ES2237121T3 - Preparacion solida disgregable rapidamente. - Google Patents
Preparacion solida disgregable rapidamente.Info
- Publication number
- ES2237121T3 ES2237121T3 ES99931559T ES99931559T ES2237121T3 ES 2237121 T3 ES2237121 T3 ES 2237121T3 ES 99931559 T ES99931559 T ES 99931559T ES 99931559 T ES99931559 T ES 99931559T ES 2237121 T3 ES2237121 T3 ES 2237121T3
- Authority
- ES
- Spain
- Prior art keywords
- weight
- preparation
- parts
- sugar
- solid preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 139
- 239000007787 solid Substances 0.000 title claims abstract description 88
- -1 hydroxypropyl groups Chemical group 0.000 claims abstract description 59
- 235000000346 sugar Nutrition 0.000 claims abstract description 37
- 239000004615 ingredient Substances 0.000 claims abstract description 24
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims abstract description 7
- 239000008187 granular material Substances 0.000 claims description 73
- 238000000034 method Methods 0.000 claims description 67
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 66
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 53
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 50
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 42
- 239000002831 pharmacologic agent Substances 0.000 claims description 29
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 22
- 239000002253 acid Substances 0.000 claims description 21
- 235000010355 mannitol Nutrition 0.000 claims description 21
- 229930195725 Mannitol Natural products 0.000 claims description 20
- 239000000594 mannitol Substances 0.000 claims description 20
- 239000004386 Erythritol Substances 0.000 claims description 14
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 14
- 235000019414 erythritol Nutrition 0.000 claims description 14
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 14
- 229940009714 erythritol Drugs 0.000 claims description 14
- 150000007513 acids Chemical class 0.000 claims description 11
- 229960003174 lansoprazole Drugs 0.000 claims description 11
- MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 claims description 11
- 238000006467 substitution reaction Methods 0.000 claims description 11
- 150000005846 sugar alcohols Chemical group 0.000 claims description 9
- 239000002245 particle Substances 0.000 description 57
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- 239000000203 mixture Substances 0.000 description 36
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- 229940079593 drug Drugs 0.000 description 27
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 21
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 17
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 17
- 229920003169 water-soluble polymer Polymers 0.000 description 17
- 239000008213 purified water Substances 0.000 description 16
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 15
- 239000007888 film coating Substances 0.000 description 15
- 238000009501 film coating Methods 0.000 description 15
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 14
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- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 14
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
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- 229910017053 inorganic salt Inorganic materials 0.000 description 10
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- 239000002202 Polyethylene glycol Substances 0.000 description 9
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- FZNCGRZWXLXZSZ-CIQUZCHMSA-N Voglibose Chemical group OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O FZNCGRZWXLXZSZ-CIQUZCHMSA-N 0.000 description 9
- 239000000314 lubricant Substances 0.000 description 9
- 229910052749 magnesium Inorganic materials 0.000 description 9
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 9
- 229920001223 polyethylene glycol Polymers 0.000 description 9
- 235000019698 starch Nutrition 0.000 description 9
- 239000008107 starch Substances 0.000 description 9
- 229960001729 voglibose Drugs 0.000 description 9
- 108010011485 Aspartame Proteins 0.000 description 8
- 101100288387 Caenorhabditis elegans lab-1 gene Proteins 0.000 description 8
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 8
- 239000000605 aspartame Substances 0.000 description 8
- 235000010357 aspartame Nutrition 0.000 description 8
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 8
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- 238000004090 dissolution Methods 0.000 description 8
- 239000001095 magnesium carbonate Substances 0.000 description 8
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 8
- 235000019359 magnesium stearate Nutrition 0.000 description 8
- 210000000214 mouth Anatomy 0.000 description 8
- 230000002265 prevention Effects 0.000 description 8
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 7
- 239000003513 alkali Substances 0.000 description 7
- 239000011575 calcium Substances 0.000 description 7
- 229910052791 calcium Inorganic materials 0.000 description 7
- ANEBWFXPVPTEET-UHFFFAOYSA-N manidipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN2CCN(CC2)C(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ANEBWFXPVPTEET-UHFFFAOYSA-N 0.000 description 7
- 229960003963 manidipine Drugs 0.000 description 7
- 239000000546 pharmaceutical excipient Substances 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 7
- 235000019640 taste Nutrition 0.000 description 7
- GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical group C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 239000000654 additive Substances 0.000 description 6
- 229960004543 anhydrous citric acid Drugs 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 6
- 229960004349 candesartan cilexetil Drugs 0.000 description 6
- 239000002552 dosage form Substances 0.000 description 6
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 6
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 6
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 6
- 239000011812 mixed powder Substances 0.000 description 6
- 239000000825 pharmaceutical preparation Substances 0.000 description 6
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 150000008163 sugars Chemical class 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
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- 229920001577 copolymer Polymers 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
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- 239000011734 sodium Substances 0.000 description 5
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- 229910052708 sodium Inorganic materials 0.000 description 5
- 231100000397 ulcer Toxicity 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 4
- 229920003138 Eudragit® L 30 D-55 Polymers 0.000 description 4
- 229920003163 Eudragit® NE 30 D Polymers 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
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- GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 4
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- NDLPOXTZKUMGOV-UHFFFAOYSA-N oxo(oxoferriooxy)iron hydrate Chemical compound O.O=[Fe]O[Fe]=O NDLPOXTZKUMGOV-UHFFFAOYSA-N 0.000 description 4
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- 239000005720 sucrose Substances 0.000 description 4
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 4
- 206010020772 Hypertension Diseases 0.000 description 3
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- GHUUBYQTCDQWRA-UHFFFAOYSA-N Pioglitazone hydrochloride Chemical compound Cl.N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 GHUUBYQTCDQWRA-UHFFFAOYSA-N 0.000 description 3
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Classifications
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- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Landscapes
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- Pulmonology (AREA)
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21304998 | 1998-07-28 | ||
| JP21304998 | 1998-07-28 |
Publications (1)
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| ES2237121T3 true ES2237121T3 (es) | 2005-07-16 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
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| ES99931559T Expired - Lifetime ES2237121T3 (es) | 1998-07-28 | 1999-07-27 | Preparacion solida disgregable rapidamente. |
| ES05075132T Expired - Lifetime ES2347968T3 (es) | 1998-07-28 | 1999-07-27 | Preparacion solida que se disgrega rapidamente. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05075132T Expired - Lifetime ES2347968T3 (es) | 1998-07-28 | 1999-07-27 | Preparacion solida que se disgrega rapidamente. |
Country Status (19)
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| EP (2) | EP1100469B1 (enExample) |
| JP (3) | JP3404648B2 (enExample) |
| KR (1) | KR100536783B1 (enExample) |
| CN (1) | CN1149077C (enExample) |
| AR (2) | AR019935A1 (enExample) |
| AT (2) | ATE481090T1 (enExample) |
| AU (1) | AU4802099A (enExample) |
| CA (3) | CA2581111A1 (enExample) |
| CY (1) | CY1110988T1 (enExample) |
| DE (2) | DE69942777D1 (enExample) |
| DK (2) | DK1100469T3 (enExample) |
| ES (2) | ES2237121T3 (enExample) |
| MY (2) | MY154010A (enExample) |
| PT (2) | PT1100469E (enExample) |
| SI (1) | SI1100469T1 (enExample) |
| TW (2) | TW585786B (enExample) |
| WO (1) | WO2000006126A1 (enExample) |
| ZA (1) | ZA200100285B (enExample) |
Families Citing this family (137)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2323680C (en) | 1998-05-18 | 2007-05-22 | Takeda Chemical Industries, Ltd. | Orally disintegrable tablets |
| CA2581111A1 (en) * | 1998-07-28 | 2000-02-10 | Takeda Pharmaceutical Company Limited | Rapidly disintegrable solid preparation |
| JP2001058944A (ja) * | 1999-06-18 | 2001-03-06 | Takeda Chem Ind Ltd | 速崩壊性固形製剤 |
| AU5248900A (en) | 1999-06-18 | 2001-01-09 | Takeda Chemical Industries Ltd. | Quickly disintegrating solid preparations |
| DE60110666T2 (de) | 2000-03-17 | 2006-02-02 | Shin-Etsu Chemical Co., Ltd. | Feste Zubereitung enthaltend niedersubstituierte Hydroxypropylcellulose und Herstellungsverfahren |
| CA2403594A1 (en) * | 2000-03-27 | 2002-09-18 | Kyowa Hakko Kogyo Co., Ltd. | Granules having good taking property |
| WO2001076565A1 (fr) * | 2000-04-12 | 2001-10-18 | Banyu Pharmaceutical Co., Ltd. | Compositions et preparations se desintegrant dans la cavite buccale |
| US6316029B1 (en) * | 2000-05-18 | 2001-11-13 | Flak Pharma International, Ltd. | Rapidly disintegrating solid oral dosage form |
| JP4840549B2 (ja) * | 2000-11-20 | 2011-12-21 | トーアエイヨー株式会社 | 安定な血管拡張剤及びその製造方法 |
| EP1341528B1 (en) * | 2000-12-07 | 2012-01-18 | Nycomed GmbH | Rapidly disintegrating tablet comprising an acid-labile active ingredient |
| BR0207297A (pt) | 2001-02-15 | 2005-04-19 | King Pharmaceuticals Inc | Composição farmacêutica em forma sólida e método de preparar uma forma de dosagem sólida de um ingrediente farmaceuticamente ativo |
| ATE472319T1 (de) * | 2001-02-15 | 2010-07-15 | Mitsubishi Tanabe Pharma Corp | Tabletten, die in der mundhöhle schnell zerfallen |
| US20030224047A1 (en) * | 2001-02-15 | 2003-12-04 | Franz G. Andrew | Levothyroxine compositions and methods |
| WO2002092058A1 (fr) * | 2001-05-15 | 2002-11-21 | Takeda Chemical Industries, Ltd. | Preparation solide se desintegrant rapidement |
| EP1405621B1 (en) | 2001-06-20 | 2011-05-11 | Takeda Pharmaceutical Company Limited | Method of manufacturing tablet |
| WO2003007968A1 (en) * | 2001-07-17 | 2003-01-30 | Sun Pharmaceutical Industries Ltd. | A cardiotonic composition |
| US7101569B2 (en) | 2001-08-14 | 2006-09-05 | Franz G Andrew | Methods of administering levothyroxine pharmaceutical compositions |
| JPWO2003028706A1 (ja) * | 2001-09-28 | 2005-01-13 | 株式会社三和化学研究所 | 有核型速溶崩壊性成型品 |
| CA2463690C (en) | 2001-10-17 | 2011-08-23 | Takeda Chemical Industries, Ltd. | Granules containing acid-unstable chemical in large amount |
| JP4108605B2 (ja) * | 2001-11-13 | 2008-06-25 | 協和醗酵工業株式会社 | アミノ酸含有口腔内速崩壊錠及びその製造方法 |
| JP2003238393A (ja) * | 2002-02-15 | 2003-08-27 | Otsuka Pharmaceut Co Ltd | 施錠性が改善された錠剤及びその製造方法 |
| US20030181488A1 (en) | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof |
| DE10209982A1 (de) * | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma | Oral zu applizierende Darreichungsform für schwerlösliche basische Wirkstoffe |
| CO5400144A1 (es) * | 2002-03-11 | 2004-05-31 | Novartis Ag | Compuestos organicos |
| EP1551457A1 (en) * | 2002-07-16 | 2005-07-13 | Elan Pharma International Limited | Liquid dosage compositions of stable nanoparticulate active agents |
| US20040018990A1 (en) * | 2002-07-25 | 2004-01-29 | Harvey Rosner | Treatment of obesity |
| EP1555024B1 (en) * | 2002-10-02 | 2010-09-29 | Meiji Seika Kaisha Ltd. | Antibacterial medicinal composition of enhanced oral absorptivity |
| UA80991C2 (en) | 2002-10-07 | 2007-11-26 | Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes | |
| MY148805A (en) | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
| JP4493970B2 (ja) * | 2002-10-16 | 2010-06-30 | 武田薬品工業株式会社 | 持続性製剤 |
| EP2596792A1 (en) | 2002-10-16 | 2013-05-29 | Takeda Pharmaceutical Company Limited | Stable solid preparations |
| US20050220870A1 (en) * | 2003-02-20 | 2005-10-06 | Bonnie Hepburn | Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid |
| EP1759692A3 (en) * | 2003-03-10 | 2007-09-12 | Novartis AG | Taste-masked solid veterinary compositions |
| US8449911B2 (en) | 2003-03-12 | 2013-05-28 | Takeda Pharmaceutical Company Limited | Drug composition having active ingredient adhered at high concentration to spherical core |
| EP1631263B1 (fr) | 2003-06-06 | 2014-02-26 | Ethypharm | Comprime orodispersible multicouche |
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| JP2006528181A (ja) * | 2003-07-18 | 2006-12-14 | サンタラス インコーポレイティッド | 酸分泌を阻害するために有用な薬学的製剤ならびにそれらを作製および使用する方法 |
| US7838029B1 (en) | 2003-07-31 | 2010-11-23 | Watson Laboratories, Inc. | Mirtazapine solid dosage forms |
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| JP4767492B2 (ja) * | 2003-12-25 | 2011-09-07 | ライオン株式会社 | 高分子被覆粒子の製造方法、高分子被覆粒子、並びにこれを用いた圧縮成形品 |
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| US8815916B2 (en) | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
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| CA2582299A1 (en) * | 2004-10-05 | 2006-04-13 | Altana Pharma Ag | Oral pharmaceutical preparation for proton pump antagonists |
| CN101068546A (zh) * | 2004-10-06 | 2007-11-07 | 卫材R&D管理有限公司 | 医药组合物及其制造方法以及医药组合物中的二氢吡啶类化合物的稳定化方法 |
| US20060160871A1 (en) * | 2004-12-07 | 2006-07-20 | Nektar Therapeutics | Stable non-crystalline formulation comprising losartan |
| DK1843754T3 (da) * | 2005-01-26 | 2011-11-21 | Lek Pharmaceuticals | Ny farmaceutisk sammensætning indeholdende candesartan-cilexetil som lipofilt krystallinsk stof |
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| KR100730393B1 (ko) * | 2005-06-10 | 2007-06-20 | 한국콜마 주식회사 | 이부프로펜 및 아르기닌을 함유하는 약학 조성물의제조방법 |
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- 1999-07-27 TW TW088112661A patent/TW585786B/zh not_active IP Right Cessation
- 1999-07-27 AT AT99931559T patent/ATE291418T1/de active
- 1999-07-27 WO PCT/JP1999/004015 patent/WO2000006126A1/en not_active Ceased
- 1999-07-27 CA CA002525555A patent/CA2525555A1/en not_active Withdrawn
- 1999-07-27 TW TW091134035A patent/TWI257311B/zh not_active IP Right Cessation
- 1999-07-27 EP EP99931559A patent/EP1100469B1/en not_active Expired - Lifetime
- 1999-07-27 US US11/403,799 patent/US20060182802A1/en not_active Abandoned
- 1999-07-27 DE DE69942777T patent/DE69942777D1/de not_active Expired - Lifetime
- 1999-07-27 CA CA002338792A patent/CA2338792C/en not_active Expired - Lifetime
- 1999-07-27 AU AU48020/99A patent/AU4802099A/en not_active Abandoned
- 1999-07-27 DK DK05075132.0T patent/DK1561458T3/da active
- 1999-07-27 EP EP05075132A patent/EP1561458B1/en not_active Expired - Lifetime
- 1999-07-27 MY MYPI9903159 patent/MY151098A/en unknown
- 1999-07-27 ES ES05075132T patent/ES2347968T3/es not_active Expired - Lifetime
- 1999-07-27 PT PT99931559T patent/PT1100469E/pt unknown
- 1999-07-27 DE DE69924381T patent/DE69924381T2/de not_active Expired - Lifetime
- 1999-07-27 SI SI9930784T patent/SI1100469T1/xx unknown
- 1999-07-27 PT PT05075132T patent/PT1561458E/pt unknown
- 1999-07-27 CN CNB998089699A patent/CN1149077C/zh not_active Expired - Lifetime
-
2000
- 2000-05-12 JP JP2000139628A patent/JP4573397B2/ja not_active Expired - Lifetime
-
2001
- 2001-01-10 ZA ZA200100285A patent/ZA200100285B/en unknown
- 2001-03-07 US US09/800,839 patent/US7070805B2/en not_active Expired - Fee Related
-
2007
- 2007-06-28 US US11/823,603 patent/US20070254031A1/en not_active Abandoned
-
2010
- 2010-03-05 JP JP2010049539A patent/JP2010132709A/ja not_active Withdrawn
- 2010-12-10 CY CY20101101146T patent/CY1110988T1/el unknown
-
2011
- 2011-03-01 AR ARP110100626A patent/AR080436A2/es not_active Application Discontinuation
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