
| US6280054B1 (en) * | 1999-07-02 | 2001-08-28 | Zight Corporation | Image generator having an improved illumination system |
| US6242188B1 (en) | 1999-07-30 | 2001-06-05 | Applied Gene Technologies, Inc. | Sample processing to release nucleic acids for direct detection |
| WO2001011826A1 (en) * | 1999-08-09 | 2001-02-15 | Fujitsu Limited | Package control device and method |
| WO2001015691A1 (fr) | 1999-08-30 | 2001-03-08 | Debiopharm S.A. | Preparation pharmaceutique stable d'oxaliplatine pour administration par voie parenterale |
| CN1433478A (zh) | 1999-12-30 | 2003-07-30 | 诺瓦提斯公司 | 用于基因治疗的新的胶体合成载体 |
| WO2001049266A2 (en) | 1999-12-30 | 2001-07-12 | Gwathemy Judith K | Iron chelator delivery system |
| AU785017B2 (en) * | 2000-01-10 | 2006-08-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of disease |
| US6530944B2 (en) | 2000-02-08 | 2003-03-11 | Rice University | Optically-active nanoparticles for use in therapeutic and diagnostic methods |
| US7001735B2 (en) | 2000-03-01 | 2006-02-21 | Albert Einstein College Of Medicine Of Yeshiva University | Glucose transporter/sensor protein and uses thereof |
| EP1262490B1 (en) | 2000-03-02 | 2007-10-03 | Mitsubishi Pharma Corporation | GPib-LIPID BOND CONSTRUCT AND USE THEREOF |
| JP4449147B2 (ja) | 2000-03-22 | 2010-04-14 | 日油株式会社 | ホスファチジルエタノールアミン誘導体の製造方法 |
| FR2806727A1 (fr) | 2000-03-23 | 2001-09-28 | Pf Medicament | Molecule d'interet pharmaceutique comprotant en son extremite n-terminale un acide glutamique ou une glutamine sous forme de sel d'addition d'acide fort physiologiquement acceptable |
| DE60132184T2 (de) | 2000-04-12 | 2009-01-15 | Liplasome Pharma A/S | Auf lipiden basierende arzneistoffabgabesysteme gegen parasitäre infektionen |
| WO2001082899A2 (en) | 2000-05-03 | 2001-11-08 | Mbt Munich Biotechnology Ag | Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites |
| US20030059461A1 (en) | 2000-06-06 | 2003-03-27 | Sibtech, Inc. | Molecular delivery vehicle for delivery of selected compounds to targets |
| US20030072794A1 (en) | 2000-06-09 | 2003-04-17 | Teni Boulikas | Encapsulation of plasmid DNA (lipogenes™) and therapeutic agents with nuclear localization signal/fusogenic peptide conjugates into targeted liposome complexes |
| ATE415414T1 (de) | 2000-09-11 | 2008-12-15 | Pasteur Institut | Mitochondrialen membrane permeabilisierung durch hiv-1 vpr und screeningsverfahren |
| US20040234588A1 (en) | 2000-09-21 | 2004-11-25 | University Of Georgia Research Foundation, Inc. | Artificial lipoprotein carrier system for bioactive materials |
| EP1324758B1 (fr) | 2000-10-03 | 2005-01-12 | Debiopharm S.A. | Microspheres de polymere de type plga/pla encapsulant des substances solubles dans l'eau, et leur procede de preparation |
| US20030129223A1 (en) * | 2000-10-11 | 2003-07-10 | Targesome, Inc. | Targeted multivalent macromolecules |
| AU2002231637A1 (en) * | 2000-11-22 | 2002-06-03 | Vectron Therapeutics Ag | Production and use of a targeted diagnostic system |
| CN1559007A (zh) | 2000-12-12 | 2004-12-29 | 澳大利亚海洋科学研究院 | 致瘫痪水生有壳类动物毒素的分析 |
| US7012072B2 (en) * | 2000-12-12 | 2006-03-14 | Debiopharm S.A. | Pharmaceutical oxaliplatinum preparation for parenteral administration and method for obtaining same |
| US6897196B1 (en) | 2001-02-07 | 2005-05-24 | The Regents Of The University Of California | pH sensitive lipids based on ortho ester linkers, composition and method |
| US6703524B2 (en) | 2001-02-20 | 2004-03-09 | Lkt Laboratories, Inc. | Organoselenium compounds for cancer chemoprevention |
| DK1368022T3 (da) | 2001-03-02 | 2007-10-01 | Debiopharm Sa | Anvendelse af en flaske indeholdende en oxaliplatinoplösning |
| FI113840B (fi) | 2001-03-26 | 2004-06-30 | Ctt Cancer Targeting Tech Oy | Matriisi-metalloproteinaasi-inhibiittorien käyttö liposomien kohdentamisessa |
| US20040049022A1 (en) | 2001-04-24 | 2004-03-11 | Nyce Jonathan W. | Composition & methods for treatment and screening |
| US20030203865A1 (en) | 2001-04-30 | 2003-10-30 | Pierrot Harvie | Lipid-comprising drug delivery complexes and methods for their production |
| US20030082228A1 (en) | 2001-05-09 | 2003-05-01 | Inex Pharmaceuticals Corporation | Anti-angiogenic therapy using liposome-encapsulated chemotherapeutic agents |
| US20030108986A1 (en) | 2001-06-21 | 2003-06-12 | Euroscreen, S.A. | Compositions and methods comprising G-protein coupled receptors |
| US20040186172A1 (en) | 2001-07-02 | 2004-09-23 | Houssam Ibrahim | Oxaliplatin active substance with a very low content of oxalic acid |
| US20030096299A1 (en) | 2001-07-09 | 2003-05-22 | Valerie Wittamer | Natural ligand of G protein coupled receptor ChemR23 and uses thereof |
| CA2457148A1 (en) | 2001-08-20 | 2003-02-27 | Transave, Inc. | Treatment of cancers by inhalation of stable platinum-containing formulations |
| DE10144252A1 (de) | 2001-08-31 | 2003-03-27 | Fraunhofer Ges Forschung | Nanopartikel mit daran immobilisiertem biologisch aktivem TNF |
| WO2003028640A2 (en) | 2001-10-03 | 2003-04-10 | Vanderbilt University | In vivo panning for ligands to radiation-induced molecules |
| WO2003044214A2 (en) | 2001-11-20 | 2003-05-30 | Baylor College Of Medicine | Methods and compositions in checkpoint signaling |
| JP4468617B2 (ja) | 2001-12-04 | 2010-05-26 | デビオファーム エス．アー． | 抗癌剤の併用投与方法及び併用可能な抗癌剤 |
| US6476068B1 (en) | 2001-12-06 | 2002-11-05 | Pharmacia Italia, S.P.A. | Platinum derivative pharmaceutical formulations |
| CA2471504C (en) | 2002-01-07 | 2014-05-20 | Euroscreen S.A. | Ligand for g-protein coupled receptor gpr43 and uses thereof |
| US20030220284A1 (en) | 2002-02-22 | 2003-11-27 | Patricia Yotnda | Delivery of adenoviral DNA in a liposomal formulation for treatment of disease |
| EP1587944A4 (en) | 2002-03-01 | 2007-03-21 | Dyax Corp | KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES |
| ATE477276T1 (de) | 2002-03-01 | 2010-08-15 | Immunomedics Inc | Internalisierung von anti cd74 monoklonalen antikörpern und deren verwendungen |
| AU2003221533A1 (en) | 2002-03-29 | 2003-10-13 | Euroscreen Sa | Ligands for g protein coupled receptor gpr7 and uses thereof |
| CA2391438A1 (en) | 2002-05-01 | 2003-11-01 | Procyon Biopharma Inc. | Psp94 diagnostic reagents and assays |
| US20030228285A1 (en) | 2002-05-03 | 2003-12-11 | Mien-Chie Hung | Bipartite T-cell factor (Tcf)-responsive promoter |
| US7460960B2 (en) | 2002-05-10 | 2008-12-02 | Epitome Biosystems, Inc. | Proteome epitope tags and methods of use thereof in protein modification analysis |
| JP3415131B1 (ja) | 2002-06-03 | 2003-06-09 | メビオファーム株式会社 | リポソーム製剤 |
| FR2840236B1 (fr) | 2002-06-03 | 2005-02-04 | Inst Francais Du Petrole | Membrane zeolithique de faible epaisseur, sa preparation et son utilisation en separation |
| US20040022842A1 (en) | 2002-06-03 | 2004-02-05 | Mebiopharm Co., Ltd. | Liposome preparations containing oxaliplatin |
| EP1511518A2 (en) | 2002-06-07 | 2005-03-09 | Immunomedics, Inc. | Neutrophil imaging methods in cystic fibrosis |
| JP5110768B2 (ja) | 2002-06-14 | 2012-12-26 | イミューノメディクス、インコーポレイテッド | モノクローナル抗体ｐａｍ４ならびに膵臓癌の診断および治療のためのその使用 |
| CN1675245B (zh) | 2002-06-14 | 2011-01-12 | 免疫医疗公司 | 人源化单克隆抗体hPAM4 |
| US6790632B2 (en) | 2002-06-17 | 2004-09-14 | Stephen Eliot Zweig | Membrane receptor reagent and assay |
| EP1519714B1 (en) | 2002-06-28 | 2010-10-20 | Protiva Biotherapeutics Inc. | Method and apparatus for producing liposomes |
| CA2494310A1 (en) | 2002-08-01 | 2004-02-12 | Immunomedics, Inc. | Alpha-fetoprotein immu31 antibodies and fusion proteins and methods of use thereof |
| US20040132652A1 (en) | 2002-08-30 | 2004-07-08 | Shire Biochem Inc. | Pharmaceutical compositions |
| EP1572104A4 (en) | 2002-11-14 | 2007-01-17 | Kirk Sperber | INDUCTION OF APOPTOSIS DURCHHIV-1-INFECTED MONOCYTE CELLS |
| AU2003280761B2 (en) | 2002-11-15 | 2009-10-01 | Nipro Corporation | Liposome |
| CA2511623A1 (en) | 2003-02-17 | 2004-08-26 | Mebiopharm Co., Ltd. | Remedy for cancer |
| CA2522819A1 (en) | 2003-04-22 | 2004-11-04 | Immunomedics, Inc. | Polyvalent protein complex |
| US7172751B2 (en) | 2003-06-13 | 2007-02-06 | Immunomedics, Inc. | D-amino acid peptides |
| EP2216342B1 (en) | 2003-07-31 | 2015-04-22 | Immunomedics, Inc. | Anti-CD19 antibodies |
| JP2005154282A (ja) | 2003-11-20 | 2005-06-16 | Mebiopharm Co Ltd | ガス封入リポソームの製造法 |
| US7582430B2 (en) * | 2004-01-20 | 2009-09-01 | United States Of America As Represented By The Secretary Of The Army | Immunoliposome-nucleic acid amplification (ILNAA) assay |
| US7212869B2 (en) * | 2004-02-04 | 2007-05-01 | Medtronic, Inc. | Lead retention means |
| EP1579850A3 (en) | 2004-03-15 | 2009-12-16 | Nipro Corporation | A pharmaceutical composition containing liposomes for treating a cancer |
| JP2006248978A (ja) | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| WO2008030818A2 (en) | 2006-09-05 | 2008-03-13 | Mebiopharm Co., Ltd. | Novel liposome compositions |
-
2005
- 2005-03-10 JP JP2005067469A patent/JP2006248978A/ja active Pending
-
2006
- 2006-03-08 RU RU2007137492/15A patent/RU2454229C2/ru not_active IP Right Cessation
- 2006-03-08 CN CN2006800159670A patent/CN101170995B/zh not_active Expired - Fee Related
- 2006-03-08 WO PCT/US2006/008650 patent/WO2006099169A2/en not_active Ceased
- 2006-03-08 AU AU2006223329A patent/AU2006223329B2/en not_active Ceased
- 2006-03-08 MX MX2007010996A patent/MX2007010996A/es active IP Right Grant
- 2006-03-08 ES ES06737793.7T patent/ES2529453T3/es active Active
- 2006-03-08 BR BRPI0608297-1A patent/BRPI0608297A2/pt not_active IP Right Cessation
- 2006-03-08 ZA ZA200708600A patent/ZA200708600B/xx unknown
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- 2006-03-08 KR KR1020077023219A patent/KR101352490B1/ko not_active Expired - Fee Related
- 2006-03-08 PL PL06737793T patent/PL1863448T3/pl unknown
- 2006-03-08 DK DK06737793.7T patent/DK1863448T3/en active
- 2006-03-08 SI SI200631892T patent/SI1863448T1/sl unknown
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-
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- 2007-10-09 NO NO20075136A patent/NO20075136L/no not_active Application Discontinuation
-
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- 2010-09-27 US US12/891,568 patent/US8758810B2/en not_active Expired - Fee Related
-
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- 2014-05-09 US US14/274,377 patent/US20140363491A1/en not_active Abandoned
-
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- 2015-02-06 CY CY20151100123T patent/CY1116075T1/el unknown
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| WO2014025042A1 (ja) | 2012-08-10 | 2014-02-13 | 大鵬薬品工業株式会社 | 安定なオキサリプラチン封入リポソーム水分散液及びその安定化方法 |
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| US10993913B2 (en) | 2012-08-10 | 2021-05-04 | Taiho Pharmaceutical Co., Ltd | Stable oxaliplatin-encapsulating liposome aqueous dispersion and method for stabilizing same |
| JP2016512550A (ja) * | 2013-03-13 | 2016-04-28 | マリンクロッド エルエルシー | がん治療のためのリポソームオキサリプラチン組成物 |
| JP2019512489A (ja) * | 2016-03-07 | 2019-05-16 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | マイクロｒｎａおよびその使用方法 |
| US11655469B2 (en) | 2016-03-07 | 2023-05-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | MicroRNAs and methods of their use |
| JP2021521279A (ja) * | 2018-04-11 | 2021-08-26 | ニュー メキシコ テック ユニバーシティ リサーチ パーク コーポレーション | 薬物送達における使用のための脂質プロドラッグ |
| US11597930B2 (en) | 2020-04-02 | 2023-03-07 | Mirecule, Inc. | Targeted inhibition using engineered oligonucleotides |
| US11795459B2 (en) | 2020-04-02 | 2023-10-24 | Mirecule, Inc. | Targeted inhibition using engineered oligonucleotides |
| US12104157B2 (en) | 2020-04-02 | 2024-10-01 | Mirecule, Inc. | Targeted inhibition using engineered oligonucleotides |
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| AU2006223329A1 (en) | 2006-09-21 |
| NO20075136L (no) | 2007-12-07 |
| KR20080002819A (ko) | 2008-01-04 |
| WO2006099169A2 (en) | 2006-09-21 |
| HUE024290T2 (en) | 2016-01-28 |
| MX2007010996A (es) | 2007-11-07 |
| HK1111625A1 (en) | 2008-08-15 |
| US7829113B2 (en) | 2010-11-09 |
| AU2006223329B2 (en) | 2011-11-17 |
| JP5438317B2 (ja) | 2014-03-12 |
| ES2529453T3 (es) | 2015-02-20 |
| EP1863448B1 (en) | 2014-11-26 |
| RU2007137492A (ru) | 2009-04-20 |
| CY1116075T1 (el) | 2017-02-08 |
| NZ561569A (en) | 2011-03-31 |
| CN101170995B (zh) | 2013-01-16 |
| PL1863448T3 (pl) | 2015-05-29 |
| KR101352490B1 (ko) | 2014-02-04 |
| US20110081404A1 (en) | 2011-04-07 |
| US20060222696A1 (en) | 2006-10-05 |
| ZA200708600B (en) | 2009-01-28 |
| BRPI0608297A2 (pt) | 2009-12-08 |
| JP2008538105A (ja) | 2008-10-09 |
| DK1863448T3 (en) | 2015-02-16 |
| US8758810B2 (en) | 2014-06-24 |
| RU2454229C2 (ru) | 2012-06-27 |
| EP1863448A2 (en) | 2007-12-12 |
| PT1863448E (pt) | 2015-02-10 |
| SI1863448T1 (sl) | 2015-03-31 |
| CN101170995A (zh) | 2008-04-30 |
| CA2600446A1 (en) | 2006-09-21 |
| US20140363491A1 (en) | 2014-12-11 |
| WO2006099169A3 (en) | 2007-02-22 |
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