ES2280835T3 - Formulacion no higroscopica que comprende un farmaco higroscopico. - Google Patents
Formulacion no higroscopica que comprende un farmaco higroscopico. Download PDFInfo
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- ES2280835T3 ES2280835T3 ES03796731T ES03796731T ES2280835T3 ES 2280835 T3 ES2280835 T3 ES 2280835T3 ES 03796731 T ES03796731 T ES 03796731T ES 03796731 T ES03796731 T ES 03796731T ES 2280835 T3 ES2280835 T3 ES 2280835T3
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| ATE228358T1 (de) * | 2001-03-21 | 2002-12-15 | Sanol Arznei Schwarz Gmbh | Neue verwendung einer klasse von peptidverbindungen zur behandlung von allodynie oder andere arten von chronischen oder phantomschmerzen |
| SE521512C2 (sv) * | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
| JP2006513238A (ja) * | 2002-12-19 | 2006-04-20 | ファルマシア・コーポレーション | 吸湿性薬物を含む非‐吸湿性製剤 |
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| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| FR2865133B1 (fr) * | 2004-01-19 | 2008-01-18 | Rytek | Compositions pour le traitement de pathologies digestives |
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| US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
| JP2007532607A (ja) | 2004-04-16 | 2007-11-15 | シュバルツ ファルマ アクチェンゲゼルシャフト | 慢性頭痛の予防及び治療のためのペプチド化合物の使用 |
| EP1765309B1 (en) * | 2004-07-02 | 2009-08-05 | Radi Medical Biodegradable AB | Smokeless toabacco product |
| ATE471717T1 (de) * | 2004-08-27 | 2010-07-15 | Ucb Pharma Gmbh | Verwendung von peptidverbindungen zur behandlung von schmerzen durch knochenkrebs, chemotherapie- und nucleosid-bedingten schmerzen |
| US20060147518A1 (en) * | 2004-12-30 | 2006-07-06 | Pierre Fabre Medicament | Stable solid dispersion of a derivative of vinca alkaloid and process for manufacturing it |
| US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
| EP1754476A1 (en) * | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
| US20070048372A1 (en) * | 2005-08-18 | 2007-03-01 | Srz Properties, Inc. | Method for treating non-inflammatory osteoarthritic pain |
| US20090304786A1 (en) * | 2005-11-25 | 2009-12-10 | Viswaprasad Varanasi | Stable Dosage Forms of an Antidepressant |
| CA2646942C (en) | 2006-03-16 | 2014-07-29 | Niconovum Ab | Improved snuff composition |
| RU2406502C2 (ru) * | 2006-06-06 | 2010-12-20 | Тиботек Фармасьютикалз Лтд. | Способ получения препаратов тмс125, полученных сушкой распылением |
| EP2037965B1 (en) | 2006-06-15 | 2017-08-30 | UCB Pharma GmbH | Pharmaceutical composition with synergistic anticonvulsant effect |
| EP1920785A1 (en) | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
| CA2673536A1 (en) * | 2006-12-22 | 2008-07-03 | Yuhan Corporation | Revaprazan-containing solid dispersion and process for the preparation thereof |
| US9358242B2 (en) * | 2007-08-30 | 2016-06-07 | Prelief Inc. | Calcium glycerophosphate for treating and preventing respiratory diseases or conditions |
| CA2701388C (en) * | 2007-08-30 | 2015-06-23 | Prelief Inc. | Calcium glycerophosphate for treating and preventing respiratory diseases or conditions |
| KR101499533B1 (ko) * | 2008-02-15 | 2015-03-09 | 주식회사 씨티씨바이오 | 콜린 알포세레이트 함유 약학 제제 |
| DE102008020701A1 (de) * | 2008-04-24 | 2009-10-29 | Bayer Technology Services Gmbh | Formulierung mit reduzierter Hygroskopizität |
| DE102008047910A1 (de) | 2008-09-19 | 2010-03-25 | Molkerei Meggle Wasserburg Gmbh & Co. Kg | Tablettierhilfsstoff auf Laktose- und Cellulosebasis |
| KR101172699B1 (ko) | 2011-05-16 | 2012-08-09 | 한국프라임제약주식회사 | 콜린알포세레이트를 함유하는 약학 제제, 및 그의 제조방법 |
| JP2014522893A (ja) | 2011-07-07 | 2014-09-08 | ザ ルブリゾル コーポレイション | ２ストロークサイクルエンジンのための改善された清浄性を提供する潤滑剤 |
| CN102525992A (zh) * | 2012-03-09 | 2012-07-04 | 徐奎 | L-α-甘油磷酸胆碱薄膜衣片及其制备方法 |
| ES2924478T3 (es) | 2012-03-15 | 2022-10-07 | Boehringer Ingelheim Vetmedica Gmbh | Formulación de comprimidos farmacéuticos para el sector médico veterinario, método de producción y uso de los mismos |
| WO2013175505A1 (en) * | 2012-05-21 | 2013-11-28 | Hetero Research Foundation | Elvitegravir solid dispersion |
| HRP20251029T1 (hr) | 2013-07-19 | 2025-10-24 | Boehringer Ingelheim Vetmedica Gmbh | Konzervirani eterificirani derivati ciklodekstrina koji sadrže tekući vodeni farmaceutski pripravak |
| PL3106150T3 (pl) * | 2013-12-04 | 2022-01-03 | Boehringer Ingelheim Vetmedica Gmbh | Ulepszone kompozycje farmaceutyczne pimobendanu |
| GB2525170A (en) * | 2014-04-07 | 2015-10-21 | Nokia Technologies Oy | Stereo viewing |
| CN104739776A (zh) * | 2015-04-15 | 2015-07-01 | 福州乾正药业有限公司 | 左卡尼汀的固体分散体组合物及其制备方法和药物应用 |
| WO2017013591A1 (en) * | 2015-07-22 | 2017-01-26 | Leiutis Pharmaceuticals Pvt Ltd | Stabilized liquid formulation of levothyroxine |
| BR112018068986B1 (pt) * | 2016-03-18 | 2023-03-21 | Christopher Brian Reid | Composição para reduzir a expressão oncógena de uma célula, tecido ou órgão de um indivíduo |
| US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
| JP7319247B2 (ja) * | 2018-03-30 | 2023-08-01 | 株式会社カネカ | 酸化型グルタチオンを含む固体組成物及びその製造方法 |
| CN112316678A (zh) * | 2020-10-12 | 2021-02-05 | 常州市永勃机械有限公司 | 一种变电站柜体用驱潮剂制备工艺制备方法 |
| IT202100018578A1 (it) * | 2021-07-14 | 2023-01-14 | Indena Spa | Dispersione amorfa di maltolo ferrico e relativo processo di preparazione |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4835187A (en) * | 1987-06-15 | 1989-05-30 | American Home Products Corporation | Spray dried ibuprofen |
| JPH02218621A (ja) * | 1989-02-20 | 1990-08-31 | Nippon Chemiphar Co Ltd | 徐放性製剤 |
| US5582837A (en) * | 1992-03-25 | 1996-12-10 | Depomed, Inc. | Alkyl-substituted cellulose-based sustained-release oral drug dosage forms |
| SE9303574D0 (sv) * | 1993-11-01 | 1993-11-01 | Kabi Pharmacia Ab | Composition for drug delivery and method the manufacturing thereof |
| US5688510A (en) * | 1993-11-18 | 1997-11-18 | Nippon Shinyaku Co. Ltd. | Process for producing stable medicinal composition, and pharmaceutical preparation |
| JPH08157392A (ja) * | 1994-12-01 | 1996-06-18 | Kanegafuchi Chem Ind Co Ltd | 放出制御型製剤 |
| GB9607955D0 (en) * | 1996-04-17 | 1996-06-19 | Tillotts Pharma Ag | Hydrophobic carbomer salt compositions |
| JPH10182448A (ja) * | 1996-12-24 | 1998-07-07 | Zensei Yakuhin Kogyo Kk | 圧縮製剤用組成物の製造方法 |
| MA25590A1 (fr) * | 1998-09-14 | 2002-12-31 | Inhale Therapeutic Syst | Agent actif de delivraison de poudre seche |
| US6264981B1 (en) * | 1999-10-27 | 2001-07-24 | Anesta Corporation | Oral transmucosal drug dosage using solid solution |
| ZA200206459B (en) * | 2000-03-24 | 2003-08-13 | Pharmacia Corp | Amidino compound and salts thereof useful as nitric oxide synthase inhibitors. |
| US20020143058A1 (en) * | 2001-01-24 | 2002-10-03 | Taro Pharmaceutical Inductries Ltd. | Process for preparing non-hygroscopic sodium valproate composition |
| JP2006513238A (ja) * | 2002-12-19 | 2006-04-20 | ファルマシア・コーポレーション | 吸湿性薬物を含む非‐吸湿性製剤 |
-
2003
- 2003-12-05 JP JP2004565235A patent/JP2006513238A/ja active Pending
- 2003-12-05 AU AU2003298010A patent/AU2003298010A1/en not_active Abandoned
- 2003-12-05 MX MXPA05006802A patent/MXPA05006802A/es unknown
- 2003-12-05 BR BR0317392-5A patent/BR0317392A/pt not_active IP Right Cessation
- 2003-12-05 WO PCT/US2003/038792 patent/WO2004060352A1/en not_active Ceased
- 2003-12-05 CA CA002511385A patent/CA2511385A1/en not_active Abandoned
- 2003-12-05 EP EP03796731A patent/EP1575563B1/en not_active Expired - Lifetime
- 2003-12-05 AT AT03796731T patent/ATE353633T1/de not_active IP Right Cessation
- 2003-12-05 ES ES03796731T patent/ES2280835T3/es not_active Expired - Lifetime
- 2003-12-05 DE DE60311875T patent/DE60311875T2/de not_active Expired - Fee Related
- 2003-12-11 BR BR0317103-5A patent/BR0317103A/pt not_active IP Right Cessation
- 2003-12-11 JP JP2004565403A patent/JP2006514052A/ja not_active Withdrawn
- 2003-12-11 WO PCT/US2003/039510 patent/WO2004060353A1/en not_active Ceased
- 2003-12-11 AU AU2003296948A patent/AU2003296948A1/en not_active Abandoned
- 2003-12-11 CA CA002509261A patent/CA2509261A1/en not_active Abandoned
- 2003-12-11 MX MXPA05005667A patent/MXPA05005667A/es unknown
- 2003-12-11 EP EP03814729A patent/EP1575564A1/en not_active Withdrawn
- 2003-12-17 TW TW092135756A patent/TW200423971A/zh unknown
- 2003-12-17 AR ARP030104684A patent/AR042511A1/es unknown
- 2003-12-18 NL NL1025069A patent/NL1025069C2/nl not_active IP Right Cessation
- 2003-12-18 US US10/741,530 patent/US20040197411A1/en not_active Abandoned
- 2003-12-18 AR ARP030104716A patent/AR042536A1/es unknown
- 2003-12-18 TW TW092135960A patent/TW200413006A/zh unknown
- 2003-12-18 US US10/741,526 patent/US20050013856A1/en not_active Abandoned
- 2003-12-19 UY UY28138A patent/UY28138A1/es not_active Application Discontinuation
- 2003-12-19 HN HN2003000417A patent/HN2003000417A/es unknown
-
2004
- 2004-01-05 PE PE2004000027A patent/PE20040972A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004060353A1 (en) | 2004-07-22 |
| AR042511A1 (es) | 2005-06-22 |
| EP1575564A1 (en) | 2005-09-21 |
| NL1025069C2 (nl) | 2005-02-16 |
| HN2003000417A (es) | 2005-11-01 |
| US20050013856A1 (en) | 2005-01-20 |
| JP2006513238A (ja) | 2006-04-20 |
| TW200423971A (en) | 2004-11-16 |
| UY28138A1 (es) | 2004-08-31 |
| AR042536A1 (es) | 2005-06-22 |
| CA2511385A1 (en) | 2004-07-22 |
| MXPA05005667A (es) | 2005-07-26 |
| US20040197411A1 (en) | 2004-10-07 |
| EP1575563A1 (en) | 2005-09-21 |
| WO2004060352A1 (en) | 2004-07-22 |
| DE60311875D1 (de) | 2007-03-29 |
| WO2004060352A8 (en) | 2005-09-15 |
| PE20040972A1 (es) | 2004-12-14 |
| AU2003296948A1 (en) | 2004-07-29 |
| CA2509261A1 (en) | 2004-07-22 |
| BR0317103A (pt) | 2005-10-25 |
| EP1575563B1 (en) | 2007-02-14 |
| NL1025069A1 (nl) | 2004-07-01 |
| BR0317392A (pt) | 2005-12-20 |
| ATE353633T1 (de) | 2007-03-15 |
| MXPA05006802A (es) | 2005-09-08 |
| TW200413006A (en) | 2004-08-01 |
| WO2004060353A9 (en) | 2004-10-07 |
| JP2006514052A (ja) | 2006-04-27 |
| AU2003298010A1 (en) | 2004-07-29 |
| DE60311875T2 (de) | 2007-08-30 |
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