JP2009537478A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009537478A5 JP2009537478A5 JP2009510416A JP2009510416A JP2009537478A5 JP 2009537478 A5 JP2009537478 A5 JP 2009537478A5 JP 2009510416 A JP2009510416 A JP 2009510416A JP 2009510416 A JP2009510416 A JP 2009510416A JP 2009537478 A5 JP2009537478 A5 JP 2009537478A5
- Authority
- JP
- Japan
- Prior art keywords
- binder
- weight
- group
- cellulose
- granules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 claims 14
- 239000011230 binding agent Substances 0.000 claims 6
- 239000008187 granular material Substances 0.000 claims 5
- FAEKWTJYAYMJKF-QHCPKHFHSA-N GlucoNorm Chemical compound C1=C(C(O)=O)C(OCC)=CC(CC(=O)N[C@@H](CC(C)C)C=2C(=CC=CC=2)N2CCCCC2)=C1 FAEKWTJYAYMJKF-QHCPKHFHSA-N 0.000 claims 3
- 239000007884 disintegrant Substances 0.000 claims 3
- 239000000945 filler Substances 0.000 claims 3
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 3
- 229960003105 metformin Drugs 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- 229960002354 repaglinide Drugs 0.000 claims 3
- 239000007916 tablet composition Substances 0.000 claims 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 2
- 229920002261 Corn starch Polymers 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 239000008120 corn starch Substances 0.000 claims 2
- 239000002706 dry binder Substances 0.000 claims 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000003495 polar organic solvent Substances 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- 238000005550 wet granulation Methods 0.000 claims 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 239000004386 Erythritol Substances 0.000 claims 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000004349 Polyvinylpyrrolidone-vinyl acetate copolymer Substances 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 229960004977 anhydrous lactose Drugs 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
- 235000011010 calcium phosphates Nutrition 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 claims 1
- 229920001531 copovidone Polymers 0.000 claims 1
- 229960005168 croscarmellose Drugs 0.000 claims 1
- 229960000913 crospovidone Drugs 0.000 claims 1
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims 1
- 235000019414 erythritol Nutrition 0.000 claims 1
- 229940009714 erythritol Drugs 0.000 claims 1
- 238000009477 fluid bed granulation Methods 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 229960001375 lactose Drugs 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 229960001021 lactose monohydrate Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229960000540 polacrilin potassium Drugs 0.000 claims 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000019448 polyvinylpyrrolidone-vinyl acetate copolymer Nutrition 0.000 claims 1
- WVWZXTJUCNEUAE-UHFFFAOYSA-M potassium;1,2-bis(ethenyl)benzene;2-methylprop-2-enoate Chemical compound [K+].CC(=C)C([O-])=O.C=CC1=CC=CC=C1C=C WVWZXTJUCNEUAE-UHFFFAOYSA-M 0.000 claims 1
- 229940069328 povidone Drugs 0.000 claims 1
- 239000008213 purified water Substances 0.000 claims 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
- 239000008109 sodium starch glycolate Substances 0.000 claims 1
- 229940079832 sodium starch glycolate Drugs 0.000 claims 1
- 229920003109 sodium starch glycolate Polymers 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- 238000001665 trituration Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06009902 | 2006-05-13 | ||
| EP06121953 | 2006-10-09 | ||
| PCT/EP2007/054510 WO2007131930A1 (en) | 2006-05-13 | 2007-05-10 | Tablet formulation comprising repaglinide and metformin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009537478A JP2009537478A (ja) | 2009-10-29 |
| JP2009537478A5 true JP2009537478A5 (enExample) | 2010-07-01 |
Family
ID=38293358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009510416A Ceased JP2009537478A (ja) | 2006-05-13 | 2007-05-10 | レパグリニドとメトホルミンを含む錠剤配合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20090252790A1 (enExample) |
| EP (1) | EP2026787B1 (enExample) |
| JP (1) | JP2009537478A (enExample) |
| WO (1) | WO2007131930A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101516347A (zh) * | 2006-09-29 | 2009-08-26 | 诺沃-诺迪斯克有限公司 | 包含二甲双胍和瑞格列奈的药物制剂 |
| FI20080355A0 (fi) * | 2008-05-09 | 2008-05-09 | Atacama Labs Oy | Prosessi metforminia käsittävien tablettien valmistamiseksi |
| ES2611077T3 (es) | 2007-12-07 | 2017-05-04 | Vertex Pharmaceuticals Incorporated | Forma solida de ácido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il) ciclopropanocarboxamida)-3-metilpiridin-2-il) benzoico |
| CN101756971B (zh) * | 2008-10-09 | 2013-09-18 | 北京德众万全药物技术开发有限公司 | 一种盐酸二甲双胍瑞格列奈的口服固体药物组合物 |
| RS57926B1 (sr) * | 2009-11-13 | 2019-01-31 | Astrazeneca Ab | Formulacije tablete sa trenutnim oslobađanjem |
| RU2482846C2 (ru) * | 2011-04-12 | 2013-05-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Фармацевтическая противодиабетическая композиция и способ получения противодиабетической композиции |
| CN102319245B (zh) * | 2011-07-08 | 2014-07-09 | 杭州华东医药集团新药研究院有限公司 | 一种含有瑞格列奈和盐酸二甲双胍的组合物及其制备 |
| CN102283813B (zh) * | 2011-07-28 | 2017-05-24 | 万全万特制药江苏有限公司 | 一种含有瑞格列奈的药物组合物及其制备方法 |
| WO2013074049A1 (en) * | 2011-11-03 | 2013-05-23 | Mahmut Bilgic | Micronized metformin |
| WO2013077825A1 (en) * | 2011-11-23 | 2013-05-30 | Mahmut Bilgic | Preparation process for a formulation comprising metformin |
| CN103494816B (zh) * | 2013-09-29 | 2019-06-14 | 威海迪素制药有限公司 | 一种治疗糖尿病的药物组合物 |
| PL3068392T3 (pl) * | 2013-11-12 | 2021-07-19 | Vertex Pharmaceuticals Incorporated | Proces wytwarzania kompozycji farmaceutycznych do leczenia chorób, w których pośredniczy cftr |
| KR101545268B1 (ko) * | 2015-02-05 | 2015-08-20 | 보령제약 주식회사 | 정제 및 이의 제조방법 |
| CN105535980B (zh) * | 2015-12-24 | 2019-02-26 | 江苏豪森药业集团有限公司 | 稳定的瑞格列奈药物组合物及其制备方法 |
| JP7023186B2 (ja) * | 2017-05-29 | 2022-02-21 | 第一三共株式会社 | 認知症治療薬を含有する口腔内崩壊性錠剤 |
| TW201938147A (zh) * | 2017-12-18 | 2019-10-01 | 德商拜耳廠股份有限公司 | 阿卡波糖與甲福明之固定劑量組合錠劑配製物及其製法 |
| KR20220024559A (ko) * | 2019-06-17 | 2022-03-03 | 디에스엠 아이피 어셋츠 비.브이. | 분무 건조된 비타민 b12를 포함하는 고체 약학적 투여 형태 |
| JP7711052B2 (ja) | 2019-10-16 | 2025-07-22 | バイエル・アクチエンゲゼルシヤフト | アカルボースの改善された形成方法 |
| LT6874B (lt) | 2020-04-17 | 2021-12-10 | Lietuvos sveikatos mokslų universitetas | Valpro rūgšties ir dichloroacetato druskų derinio taikymas vėžio gydymui |
| GB2599950A (en) * | 2020-10-16 | 2022-04-20 | Zentiva Ks | Pharmaceutical compositions with low amounts of nitrosamine impurities and methods for producing the same |
| LT7129B (lt) | 2023-08-22 | 2025-03-25 | Lietuvos sveikatos mokslų universitetas | Natrio dichloroacetato ir valpro rūgšties druskų derinys, skirtas virusinėms ir bakterinėms infekcijoms, ir uždegiminėms ligoms gydyti |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3174901A (en) * | 1963-01-31 | 1965-03-23 | Jan Marcel Didier Aron Samuel | Process for the oral treatment of diabetes |
| FR2758459B1 (fr) * | 1997-01-17 | 1999-05-07 | Pharma Pass | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
| AU7906898A (en) * | 1997-06-13 | 1998-12-30 | Novo Nordisk A/S | Novel niddm regimen |
| US6559188B1 (en) * | 1999-09-17 | 2003-05-06 | Novartis Ag | Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes |
| US6878749B2 (en) * | 1999-09-17 | 2005-04-12 | Novartis Ag | Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes |
| US20010036479A1 (en) * | 2000-01-14 | 2001-11-01 | Gillian Cave | Glyburide composition |
| GB0003232D0 (en) * | 2000-02-11 | 2000-04-05 | Smithkline Beecham Plc | Novel composition |
| BRPI0206432A2 (pt) * | 2001-01-12 | 2016-10-25 | Sun Pharmaceutical Ind Ltd | métodos para administrar dois ou mais agentes terapêuticos ativos e para tratar diabetes melito ou sintomas associados com diabetes melito em um humano e sistema de liberação espaçada de medicamento |
| US20030224046A1 (en) * | 2002-06-03 | 2003-12-04 | Vinay Rao | Unit-dose combination composition for the simultaneous delivery of a short-acting and a long-acting oral hypoglycemic agent |
| US20050054731A1 (en) * | 2003-09-08 | 2005-03-10 | Franco Folli | Multi-system therapy for diabetes, the metabolic syndrome and obesity |
| AU2006311601A1 (en) * | 2005-11-07 | 2007-05-18 | Elixir Pharmaceuticals, Inc. | Combinations of metformin and meglitinide |
-
2007
- 2007-05-10 JP JP2009510416A patent/JP2009537478A/ja not_active Ceased
- 2007-05-10 US US12/300,662 patent/US20090252790A1/en not_active Abandoned
- 2007-05-10 EP EP07728962.7A patent/EP2026787B1/en not_active Not-in-force
- 2007-05-10 WO PCT/EP2007/054510 patent/WO2007131930A1/en not_active Ceased
-
2011
- 2011-09-23 US US13/241,768 patent/US20120012499A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009537478A5 (enExample) | ||
| ES2280835T3 (es) | Formulacion no higroscopica que comprende un farmaco higroscopico. | |
| JP2009545560A5 (enExample) | ||
| US20090186086A1 (en) | Solid multilayer oral dosage forms | |
| CN103127109B (zh) | 含达比加群酯或其盐和水合物的药用组合 | |
| JP2003504324A5 (enExample) | ||
| CA2601955A1 (en) | Pharmaceutical composition comprising an omega-carboxyaryl substituted diphenyl urea for the treatment of cancer | |
| JP6301934B2 (ja) | チカグレロルを含む固形経口医薬製剤 | |
| US20170056365A1 (en) | Dapagliflozin compositions | |
| JP6399115B2 (ja) | アンギオテンシンｉｉ拮抗作用を有する化合物を含有する固形医薬組成物 | |
| JP2011500811A5 (enExample) | ||
| JP2012502902A (ja) | アデホビルジピボキシルの安定化した固体分散体及びその製造方法 | |
| JP2010120959A5 (enExample) | ||
| JP2009541239A5 (enExample) | ||
| CN101854921B (zh) | 用于口服施用ppi的药物制剂 | |
| WO2014058047A1 (ja) | カルシウム拮抗薬／アンジオテンシンｉｉ受容体拮抗薬含有医薬製剤の製造方法 | |
| CN102846573B (zh) | 水飞蓟宾双层缓释片及其制备方法 | |
| WO2013077825A1 (en) | Preparation process for a formulation comprising metformin | |
| WO2016079687A1 (en) | Oral pharmaceutical composition of teriflunomide | |
| JP2017520619A (ja) | セリチニブ製剤 | |
| WO2012120522A1 (en) | A taste masked chewable tablet of sildenafil | |
| WO2013077823A1 (en) | Fast-dispersing nateglinide formulations | |
| CN108721238A (zh) | 一种碳酸锂缓释片 | |
| CN104000821B (zh) | 含有替米沙坦和苯磺酸氨氯地平的口服双层片剂及其制备方法 | |
| EP2185130B1 (de) | Verfahren zur herstellung einer donepezilhydrochlorid in amorpher form enthaltenden tablette |